Kidney injury and renal replacement therapy in heart transplant recipient

The development of kidney injury and the characteristics of renal replacement therapy were considered in patient with dilated cardiomyopathy, who consequently underwent two heart transplantations and two kidney transplantations. Since the number of the patients needed both kidney and heart transplantation increases constantly, the multifaceted thorough research in this specific patient population is extremely important.

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Iatrogenic Pulmonary Nodule in a Heart Transplant Recipient

Case Reports in Pulmonology ◽

10.1155/2014/546209 ◽

2014 ◽

Vol 2014 ◽

pp. 1-3 ◽

Cited By ~ 1

Author(s):

Atul C. Mehta ◽

Juan Wang ◽

Jarmanjeet Singh ◽

Joseph Cicenia

Keyword(s):

Transplant Recipient ◽

Heart Transplantation ◽

Heart Transplant ◽

Pulmonary Nodule ◽

Lung Nodule ◽

Invasive Pulmonary Aspergillosis ◽

Heart Transplant Recipient ◽

Non Hodgkin Lymphoma ◽

First Case ◽

End Stage

A 58-year-old female with a history of non-Hodgkin lymphoma and end-stage nonischemic cardiomyopathy from Adriamycin toxicity underwent orthotic heart transplantation during June 2013. She developed shortness of breath in September 2013 and was suspected to have invasive pulmonary aspergillosis. A flexible bronchoscopy (FB) with a transbronchial biopsy (TBBx) was performed. She was found to have a focal lung nodule in the same location at the site of the TBBx on day 13 after the FB. Spontaneous resolution of the nodule was confirmed on the computed tomography (CT) scan of chest performed at 3 months. We believe that this nodule was as a consequence of the TBBx. Formation of a peripheral pulmonary nodule (PPN) following a TBBx is occasionally encountered among the recipients of the lung transplantation. To our knowledge, this is the first case of TBBx producing a pulmonary nodule in a heart transplant recipient. Physicians caring for the patients with heart transplantation should be cognizant of the iatrogenic nature of such nodule to avoid unnecessary diagnostic work-up.

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Hypertrophic obstructive cardiomyopathy in a heart transplant recipient: a case report

Russian Journal of Cardiology ◽

10.15829/1560-4071-2021-4625 ◽

2021 ◽

Vol 26 (3S) ◽

pp. 4625

Author(s):

G. A. Golovina ◽

T. V. Stavenchuk ◽

N. V. Kizhvatova ◽

E. D. Kosmacheva

Keyword(s):

Case Report ◽

Transplant Recipient ◽

Heart Transplantation ◽

Heart Transplant ◽

Heart Transplant Recipient ◽

Hypertrophic Obstructive Cardiomyopathy ◽

Orthotopic Heart Transplantation

The article presents a case report of developing the classic hypertrophic obstructive cardiomyopathy in a 66-year-old male heart transplant recipient within 5 years after orthotopic heart transplantation. The characteristics of this pathology are discussed.

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Fatal West Nile Virus Encephalitis in a Heart Transplant Recipient

Journal of Clinical Microbiology ◽

10.1128/jcm.00834-15 ◽

2015 ◽

Vol 53 (8) ◽

pp. 2749-2752 ◽

Cited By ~ 9

Author(s):

Adam J. Gomez ◽

Jesse J. Waggoner ◽

Megumi Itoh ◽

Seth A. Hollander ◽

Kathleen M. Gutierrez ◽

...

Keyword(s):

Cerebrospinal Fluid ◽

West Nile Virus ◽

Transplant Recipient ◽

Heart Transplantation ◽

Heart Transplant ◽

Heart Transplant Recipient ◽

Immunocompromised Patients ◽

West Nile ◽

Virus Encephalitis ◽

West Nile Virus Encephalitis

The diagnosis of encephalitis is particularly challenging in immunocompromised patients. We report here a case of fatal West Nile virus encephalitis confounded by the presence of budding yeast in the cerebrospinal fluid (CSF) from a patient who had undergone heart transplantation for dilated cardiomyopathy 11 months prior to presentation of neurologic symptoms.

