scholarly journals Antioxidant properties of Mentha pulegium and histopathological evaluation of its ameliorating effect on experimental acute hepatic injury

2017 ◽  
Vol 1 (1) ◽  
Author(s):  
Ismail H. Osman ◽  
Ahmed A. Tantawy ◽  
Hussein M. Ibrahim ◽  
Abd El Ghany A. Moustafa
Keyword(s):  
Hepatic Injury ◽  
Antioxidant Properties ◽  
Mentha Pulegium ◽  
Acute Hepatic Injury ◽  
Histopathological Evaluation

scholarly journals Acute liver injury associated with Oxyfluorfen toxicity

2021 ◽  
Vol 9 ◽  
pp. 2050313X2110004
Author(s):  
Selladurai Pirasath ◽  
Ayshanie Gayanthika Samasundara Mudiyanselage ◽  
Manosha Harshani Seneviratne
Keyword(s):  
Sri Lanka ◽  
Liver Injury ◽  
Young Woman ◽  
Broad Spectrum ◽  
Hepatic Injury ◽  
Acute Liver Injury ◽  
Toxic Dose ◽  
Acute Hepatic Injury ◽  
Haem Biosynthesis ◽  
Spectrum Control

Oxyfluorfen is a phenoxyphenyl-type herbicide which is used for broad-spectrum control of broadleaf and grassy weeds. Ingestion of toxic dose of oxyfluorfen can be fatal among animals. However, toxicity to humans are rare in literature. The alterations in haem biosynthesis (anaemia) and in liver are the primary toxic effects. There are no specific antidotes and none of the current treatments have proven efficacious till date. Therefore, prevention needs to be the utmost priority, and on exposure, aggressive decontamination should be initiated. Herein, we described an oxyfluorfen toxicity with acute hepatic injury in a young woman who presented with a deliberate self-harming with an oxyfluorfen poisoning in Sri Lanka.

Liver cirrhosis developed after ketoconazole-induced acute hepatic injury

2003 ◽  
Vol 18 (12) ◽  
pp. 1426-1429 ◽  
Author(s):  
TAE-HYUNG KIM ◽  
BYUNG-HO KIM ◽  
YOUN-WHA KIM ◽  
DAL MO YANG ◽  
YO-SEB HAN ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Hepatic Injury ◽  
Acute Hepatic Injury

scholarly journals Sesamin reduces acute hepatic injury induced by lead coupled with lipopolysaccharide

2014 ◽  
Vol 77 (5) ◽  
pp. 227-233 ◽  
Author(s):  
Hsiu-Mei Chiang ◽  
Hsiang Chang ◽  
Pei-Wun Yao ◽  
Yuh-Shuen Chen ◽  
Kee-Ching Jeng ◽  
...  
Keyword(s):  
Hepatic Injury ◽  
Acute Hepatic Injury

The Hepatoprotective Role of Warburgia salutaris and Iso-Mukaadial Acetate on Carbon tetrachloride Intoxicated Rats Model

2021 ◽  
Vol 17 ◽  
Author(s):  
Gideon Ayeni ◽  
Mthokozisi Blessing Cedric Simelane ◽  
Shahidul Islam ◽  
Ofentse Jacob Pooe
Keyword(s):  
Carbon Tetrachloride ◽  
Hepatic Injury ◽  
Antioxidant Properties ◽  
Hepatic Necrosis ◽  
Protective Role ◽  
Dependent Manner ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Isolated Compound

Background: Medicinal plants together with their isolated bioactive compounds are known for their antioxidant properties which constitute therapeutic agents that are routinely employed in the treatment of liver diseases. Aims of the Study: The current study sought to explore the protective role of Warburgia salutaris and its isolated compound, iso-mukaadial acetate against carbon tetrachloride (CCl4)-induced hepatic injury. Methods: Thirty-five male Sprague Dawley rats were divided into seven groups of five animals each and injected with CCl4 to induce hepatic injury. Results: Treatment with the crude extract of W. salutaris and of iso-mukaadial acetate significantly reduced the levels of alkaline phosphatase, alanine and aspartate aminotransaminases, total bilirubin and malondialdehyde in a dose dependent manner, when compared to untreated groups. Liver histology revealed a reduction in hepatic necrosis and inflammation. Conclusion: The current investigation has demonstrated that W. salutaris extract and iso-mukaadial acetate could mitigate the acute liver injury inflicted by a hepatotoxic inducer in rats.

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