Molecularly Imprinted Polymers Used as Optical Waveguides for the Detection of Fluorescent Analytes

2002 ◽  
Vol 723 ◽  
Author(s):  
Jennifer J. Brazier ◽  
Mingdi Yan ◽  
Scott Prahl ◽  
Yin-Chu Chen
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Optical Waveguides ◽  
Soft Lithography ◽  
The Novel ◽  
Binding Studies ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Novel Approach ◽  
Micromolding In Capillaries ◽  
Fiber Optic Waveguides

AbstractThis article demonstrates the novel approach of fabricating molecularly imprinted polymers (MIPs) as fiber optic waveguides for the detection of fluorescent analytes. Combining a polyurethane system and the soft lithography technique of micromolding in capillaries (MIMIC), polymer waveguides of 50 νm and 100 νm dimensions were patterned onto a silicon substrate. Laser coupling into small waveguide segments has been verified visually. Binding experiments using the waveguides are currently being explored. Some preliminary binding studies have been performed, however, for smaller, freestanding filaments of sizes consistent with conventionally prepared MIP particles. Using fluorimetry measurements, templated fibers of 20 νm dimension preferentially bound the analyte molecules by a factor of 1.5 as compared to control polymers.

scholarly journals “Monoclonal-type” plastic antibodies for SARS-CoV-2 based on Molecularly Imprinted Polymers

2020 ◽  
Author(s):  
Ortensia Ilaria Parisi ◽  
Marco Dattilo ◽  
Francesco Patitucci ◽  
Rocco Malivindi ◽  
Vincenzo Pezzi ◽  
...  
Keyword(s):  
Light Scattering ◽  
Molecularly Imprinted Polymers ◽  
Polymeric Nanoparticles ◽  
Infection Process ◽  
Spike Protein ◽  
The Novel ◽  
Receptor Binding Domain ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Novel Coronavirus

Summary of the ideaOur idea is focused on the development of “monoclonal-type” plastic antibodies based on Molecularly Imprinted Polymers (MIPs) able to selectively bind a portion of the novel coronavirus SARS-CoV-2 spike protein to block its function and, thus, the infection process. Molecular Imprinting, indeed, represents a very promising and attractive technology for the synthesis of MIPs characterized by specific recognition abilities for a target molecule. Given these characteristics, MIPs can be considered tailor-made synthetic antibodies obtained by a templating process.In the present study, the developed imprinted polymeric nanoparticles were characterized in terms of particles size and distribution by Dynamic Light Scattering (DLS) and the imprinting effect and selectivity were investigated by performing binding experiments using the receptor-binding domain (RBD) of the novel coronavirus and the RBD of SARS-CoV spike protein, respectively. Finally, the hemocompatibility of the prepared MIP-based plastic antibodies was also evaluated.

Materials Strategies for Advanced Nano Technology

2007 ◽  
Vol 1004 ◽  
Author(s):  
Kyung Choi
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Soft Lithography ◽  
Functional Polymers ◽  
High Fidelity ◽  
Nano Technology ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Synthetic Receptor ◽  
Receptor Sites ◽  
Molecular Imprinting Technique

AbstractWe demonstrate functional microfabrications generated using photocurable functional polymers. We synthesized photocurable silicon elastomers, which can be useful for high fidelity, nano-scale soft lithography. ‘Elastic photopatterns’ generated by using the designed photocuarble silicon elastomers was presented. Molecularly imprinted polymers (MIP) are produced by “molecular imprinting technique”, which is a general protocol for the preparation of “synthetic receptor sites”. We then used the MIP's system for functional pattern fabrications to improve the sensitivity of molecular recognitions. Those functional microfabrications are beneficial to develop actual devices with high performances.

Novel β- Cyclodextrin Functional Monomers and its Application for Molecularly Imprinted Polymers

2015 ◽  
Vol 1101 ◽  
pp. 256-260 ◽  
Author(s):  
Feng Feng ◽  
Zhi Min Liu ◽  
Zhi Gang Xu
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Chemical Properties ◽  
Development Trend ◽  
The Novel ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
Imprinted Polymers ◽  
Cavity Structure ◽  
Recognition Ability ◽  
Physical And Chemical

β-Cyclodextrin shows good molecular recognition ability for its unique physical and chemical properties and suitable cavity structure. The selective recognition can be further improved if β-cyclodextrin combines with molecularly imprinted technique. In this paper, the novel β-cyclodextrin functional monomers were introduced. And the preparation and application of molecularly imprinted polymers based on β-cyclodextrin functional monomers were reviewed. The development trend of β-cyclodextrin molecularly imprinted polymers were also prospected.

Synthesis and Evaluation of a Molecularly Imprinted Polymer Selective to 2,4,6-Trichlorophenol

2004 ◽  
Vol 57 (8) ◽  
pp. 759 ◽  
Author(s):  
Lachlan Schwarz ◽  
Clovia I. Holdsworth ◽  
Adam McCluskey ◽  
Michael C. Bowyer
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Molecularly Imprinted Polymers ◽  
Competitive Binding ◽  
Imprinted Polymer ◽  
Binding Studies ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Target Molecule ◽  
High Preference ◽  
Structural Analogues

Molecularly imprinted polymers (MIPs) selective for the phenolic contaminant 2,4,6-trichlorophenol (2,4,6-TCP) were prepared and evaluated in three porogens of differing character (hexane, acetonitrile, dichloromethane). Rebinding of 2,4,6-TCP was found to be most effective in dichloromethane (imprinting factor: 13.2). Competitive binding studies performed against a range of close structural analogues showed a high preference for the target molecule, although partial recognition towards 2,4-dichlorophenol was also observed. Specificity was found to be dependent upon the presence of ring chlorine on the target, which suggested that these atoms participate in secondary binding interactions that are essential for successful recognition in the polymer cavity.

