Experience in Reconstructive Surgery of Craniomaxillofacial Deformities: With Osteomesh, Eleven Years Experience

1985 ◽  
Vol 55 ◽  
Author(s):  
Mutaz B. Habal ◽  
Donald L. Leake
Keyword(s):  
Bone Graft ◽  
Reconstructive Surgery ◽  
Composite Graft ◽  
The Body ◽  
Autogenous Bone ◽  
Alloplastic Material ◽  
Skull Defect ◽  
Alloplastic Materials ◽  
The Individual ◽  
Autogenous Bone Grafts

ABSTRACTThe best possible implantable biomaterial for bony contour abnormalities is autogenous bone grafts. However, some conditions may be present that require use of alloplastic materials. Such alloplastic material must be inert and there should be no reaction in the body to it. The composite graft described in this chapter is a combination of the two different materials described. To have a better take, the bone graft used is ground with a craniotome, and then mixed with blood. This produces an inductive matrix that promotes osteoneogenesis. The alloplastic material is a tray or a template where the bone is placed “in”, “on”, or “under” the implant to allow for complete solidification and better healing. The material used is polyetherurethane-impregnated terephthalate (Dacon) also referred to as osteomesh (R) (Xomed Corporation, Jacksonville, Florida). In a few instances the osteomesh was removed and we noted complete solidification of the bone (resembling skull in the case of the skull defect). For over eleven years, since the success in the experimental animal [1], this composite graft was used in clinical situations with good success [2] in over 100 patients. These patients treated were selected and a strict set of indications and contraindications were instituted and implemented, prior to the applications of this treatment in the individual patient.

Onlay Bone Augmentation with an Osteoinductive Implant

1996 ◽  
Vol 105 (7) ◽  
pp. 568-573 ◽  
Author(s):  
Hugh E. Hetherington ◽  
Michael R. Morris ◽  
Jeffrey O. Hollinger ◽  
William R. Panje
Keyword(s):  
Bone Density ◽  
Local Reaction ◽  
Autogenous Bone ◽  
Bone Augmentation ◽  
Bone Replacement ◽  
Alloplastic Materials ◽  
Significant Difference ◽  
New Zealand White Rabbits ◽  
Contour Defects ◽  
Autogenous Bone Grafts

The repair of contour defects of craniofacial bone can be accomplished by several methods, including autogenous bone grafts, demineralized bone, and alloplastic materials. The objective of this study was to assess a biodegradable, xenogeneic, osteoinductive implant for craniofacial onlay bone augmentation. Twelve New Zealand White rabbits each had craniofacial onlays consisting of three experimental materials: 1) autograft; 2) allogeneic, demineralized block implant; and 3) partially purified osteoinductive protein (osteogenin) with allogeneic collagen and 50:50 poly(DL-lactide-co-glycolide). Implants with host bone were recovered after 20 weeks and assessed by histomorphometric methods. There was no evidence of adverse local reaction to the three treatments. No significant difference in bone replacement or bone density resulting from each of the implant types was demonstrated. In conclusion, the osteoinductive implants were well tolerated, and over the 20-week period they appeared to maintain their contour as onlays.

scholarly journals Reconstruction of maxillary anterior defect using autogenous bone graft-A case report.

2019 ◽  
Author(s):  
R Muthunagai ◽  
Mudit Agarwal ◽  
R Sivasankary
Keyword(s):  
Bone Graft ◽  
Gold Standard ◽  
Autogenous Bone Graft ◽  
Autogenous Bone ◽  
Defect Classification ◽  
Autogenous Bone Grafting ◽  
Synthetic Materials ◽  
Alloplastic Materials ◽  
Maxillary Defect ◽  
Osseous Defects

