scholarly journals Antigen valence determines the binding of nominal antigen to cytolytic T cell clones.

1985 ◽  
Vol 162 (2) ◽  
pp. 768-773 ◽  
Author(s):  
R F Siliciano ◽  
R M Colello ◽  
A D Keegan ◽  
R Z Dintzis ◽  
H M Dintzis ◽  
...  
Keyword(s):  
Molecular Weight ◽  
T Cell ◽  
High Molecular Weight ◽  
Cytotoxic T Cell ◽  
High Molecular Weight Polymer ◽  
Molecular Weight Polymer ◽  
T Cell Clones ◽  
Cell Clones ◽  
Nominal Antigen ◽  
Epitope Density

We have shown that cytotoxic T cell clones specific for the nominal antigen FL will bind high molecular weight (600,000 to 2,000,000) polyacrylamide and Ficoll polymers conjugated with 200-600 FL groups per molecule. Low molecular weight polymers (40,000) with the same epitope density did not give stable binding. A high molecular weight polymer with a lower epitope density also failed to bind. Taken together, these results suggest that a substantial degree of multivalence is a necessary factor in the stable binding of nominal antigen to T cell clones.

scholarly journals Self-sparing of long-term in vitro-cloned or uncloned cytotoxic T lymphocytes.

1986 ◽  
Vol 164 (3) ◽  
pp. 962-967 ◽  
Author(s):  
M F Luciani ◽  
J F Brunet ◽  
M Suzan ◽  
F Denizot ◽  
P Golstein
Keyword(s):  
T Cell ◽  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
Cytotoxic T Cell ◽  
Cell Populations ◽  
Con A ◽  
T Cell Clones ◽  
Cell Clones

At least some long-term in vitro-cultured cytotoxic T cell clones and uncloned cell populations are able, in the presence of Con A, to lyse other cells, to be lysed by other cells, but not to lyse themselves. This as-yet-unexplained result may have implications as to the mechanism of T cell-mediated cytotoxicity.

Xenogeneic cytotoxic T-cell clones recognize alloantigenic determinants on HLA-A2

1983 ◽  
Vol 18 (5) ◽  
pp. 461-473 ◽  
Author(s):  
Victor H. Engelhard ◽  
Christopher Benjamin
Keyword(s):  
T Cell ◽  
Cytotoxic T Cell ◽  
T Cell Clones ◽  
Cell Clones

Intrinsic viscoelasticity in thin high-molecular-weight polymer films

2014 ◽  
Vol 89 (6) ◽  
Author(s):  
Xiaoyuan Sheng ◽  
Frédéric Wintzenrieth ◽  
Katherine R. Thomas ◽  
Ullrich Steiner
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Polymer Films ◽  
High Molecular Weight Polymer ◽  
Molecular Weight Polymer

scholarly journals Recognition of envelope protein by dengue virus serotype-specific human CD4+ CD8- cytotoxic T-cell clones.

1994 ◽  
Vol 68 (5) ◽  
pp. 3283-3288 ◽  
Author(s):  
P G Livingston ◽  
I Kurane ◽  
C J Lai ◽  
M Bray ◽  
F A Ennis
Keyword(s):  
T Cell ◽  
Dengue Virus ◽  
Envelope Protein ◽  
Cytotoxic T Cell ◽  
T Cell Clones ◽  
Cell Clones ◽  
Virus Serotype
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