scholarly journals FABRICATION OF BIODEGRADABLE POLYESTER MICROSPHERES BY ELECTROSPRAYING METHODS FOR DRUG CARRIER APPLICATION

2018 ◽  
Vol 54 (5A) ◽  
pp. 99
Author(s):  
Nguyen Vu Viet Linh
Keyword(s):  
Molecular Weight ◽  
Encapsulation Efficiency ◽  
Drug Carrier ◽  
Polymer Concentration ◽  
Loading Capacity ◽  
High Molecular Weight Polymer ◽  
Molecular Weight Polymer ◽  
Micro Particles ◽  
Morphology And Structure ◽  
Chain Entanglements

This research investigated the effects of polymer concentration, molecular weight polymer and type of polymer on the morphology of electrosprayed microparticles by Scanning Electron Microscopy. Electrospraying process has been studied to produce nano- and micro- particles for drug carrier application because of high loading capacity and high encapsulation efficiency. Controlling morphology and structure of electrosprayed particles can decide the release of drug from these particles. Particles were hollow and wrinkled semi-spheres as using low polymer concentration while wrinkled spheres as using higher polymer concentration. The electrosprayed particles obtained spherical morphology when the polymer concentration is high enough to generate significant chain entanglements. The results also indicated that high molecular weight polymer could produce spherical microspheres, even with low polymer concentration. The electrospraying process fabricated the microspheres from biodegradable PLA and PCL for drug carrier application. 

SYNTHESIS OF ELECTROSPRAYED CHITOSAN NANOPARTICLES FOR DRUG SUSTAINED RELEASE

Nano LIFE ◽  
2012 ◽  
Vol 02 (01) ◽  
pp. 1250003 ◽  
Author(s):  
DOAN VAN HONG THIEN ◽  
SHENG WEN HSIAO ◽  
MING HUA HO
Keyword(s):  
Drug Delivery ◽  
Molecular Weight ◽  
Encapsulation Efficiency ◽  
Drug Carrier ◽  
Chitosan Nanoparticles ◽  
Average Diameter ◽  
Loading Capacity ◽  
Model Drug ◽  
Size And Morphology ◽  
Two Stages

Chitosan (CS) nanoparticles for drug delivery were fabricated by an electrospraying method. The effects of CS molecular weight on electrospraying were investigated. The size and morphology of CS particles were strongly influenced by CS molecular weight. Besides, CS concentration, electrical field, acetic acid concentration, and solution feeding rate in the electrospraying process were also studied. To evaluate the potential of electrosprayed CS nanoparticles in drug delivery, indomethacin (ID) was used as a model drug, where the encapsulation efficiency, the loading capacity, and the releasing profiles were identified. The CS-ID spherical nanoparticles were fabricated by the electrospraying technique, with the average diameter of 340 nm. Zeta potential of the ID-CS particles indicated that the particles were stable in the suspension. The encapsulation efficiency (EE) and loading capacity (LC) of ID were higher for 150-kDa CS than for 310-kDa CS. The EE of ID in electrosprayed CS particles was higher than that in particles prepared by other methods. The release profiles revealed that there were two stages for releasing and the long-term delivery could be obtained in the second stage. In summary, this research optimized the electrospraying process for the fabrication of CS nanoparticles and demonstrated the potential of electrosprayed CS nanoparticles as a drug carrier.

Intrinsic viscoelasticity in thin high-molecular-weight polymer films

2014 ◽  
Vol 89 (6) ◽  
Author(s):  
Xiaoyuan Sheng ◽  
Frédéric Wintzenrieth ◽  
Katherine R. Thomas ◽  
Ullrich Steiner
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Polymer Films ◽  
High Molecular Weight Polymer ◽  
Molecular Weight Polymer

Structural studies of the capsular polysaccharide from Haemophilus pleuropneumoniae serotype 2

1987 ◽  
Vol 65 (5) ◽  
pp. 414-422 ◽  
Author(s):  
Eleonora Altman ◽  
Jean-Robert Brisson ◽  
Malcolm B. Perry
Keyword(s):  
Molecular Weight ◽  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
High Molecular Weight ◽  
Capsular Polysaccharide ◽  
Structural Studies ◽  
High Molecular Weight Polymer ◽  
Molecular Weight Polymer ◽  
Structure Formula ◽  
Nuclear Magnetic

The capsular polysaccharide of Haemophilus pleuropneumoniae serotype 2 (ATCC 27089) is composed of D-glucose (two parts), D-galactose (one part), glycerol (one part), and phosphate (one part). Hydrolysis, dephosphorylation, methylation, enzymic studies, and 1H and 13C nuclear magnetic resonance experiments showed that the polysaccharide is a high molecular weight polymer of a tetrasaccharide repeating units, linked by monophosphate diester and having the following structure:[Formula: see text]

scholarly journals Antigen valence determines the binding of nominal antigen to cytolytic T cell clones.

1985 ◽  
Vol 162 (2) ◽  
pp. 768-773 ◽  
Author(s):  
R F Siliciano ◽  
R M Colello ◽  
A D Keegan ◽  
R Z Dintzis ◽  
H M Dintzis ◽  
...  
Keyword(s):  
Molecular Weight ◽  
T Cell ◽  
High Molecular Weight ◽  
Cytotoxic T Cell ◽  
High Molecular Weight Polymer ◽  
Molecular Weight Polymer ◽  
T Cell Clones ◽  
Cell Clones ◽  
Nominal Antigen ◽  
Epitope Density

We have shown that cytotoxic T cell clones specific for the nominal antigen FL will bind high molecular weight (600,000 to 2,000,000) polyacrylamide and Ficoll polymers conjugated with 200-600 FL groups per molecule. Low molecular weight polymers (40,000) with the same epitope density did not give stable binding. A high molecular weight polymer with a lower epitope density also failed to bind. Taken together, these results suggest that a substantial degree of multivalence is a necessary factor in the stable binding of nominal antigen to T cell clones.

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