Pregnancy and labors at women with a hysteromyoma after reconstructive operations

2017 ◽  
pp. 54-55
Author(s):  
O.V. Zhovtenko ◽  
Keyword(s):  
High Risk ◽  
Pregnant Women ◽  
Key Words ◽  
Clinical Course ◽  
Perinatal Outcomes ◽  
Morphological Features ◽  
Perinatal Pathology ◽  
Fetoplacental Complex ◽  
Reconstructive Operations

The objective: depression of frequency of obstetric and perinatal pathology at women who transferred before pregnancy a conservative myomectomy із on the basis of studying the clinical-ekhografical, hemodynamic, endocrinologic, metabolic and morphological features a condition of fetoplacental complex, and also improvement of algorithm of diagnostic and treatment-and-prophylactic actions. Patients and methods. Features of a clinical course of pregnancy and labors at 266 women with a hysteromyoma (in the anamnesis there was no expeditious treatment), which were divided into two groups depending on the sizes of myomatous knots are studied. Features of a clinical course of pregnancy and labors at 126 women who transferred a conservative myomectomy before pregnancy are studied. Pregnant women were divided into two groups from a technique of the performed operation and tactics of conducting pregnancy. Results. Results of the conducted researches testify to high risk of development of perinatal pathology at women with a hysteromyoma who were operated before pregnancy in volume of a conservative myomectomy. Conclusion. Use of the algorithm of diagnostic and treatment-and-prophylactic actions added with us allows to improve perinatal outcomes of a delivery of women of group of high risk. Key words: hysteromyoma, reconstructive operations, pregnancy, labors.

Prophylaxis of obstetric and perinatal pathology at women with pathological increase of body weight during pregnancy

2018 ◽  
pp. 7-79
Author(s):  
S.Yu. Vdovichenko ◽  
◽  
T.D. Fakhrutdinova ◽  
Keyword(s):  
Health Care ◽  
Body Weight ◽  
Pregnant Women ◽  
Key Words ◽  
Perinatal Outcomes ◽  
Perinatal Complications ◽  
Perinatal Pathology ◽  
Fetoplacental Complex ◽  
The Right ◽  
Selection Of

The objective: depression of obstetric and perinatal complications at pregnant women with pathological increase of body weight during pregnancy on the basis of studying of clinical-functional, endocrinologic, metabolic, morphological features of condition of fetoplacental complex and development of advanced algorithm of treatment-and-prophylactic actions. Materials and methods. We conducted examination of 264 patients who consisted on the account concerning pregnancy in female consultations of Kiev. By a method of selection of 178 women were included in retrospective research and 86 – in prospective. The main group was made by 39 pregnant women with whom led individual discussions, control – 142 women, that received traditional references in female consultation. Results. Use of the algorithm improved by us allows to improve obstetric (decrease of frequency of a preeclampsia by 12.3%; anomalies of a patrimonial deyalnost for 8.4%) and perinatal outcomes (depression of level of an asphyxia at a delivery for 9.4% and post-natal adaptation for 7.8%) deliveries of women with an excessive increase of body weight during pregnancy. Conclusion. The received results grant the right to recommend the algorithm improved by us for wide use in practical health care. Key words: obstetric and perinatal pathology, pathological increase of body weight, prophylaxis.

Optimization of diagnostics and tactics of maintaining pregnant women with benign tumors and tumorous formations of ovaries

2017 ◽  
pp. 63-65
Author(s):  
V.I. Boyko ◽  
◽  
N.P. Sukhostavets ◽  
Keyword(s):  
High Risk ◽  
Cesarean Section ◽  
Pregnant Women ◽  
Key Words ◽  
High Frequency ◽  
Clinical Course ◽  
Perinatal Outcomes ◽  
Benign Tumors ◽  
Placental Dysfunction

