scholarly journals Features of systemic cytokine production in Behcet's disease associated with uveitis without ocular lesions

2021 ◽  
Vol 23 (5) ◽  
pp. 1079-1088
Author(s):  
E. S. Sorozhkina ◽  
G. I. Krichevskaya ◽  
N. V. Balatskaya ◽  
I. G. Kulikova ◽  
A. E. Andryushin ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Detection Rate ◽  
Behcet’S Disease ◽  
Clinical Symptoms ◽  
Behçet's Disease ◽  
Systemic Disease ◽  
Control Group ◽  
People Detection ◽  
Detection Rates ◽  
Behcet's Disease

Behcet's disease (BD) is a systemic disease underlyed by chronic vasculitis. Hyperactivity of innate and adaptive immunity plays important role in its pathogenesis. Uveitis occurs in 30-70% of the patients, often recurring and reducing visual function. The objective of our work was to study the features of systemic production of immune mediators in BD patients, depending on presence and activity of uveitis. 116 BD patients were divided into 3 groups: (1) 41 patients with active uveitis (UA), (2) 64 subjects with uveitis remission (UR), (3) 11 uveitis-free BD patients (WU). Control group (CG) comprised 34 conditionally healthy people. Detection rate (%) and contents (pg/ml) were measured for IL-1β IL-2, IL-4, IL-5, IL-6, IL-12p70, IL-13, IL-18, IFNγ, CCL2/MCP-1, CCL3/MIP-1α, CCL4/MIP-1β, CCL5/RANTES, CCL11/Eotaxin, СXCL1/GRO-α, CXCL8/IL-8, CXCL10/IP-10, CXCL12/SDF-1α, GM-CSF, TNFα in blood serum by means of multiplex analysis using MAGPIX analyzer (Luminex Corp., USA), Procarta Plex “Human Th1/Th2&Chemokine Panel 20 plex” kits (Bioscience, Austria). TGF-P1, TGF-P2 levels were assayed by ELISA-test (“Vfector-Best”). All the BD patients showed high detection rates of CXCL1/GRO-α (but not its level) in comparison with CG. Detection rate and levels of IL-6, IL-8 were increased in 1st and 2nd BD groups, compared to CG. In UR, unlike UA and WU groups, IL-4 was detected more often than in CG. WU patients showed increased detection rate of only CXCL1/GRO -α. When compared with UA, WU patients had lower serum concentrations of IFNγ, MCP-1, IP-10, MIP-1a, SDF-1α, TGF-β1; UR patients also showed decreased serum levels of IL-18, Eotaxin, GRO-α, RANTES, TGF-β2. Our results indicate the importance of angiogenic and proinflammatory chemokines and cytokines in pathogenesis of BD uveitis, as well as imbalanced production of various immunomediators. Higher detection rates and levels of IL-6 and IL-8 in UA and UR patients may result from weak persistent intraocular inflammation, even upon relief of clinical symptoms, thus, probably, requiring therapeutic correction.

scholarly journals Hyperhomocysteinaemia in Behçet's Disease

2010 ◽  
Vol 2010 ◽  
pp. 1-5 ◽  
Author(s):  
Amira Hamzaoui ◽  
Olfa Harzallah ◽  
Rim Klii ◽  
Silvia Mahjoub
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Homocysteine Level ◽  
Behçet's Disease ◽  
Negative Control Group ◽  
Negative Control ◽  
Control Group ◽  
Behcet's Disease ◽  
Homocysteine Concentration ◽  
Significant Difference

Objectives. The aim of this study was to investigate if hyperhomocysteinaemia is a contributive risk factor for the pathogenesis and the activity of Behçet's disease (BD).Design and Methods. Fifty four patients fullfiling the criteria of the International Study Group for BD were enrolled. Fifty healthy volunteers matched for age and sex with the BD group were included as a negative control group. Patients, with any condition that might affect plasma homocysteine concentration, were excluded.Results. Mean serum homocysteine concentration was significantly higher in patients with BD than in the healthy controls (), in patients with active disease (), and in masculine gender (). There was no significant difference between homocysteine level and clinical involvement.Conclusions. We demonstrated that plasma total homocysteine level (tHcy) is increased in BD and correlated with disease activity. No association was found between homocysteine levels and clinical involvement.

scholarly journals Colonic perforation as an unusual manifestation of Behcet's disease

2011 ◽  
Vol 68 (11) ◽  
pp. 992-995
Author(s):  
Aleksandra Tomic-Lucic ◽  
Snezana Jovanovic ◽  
Milan Petronijevic ◽  
Mirjana Veselinovic
Keyword(s):  
Behçet’S Disease ◽  
Transverse Colon ◽  
Behcet’S Disease ◽  
Clinical Symptoms ◽  
Behçet's Disease ◽  
Clinical Manifestations ◽  
Unusual Manifestation ◽  
Behcet's Disease ◽  
Abdominal Symptoms ◽  
Emergent Laparotomy

