Dyadic Perceptions of COVID-19 Pandemic Impact on Everyday Life

It is important to understand the effects of the COVID-19 pandemic not only on individuals’ daily lives, but also their close partners. Current literature suggests that the COVID-19 pandemic has impacted older adults’ lives in several ways, including the frequency of social interactions and change in various life habits (Lesbrasseur et al., 2021). Data from 42 middle-aged and older, long-term married or cohabitating dyads were collected as part of an ongoing study of everyday cognition and functioning among couples. Participant age ranged from 40-85+, and couples were partnered for 9-60+ years. During this study, COVID-19 pandemic impact was assessed using six items (1 = No change to 4 = Severe change) examining daily routines, medical and mental health access, social contacts, and pandemic and family-related stress; reports ranged from six to 19. On average, women reported significantly higher COVID-19 pandemic impact compared to men. For both partners, the greatest disruptions reported related to routines and social contacts. Further analysis examined COVID-19 pandemic impact in dyads. For eight dyads, both partners reported relatively lower COVID-19 impact (6-11), whereas for six dyads, both partners reported higher impact scores (14-19). Discussion focuses on within-dyad and between-dyad differences related to perceptions of the pandemic’s impact.

Anatomomopathological and immunohistochemical analyses of the spleen and lymph node of dogs seropositives for leishmaniasis in serological tests

Canine leishmaniasis (CanL) is a zoonosis caused by the protozoan of the species Leishmania infantum. The spleen and lymph nodes undergo morphological changes during CanL. This research aimed to perform an anatomopathological and immunohistochemical study of these organs in dogs reactive to leishmaniasis in the Dual-path Platform chromatographic immunoassay (DPP®) and Enzyme Immunoabsorption Assay (ELISA). Twenty-seven dogs were evaluated for anatomopathological examination with 92.6% showing changes at gross evaluation, specially splenomegaly and lymphadenomegaly. All dogs showed changes in the spleen unrelated to the parasitic load, with granulomatous splenitis being the most severe change. Diffuse cortical and paracortical hyperplasia, and hyperplasia and hypertrophy of the medullary cords were observed in the lymph node. Amastigote forms of Leishmania spp. were found in the spleen and lymph node at histopathological and immunohistochemical evaluations, with good agreement between these evaluations (k = 0.55, p = 0.00124), but no difference was observed in the parasitic intensity of these organs at immunohistochemistry (p = 0.23). It was concluded that spleen and lymph node from dogs reactive to leishmaniasis on the DPP® and ELISA tests show histomorphological changes resulting from the disease, independent to the parasitic load, as well as these organs show similar parasitic load at immunohistochemical test.

Hypericin ameliorates maternal separation-induced cognitive deficits and hippocampal inflammation in rats

Objective: Maternal separation as an epigenetic agent provokes a severe change in the brain such as inflammation response, which is a key risk factor for the progression of autism spectrum disorders (ASD). Methods: This study evaluated the preventive effect of hypericin on maternal separation-induced cognitive deficits and hippocampal inflammation. Here, we reported that pups are subjected to maternal separations for 1 h per day from postnatal days (PND) 1–9 displayed apparent memory impairment in young rats (postnatal day 34) compared to controls group. Furthermore, the maternal separation significantly increased inflammation factors in hippocampus area. Anti-inflammation constituent shed light on treating ASD. Results: In this study, we found that, treatment with hypericin (10 and 50 mg/kg) significantly suppresses expression of hippocampal interleukin-6 (IL-6) and tumor necrosis factor α (TNF- α) in maternal separation rat model. Also, we found that hypericin prevented the decrease of hippocampal dopamine level in offspring of maternal separation rats. Conclusion: The data indicated that hypericin may play a neuroprotective role in hippocampal cell and ameliorates dysfunctions in memory and level of inflammation factor in this autism model. Thus, hypericin could be used as an intervention for treating ASD.