The objective: optimization of diagnostics and tactics of conducting pregnancy at women with benign tumors and tumorous formations of ovaries by improvement of diagnostic and treatment-and-prophylactic actions. Patients and methods. 129 patients in various durations of gestation from which 104 were with benign tumors and tumorous formations of ovaries were surveyed. Results. The clinical course of pregnancy at course of pregnancy at women with benign tumors and tumorous formations of ovaries is characterized by the high frequency of threat of discontinuing in І (49.7%) that ІІ trimesters (50.8%). Level of other complications depends on maintaining tactics, and it considerably vichy at refusal of women of expeditious treatment and their conservative maintaining: placental dysfunction – 44.0% and 16.2%; fetus distress – 30.0% and 6.7%; delivery by operation of cesarean section – 33.3% and 10.8%; disturbances of post-natal adaptation of newborns – 9.5% and 6.8% respectively. Conclusion. The improved and introduced algorithm of maintaining women with benign tumors and tumorous formations of ovaries allows to improve obstetric and perinatal outcomes of delivery of women of group of high risk. Key words: benign tumors and tumorous formations of ovaries, pregnancy, maintaining tactics.

Diagnostics, prophylaxis and forecasting of perinatal pathology at anomalies of placentation (retrochorial hematomas and anomalies of locating of placenta)

2017 ◽  
pp. 60-62
Author(s):  
S.A. Kuritsyna ◽  
Keyword(s):  
Pregnant Women ◽  
Key Words ◽  
Retrospective Analysis ◽  
Perinatal Mortality ◽  
Clinical Course ◽  
Premature Births ◽  
Placental Dysfunction ◽  
Perinatal Pathology ◽  
Case Rate ◽  
Two Stages

The objective: depression of frequency of perinatal pathology at various pathology of placentation (retrochorial hematomas and anomalies of locating of placenta) on the basis of improvement and introduction of algorithm of diagnostic, treatment-and-prophylactic and prognostic actions. Patients and methods. Researches were conducted in two stages - on 1 us at first the retrospective analysis of clinical course of pregnancy and labors at 100 women (retrospective group) with a retrochorial hematoma is carried out, and then 150 pregnant women who were divided into three subgroups prospective are surveyed. At the 2 stage 250 women entered research – 2 group, from which 200 – with misplaced of placenta and 50 – with normal. Results. Use of the algorithm of maintaining women improved by us with retrochorial hematomas allows to reduce the frequency of early genesial losses (from 25.0% to 10.0%), to improve perinatal results (lack of cases of perinatal losses in the prospective researches and 40,0‰ in retrospective, to reduce perinatal case rate (from 30.0% to 15.6%), and also promotes pregnancy prolongation. At women with misplaced of placenta allows to reduce the frequency of placental dysfunction from 42.0% to 28.0%; fetus arrests of development – from 30.0% to 18,0%; premature births – from 18.0% to 8.0%; perinatal mortality – from 30.0‰ to 10.0‰ and a post-natal case rate – from 28.0% to 16.0%. Conclusion. Results of the conducted researches testify that prophylaxis of perinatal pathology at women with various options of pathology of placentation to which we referred existence of retrochorial hematomas and placenta misplaced, has to have complex stage-by-stage character taking into account results of clinical and additional methods of researches, and also on the basis of introduction improved by us to algorithm. Key words: retrochorial hematoma, placenta misplaced, perinatal pathology, prophylaxis.

Decompensation placental dysfunction: diagnostics and delivery tactics

2017 ◽  
pp. 66-68
Author(s):  
V.I. Boyko ◽  
◽  
S.A. Tkachenko ◽  
Keyword(s):  
Pregnant Women ◽  
Key Words ◽  
Retrospective Analysis ◽  
Control Group ◽  
Present Stage ◽  
Placental Dysfunction ◽  
Perinatal Pathology ◽  
Delivery Times ◽  
Case Rate ◽  
Major Factors

