scholarly journals Postgenomic Medicine: Alternative to Biomarkers

2016 ◽  
Vol 71 (3) ◽  
Author(s):  
A. V. Lisitsa ◽  
E. A. Ponomarenko ◽  
P. G. Lokhov ◽  
A. I. Archakov
Keyword(s):  
High Performance ◽  
Technological Development ◽  
Routine Clinical Practice ◽  
Human Blood Plasma ◽  
Evidence Based ◽  
Data Intensive ◽  
Development Level ◽  
Severe Change ◽  
Based Medicine ◽  
Further Development

In the article relevance of high-performance postgenomic technologies is tackled. The intrinsic problems of the implementation of genomics, proteomics and metabolomics in routine clinical practice are considered. Further development of postgenomic medicine requires severe change in the current research approaches. Avenue for development of such approaches are illustrated by metabolome research of human blood plasma. The postgenomic biomarkers are pictured as molecular iceberg, greater part of which is inaccessible for detection with measurement methods. Due to diversity of protein forms the spectrum of molecular markers will always evaluate in terms of incompleteness and inconsistence regardless of technological development level. These properties of «big data» are typical of data intensive domains. Special computational methods are essential for data intensive analytics and hardly suitable for the evidence-based medicine.

scholarly journals Psychiatry in the future

2004 ◽  
Vol 28 (8) ◽  
pp. 277-278
Author(s):  
Frank Holloway
Keyword(s):  
Mental Health ◽  
Clinical Practice ◽  
Evidence Based Medicine ◽  
Cochrane Collaboration ◽  
Routine Clinical Practice ◽  
Evidence Based ◽  
Policy Makers ◽  
The Future ◽  
The Cochrane Collaboration ◽  
Based Medicine

In an era of evidence-based medicine, policy-makers and researchers are preoccupied by the task of ensuring that advances in research are implemented in routine clinical practice. This preoccupation has spawned a small but growing research industry of its own, with the development of resources such as the Cochrane Collaboration database and journals such as Evidence-Based Mental Health. In this paper, I adopt a philosophically quite unfashionable methodology – introspection – to address the question: how has research affected my practice?

scholarly journals Knowledge Transfer in Surgery: Skills, Process and Evaluation

2007 ◽  
Vol 89 (8) ◽  
pp. 749-753 ◽  
Author(s):  
Martin Dawes ◽  
Marko Lens
Keyword(s):  
Health Care ◽  
Knowledge Transfer ◽  
Clinical Evidence ◽  
Essential Element ◽  
Routine Clinical Practice ◽  
Evidence Based ◽  
Literature Teaching ◽  
Based Medicine ◽  
Practice Skills

INTRODUCTION Knowledge transfer is an essential element in the management of surgical health care. In a routine clinical practice, surgeons need to make changes to the health care they provide as new clinical evidence emerges. MATERIALS AND METHODS The information was derived from the authors' experience and research in evidence-based practice, searching of the literature, teaching and organisation of various national and international workshops on evidence-based medicine. DISCUSSION This manuscript discusses principles of knowledge transfer in surgery including evaluation of recommended changes that can improve quality of health care in routine surgical practice. Skills, process and evaluation are carefully described. Continuous information delivery is required to enable surgeons to improve knowledge transfer and to keep up to date their knowledge.

scholarly journals Laboratory medicine in modern teaching clinical physicians

2021 ◽  
Vol 26 ◽  
pp. 4385
Author(s):  
T. V. Vavilova ◽  
O. V. Sirotkina ◽  
N. Yu. Chernysh ◽  
V. S. Berestovskaya ◽  
Yu. I. Zhilenkova ◽  
...  
Keyword(s):  
High Performance ◽  
Laboratory Tests ◽  
Clinical Laboratory ◽  
Practical Experience ◽  
Laboratory Medicine ◽  
High Tech ◽  
Laboratory Diagnostics ◽  
Evidence Based ◽  
Technological Breakthrough ◽  
Based Medicine

