scholarly journals COMBINATION THERAPY IN THE MANAGEMENT OF ARTERIAL HYPERTENSION: EFFECTIVENESS OF THE LERCANIDIPINE AND ENALAPRIL COMBINATION

2013 ◽  
Vol 12 (5) ◽  
pp. 75-80
Author(s):  
L. O. Minushkina
Keyword(s):  
Combination Therapy ◽  
Arterial Hypertension ◽  
Marked Reduction ◽  
Ace Inhibitor ◽  
Fixed Dose ◽  
Therapeutic Effects ◽  
Organ Protection ◽  
Vascular Selectivity ◽  
Patients With Diabetes ◽  
Dose Combination

This review presents the evidence on the benefits of fixed-dose combination therapy for arterial hypertension management. The focus is on the combination of a third-generation dihydropyridine calcium antagonist lercanidipine and an ACE inhibitor enalapril. Lercanidipine is characterised by high vascular selectivity and lipophilicity, good antihypertensive effectiveness, and prolonged, gradually developing therapeutic effects. Literature data on the effectiveness of the lercanidipine-enalapril combination are presented. This combination facilitates a marked reduction in blood pressure levels, which is particularly relevant for elderly patients and patients with diabetes mellitus or obesity. The combination of pharmacologic effects of lercanidipine and enalapril provides additional benefits in terms of organ protection and reduction of adverse effects of the antihypertensive treatment. 

scholarly journals Selection of antihypertensive therapy in elderly patients, combination therapy: thiazide-like diuretics and calcium channel blockers

2018 ◽  
pp. 117-122
Author(s):  
Z. M. Galeyeva ◽  
A. S. Galyavich ◽  
L. V. Baleyeva ◽  
E. G. Safina ◽  
O. V. Sorokina
Keyword(s):  
Combination Therapy ◽  
Elderly Patients ◽  
Arterial Hypertension ◽  
Antihypertensive Therapy ◽  
Calcium Channel Blockers ◽  
Fixed Dose ◽  
Channel Blockers ◽  
Dose Combination ◽  
Positive Effect ◽  
Selection Of

The article presents data about the prevalence and expected prognosis for arterial hypertension. Emphasis is placed on the selection of antihypertensive therapy in elderly patients. The features concerning the positive effect of the calcium channelblocking agent — amlodipine, thiazid­like diuretic — indapamide retard in the form of monotherapy and a combination of the above drugs on the course and prognosis of arterial hypertension in elderly patients are investigated. A clinical example of the use of the fixed dose combination amlodipine + indapamide retard is also introduced.

scholarly journals DIURETIC-BASED COMBINATION THERAPY IN PATIENTS WITH ARTERIAL HYPERTENSION: RESULTS OF THE RUSSIAN TRUST STUDY

2013 ◽  
Vol 12 (4) ◽  
pp. 62-66
Author(s):  
N. E. Gavrilova ◽  
R. G. Oganov
Keyword(s):  
Combination Therapy ◽  
Arterial Hypertension ◽  
Clinical Diagnosis ◽  
Modern Medicine ◽  
Fixed Dose Combination ◽  
Fixed Dose ◽  
High Prevalence ◽  
Dose Combination ◽  
Stage 1

Arterial hypertension (AH) is one of the most important problems of the modern medicine, due to its exceptionally high prevalence. This study focused on effectiveness and safety of the diuretic-based combination therapy among patients aged >18 years (1476 men and 2989 women) with a clinical diagnosis of Stage 1–3 AH. All patients received fixed-dose combination therapy with atenolol and chlorthalidone. The findings from the TRUST study have confirmed safety and effectiveness of the fixed-dose combination of atenolol and chlorthalidone. 

scholarly journals MECHANISMS OF COMBINED ACTION OF ACE INHIBITORS AND CALCIUM ANTAGONISTS IN ARTERIAL HYPERTENSION

2013 ◽  
Vol 12 (3) ◽  
pp. 72-77 ◽  
Author(s):  
E. I. Astashkin ◽  
M. G. Glezer
Keyword(s):  
Arterial Hypertension ◽  
Calcium Antagonists ◽  
Inhibitory Effect ◽  
Water Soluble ◽  
Fixed Dose Combination ◽  
Fixed Dose ◽  
Therapeutic Effects ◽  
Protective Effects ◽  
Renin Angiotensin ◽  
Dose Combination

This review presents the modern views on the effectiveness of water-soluble angiotensin-converting enzyme (ACE) antagonists and calcium antagonists (CA), as monotherapy or as fixed-dose combination therapy, in the treatment of arterial hypertension (AH). The results of the X-ray structural analysis of crystal ACE-lisinopril complexes suggest a highly selective, strong inhibitory effect of lisinopril on various ACE forms of the hormonal renin-angiotensin-aldosterone system and tissue renin-angiotensin systems. The association between specific action mechanisms and therapeutic effects in hypertension is analysed for a third-generation CA amlodipine. The benefits of a fixed-dose combination medication Ekvator (amlodipine 5 mg plus lisinopril 10 mg) in hypertension are described, including its synergetic protective effects. 

Fixed Dose Combination Therapy

1997 ◽  
Vol 90 (Supplement) ◽  
pp. 10-11
Author(s):  
William J. Elliott
Keyword(s):  
Combination Therapy ◽  
Fixed Dose Combination ◽  
Fixed Dose ◽  
Dose Combination
Sign in / Sign up

Export Citation Format

Share Document