The objective: depression of frequency of perinatal pathology at women with decompensation form of placental dysfunction by improvement of the main diagnostic and treatment-and-prophylactic actions. Patients and methods. 154 pregnant women in gestation term from 22 to 40 weeks were surveyed. Depending on features of course of pregnancy and families of all surveyed it was divided into 4 groups. The group of the retrospective analysis was made by 45 pregnant women with decompensation placental dysfuction, the group of prospective research included 109 pregnant women of whom the main group was made by 38 women with decompensation form of placental dysfunction, the group of comparison included 47 pregnant women with the compensated form of placental dysfunction. The control group was made by 24 pregnant women with the uncomplicated course of pregnancy and labors. The complex of the conducted researches included clinical, ehografical, dopplerometrical, laboratory, morphological and statistical methods. Results. Use of advanced algorithm of diagnostic and treatment-and-prophylactic actions allows to increase efficiency of diagnostics of decompensation form of placental dysfunction for 33.3%, and rational tactics of a delivery leads to depression of perinatal pathology for 22.7%. Conclusion. Decompensation placental dysfuction is one of the main reasons for perinatal mortality and a case rate at the present stage. Use of the algorithm of diagnostic and treatment-and-prophylactic actions improved by us allows major factors of risk of this complication and the indication for change of tactics and delivery times. Key words: decompensation placental dysfunction, diagnostics, delivery tactics.

Features of obstetric and perinatal pathology at women with an undifferentiated dysplasia of connecting tissue

2017 ◽  
pp. 96-98
Author(s):  
A.L. Kostiuk ◽  
Keyword(s):  
Pregnant Women ◽  
Key Words ◽  
High Frequency ◽  
Clinical Laboratory ◽  
Perinatal Pathology

The objective: to study features of obstetric and perinitalny pathology at women with undifferentiated dysplasia of a connecting tissue. Patients and methods. 100 patients with clinical-laboratory signs of an undifferentiated dysplasia of connecting tissue are surveyed. On the basis of the received results of the patient were divided into two groups: the main – 50 women (expression of і6 points) whom regarded as patients with the expressed undifferentiated dysplasia of connecting tissue, and group of comparison – 50 women (expression <6 points) whom regarded as patients without the expressed undifferentiated dysplasia of connecting tissue. Results. Results of the conducted researches testify to the high frequency of obstetric and perinatal pathology at pregnant women with clinical-laboratory and functional signs of an undifferentiated dysplasia of connecting tissue. Conclusion. The received results are the basis for algorithm improvement the diagnostical and treatment-and-prophylactic actions at women with an undifferentiated dysplasia of connecting tissue. Key words: undifferentiated dysplasia of connecting tissue, obstetric and perinatal pathology.

INOVASIA Study: A Randomized Open Controlled Trial to Evaluate Pravastatin to Prevent Preeclampsia and its Effects on sFlt1/PLGF Levels

2021 ◽  
Author(s):  
Muhammad Ilham Aldika Akbar ◽  
Angelina Yosediputra ◽  
Raditya Eri Pratama ◽  
Nur Lailatul Fadhilah ◽  
Sulistyowati Sulistyowati ◽  
...  
Keyword(s):  
High Risk ◽  
Pregnant Women ◽  
Controlled Trial ◽  
Intervention Group ◽  
Perinatal Outcomes ◽  
Neonatal Morbidity ◽  
Clinical Risk Factor ◽  
Control Group ◽  
Significant Deterioration ◽  
Plgf Ratio

