Computed Tomography-Based Study Exploring the Feasibility of Endovascular Treatment of Type A Aortic Dissection in the Chinese Population

The present study is aimed at investigating the association of NFE2L2 gene polymorphisms with risk and clinical characteristics of acute type A aortic dissection (AAAD) in a Han Chinese population. Six SNPs (rs1806649, rs13001694, rs2364723, rs35652124, rs6721961, and rs2706110) in NFE2L2 were genotyped using SNaPshot Multiplex Kit in 94 adult patients diagnosed with AAAD at our hospital, and 208 healthy Han Chinese subjects from the 1000 Genomes Project were served as the control group. The CC genotype of rs2364723 (CC versus (GC+GG), OR = 2.069 , 95% CI: 1.222-3.502, p = 0.006 ) and CC genotype of rs35652124 (CC versus (CT+TT), OR = 1.889 , 95% CI: 1.112-3.210, p = 0.018 ) were identified as risk factors for AAAD. Multivariable linear regression analysis revealed that the CC genotype of rs2364723 ( β = 5.031 , 95% CI: 1.878-8.183, p = 0.002 ) and CC genotype of rs35652124 ( β = 4.751 , 95% CI: 1.544-7.958, p = 0.004 ) were associated with increased maximum ascending aorta diameter of AAAD. Patients carrying rs2364723 CC genotype had a higher incidence of coronary artery involvement (31% vs. 12%, p = 0.027 ), while patients carrying rs35652124 CC genotype had a higher incidence of brain ischemia (9% vs. 0%, p = 0.045 ). In conclusion, NFE2L2 gene polymorphisms were correlated with risk and severity of AAAD in Han Chinese population.

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False-positive Transesophageal Echocardiography after False-positive Computed Tomography Angiography in Suspected Type A Aortic Dissection

Anesthesiology ◽

10.1097/aln.0000000000002347 ◽

2018 ◽

Vol 129 (5) ◽

pp. 1028-1028

Author(s):

Edward Gologorsky ◽

Qin N. Zhang ◽

Angela Gologorsky

Keyword(s):

Computed Tomography ◽

Aortic Dissection ◽

Transesophageal Echocardiography ◽

Computed Tomography Angiography ◽

False Positive ◽

Type A ◽

Type A Aortic Dissection

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Aortic Dissection Caused by Giant Cell Arteritis

The Heart Surgery Forum ◽

10.1532/hsf98.20101114 ◽

2011 ◽

Vol 14 (2) ◽

pp. 137 ◽

Cited By ~ 4

Author(s):

Thomas Strecker ◽

Stephan Zimmermann ◽

David-Lukas Wachter ◽

Abbas Agaimy

Keyword(s):

Computed Tomography ◽

Connective Tissue ◽

Aortic Dissection ◽

Giant Cell Arteritis ◽

Giant Cell ◽

Surgical Repair ◽

Rare Complication ◽

Type A ◽

Degenerative Diseases ◽

Type A Aortic Dissection

Aortic dissection is a very serious condition mainly caused by degenerative diseases of the connective tissue and hypertension. Ascending aortic dissection as a consequence of aortitis in association with giant cell arteritis is very rarely seen. In this article we report on the successful surgical repair of a Stanford type A aortic dissection caused by giant cell arteritis in a 74-year-old patient. We could visualize this dissection via echocardiography and computed tomography. Histopathology confirmed this rare complication of giant cell aortitis.

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Preoperative evaluation value of aortic arch lesions by multidetector computed tomography angiography in type A aortic dissection

Medicine ◽

10.1097/md.0000000000004984 ◽

2016 ◽

Vol 95 (39) ◽

pp. e4984

Author(s):

Fang Huang ◽

Qiang Chen ◽

Qing-quan Lai ◽

Wen-han Huang ◽

Hong Wu ◽

...

Keyword(s):

Computed Tomography ◽

Aortic Dissection ◽

Multidetector Computed Tomography ◽

Aortic Arch ◽

Computed Tomography Angiography ◽

Preoperative Evaluation ◽

Type A ◽

Type A Aortic Dissection ◽

Multidetector Computed Tomography Angiography

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Anterograde Amnesia as a Manifestation of Acute Type A Aortic Dissection

International Journal of Angiology ◽

10.1055/s-0039-1693029 ◽

2019 ◽

Vol 29 (04) ◽

pp. 263-266 ◽

Cited By ~ 1

Author(s):

Claudia Stöllberger ◽

Julia Koller ◽

Josef Finsterer ◽

Dominic Schauer ◽

Marek Ehrlich

Keyword(s):

Computed Tomography ◽

Chest Pain ◽

Aortic Dissection ◽

Memory Impairment ◽

Acute Aortic Dissection ◽

Anterograde Amnesia ◽

Type A ◽

Type A Aortic Dissection ◽

D Dimer ◽

Aortic Dissection Type A

Objectives Memory impairment has been only rarely reported in association with acute aortic dissection type A. We report a patient with pure anterograde amnesia and memory impairment of contents occurring after the event, accompanying acute aortic dissection type A. Case Report A previously healthy 53-year-old Caucasian male was admitted because of sudden chest pain after having lifted a heavy object. Clinical examination and electrocardiogram showed no abnormalities. Since blood tests showed leukocytosis, anemia, and elevated D-dimer level, either pulmonary embolism or aortic dissection was suspected; therefore, computed tomography was suggested. The patient seemed disoriented to time, and neurologic investigation confirmed that the patient was disoriented to time; short time memory was severely impaired and concentration was reduced. An amnestic episode with anterograde amnesia was diagnosed. Computed tomography showed type A aortic dissection. A supracoronary replacement of the ascending aorta was performed. The patient was discharged on the 7th postoperative day. Three months postoperatively, the patient is clinically stable; however, amnesia for the interval between pain onset and cardiac surgery persists. Conclusions Transient amnesia, usually considered a benign syndrome, may be more common than generally recognized in aortic dissection. The suspicion for aortic dissection or other cardiovascular emergencies is substantiated when amnesia is associated with sudden onset of chest pain, leukocytosis, and elevated D-dimer levels. Computed tomography of the aorta with contrast medium is the imaging method of choice to confirm or exclude the diagnosis.

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