Introduction. Behcet's disease is multisystemic vasculitis which affects vein and artery blood vessels. Intestinal perforation rarely occurs as clinic manifestation in as litle as 1% of patients. The transverse colon is the most infrequent site of perforation. We presented a patient diagnosed with Behcet's disease who underwent both surgical and conversative treatment due to perforation of the colon. Case report. A 34-year-old patient was admitted to the hospital with fever, aphthous ulcerations on oral mucosa and genitals and bilateral uveitis. On the basis of clinical symptoms and the International Criteria developed in 1990 Behcet's disease was diagnosed. During the next few days the patient developed erythema nodosum, diarrheic syndrome and acute abdominal symptoms due to perforation of the transverse colon. An emergent laparotomy was undertaken involving resection of a perforated segment of the colon, and bipolar colostomy on the left side of abdomen. Following the surgery the patient was treated except for antibiotics with three successive pulse doses of methylprednisolone (500 mg/daily) and cyclophosphamide (15 mg/kg). The treatment was continued by gradual decrease in the close of the corticosteroid (perorally) and by cyclophosphamide first with monthly doses (5 monthly pulse doses of 15 mg/kg cyclophosphoamide), and then with 3-month doses (totally 6 doses) up to totally 12 g. Conclusion. The therapy with pulse doses of methylprednisolone combined with pulse doses of cyclophosphamide was very effective in the reported case with the complex clinical manifestations leading to resolution of gastrointenstinal, ocular and orogenital lesions.

Recurrent vulval ulceration: could it be Behçet's disease?

2012 ◽  
Vol 23 (9) ◽  
pp. 683-684
Author(s):  
S Patel ◽  
K Prime
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Systemic Disease ◽  
Holistic Approach ◽  
Nucleic Acid Amplification ◽  
Behcet's Disease ◽  
Oral Ulcers ◽  
Caribbean Woman ◽  
History Of

This report describes a young black Caribbean woman with a three-year history of recurrent genital ulceration initially diagnosed as genital herpes. This diagnosis had been made clinically by the general practitioner but never confirmed on culture or nucleic acid amplification testing; sequential treatment with aciclovir and famciclovir over a four-month period did not alleviate her genital symptoms. Presentation to our genitourinary (GU) medicine clinic identified painful aphthous genital and oral ulcers, erythema nodosum bilaterally and a history of eye irritation. A clinical diagnosis of Behçet's disease was made. Treatment with hydrocortisone mouth pellets and dermovate ointment was initiated in addition to dermatology and ophthalmology referral. This report reminds clinicians to consider alternative diagnoses in clinical practice when faced with patients who are resistant to treatment. It also highlights the importance of recognizing systemic disease and maintaining a holistic approach when treating patients.

scholarly journals Clinical Significance of Serum Bilirubin in Behçet's Disease

2018 ◽  
Vol 6 (4) ◽  
pp. 185-188 ◽  
Author(s):  
Tuba Tülay Koca
Keyword(s):  
Clinical Significance ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Area Under The Curve ◽  
Control Group ◽  
Roc Curve Analysis ◽  
Acute Phase Reactants ◽  
Behcet's Disease ◽  
Almost All

Abstract Background and Objective Bilirubin (Bb) is the product of the intravascular compartment of catabolic pathway. In a small number of clinical trials, it has been shown that Bb molecules are associated with cardiovascular diseases, diabetes, cancer, autoimmune (lupus, rheumatoid arthritis) diseases and schizophrenia. Behçet's disease is a chronic, multisystemic, inflammatory vasculitis that was first described by Hulusi Behçet in 1937, which affects almost all organs and systems without any known aetiology. Here, we investigated the clinical significance of serum Bb as a biomarker in the patients with Behçet's disease. Methods Seventy-one (N = 71) patients with Behcet's diagnosis within the last 1 year were included retrospectively. Control group consisted of 75 subjects with similar age and sex distribution. Serum Bb, indirect Bb, total Bb, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) data were recorded from the hospital records. Results In the Behçet group, direct Bb was significantly lower (P = 0.011), ESR and CRP were significantly higher (P = 0.00). No significant differences were observed in other parameters. In the whole group, total Bb and indirect Bb were negatively correlated with ESR (P = 0.025, P = 0.01). Direct Bb was negatively correlated with CRP (P = 0.002). For the diagnosis of Behçet, direct Bb with a threshold of < 0.14 can be used as a diagnostic test (P = 0.000) with 70% sensitivity, 68% specificity (area under the curve = 0.69; 95% confidence interval 0.59–0.80) in ROC curve analysis. Conclusion According to our study, we found that inflammatory markers were high and direct Bb values were low in patients with Behcet's disease. In addition, Bb parameters were negatively associated with acute phase reactants. As a practical biomarker with anti-oxidative properties, the direct Bb can be used to diagnose and clinical follow-up in cases with Behçet's disease.

