Natural remedies for acute post-viral cough in children

The post-viral acute cough is the most common symptom in childhood. Consequently, the use of cough relievers is frequent. Many products for treating cough contain natural compo-nents. An ancient tradition has always established herbal medicine and honey as effective and safe means to relieve cough. Nevertheless, very few studies adequately investigated the real effectiveness and safety of natural products in treating acute cough. There is some evidence, provided by pediatric randomized controlled trials, about honey, one multicomponent product (containing Plantagolanceolata, Grindelia robusta, Helichrysum italicum, and honey), and Pelargonium sidoides. Other group of substances, including glycerol and isolated natural compounds, can help manage cough but robust evidence still lacks in children. There is an urgent need to perform rigorous studies that confirm the natural products’ efficacy and safety for relieving post-viral acute cough.Key points: Acute post-viral cough is prevalent in childhood and adolescence. There is a grow-ing interest concerning the use of natural remedies for post-viral cough. Many herbal medicines could be used satisfactorily for this issue.

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Non-pharmacological remedies for post-viral acute cough

Monaldi Archives for Chest Disease ◽

10.4081/monaldi.2021.1821 ◽

2021 ◽

Author(s):

Giorgio Ciprandi ◽

Maria Angela Tosca

Keyword(s):

Thymus Vulgaris ◽

Childhood And Adolescence ◽

Acute Cough ◽

Hedera Helix ◽

Upper Respiratory Infection ◽

Pelargonium Sidoides ◽

Natural Substances ◽

Ancient People ◽

Natural Remedies ◽

Saline Solutions

The post-viral acute cough (PAC) is a widespread symptom, mainly in childhood and adolescence, and is usually associated with an acute upper respiratory infection, namely the common cold. The use of cough relievers is, therefore, impressive, as documented by the market data. There are many medical devices and dietary supplements for treating PAC, which contain non-pharmacological components. Ancient people used traditional herbs to treat PAC. Thus, a well-established tradition considers natural remedies as an effective and safe way to relieve PAC. The herbal agents include polyphenols, flavonoids, saponins, glucosides, and alkaloids. Also, the European Medicine Agency has recognized the value of plant extracts and other natural substances to treat PAC. Nevertheless, a few studies investigated the role of non-pharmacologic remedies for PAC. There is some evidence for honey, glycerol, Althea officinalis, Drosera rotundifolia, Grindelia, Hedera helix, Pelargonium sidoides, Sambucus nigra, Thymus vulgaris, hyaluronic acid, and saline solutions. However, further rigorous studies should confirm natural products' efficacy and safety to relieve PAC.

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Comparative Efficacy and Safety of Antipsychotic Drugs for Tic Disorders: A Systematic Review and Bayesian Network Meta-Analysis

Pharmacopsychiatry ◽

10.1055/s-0043-124872 ◽

2018 ◽

Vol 52 (01) ◽

pp. 07-15 ◽

Cited By ~ 6

Author(s):

Chunsong Yang ◽

Zilong Hao ◽

Ling-Li Zhang ◽

Cai-Rong Zhu ◽

Ping Zhu ◽

...

Keyword(s):

Symptom Score ◽

Atypical Antipsychotics ◽

Antipsychotic Drugs ◽

Meta Analysis ◽

Tic Disorders ◽

Cochrane Library ◽

Efficacy And Safety ◽

Randomized Controlled ◽

Mean Differences ◽

Robust Evidence

Abstract Objective The purpose of this study was to evaluate the efficacy and safety of antipsychotic drugs for tic disorders (TDs) in a network meta-analysis. Methods PubMed, Embase, Cochrane Library, and 4 Chinese databases were searched. Randomized controlled trials (RCTs) evaluating the efficacy of antipsychotic drugs for TDs were included. Results Sixty RCTs were included. In terms of tic symptom score, compared with placebo, haloperidol, risperidone, aripiprazole, quetiapine, olanzapine, and ziprasidone can significantly improve tic symptom score (standardized mean differences [SMD] ranged from −12.32 to −3.20). Quetiapine was superior to haloperidol, pimozide, risperidone, tiapride, aripiprazole, and penfluridol for improving tic symptom score (SMD ranged from −28.24 to −7.59). Compared with tiapride, aripiprazole could significantly improve tic symptom score (SMD=−4.27). Compared with all other drugs, penfluridol was not effective. Atypical antipsychotics were generally well tolerated. Conclusions Atypical antipsychotics (risperidone and aripiprazole) appear to be the most robust evidence-based options for the treatment of TDs. Quetiapine may be a promising therapy. Ziprasidone and olanzapine are also effective, but the evidence is lacking. Further high-quality directly comparing different pharmacological treatment studies are justified.

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A Systematic Review on Vitex negundo (NIRPROMP formulations) for the Treatment of Acute Cough of Mild to Moderate Severity in Pediatric Patients

Acta Medica Philippina ◽

10.47895/amp.v54i1.1096 ◽

2020 ◽

Vol 54 (1) ◽

Author(s):

Daisy-Mae Alegado-Bagaoisan ◽

Mary Christine R. Castro ◽

Jaime M. Purificacion

Keyword(s):

Systematic Review ◽

Clinical Trials ◽

Adverse Effects ◽

Pediatric Patients ◽

Controlled Trials ◽

Vitex Negundo ◽

Efficacy And Safety ◽

Acute Cough ◽

Moderate Severity ◽

Randomized Controlled

Objective. The aim of this systematic review was to evaluate the efficacy and safety of Vitex negundo (lagundi) for the treatment of acute cough of mild to moderate severity among pediatric patients.Methods. A systematic review of randomized controlled trials (RCTs) comparing lagundi to placebo for acute cough of mild to moderate severity in children and adolescents aged two to twenty one years in ambulatory settings was performed. Authors of unpublished clinical trials with existing patent numbers were contacted and permission was obtained to access and include their studies in this review. Results. Seven studies were included, with a total of 308 participants. Lagundi increased the peak exploratory flow rate (PEFR) at the end of therapy compared with placebo but this was not statistically significant (p=0.36). The increase in PEFR was consistent with the results of the mechanistic isolated tissue studies that showed bronchodilating effect of lagundi. Studies using lagundi syrup showed decrease in the frequency of cough by 44–71%. Conclusion. Lagundi therapy in acute cough of mild to moderate severity among pediatric patients has a bronchodilating effect and decreases the frequency and duration of coughing, with no serious adverse effects.

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