Nanopatterning molecularly imprinted polymers by soft lithography: a hierarchical approach

Lab on a Chip ◽  
2010 ◽  
Vol 10 (10) ◽  
pp. 1316 ◽  
Author(s):  
Hélène Lalo ◽  
Cédric Ayela ◽  
Etienne Dague ◽  
Christophe Vieu ◽  
Karsten Haupt
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Soft Lithography ◽  
Hierarchical Approach ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

scholarly journals A novel approach to identify molecular binding to the influenza virus H5N1: screening using molecularly imprinted polymers (MIPs)

MedChemComm ◽  
2014 ◽  
Vol 5 (5) ◽  
pp. 617-621 ◽  
Author(s):  
Thipvaree Wangchareansak ◽  
Arunee Thitithanyanont ◽  
Daungmanee Chuakheaw ◽  
M. Paul Gleeson ◽  
Peter A. Lieberzeit ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Molecularly Imprinted Polymers ◽  
Influenza A ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Molecular Binding ◽  
Virus H5n1 ◽  
Novel Approach ◽  
Allosteric Mechanisms

We investigate whether a molecularly imprinted polymer (MIP) of influenza A H5N1 could be used to help identify molecules capable of binding to, and inhibiting the function of the virus,viaeither competitive or allosteric mechanisms.

scholarly journals Smart Bandage Based on Molecularly Imprinted Polymers (MIPs) for Diclofenac Controlled Release

2018 ◽  
Vol 11 (4) ◽  
pp. 92 ◽  
Author(s):  
Ortensia Parisi ◽  
Mariarosa Ruffo ◽  
Luca Scrivano ◽  
Rocco Malivindi ◽  
Antonio Vassallo ◽  
...  
Keyword(s):  
Controlled Release ◽  
Molecularly Imprinted Polymers ◽  
Specific Binding ◽  
Skin Irritation ◽  
Spherical Particles ◽  
Batch Adsorption ◽  
Scatchard Analysis ◽  
Binding Studies ◽  
Molecularly Imprinted ◽  
Imprinted Polymers

The aim of the present study was the development of a “smart bandage” for the topical administration of diclofenac, in the treatment of localized painful and inflammatory conditions, incorporating Molecularly Imprinted Polymers (MIPs) for the controlled release of this anti-inflammatory drug. For this purpose, MIP spherical particles were synthesized by precipitation polymerization, loaded with the therapeutic agent and incorporated into the bandage surface. Batch adsorption binding studies were performed to investigate the adsorption isotherms and kinetics and the selective recognition abilities of the synthesized MIP. In vitro diffusion studies were also carried out using Franz cells and the obtained results were reported as percentage of the diffused dose, cumulative amount of diffused drug, steady-state drug flux and permeability coefficient. Moreover, the biocompatibility of the developed device was evaluated using the EPISKIN™ model. The Scatchard analysis indicated that the prepared MIP is characterized by the presence of specific binding sites for diclofenac, which are not present in the corresponding non-imprinted polymer, and the obtained results confirmed both the ability of the prepared bandage to prolong the drug release and the absence of skin irritation reactions. Therefore, these results support the potential application of the developed “smart bandage” as topical device for diclofenac sustained release.

scholarly journals Engineering molecularly imprinted polymers (MIPs) for the selective extraction and quantification of the novel psychoactive substance (NPS) methoxphenidine and its regioisomers

The Analyst ◽  
2018 ◽  
Vol 143 (9) ◽  
pp. 2002-2007 ◽  
Author(s):  
J. W. Lowdon ◽  
S. M. O. Alkirkit ◽  
R. E. Mewis ◽  
D. Fulton ◽  
C. E. Banks ◽  
...  
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Selective Extraction ◽  
The Novel ◽  
Psychoactive Substance ◽  
Specific Detection ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Novel Psychoactive Substance

The first developed Molecularly Imprinted Polymers (MIPs) for the specific detection of methoxphenidine (MXP) and its regioisomers.

Design and Development of Plastic Antibodies against SARS-CoV-2 RBD based on Molecularly Imprinted Polymers that Inhibit In Vitro Virus Infection

Nanoscale ◽  
2021 ◽  
Author(s):  
Ortensia Ilaria Parisi ◽  
Marco Dattilo ◽  
Francesco Patitucci ◽  
Rocco Malivindi ◽  
Serena Delbue ◽  
...  
Keyword(s):  
Virus Infection ◽  
Molecularly Imprinted Polymers ◽  
Research Study ◽  
Spike Protein ◽  
The Novel ◽  
Design And Development ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Novel Coronavirus

The present research study reports the development of plastic antibodies based on Molecularly Imprinted Polymers (MIPs) able to selectively bind a portion of the novel coronavirus SARS-CoV-2 spike protein. Indeed,...

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