Association of Colonoscopic Findings and Clinical Symptoms of Intestinal Involvement in Behcet's Disease

2008 ◽  
Vol 67 (5) ◽  
pp. AB248
Author(s):  
Yun Jung Lee ◽  
Sung Hee Jung ◽  
Hyang Ie Lee ◽  
Hyeon Woong Yang ◽  
Jeong Eun Shin ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Clinical Symptoms ◽  
Behçet's Disease ◽  
Behcet's Disease ◽  
Intestinal Involvement

scholarly journals The Role of Fecal Calprotectin in Evaluating Intestinal Involvement of Behçet’s Disease

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Burak Özşeker ◽  
Cem Şahin ◽  
Havva Solak Özşeker ◽  
S. Cumali Efe ◽  
Taylan Kav ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Fecal Calprotectin ◽  
Unknown Etiology ◽  
Control Group ◽  
Behcet's Disease ◽  
Intestinal Involvement ◽  
Gi Symptoms

One of the regions of involvement of Behçet’s disease (BD), a systematic inflammatory vasculitis with unknown etiology, is the gastrointestinal (GI) tract. Upper GI endoscopy, colonoscopy, and capsule endoscopy are frequently used methods to diagnose the intestinal involvement of BD. The aim of this study was to investigate the role of fecal calprotectin (FC) in the evaluation of intestinal involvement in BD.Material and Method. A total of 30 patients who were diagnosed with BD and had no GI symptoms and 25 individuals in the control group were included in this study.Results. Levels of FC were statistically significantly higher in patients with BD compared to the control group (p<0.001). The correlation analysis performed including FC and markers of disease activity revealed a positive and statistically significant correlation between FC level and CRP and erythrocyte sedimentation rate (r: 0.255,p<0.049, andr: 0.404,p<0.001, resp.). FC levels in patients who were detected to have ulcers in the terminal ileum and colon in the colonoscopic examination were statistically significantly higher compared to the patients with BD without intestinal involvement (p=0.01).Conclusion. The measurement of FC levels, in patients with BD who are asymptomatic for GI involvement, may be helpful to detect the possible underlying intestinal involvement.

scholarly journals Mean Platelet Volume in Ocular Behçet’s Disease

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Fatih Mehmet Türkcü ◽  
Abdullah Kürşat Cingü ◽  
Harun Yüksel ◽  
Yasin Çınar ◽  
Meltem Akkurt ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Mean Platelet Volume ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Immunosuppressive Treatment ◽  
Control Group ◽  
Platelet Volume ◽  
Behcet's Disease ◽  
Significant Difference ◽  
The Mean

Objective. To determine whether mean platelet volume (MPV) is an indicator of disease severity in ocular Behçet’s Disease (BD).Materials and Methods. The study population was 30 newly diagnosed ocular BD patients who presented with active uveitis. These patients had no past history of smoking, drug use, or systemic diseases including diabetes mellitus, hypertension, cardiovascular disease, and renal disease. A control group consisting of 34 healthy individuals was included for comparison. MPV measurements were performed serially upon presentation with active uveitis and at one and three month thereafter in BD group whereas only at presentation in the controls.Results. Upon presentation with active uveitis, the mean MPV levels were 7.88 ± 1.14 femtoliters (fL) for BD group. During the posttreatment follow-up period at first and third months, BD patients demonstrated a mean MPV level of 7.71 ± 1.12 fL and 7.65 ± 1.04 fL, respectively. The mean MPV value of control group, was 8.39 ± 0.66 fL at presentation. Fluctuations in MPV values were not significant in the BD group, while there was a significant difference between the initial measurements of the BD and control groups.Conclusion. MPV measurement in ocular BD is not a predictive laboratory test to determine the clinical improvement in early stages following classical immunosuppressive treatment.

scholarly journals Depression and Anxiety in Iranian Patients with Behcet's Disease: A Single Center Experience

2013 ◽  
Vol 2 (3) ◽  
pp. 100-105
Author(s):  
Mohammad Mehdi Fani ◽  
Elham Aflaki ◽  
Hooman Ebrahimi ◽  
Anahita Safari ◽  
Sina Ghanizadeh ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Control Group ◽  
Depression And Anxiety ◽  
Disease Treatment ◽  
Behcet's Disease ◽  
Single Center Experience ◽  
High Level ◽  
Anxiety Index

Background: This study was designed to determine and compare the stress, anxiety and depression levels in Behcet’s disease (BD) patients and a control group of normal individuals.Materials and Methods: One-hundred and six patients with BD were selected as cases and controls were 106 age- and sex-matched participants referred to the Shiraz Dental school clinics due to dental problems. We collected the information with 3 validated Farsi questionnaires: Perceived Stress Scale (PSS) for stress, Beck Anxiety Index (BDI) for depression and Beck Depression Index (BAI) for anxiety.Results: Stress, depression and anxiety levels were significantly higher in patients with BD in comparison with the control group (p<0.001).Conclusions: A high level of stress and depression in BD patients is frequent and PSS, BDI and BAI are useful for determining these variations. Finally, we suggest a psychiatrist consultation in all periods of disease treatment.

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