Onlay Bone Augmentation with an Osteoinductive Implant

1996 ◽  
Vol 105 (7) ◽  
pp. 568-573 ◽  
Author(s):  
Hugh E. Hetherington ◽  
Michael R. Morris ◽  
Jeffrey O. Hollinger ◽  
William R. Panje
Keyword(s):  
Bone Density ◽  
Local Reaction ◽  
Autogenous Bone ◽  
Bone Augmentation ◽  
Bone Replacement ◽  
Alloplastic Materials ◽  
Significant Difference ◽  
New Zealand White Rabbits ◽  
Contour Defects ◽  
Autogenous Bone Grafts

The repair of contour defects of craniofacial bone can be accomplished by several methods, including autogenous bone grafts, demineralized bone, and alloplastic materials. The objective of this study was to assess a biodegradable, xenogeneic, osteoinductive implant for craniofacial onlay bone augmentation. Twelve New Zealand White rabbits each had craniofacial onlays consisting of three experimental materials: 1) autograft; 2) allogeneic, demineralized block implant; and 3) partially purified osteoinductive protein (osteogenin) with allogeneic collagen and 50:50 poly(DL-lactide-co-glycolide). Implants with host bone were recovered after 20 weeks and assessed by histomorphometric methods. There was no evidence of adverse local reaction to the three treatments. No significant difference in bone replacement or bone density resulting from each of the implant types was demonstrated. In conclusion, the osteoinductive implants were well tolerated, and over the 20-week period they appeared to maintain their contour as onlays.

scholarly journals Autogenous Chin Block Grafts in the Aesthetic Zone: A 20-Year Follow-Up Case Report

2020 ◽  
Vol 2020 ◽  
pp. 1-6 ◽  
Author(s):  
Carlo Maiorana ◽  
Susanna Ferrario ◽  
Pier Paolo Poli ◽  
Mattia Manfredini
Keyword(s):  
Autogenous Bone ◽  
Bone Augmentation ◽  
Reliable Technique ◽  
Implant Placement ◽  
Osseointegrated Implants ◽  
Clinical And Radiological Outcome ◽  
The Aesthetic ◽  
Autogenous Bone Grafts

The successful use of osseointegrated implants in the treatment of partial or complete edentulism requires a sufficient bone support. Whenever rehabilitation in atrophic edentulous areas is needed, bone augmentation procedures are recommended. The aim is to provide adequate amount of supporting bone to achieve a prosthetically guided implant placement. This in turn leads to functional and aesthetic improvements that can be maintained on the long term. Bone grafting of the atrophic site can be performed either prior to implant placement or at the time of implantation. Irrespective of the timing, bone augmentation by means of autogenous bone grafts is a reliable technique, as confirmed by several studies. On the other hand, long-term evidence on the use of autogenous chin block grafts in preprosthetic implant surgery is still scarce. Thus, the purpose of the present case is to report the 20-year clinical and radiological outcome of autogenous chin block grafts used to augment a bilateral defect due to agenesis of the upper lateral incisors for implant placement purposes.

Experience in Reconstructive Surgery of Craniomaxillofacial Deformities: With Osteomesh, Eleven Years Experience

1985 ◽  
Vol 55 ◽  
Author(s):  
Mutaz B. Habal ◽  
Donald L. Leake
Keyword(s):  
Bone Graft ◽  
Reconstructive Surgery ◽  
Composite Graft ◽  
The Body ◽  
Autogenous Bone ◽  
Alloplastic Material ◽  
Skull Defect ◽  
Alloplastic Materials ◽  
The Individual ◽  
Autogenous Bone Grafts

ABSTRACTThe best possible implantable biomaterial for bony contour abnormalities is autogenous bone grafts. However, some conditions may be present that require use of alloplastic materials. Such alloplastic material must be inert and there should be no reaction in the body to it. The composite graft described in this chapter is a combination of the two different materials described. To have a better take, the bone graft used is ground with a craniotome, and then mixed with blood. This produces an inductive matrix that promotes osteoneogenesis. The alloplastic material is a tray or a template where the bone is placed “in”, “on”, or “under” the implant to allow for complete solidification and better healing. The material used is polyetherurethane-impregnated terephthalate (Dacon) also referred to as osteomesh (R) (Xomed Corporation, Jacksonville, Florida). In a few instances the osteomesh was removed and we noted complete solidification of the bone (resembling skull in the case of the skull defect). For over eleven years, since the success in the experimental animal [1], this composite graft was used in clinical situations with good success [2] in over 100 patients. These patients treated were selected and a strict set of indications and contraindications were instituted and implemented, prior to the applications of this treatment in the individual patient.

scholarly journals Replacement Process of Carbonate Apatite by Alveolar Bone in a Rat Extraction Socket

