Effect of Enamel Matrix Derivative (Emdogain) on Bone Defects in Rabbit Tibias

2004 ◽  
Vol 30 (2) ◽  
pp. 69-73 ◽  
Author(s):  
Roberto Cornelini ◽  
Antonio Scarano ◽  
Maurizio Piattelli ◽  
Sebastiano Andreana ◽  
Ugo Covani ◽  
...  
Keyword(s):  
Test Group ◽  
Inflammatory Cells ◽  
Bone Defects ◽  
Enamel Matrix Derivative ◽  
Enamel Matrix ◽  
The Right ◽  
Observation Times ◽  
Microscopy Examination ◽  
Observation Period ◽  
Matrix Derivative

Abstract The aim of this study was to assess the effect of an enamel matrix derivative (Emdogain, Biora, AB, Malmö, Sweden) on bone healing. Ten New Zealand rabbits, weighing about 2.5 kg, were used. One 8-mm bone defect was created in each tibia. The defect on the right leg was filled with Emdogain, whereas the defect on the opposite leg was left unfilled as control. A total of 20 defects were created. Five rabbits each were killed at 4 and 8 weeks with an overdose of Tanax. Block sections containing the defects were retrieved and the specimens processed for light microscopy examination. The slides were stained with acid and basic fuchsin and toluidine blue. Histologically, no differences were noted in both groups at each observation period; in the test group, remnants of the implanted Emdogain were not present at 4 weeks. Newly formed bone was detectable in both groups at all observation times. At 8 weeks, both groups showed mature bone, and in the test group the material implanted was not visible. No inflammatory cells were visible in both groups. In conclusion, our results indicate that Emdogain implanted in bone defects is fully resorbed after 4 to 8 weeks and does not adversely affect bone formation.

Treatment of Periodontal Intrabony Defects Using Enamel Matrix Derivative: Surgical Reentry After an Observation Period of at Least 5 Years

2019 ◽  
Vol 39 (4) ◽  
pp. 537-543 ◽  
Author(s):  
Vincenzo Iorio-Siciliano ◽  
Andrea Blasi ◽  
Paolo Nuzzolo ◽  
Marco Matarasso ◽  
Gaetano Isola ◽  
...  
Keyword(s):  
Enamel Matrix Derivative ◽  
Enamel Matrix ◽  
Intrabony Defects ◽  
Observation Period ◽  
Matrix Derivative

scholarly journals The role of surgical flap design (minimally invasive flap vs. extended flap with papilla preservation) on the healing of intrabony defects treated with an enamel matrix derivative: a 12-month two-center randomized controlled clinical trial

2021 ◽  
Author(s):  
Peter Windisch ◽  
Vincenzo Iorio-Siciliano ◽  
Daniel Palkovics ◽  
Luca Ramaglia ◽  
Andrea Blasi ◽  
...  
Keyword(s):  
Surgical Technique ◽  
Minimally Invasive ◽  
Test Group ◽  
Enamel Matrix Derivative ◽  
Control Group ◽  
Enamel Matrix ◽  
Intrabony Defects ◽  
Minimally Invasive Surgical ◽  
And Control ◽  
Matrix Derivative

Abstract Objectives Minimally invasive flap designs have been introduced to enhance blood clot stability and support wound healing. Limited data appear to suggest, that in intrabony defects, better clinical outcomes can be achieved by means of minimally invasive flap compared to more extended flaps. The aim of this study was to evaluate the healing of intrabony defects treated with either minimally invasive surgical flaps or with modified or simplified papilla preservation techniques in conjunction with the application of an enamel matrix derivative (EMD). Materials and methods Forty-seven subjects were randomly assigned to either test (N = 23) or control (N = 24) procedures. In the test group, the intrabony defects were accessed by means of either minimally invasive surgical technique (MIST) or modified minimally invasive surgical technique (M-MIST) according to the defect localization while the defects in the control group were treated with either the modified or simplified papilla preservation (MPP) or the simplified papilla preservation technique (SPP). EMD was used as regenerative material in all defects. The following clinical parameters were recorded at baseline and after 12 months: full-mouth plaque score (FMPS), full-mouth bleeding score (FMBS), probing depths (PD), clinical attachment level (CAL), and gingival recession (GR). Early healing index (EHI) score was assessed in both groups 1 week following the surgery. CAL gain was set as primary outcome. Results After 12 months follow-up, the CAL gain was 4.09 ± 1.68 mm in test group and 3.79 ± 1.67 mm in control group, while the PD reduction was 4.52 ± 1.34 mm and 4.04 ± 1.62 mm for test and control sites. In both groups, a minimal GR increase (0.35 ± 1.11 mm and 0.25 ± 1.03 mm) was noted. No residual PDs ≥ 6 mm were recorded in both groups. CAL gains of 4–5 mm were achieved in 30.4% and in 29.2% of test and control group, respectively. Moreover, CAL gains ≥ 6 mm were recorded in 21.7% of experimental sites and in 20.8% of control sites. No statistically significant differences in any of the evaluated parameters were found between the test and control procedures (P > 0.05). After 1 week post-surgery, a statistically significant difference (P < 0.05) between the groups was found in terms of EHI score. Conclusions Within the limits of this pilot RCT, the results have failed to show any differences in the measured parameters following treatment of intrabony defects with EMD, irrespective of the employed surgical technique. Clinical relevance In intrabony defects, the application of EMD in conjunction with either MIST/M-MIST or M-PPT/SPPT resulted in substantial clinical improvements.