Maxilla-mandibular discontinuity produces severe cosmetic and functional deformities. There are many options available for the reconstruction of the maxilla-mandibular osseous defects. Alloplastic materials like organic calcium salts or synthetic materials such as methylmethacylate, proplast and Teflon and larger reconstruction plates, have all been used for reconstruction with varying degrees of success. At present, autogenous bone grafting is the gold standard and mainstay for maxilla-mandibular bony reconstruction. Key Words- Autogenous bone graft, Maxillary defect, Classification

Development of a Synthetic Tissue Engineered 3D Printed Calciumalkaliphosphate-Based Bone Graft with Homogenously Distributed Osteoblasts and Mineralizing Bone Matrix In Vitro

2016 ◽  
Vol 720 ◽  
pp. 82-89 ◽  
Author(s):  
Doaa Adel-Khattab ◽  
Francesca Giacomini ◽  
Barbara Peleska ◽  
Renate Gildenhaar ◽  
Georg Berger ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Compressive Strength ◽  
Bone Graft ◽  
Bone Matrix ◽  
Autogenous Bone ◽  
Synthetic Bone ◽  
Synthetic Bone Graft ◽  
Autogenous Bone Grafts

Over the last decade there have been increasing efforts to develop adequate 3D scaffolds for bone tissue engineering from bioactive ceramics with 3D printing emerging as a promising technology. The overall objective of the present study was to generate a tissue engineered synthetic bone graft with homogenously distributed osteoblasts and mineralizing bone matrix in vitro, thereby mimicking the advantageous properties of autogenous bone grafts and facilitating usage for reconstructing segmental discontinuity defects in vivo. To this end, 3D scaffolds were developed from a silica containing calciumalkaliorthophosphate (code: GB9S14) utilizing two different fabrication processes, first a replica technique (SSM), and second 3D printing (RP). The mechanical and physical properties of the scaffolds (porosity, compressive strength, solubility) and their potential to facilitate homogenous colonization by osteogenic cells and extracellular bone matrix formation throughout the porous scaffold architecture prior to in vivo implantation were examined. To this end, murine osteoblastic cells (MT3T3-E1) were dynamically seeded and cultured for 7 days on both scaffold types under perfusion with two different concentrations of 1.5 and 3x106 cells per ml. The amount of cells and extracellular matrix formed and osteogenic marker expression were evaluated using hard tissue histology, immunohistochemical and histomorphometric analysis. SSM scaffolds (SSMS) displayed a significantly greater total porosity (86.9%) than RP scaffolds (RPS) (50%), while RPS exhibited significantly more open micropores, greater compressive strength and silica release. RPS seeded with a 3x106 cells per ml displayed greatest cell and extracellular matrix formation, mineralization and osteocalcin expression. In conclusion, RPS displayed superior mechanical and biological properties and facilitated generating a tissue engineered synthetic bone graft in vitro, which mimics the advantageous properties of autogenous bone grafts, by containing homogenously distributed terminally differentiated osteoblasts and mineralizing bone matrix and therefore is suitable for subsequent in vivo implantation for regenerating segmental discontinuity bone defects.

Computerized Tomographic Evaluation of Symphyseal Donor Sites Used in the Reconstruction of the Posterior Maxilla: A Case Report of 2 Patients

2011 ◽  
Vol 37 (1) ◽  
pp. 65-71 ◽  
Author(s):  
Jun-Beom Park
Keyword(s):  
Bone Graft ◽  
Dimensional Change ◽  
Bone Grafts ◽  
Long Term Results ◽  
Autogenous Bone ◽  
Posterior Maxilla ◽  
Donor Area ◽  
Ct Analysis ◽  
Autogenous Bone Grafts

Abstract Autogenous bone grafts are commonly used for reconstruction of the deficient maxillary alveolar ridge. Mandibular ramus, symphysis, extraction sites, and retromolar sites are the most common sources for harvesting autogenous bone grafts from intraoral regions. Several authors have used computerized tomography (CT) to evaluate the dimensional change of bone graft, but there are limited reports evaluating donor sites for autogenous bone. In this report, 2 patients were treated with autogenous bone graft from the mandibular symphysis. Postoperative CT scans were used to evaluate the radiographic change in the symphyseal area. The patients treated with autogenous bone showed uneventful healing at the donor and recipient sites and good acceptance of the procedure. At the final evaluation, CT analysis demonstrated a persisting radiolucency in the donor area, even though the defect size was reduced. Further evaluation may be needed to evaluate the progress of remineralization and long-term results.