Materials ◽  
2021 ◽  
Vol 14 (16) ◽  
pp. 4457
Author(s):  
Xiaoxu Zhang ◽  
Ikiru Atsuta ◽  
Ikue Narimatsu ◽  
Nobuyuki Ueda ◽  
Ryosuke Takahashi ◽  
...  
Keyword(s):  
Bone Formation ◽  
Alveolar Bone ◽  
Autogenous Bone ◽  
Control Group ◽  
Tartrate Resistant Acid Phosphatase ◽  
Carbonate Apatite ◽  
Micro Computed Tomography ◽  
Extraction Socket ◽  
Bone Replacement ◽  
Significant Difference

The objective of this study was to investigate a bone graft substitute containing carbonate apatite (CO3Ap) to analyze bone replacement and the state of bone formation in vitro and in vivo compared with autogenous bone (AB) or control. An osteoclast precursor cell line was cultured with AB or CO3Ap, and morphological analysis using scanning electron microscopy and a tartrate-resistant acid phosphatase activity assay were performed. The right maxillary first and second molars of Wistar rats were extracted and compensated by AB or CO3Ap granules. Following implantation, the bone formation state was evaluated after 3, 5, 7, 14, and 28 days of surgery by micro-computed tomography and immunohistostaining. The osteoclast-like cell morphology was typical with many cell protrusions in the AB and CO3Ap groups. Additionally, the number of osteoclast-like cells formed in the culture increased in each group; however, there was no significant difference between the AB and CO3Ap groups. Five days after tooth extraction, osteoclasts were observed near CO3Ap. The bone thickness in the CO3Ap group was significantly increased than that in the control group and the bone formation in the CO3Ap group increased by the same level as that in the AB group. CO3Ap is gradually absorbed by osteoclasts in the extraction socket and is easily replaced by alveolar bone. The process of bone replacement by osteoclasts is similar to that of autologous bone. By observing the process of bone replacement in more detail, it may be possible to gain a better understanding of the bone formation and control the amount of bone after surgery.

Histomorphometric Analysis of Bone Repair in Critical Size Defect in Rats Calvaria Treated with Hydroxyapatite and Zinc-Containing Hydroxyapatite 5%

2008 ◽  
Vol 396-398 ◽  
pp. 15-18 ◽  
Author(s):  
G.V.O. Fernandes ◽  
Monica Calasans-Maia ◽  
F.F. Mitri ◽  
Vagner Gonçalves Bernardo ◽  
Antonella M. Rossi ◽  
...  
Keyword(s):  
Bone Repair ◽  
Critical Size ◽  
Autogenous Bone ◽  
Control Group ◽  
Histomorphometric Analysis ◽  
Critical Size Defect ◽  
Treatment Groups ◽  
Alloplastic Materials ◽  
Significant Difference ◽  
Long Time

Biomaterials for treatment of bone defects have been studied for a long time. Alloplastic materials, mainly hydroxyapatite (HA), are under intense investigation due to its biocompatibility and osteoconductive properties. The HA can be modified by the incorporation of bivalent cations as Zn2+ known as a positive effectors for bone repair. The purpose of this study was to evaluate comparatively the effectiveness of 5% zinc-containing hydroxyapatite (ZnHA) in the treatment of critical size defect (CSD) in rat’s calvaria. CSD (8mm diameter) created in the skull of forty-five Wistar rats were filled with autogenous bone, HA and ZnHA. Skulls harvested after 30, 90 and 180 days were submitted to histological processing for paraffin embedding. Sections of 5 µm-thick stained with hematoxylin and eosin (HE) allowed histomorphometric analysis. The area of neoformed bone increased (p<0.001) from 30 to 180 days irrespective to treatment groups. ZnHA and the control group showed a large at 180 days but no significant difference compared to HA. Therefore, we concluded that both biomaterials are biocompatibles and osteoconductors, promoting new bone formation and apposition of bone on the surface throughout the periods and the addition of zinc improved the osteogenesis.

The Repair and Healing of Two Traumatic Ilial Body Fractures Adjacent to Cemented Total Hip Acetabular Components

1992 ◽  
Vol 05 (02) ◽  
pp. 85-89
Author(s):  
P. K. Shires ◽  
T. L. Dew
Keyword(s):  
Internal Fixation ◽  
Cancellous Bone ◽  
Surgical Techniques ◽  
Autogenous Bone ◽  
Cancellous Bone Graft ◽  
Standard Methods ◽  
Intravenous Antibiotics ◽  
Prophylactic Use ◽  
Acetabular Components ◽  
Autogenous Bone Grafts

SummaryThis report has documented the repair and healing of two ilial fractures in dogs which were compounded by the presence of a cemented acetabular prosthesis. While specific recommendations can not be made from such a small number of cases, the information presented herein suggests that such fractures will heal without complication if aseptic surgical techniques and standard methods of internal fixation are employed. The authors strongly recommend the prophylactic use of intravenous antibiotics and the placement of cancellous bone graft when the repair of such fractures is attempted.Two traumatic ilial fractures involving the cement/bone interface of acetabular prostheses were repaired using lag screws, cerclage wires, and autogenous bone grafts. The fractures healed and ambulatory function was regained.