scholarly journals Healing of intrabony defects following regenerative surgery by means of single-flap approach in conjunction with either hyaluronic acid or an enamel matrix derivative: a 24-month randomized controlled clinical trial

2021 ◽  
Author(s):  
Andrea Pilloni ◽  
Mariana A. Rojas ◽  
Lorenzo Marini ◽  
Paola Russo ◽  
Yoshinori Shirakata ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Test Group ◽  
Enamel Matrix Derivative ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Enamel Matrix ◽  
Randomized Controlled Clinical Trial ◽  
Intrabony Defects ◽  
Randomized Controlled ◽  
Matrix Derivative

Abstract Objectives The aim of this randomized controlled clinical trial was to compare the clinical outcomes obtained in intrabony defects following regenerative periodontal surgery using the single-flap approach (SFA) in conjunction with either hyaluronic acid (HA) or enamel matrix derivative (EMD). Materials and methods Thirty-two intrabony defects in 32 healthy subjects were randomly assigned: HA (test group) or EMD (control group). Clinical attachment level (CAL), probing depth (PD), gingival recession (REC), and bleeding on probing (BOP) were recorded at baseline,12, 18, and 24 months after surgery. Results At 24 months, both treatments resulted in statistically significant clinical improvements evidenced by PD-reduction and CAL-gain (p<0.001). The mean CAL-gain was 2.19±1.11 mm in the test and 2.94±1.12 mm in the control sites (p=0.067). PD-reduction was statistically significantly higher for the control group (4.5±0.97 mm) than the test group (3.31±0.70 mm), (p=0.001). CAL-gain ≤ 3 mm was observed in 87.5% and in 62.5% of the test and control sites, respectively. Test sites showed slightly lower REC values than the control sites. No statistically significant differences were found for BOP between treatments. Conclusions The present findings indicate that both treatments led to statistically significant clinical improvements compared to baseline, although the application of EMD resulted in statistically significantly higher PD-reduction compared to the use of HA. Clinical relevance The use of HA in conjunction with a SFA resulted in significant PD-reduction and CAL-gain, pointing to the potential clinical relevance of this material in regenerative periodontal surgery.

Enamel Matrix Derivative Promotes Reparative Processes in the Dental Pulp

2001 ◽  
Vol 15 (1) ◽  
pp. 105-107 ◽  
Author(s):  
Y. Nakamura ◽  
L. Hammarström ◽  
E. Lundberg ◽  
H. Ekdahl ◽  
K. Matsumoto ◽  
...  
Keyword(s):  
Calcium Hydroxide ◽  
Glass Ionomer Cement ◽  
Inflammatory Cells ◽  
Enamel Matrix Derivative ◽  
Enamel Matrix ◽  
Hard Tissue ◽  
Pulp Tissue ◽  
Miniature Swine ◽  
Maxillary Premolars ◽  
Matrix Derivative

During odontogenesis, amelogenins from the preameloblasts are translocated to differentiating odontoblasts in the dental papilla, suggesting that amelogenins may be associated with odontoblast changes during development. In the present study, we have explored the effects of enamel matrix derivative (EMD) on the healing of a pulpal wound. Coronal pulp tissue of permanent maxillary premolars of miniature swine were exposed through buccal class V cavities. The exposed pulp was capped with EMD. The contralateral teeth served as controls and were capped with a calcium hydroxide paste (Dycal®). The cavities were sealed with glass-ionomer cement. After 2 and 4 weeks, the histology of the teeth was analyzed. In the EMD-treated teeth, large amounts of newly formed dentin-like hard tissue with associated formative cells outlined the pulpal wound separating the cavity area from the remaining pulp tissue. Inflammatory cells were present in the wound area but not subjacent to the newly formed hard tissue. Morphometric analysis showed that the amount of hard tissue formed in EMD-treated teeth was more than twice that of the calcium-hydroxide-treated control teeth (p < 0.001), suggesting that EMD is capable of promoting reparative processes in the wounded pulp more strongly than is calcium hydroxide.

Enamel Matrix Derivative: An effective regenerative modality (A Literature Review)

2012 ◽  
Vol 2 (7) ◽  
pp. 323-325
Author(s):  
Dr. Ranjit Singh Uppal ◽  
◽  
Dr. Atamjit Singh Dr. Atamjit Singh ◽  
Dr. Rajbir Kaur ◽  
Dr. Navdeep Kaur Sodhi
Keyword(s):  
Literature Review ◽  
Enamel Matrix Derivative ◽  
Enamel Matrix ◽  
Matrix Derivative
Sign in / Sign up

Export Citation Format

Share Document