Objectives To evaluate the effect of pravastatin to prevent preeclampsia (PE) in pregnant women at a high risk of developing preeclampsia and the maternal and perinatal outcomes and the sFlt1/PLGF ratio. Study Design This is an open labelled RCT part of INOVASIA trial. Pregnant women at a high risk of developing PE were recruited and randomized into an intervention group (40) and a control group (40). The inclusion criteria consisted of pregnant women with positive clinical risk factor and abnormal uterine artery doppler examination at 10-20 weeks gestational age. The control group received low dose aspirin (80 mg/day) and calcium (1 g/day), while the intervention group received additional pravastatin (20 mg twice daily) starting from 14-20 weeks gestation until delivery. Research blood samples were collected before the first dose of pravastatin and before delivery. The main outcome was the rate of maternal preeclampsia, maternal-perinatal outcomes, and sFlt-1, PLGF, sFlt-1/PlGF ratio and sEng levels. Results The rate of preeclampsia was (non-significantly) lower in the pravastatin group compared with the control group (17.5% vs 35%). The pravastatin group also had a (non-significant) lower rate of severe preeclampsia, HELLP syndrome, acute kidney injury and severe hypertension. The rate of (iatrogenic) preterm delivery was significantly (p=0.048) lower in the pravastatin group (n=4) compared with the controls (n=12). Neonates in the pravastatin group had significantly higher birthweights (2931 + 537 vs 2625 + 872 g; p=0.006), lower Apgar scores < 7 (2.5 vs 27.5%, p=0.002), composite neonatal morbidity (0 vs 20%, p=0.005) and NICU admission rates (0 vs 15%, p=0.026). All biomarkers show a significant deterioration in the control group compared with non significant changes in the pravastatin group. Conclusions Pravastatin holds promise in the secondary prevention of preeclampsia and placenta-mediated adverse perinatal outcomes by improving the angiogenic imbalance.

scholarly journals INOVASIA Study: A Randomized Open Controlled Trial to Evaluate Prophylactic Pravastatin in the Prevention of Preeclampsia and its Effects on sFlt1/PLGF Levels in Pregnant Women at High Risk of Developing Preeclampsia

2021 ◽  
Author(s):  
Muhammad Ilham Aldika Akbar ◽  
Angelina Yosediputra ◽  
Raditya Eri Pratama ◽  
Nur Lailatul Fadhilah ◽  
Sulistyowati Sulistyowati ◽  
...  
Keyword(s):  
High Risk ◽  
Pregnant Women ◽  
Controlled Trial ◽  
Intervention Group ◽  
Perinatal Outcomes ◽  
Clinical Risk Factor ◽  
Control Group ◽  
Significant Deterioration ◽  
Secondary Outcomes ◽  
Plgf Ratio

Objectives The study aim is to evaluate the effect of pravastatin to prevent preeclampsia (PE) in pregnant women at a high risk of developing preeclampsia and the maternal and perinatal outcomes and the sFlt1/PLGF ratio in the Surabaya cohort of the INOVASIA trial. Setting This study involved 2 academic hospital (a tertiary and secondary center) in Surabaya, Indonesia. Participants Pregnant women at a high risk of developing PE were recruited and randomized into an intervention group (40) and a control group (40). The inclusion criteria consisted of pregnant women with positive clinical risk factor and abnormal uterine artery doppler examination at 10-20 weeks gestational age. Inteventions The control group received low dose aspirin (80 mg/day) and calcium (1 g/day), while the intervention group received additional pravastatin (20 mg twice daily) starting from 14-20 weeks gestation until delivery. Research blood samples were collected before the first dose of pravastatin, and just before delivery. Primary and Secondary Outcomes The primary outcome was the rate of maternal preeclampsia, secondary outcomes included maternal-perinatal outcomes and sFlt-1, PLGF, sFlt-1/PlGF ratio and sEng levels. Results The rate of preeclampsia was (non-significantly) lower in the pravastatin group compared with the control group (17.5% vs 35%). The pravastatin group also had a (non-significant) lower rate of severe preeclampsia, HELLP syndrome, acute kidney injury and severe hypertension. The rate of (iatrogenic) preterm delivery was significantly lower (p 0.048) in the pravastatin group (n=4) compared with the controls (n=12). Neonates in the pravastatin group had significantly higher birthweights, higher Apgar scores, and lower composite neonatal morbidity and NICU admission rates. All biomarkers show a significant deterioration in the control group compared with non-significant changes in the pravastatin group. Conclusions Pravastatin holds promise in the secondary prevention of preeclampsia and placenta-mediated adverse perinatal outcomes by improving the anti-angiogenic/pro-angiogenic imbalance. Trial Registration Clinical Trial Gov (ID: NCT03648970)

scholarly journals Experience in using dipyridamole in the group of pregnant women with a high risk of perinatal pathology