scholarly journals Autogenous bone augmentation from the zygomatic alveolar crest: a volumetric retrospective analysis in the maxilla

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Irina Kuster ◽  
Livia Osterwalder ◽  
Silvio Valdec ◽  
Bernd Stadlinger ◽  
Maximilian E. H. Wagner ◽  
...  
Keyword(s):  
Gold Standard ◽  
Donor Site ◽  
Bone Defects ◽  
Donor Site Morbidity ◽  
Bone Volume ◽  
Autogenous Bone ◽  
Bone Augmentation ◽  
Maximum Volume ◽  
Alveolar Crest ◽  
Good Access

Abstract Background Autogenous bone augmentation is the gold standard for the treatment of extended bone defects prior to implantation. Bone augmentation from the zygomatic crest is a valuable option with several advantages, but the current literature for this treatment is scant. The aim of this study was to evaluate the increase in bone volume after locoregional bone augmentation using autogenous bone from the zygomatic alveolar crest as well as the complications and success rate. Results Analysis of the augmented bone volume in seven patients showed a maximum volume gain of 0.97 cm3. An average of 0.54 cm3 of autogenous bone (SD 0.24 cm3; median: 0.54 cm3) was augmented. Implantation following bone augmentation was possible in all cases. Complications occurred in three patients. Conclusion The zygomatic alveolar crest is a valuable donor site for autogenous alveolar onlay grafting in a locoregional area such as the maxillary front. Low donor site morbidity, good access, and its suitable convexity make it a beneficial choice for autogenous bone augmentation.

scholarly journals A meta-analysis indicating extra-short implants (≤ 6 mm) as an alternative to longer implants (≥ 8 mm) with bone augmentation

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xiaoran Yu ◽  
Ruogu Xu ◽  
Zhengchuan Zhang ◽  
Yang Yang ◽  
Feilong Deng
Keyword(s):  
Survival Rate ◽  
Clinical Outcomes ◽  
Meta Analysis ◽  
Risk Of Bias ◽  
Bone Augmentation ◽  
Moderate Quality ◽  
Short Implants ◽  
Significant Difference ◽  
Complications Rate

AbstractExtra-short implants, of which clinical outcomes remain controversial, are becoming a potential option rather than long implants with bone augmentation in atrophic partially or totally edentulous jaws. The aim of this study was to compare the clinical outcomes and complications between extra-short implants (≤ 6 mm) and longer implants (≥ 8 mm), with and without bone augmentation procedures. Electronic (via PubMed, Web of Science, EMBASE, Cochrane Library) and manual searches were performed for articles published prior to November 2020. Only randomized controlled trials (RCTs) comparing extra-short implants and longer implants in the same study reporting survival rate with an observation period at least 1 year were selected. Data extraction and methodological quality (AMSTAR-2) was assessed by 2 authors independently. A quantitative meta-analysis was performed to compare the survival rate, marginal bone loss (MBL), biological and prosthesis complication rate. Risk of bias was assessed with the Cochrane risk of bias tool 2 and the quality of evidence was determined with the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach. 21 RCTs were included, among which two were prior registered and 14 adhered to the CONSORT statement. No significant difference was found in the survival rate between extra-short and longer implant at 1- and 3-years follow-up (RR: 1.002, CI 0.981 to 1.024, P = 0.856 at 1 year; RR: 0.996, CI 0.968 to 1.025, P  = 0.772 at 3 years, moderate quality), while longer implants had significantly higher survival rate than extra-short implants (RR: 0.970, CI 0.944 to 0.997, P < 0.05) at 5 years. Interestingly, no significant difference was observed when bone augmentations were performed at 5 years (RR: 0.977, CI 0.945 to 1.010, P = 0.171 for reconstructed bone; RR: 0.955, CI 0.912 to 0.999, P < 0.05 for native bone). Both the MBL (from implant placement) (WMD: − 0.22, CI − 0.277 to − 0.164, P < 0.01, low quality) and biological complications rate (RR: 0.321, CI 0.243 to 0.422, P < 0.01, moderate quality) preferred extra-short implants. However, there was no significant difference in terms of MBL (from prosthesis restoration) (WMD: 0.016, CI − 0.036 to 0.068, P = 0.555, moderate quality) or prosthesis complications rate (RR: 1.308, CI 0.893 to 1.915, P = 0.168, moderate quality). The placement of extra-short implants could be an acceptable alternative to longer implants in atrophic posterior arch. Further high-quality RCTs with a long follow-up period are required to corroborate the present outcomes.Registration number The review protocol was registered with PROSPERO (CRD42020155342).

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