At the end of the last century and, especially, in the first two decades of the 21st century, a significant technological breakthrough took place in clinical laboratory diagnostics in Russia. The transition from manual techniques to high-tech and high-performance automated systems has changed the potential of laboratory medicine. The laboratory has become a high-tech, rapidly developing branch of medical organizations. Following the changes in technology, the range of diagnostic tests began to alter, while the list of laboratory tests available grew. These dynamics are growing every year. Simple routine techniques, practiced for all patients, are complemented by more specific tests. The place of conventional routine tests has been determined by many years of practical experience, while modern analyzers allow the use of tests with a high evidence value of recommendations, which, in the context of evidence-based medicine, enable the clinician to conduct a personalized diagnostic search. At the same time, in order to use all the possibilities of laboratory medicine, the discipline Clinical Laboratory Diagnostics should be included in educational programs at different stages of a doctor's training.

scholarly journals Is the Prescription of Antidepressants for Bipolar Depression Justified from the Point of View of Evidence-Based Medicine?

Psychiatry ◽  
2020 ◽  
Vol 18 (2) ◽  
pp. 51-60
Author(s):  
S. S. Potanin ◽  
M. A. Morozova
Keyword(s):  
Clinical Practice ◽  
Evidence Based Medicine ◽  
Bipolar Depression ◽  
Routine Clinical Practice ◽  
Point Of View ◽  
Response To Therapy ◽  
Mood Stabilizers ◽  
Evidence Based ◽  
Based Medicine ◽  
High Degree

Background: prescribing antidepressants in the treatment of bipolar depression remains highly controversial due to the inconsistence between routine clinical practice and the results of controlled trials. Purpose: to assess the validity of antidepressants use in bipolar depression from the point of view of evidence-based medicine. Material: database search (Scopus and MEDLINE) followed by analysis of studies concerning the efficacy and safety of antidepressants in bipolar depression treatment. Сonclusion: the search found 23 studies. There was a high degree of inconsistency in the results, apparently related to the methodology. Only two studies compared the effectiveness of antidepressants in monotherapy with placebo, with no differences found in the study with 740 participants and in the study with 70 participants with type 2 bipolar disorder antidepressants were found to be more effective than placebo. Nevertheless, both studies had significant methodological issues. In 6 studies comparing the effectiveness of the combination of antidepressants with mood stabilizers against the combination of mood stabilizers with placebo, only the effectiveness of fluoxetine in combination with olanzapine was revealed, other antidepressants were ineffective. At the same time, studies where antidepressants were compared with each other in combination with mood stabilizers revealed a significant clinical response to therapy. Analysis of routine clinical practice studies has shown that antidepressants are prescribed very often, for about 50% of patients with bipolar depression. International guidelines for therapy differ quite widely on the use of antidepressants in bipolar depression, but in principle allow their use. Thus, despite the contradictory literature data, the use of antidepressants in bipolar depression is justified from the point of view of evidence-based medicine for certain groups of patients with taking into account risk factors.

Physical and rehabilitative medicine: fundamental principles and clinical practice

2016 ◽  
Vol 15 (6) ◽  
pp. 284-289 ◽  
Author(s):  
Gennadiy Nikolaevich Ponomarenko
Keyword(s):  
Clinical Practice ◽  
Human Body ◽  
Medical Rehabilitation ◽  
Evidence Based ◽  
Physical Medicine ◽  
Practical Medicine ◽  
Physical Methods ◽  
Methodological Approaches ◽  
Based Medicine ◽  
Further Development

This article was designed to present an overview of experimental and clinical studies making up a basis for the formulation of the fundamental principles of physical medicine. The analysis of the fundamental mechanisms of sanogenesis underlying medical rehabilitation has been undertaken which allowed to define the main lines of scientific and practical developments in physical and rehabilitative medicine as a new field of practical medicine concerned with the action of physical methods and factors on the human body when applied for the treatment and medical rehabilitation of the diseased and disabled subjects. The basic methodological approaches to this work are substantiated in the context of modern personalized and evidence-based medicine taking into consideration the totality of the currently available rehabilitative technologies and the prospects for their further development and introduction into the existing healthcare system applied in Russia.

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