Ultrastable and High-Performance Silk Energy Harvesting Textiles

Energy harvesting textiles (EHTs) have attracted much attention in wearable electronics and the internet-of-things for real-time mechanical energy harvesting associated with human activities. However, to satisfy practical application requirements, especially the demand for long-term use, it is challenging to construct an energy harvesting textile with elegant trade-off between mechanical and triboelectric performance. In this study, an energy harvesting textile was constructed using natural silk inspired hierarchical structural designs combined with rational material screening; this design strategy provides multiscale opportunities to optimize the mechanical and triboelectric performance of the final textile system. The resulting EHTs with traditional advantages of textiles showed good mechanical properties (tensile strength of 237 ± 13 MPa and toughness of 4.5 ± 0.4 MJ m−3 for single yarns), high power output (3.5 mW m−2), and excellent structural stability (99% conductivity maintained after 2.3 million multi-type cyclic deformations without severe change in appearance), exhibiting broad application prospects in integrated intelligent clothing, energy harvesting, and human-interactive interfaces.

Flexibilisation of Adult Learning and Education in the context of shifting temporalities in Nigeria and Germany

In his theory of acceleration, Rosa (2013) describes how modern societies have recently been going through a severe change in temporalities. This new dynamic confronts providers in Adult Learning and Education (ALE) with the challenge to not only adapt to shifting temporalities regarding their own processes and structures but also to support learners in adapting to a new ‘pace of life’. One way of reacting to social acceleration can be considered flexibilisation. In our contribution, we compare ALE in Nigeria and Germany to investigate how social acceleration takes effect in both societies, what challenges result for ALE and how ALE providers react in terms of flexibilisation. By examining policy papers, recent empirical studies and data reports, we can show how shifts in temporalities cause similar challenges in both countries and that they appear as a driver for the flexibilisation of ALE.

A Closer Look into the Role of Protein Tau in the Identification of Promising Therapeutic Targets for Alzheimer’s Disease

One of the most commonly known chronic neurodegenerative disorders, Alzheimer’s disease (AD), manifests the common type of dementia in 60–80% of cases. From a clinical standpoint, a patent cognitive decline and a severe change in personality, as caused by a loss of neurons, is~usually evident in AD with about 50 million people affected in 2016. The disease progression in patients is distinguished by a gradual plummet in cognitive functions, eliciting symptoms such as memory loss, and eventually requiring full-time medical care. From a histopathological standpoint, the~defining characteristics are intracellular aggregations of hyper-phosphorylated tau protein, known as neurofibrillary tangles (NFT), and depositions of amyloid β-peptides (Aβ) in the brain. The~abnormal phosphorylation of tau protein is attributed to a wide gamut of neurological disorders known as tauopathies. In addition to the hyperphosphorylated tau lesions, neuroinflammatory processes could occur in a sustained manner through astro-glial activation, resulting in the disease progression. Recent findings have suggested a strong interplay between the mechanism of Tau phosphorylation, disruption of microtubules, and synaptic loss and pathology of AD. The mechanisms underlying these interactions along with their respective consequences in Tau pathology are still ill-defined. Thus, in this review: (1) we highlight the interplays existing between Tau pathology and AD; and (2) take a closer look into its role while identifying some promising therapeutic advances including state of the art imaging~techniques.

A Closer Look into the Role of Protein Tau in the Identification of Promising Therapeutic Targets for Alzheimer’s Disease

One of the most commonly known chronic neurodegenerative disorders, Alzheimer’s disease (AD), manifests the common type of dementia in 60–80% of cases. From a clinical standpoint, a patent cognitive decline and a severe change in personality, as caused by a loss of neurons, is usually evident in AD with about 50 million people affected in 2016. The disease progression in patients is distinguished by a gradual plummet in cognitive functions, eliciting symptoms such as memory loss, and eventually requiring full-time medical care. From a histopathological standpoint, the defining characteristics are intracellular aggregations of hyper-phosphorylated tau protein, known as neurofibrillary tangles (NFT), and depositions of amyloid β-peptides (Aβ) in the brain. The abnormal phosphorylation of tau protein is attributed to a wide gamut of neurological disorders known as tauopathies. In addition to the hyperphosphorylated tau lesions, neuroinflammatory processes could occur in a sustained manner through astro-glial activation, resulting in the disease progression. Recent findings have suggested a strong interplay between the mechanism of Tau phosphorylation, disruption of microtubules, and synaptic loss and pathology of AD. The mechanisms underlying these interactions along with their respective consequences in Tau pathology are still ill-defined. Thus, in this review: (1) we highlight the interplays existing between Tau pathology and AD; and (2) take a closer look into its role while identifying some promising therapeutic advances including state of the art imaging techniques.