2018 ◽  
pp. 98-100
Author(s):  
T. M. Sokolova ◽  
I. O. Marinkin ◽  
V. M. Kuleshov ◽  
K. Yu. Makarov
Keyword(s):  
High Risk ◽  
Pregnant Women ◽  
Perinatal Pathology

Fetus arrest of development at prematurely born pregnancy: diagnostics and prophylaxis of perinatal pathology

2017 ◽  
pp. 124-126
Author(s):  
V.I. Boyko ◽  
◽  
O.I. Butenko ◽  
Keyword(s):  
Preterm Birth ◽  
Pregnant Women ◽  
Fetal Distress ◽  
Perinatal Complications ◽  
Perinatal Pathology ◽  
Fetoplacental Complex ◽  
Adaptive Agent ◽  
Threatened Abortion ◽  
Early Preterm Birth ◽  
Structural Mechanisms

The objective: to reduce the frequency of perinatal complications at pregnant women with a fetus arrest of development the pregnant at prematurely born pregnancy by improvement of the main diagnostic and treatment-and-prophylactic actions. Patients and methods. prospective research was conducted, we surveyed 120 patients, among which 90 pregnant women with syndrome of an arrest of development of a fetus who were divided by method of casual choice into two groups. Results. The use of the proposed treatment and preventive methods in pregnant women with premature birth at FGR allowed to significantly reduce the incidence of threatened abortion and placental dysfunction 1.3 times, genital tract disorders microbiocenosis 1.4 times, premature rupture of membranes by 1.4 times, the severity FGR syndrome 1.6 times, fetal distress is 1.3 times, 1.2 times of the COP, severe asphyxia in 3 times, intra-amniotic infection is 1.5 times, to change the structure of preterm birth (to prevent early preterm birth in 22–28 weeks). The overall incidence of infants in the early neonatal period, these pregnant women was significantly reduced by 1.3 times (p<0.05), but there were no perinatal loss. Conclusion. The received results: when using the technique of complex correction developed by us the dizadaptation of disturbances in fetoplacental complex at women who received algorithm offered by us, all structural mechanisms of adaptation of placenta which allow to keep morphometric and diffuse indicators of vorsine tree at level with firmness compensations that is the most important adaptive agent which allows to support vital activity of fetus turn on and to prevent development of serious degree of delay of its development. Key words: fetus arrest of development, prematurely born pregnancy, diagnostics, prophylaxis.

Optimization of tactics of maintaining women with the cicatrix on a uterus with use family focused technologies and partner labors

2016 ◽  
pp. 82-84
Author(s):  
I.P. Netskar ◽  
Keyword(s):  
Health Care ◽  
Cesarean Section ◽  
Clinical Course ◽  
Married Couple ◽  
Functional Condition ◽  
Perinatal Pathology ◽  
Fetoplacental Complex ◽  
The Family ◽  
Individual Preparation ◽  
The Right

The objective: ising of frequency of a delivery of per vias naturales and depression of perinatal pathology at women with the cicatrix on uterus on the basis of improvement and introduction of a technique of individual preparation of a married couple during pregnancy and at a delivery. Patients and methods. Complex examination of 150 patients with the cicatrix on a uterus who were distributed on two groups is conducted: 1 group was made by 100 women with the cicatrix on a uterus by which repeated Cesarean section was executed; the 2nd group included 50 women with the cicatrix on a uterus, delivery through natural patrimonial ways. Results. Use of the family focused technologies at women with the cicatrix on a uterus allows to improve the clinical course of pregnancy, to reduce the frequency of disturbances of a functional condition of a fetoplacental complex, to normalize the psychoemotional status and to promote a delivery through natural patrimonial ways without deterioration of indicators of perinatal pathology and post-natal adaptation of newborns. Conclusion. The received results grant to us the right to recommend advanced algorithm of tactics of conducting pregnancy for wide use in practical health care. Key words: the cicatrix on a uterus, Cesarean section, partner labors.

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