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Risk Factors for Acute Kidney Injury Requiring Renal Replacement Therapy after Orthotopic Heart Transplantation in Patients with Preserved Renal Function

Journal of Clinical Medicine ◽

10.3390/jcm10184117 ◽

2021 ◽

Vol 10 (18) ◽

pp. 4117

Author(s):

René M‘Pembele ◽

Sebastian Roth ◽

Alexandra Stroda ◽

Giovanna Lurati Buse ◽

Stephan U. Sixt ◽

...

Keyword(s):

Risk Factors ◽

Acute Kidney Injury ◽

Renal Function ◽

Renal Replacement Therapy ◽

Heart Transplantation ◽

Replacement Therapy ◽

Plasma Levels ◽

Kidney Injury ◽

Orthotopic Heart Transplantation ◽

Postoperative Aki

Acute kidney injury (AKI), requiring renal replacement therapy (RRT). is a serious complication after orthotopic heart transplantation (HTX). In patients with preexisting impaired renal function, postoperative AKI is unsurprising. However, even in patients with preserved renal function, AKI requiring RRT is frequent. Therefore, this study aimed to identify risk factors associated with postoperative AKI requiring RRT after HTX in this sub-cohort. This retrospective cohort study included patients ≥18 years of age with preserved renal function (defined as preoperative glomerular filtration rate ≥60 mL/min) who underwent HTX between 2010 and 2021. In total, 107 patients were included in the analysis (mean age 52 ± 12 years, 78.5% male, 45.8% AKI requiring RRT). Based on univariate logistic regression, use of extracorporeal membrane oxygenation, postoperative infection, levosimendan therapy, duration of norepinephrine (NE) therapy and maximum daily increase in tacrolimus plasma levels were chosen to be included into multivariate analysis. Duration of NE therapy and maximum daily increase in tacrolimus plasma levels remained as independent significant risk factors (NE: OR 1.01, 95%CI: 1.00–1.02, p = 0.005; increase in tacrolimus plasma level: OR 1.18, 95%CI: 1.01–1.37, p = 0.036). In conclusion, this study identified long NE therapy and maximum daily increase in tacrolimus plasma levels as risk factors for AKI requiring RRT in HTX patients with preserved renal function.

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FatalToxoplasma gondiiDissemination in a Heart Transplant Recipient: Description of a Case

Case Reports in Transplantation ◽

10.1155/2012/524279 ◽

2012 ◽

Vol 2012 ◽

pp. 1-3 ◽

Cited By ~ 2

Author(s):

S. Mastrobuoni ◽

A. M. Dell'Aquila ◽

J. Herreros

Keyword(s):

Toxoplasma Gondii ◽

Transplant Recipient ◽

Heart Transplantation ◽

Heart Transplant ◽

Respiratory Symptoms ◽

Cardiac Involvement ◽

Heart Transplant Recipient ◽

Postmortem Examination ◽

Blood Cultures ◽

Atypical Pneumonia

A 45-year-old heart transplant recipient presented with fever, anorexia, asthenia, and lethargy. She had received heart transplantation only 5 weeks earlier for primary systemic amyloidosis with severe cardiac involvement. Serum sodium was low, and tacrolimus through level was high. Blood cultures and serology tests for infection were negative, and atypical pneumonia was suspected. Despite broad antibiotic, antiviral, and antifungal treatment, the patient clinical condition rapidly deteriorated and she died within three days of admission. Postmortem examination revealed a disseminatedToxoplasma gondiiinfection as a result of donor (+)/recipient(−) mismatch forToxoplasmaserology. Although very rare, toxoplasmosis in heart transplant recipient should be suspect in case of neurological deficit and respiratory symptoms. Prophylaxis treatment is recommended in case of mismatch.

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