Effectiveness of rhBMP-2 versus iliac autogenous bone graft in reconstructive surgery of cleft patients. An umbrella review

2021 ◽  
Author(s):  
Pedro Henrique da Hora Sales ◽  
Olavo Barbosa de Oliveira Neto ◽  
Fernando José Camello de Lima ◽  
Alessandra de Albuquerque Tavares Carvalho ◽  
Jair Carneiro Leão
Keyword(s):  
Bone Graft ◽  
Reconstructive Surgery ◽  
Autogenous Bone Graft ◽  
Autogenous Bone ◽  
Umbrella Review

scholarly journals Anterior Mandibular Composite Graft for Regeneration of Knife-Edge Ridges in Implant Surgery: A Treatment Case Report

2020 ◽  
Author(s):  
Isa Abdi ◽  
Donya Maleki
Keyword(s):  
Case Report ◽  
Bone Graft ◽  
Composite Graft ◽  
Autogenous Bone ◽  
Knife Edge ◽  
Posterior Teeth ◽  
Mucosal Flap ◽  
Simultaneous Extraction ◽  
Implant Placement ◽  
Adequate Blood Supply

Implant insertion into an atrophic knife-edge ridge with non-simultaneous extraction of anterior and posterior teeth is challenging; this is why bone regeneration before implant placement is of great importance. One of the best sources for reconstruction is an intraoral autogenous bone graft. A composite bone graft is a combination of autogenic bone and mucosal flap that provides adequate blood supply and fixation compared to conventional (from the mandibular symphysis or ramus) and extraoral bone grafts.

Effect of Different Storage Media on the Regenerative Potential of Autogenous Bone Grafts: A Histomorphometrical Analysis in Rabbits

2013 ◽  
Vol 39 (6) ◽  
pp. 635-642 ◽  
Author(s):  
Flaviana Soares Rocha ◽  
Jonas Dantas Batista ◽  
Darceny Zanetta-Barbosa ◽  
Paula Dechichi
Keyword(s):  
Bone Graft ◽  
Bone Grafts ◽  
Saline Group ◽  
Histological Evaluation ◽  
Autogenous Bone ◽  
Air Exposure ◽  
Recipient Site ◽  
Storage Media ◽  
Graft Area ◽  
Autogenous Bone Grafts

The success of autogenous bone graft is related to the graft cell viability. In bone-grafting procedures, harvested grafts are often maintained in extraoral media while the recipient site is prepared. The aim of this study was to evaluate in vivo the effect of storage media over autogenous bone grafts during the transsurgical time. Two grafts were removed bilaterally from the calvaria of 18 rabbits. One graft was immediately fixed in the mandibular angle (control group), and the other was maintained in air exposure (dry group), 0.9% NaCl solution (saline group), or platelet-poor plasma (PPP group) during 30 minutes and stabilized in the symmetrical location of control grafts. After 28 days, the animals were euthanized and the bone fragments were removed, demineralized, and embedded in paraffin. Histological evaluation was performed under light microscope. Empty lacunae and bone graft area quantification were carried out for the sections. The histomorphometrical analysis revealed reduction of the graft area and increase of empty lacunae in the dry group when compared with control. No significant differences were found in the number of empty lacunae or bone graft area between the saline group and its control and also between the PPP group and its control. The dry group showed more empty lacunae and less graft area than the saline and PPP groups. In accordance with the results, PPP and physiologic solution demonstrated osteocyte preservation and bone graft area maintenance, being satisfactory storage media for autogenous bone grafts during the transsurgical period.

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