scholarly journals Exploration of the protein targets and function mechanism of tricetin based on surface plasmon resonance and reverse molecular docking

2019 ◽  
Vol 2 (3) ◽  
Author(s):  
Yuan Y ◽  
Wang N ◽  
Zhu F ◽  
Shen M ◽  
Chen K
Keyword(s):  
Molecular Docking ◽  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Protein Targets ◽  
Function Mechanism ◽  
And Function

The discovery of lactoferrin dual aptamers through surface plasmon resonance imaging combined with a bioinformation analysis

The Analyst ◽  
2020 ◽  
Vol 145 (19) ◽  
pp. 6298-6306
Author(s):  
Wenchao Jia ◽  
Zecheng Wang ◽  
Zhongyi Lu ◽  
Baiwen Ding ◽  
Zhoumin Li ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Analytical Method ◽  
Docking Simulation ◽  
Surface Plasmon Resonance Imaging ◽  
Resonance Imaging ◽  
Molecular Docking Simulation ◽  
Site Recognition

An analytical method for screening multi-site recognition aptamers in lactoferrin molecules has been developed based on Surface Plasmon Resonance imaging, combined with the cluster classification calculation and molecular docking simulation.

Assembly and function of a quaternary signal transduction complex monitored by surface plasmon resonance

Nature ◽  
1993 ◽  
Vol 365 (6444) ◽  
pp. 343-347 ◽  
Author(s):  
Stephan C. Schuster ◽  
Ronald V. Swanson ◽  
Lisa A. Alex ◽  
Robert B. Bourret ◽  
Melvin I. Simon
Keyword(s):  
Signal Transduction ◽  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
And Function

Kinetic and thermodynamic studies of sunitinib malate interaction with albumin using surface plasmon resonance and molecular docking methods

2019 ◽  
Vol 150 ◽  
pp. 104089 ◽  
Author(s):  
Saeideh Mohammadzadeh-Asl ◽  
Amir Jafari ◽  
Ayuob Aghanejad ◽  
Hananeh Monirinasab ◽  
Jafar Ezzati Nazhad Dolatabadi
Keyword(s):  
Molecular Docking ◽  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Sunitinib Malate ◽  
Thermodynamic Studies ◽  
Kinetic And Thermodynamic Studies

N-monosubstituted thiosemicarbazide as novel Ure inhibitors: synthesis, biological evaluation and molecular docking

2020 ◽  
Vol 12 (18) ◽  
pp. 1633-1645
Author(s):  
Wei-Wei Ni ◽  
Hai-Lian Fang ◽  
Ya-Xi Ye ◽  
Wei-Yi Li ◽  
Chu-Ping Yuan ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Molecular Docking ◽  
Surface Plasmon Resonance ◽  
Surface Plasmon ◽  
Plasmon Resonance ◽  
Living Cell ◽  
Biological Evaluation ◽  
High Potency ◽  
High Affinity ◽  
Excellent Activity

Background: Identification of novel Ure inhibitors with high potency has received considerable attention. Methodology & results: Ure inhibition was determined using the indophenol method, the affinities to Ure were estimated via surface plasmon resonance. Seventeen new plus ten known N-monosubstituted thiosemicarbazides were synthesized and identified as novel Ure inhibitors. Out of these compounds, compound b5 shows excellent activity against both crude Ure from Helicobacter pylori (IC50 = 0.04 μM) and Ure in living cell (IC50 = 0.27 μM), with the potency being over 600-fold higher than clinical used drug acetohyroxamic acid, respectively. Surface plasmon resonance demonstrated the high affinity ( Kd.#x00A0;= 6.32 nM) of b5 to Ure. Conclusion: This work provides a class of novel and promising Ure inhibitors.

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