A Closer Look into the Role of Protein Tau in the Identification of Promising Therapeutic Targets for Alzheimer’s Disease

One of the most commonly known chronic neurodegenerative disorders is Alzheimer’s disease (AD) that manifests the common type of dementia in 60-80% of AD cases. From a clinical standpoint, a patent cognitive decline and a severe change in personality, as caused by a loss of neurons, is usually evident in AD with about 50 million people affected in 2016. The disease progression in patients is distinguished by a gradual plummet in cognitive functions, eliciting symptoms like memory loss, and eventually requiring full-time medical care. From a pathophysiological standpoint, the defining characteristics are intracellular aggregations of hyper-phosphorylated tau protein, known as neurofibrillary tangles (NFT) and depositions of amyloid β-peptides (Aβ) in the brain. The abnormal phosphorylation of tau protein is attributed to a wide gamut of neurological disorders known as tauopathies. In addition to the hyperphosphorylated tau lesions, neuroinflammatory processes could occur in a sustained manner through astro-glial activation, resulting in the disease progression. Recent findings have suggested a strong interplay between the mechanism of tau phosphorylation, disruption of microtubules, and synaptic loss and pathology of AD. The mechanisms underlying these interactions along with their respective consequences in Tau pathology are still ill-defined. Thus, in this review, (1) we highlight the interplays existing between Tau pathology and AD and, (2) take a closer look into its role while identifying some promising therapeutic advances including state of the art imaging techniques.

A series of (E)-5-(arylideneamino)-1-tert-butyl-1H-pyrrole-3-carbonitriles and their reduction products to secondary amines: syntheses and X-ray structural studies

An efficent access to a series of N-(pyrrol-2-yl)amines, namely (E)-1-tert-butyl-5-[(4-chlorobenzylidene)amino]-1H-pyrrole-3-carbonitrile, C16H16ClN3, (7a), (E)-1-tert-butyl-5-[(2,4-dichlorobenzylidene)amino]-1H-pyrrole-3-carbonitrile, C16H15Cl2N3, (7b), (E)-1-tert-butyl-5-[(pyridin-4-ylmethylene)amino]-1H-pyrrole-3-carbonitrile, C15H16N4, (7c), 1-tert-butyl-5-[(4-chlorobenzyl)amino]-1H-pyrrole-3-carbonitrile, C16H18ClN3, (8a), and 1-tert-butyl-5-[(2,4-dichlorobenzyl)amino]-1H-pyrrole-3-carbonitrile, C16H17Cl2N3, (8b), by a two-step synthesis sequence (solvent-free condensation and reduction) starting from 5-amino-1-tert-butyl-1H-pyrrole-3-carbonitrile is described. The syntheses proceed via isolated N-(pyrrol-2-yl)imines, which are also key synthetic intermediates of other valuable compounds. The crystal structures of the reduced compounds showed a reduction in the symmetry compared with the corresponding precursors, viz. Pbcm to P\overline{1} from compound (7a) to (8a) and P21/c to P\overline{1} from compound (7b) to (8b), probably due to a severe change in the molecular conformations, resulting in the loss of planarity observed in the nonreduced compounds. In all of the crystals, the supramolecular assembly is controlled mainly by strong (N,C)—H...N hydrogen bonds. However, in the case of (7a)–(7c), C—H...Cl interactions are strong enough to help in the three-dimensional architecture, as observed in Hirshfeld surface maps.

Analyses of Morphological Properties of a Generalized Miura Origami Structure

In this paper, we generalize Miura origami and propose a method for analyzing a generalized Miura origami structure. Morphological properties of the generalized Miura origami element during the deploy motion are analyzed using the proposed method, which mainly utilizes the principle of spherical trigonometry and is verified in the folding limit state. The longitudinal length, horizontal length, and height of the generalized Miura origami element are defined and obtained using the proposed method. Results show the relationship between the range of deployment and the element parameters as well as the changes of the folding plane angles in the deployment process. During the deploy motion, both the longitudinal and horizontal length increased while the height decreased. However, the change speed of horizontal length decreased, whereas those of longitudinal length and height initially increased and then decreased. The increment of the folding element angle difference Δα reduced folding range and put off the severe change time of longitudinal length and height. The length parameters Ka, Kb, and Kab had slight effects on the results, but their changes did not alter the change trends. These results are useful to the design of fold structure and analysis of errors in standard Miura-ori structures.