scholarly journals Is a second cycle of immunoglobulin justified in axonal forms of Guillain-Barré syndrome?

2015 ◽  
Vol 73 (10) ◽  
pp. 848-851 ◽  
Author(s):  
Daniel Agustin Godoy ◽  
Alejandro Rabinstein
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Mechanical Ventilation ◽  
Case Report ◽  
Intravenous Immunoglobulin ◽  
Treatment Option ◽  
Guillain Barre Syndrome ◽  
Ivig Infusion ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

Objective In certain situations, severe forms of Guillain-Barré syndrome (GBS) show no response or continue to deteriorate after intravenous immunoglobulin (IVIg) infusion. It is unclear what the best treatment option would be in these circumstances.Method This is a case report on patients with severe axonal GBS in whom a second cycle of IVIg was used.Results Three patients on mechanical ventilation who presented axonal variants of GBS, with autonomic dysfunction, bulbar impairment and Erasmus score > 6, showed no improvement after IVIg infusion of 400 mg/kg/d for 5 days. After 6 weeks, we started a second cycle of IVIg using the same doses and regimen as in the previous one. On average, 5 days after the second infusion, all the patients were weaned off mechanical ventilation and showed resolution of their blood pressure and heart rate fluctuations.Conclusions A second cycle of IVIg may be an option for treating severe forms of GBS.

Guillain-Barre Syndrome in a Case of Typhoid Fever: an Uncommon Association

2021 ◽  
Vol 32 (2) ◽  
pp. 142-144
Author(s):  
Abdul Basit Ibne Momen ◽  
Furial Quraishi Twinkle ◽  
Aminur Rahman ◽  
Firoz Ahmed Quraishi
Keyword(s):  
Case Report ◽  
Blood Culture ◽  
Typhoid Fever ◽  
Intravenous Immunoglobulin ◽  
Case Reports ◽  
Neurological Complication ◽  
Guillain Barre Syndrome ◽  
Intravenous Antibiotics ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

Guillain-Barre syndrome (GBS) following typhoid is extremely uncommon and only few case reports are available in literature. The importance of this case report is to highlight upon the fact that a diagnosis of GBS should always be kept in mind whenever a patient of typhoid fever develops weakness. We report a young girl with blood culture proven typhoid fever that developed this very rare neurological complication quite early in the course of the disease. Following treatment with intravenous antibiotics and intravenous immunoglobulin, she was improved. Bangladesh J Medicine July 2021; 32(2) : 142-144

Short-term variability of blood pressure and heart rate in Guillain-Barré syndrome without respiratory failure

1999 ◽  
Vol 96 (6) ◽  
pp. 613 ◽  
Author(s):  
Djillali ANNANE ◽  
Véronique BAUDRIE ◽  
Anne-Sophie BLANC ◽  
Dominique LAUDE ◽  
Jean-Claude RAPHAL ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Respiratory Failure ◽  
Guillain Barre Syndrome ◽  
Short Term ◽  
Guillain Barré Syndrome ◽  
Guillain Barré ◽  
Short Term Variability

scholarly journals EXPERIENCE WITH INTRAVENOUS IMMUNOGLOBULIN IN GUILLAIN BARRE SYNDROME OR AIDP

2018 ◽  
Author(s):  
Dr. Kamlesh Kumar ◽  
Dr. Krishana Kumar Lohani
Keyword(s):  
Mechanical Ventilation ◽  
Respiratory Failure ◽  
Intravenous Immunoglobulin ◽  
Neurological Deficit ◽  
Guillain Barre Syndrome ◽  
College Hospital ◽  
Assisted Mechanical Ventilation ◽  
Medical College ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

50 Patients of Guillain Barre Syndrome (GBS) admitted in Medical word and ICU of Anugrah Narayan Magadh Medical College Hospital (ANMMCH) Gaya was studied. All patients (pts) treated with intravenous immune globulin (IVIG) Irrespective of presentation and with or without respiratory failure. Patients were diagnosed on the basis of history, clinical examination investigation (NCV + CSF) and treated with IVIG. In case of respiratory failure assisted mechanical ventilation was given. Out of 50 pts. 8 (16%) patients died. 3(6%) patients develops severe neurological deficit, 8(16%) Mild deficit and 31(62%) were recovered completely.

scholarly journals Guillain Barré Syndrome after Thrombolysis With Streptokinase for Acute Myocardial Infarction: A Case Report

2017 ◽  
Vol 33 (2) ◽  
pp. 103-104
Author(s):  
Mohammad Kafil Uddin ◽  
- Md Shahidullah ◽  
Subash Kanti Dey ◽  
Rezaul Karim Khan ◽  
Md Rafiqul Islam ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Case Report ◽  
Thrombolytic Therapy ◽  
Intravenous Immunoglobulin ◽  
Guillain Barre Syndrome ◽  
Neurologic Disorder ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

We would like to report on a patient, a 52-year-old man with acute neurologic disorder, Guillain Barré Syndrome. He was successfully treated by intravenous immunoglobulin. The patient suffered from acute extensive anterior MI. 2 weeks after thrombolytic therapy with streptokinase, he developed GBS. Bangladesh Journal of Neuroscience 2017; Vol. 33 (2): 103-104

scholarly journals Guillain–Barre Syndrome following Tuberculosis: A Rare Association

2017 ◽  
Vol 08 (02) ◽  
pp. 296-299 ◽  
Author(s):  
Akshay Navalkishor Lakhotia ◽  
Dinesh Chouksey ◽  
Rahul Jain ◽  
Ajoy Kumar Sodani
Keyword(s):  
Case Report ◽  
Pulmonary Tuberculosis ◽  
Intravenous Immunoglobulin ◽  
Axonal Neuropathy ◽  
Guillain Barre Syndrome ◽  
Early Recovery ◽  
Acute Motor Axonal Neuropathy ◽  
Rare Association ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

ABSTRACTThe co-occurrence of Guillain–Barre syndrome (GBS) and tuberculosis is rare. Even in countries like India, where tuberculosis is common, there is only one case report of co-occurrence of GBS with tuberculosis. We report a case of GBS in association with sputum-positive pulmonary tuberculosis. The earliest treatment with intravenous immunoglobulin in acute motor axonal neuropathy variant of GBS would show good early recovery despite associated pulmonary tuberculosis.

A Novel Treatment Strategy for Severe Guillain-Barré Syndrome: Zipper Method

2019 ◽  
Vol 34 (5) ◽  
pp. 277-283 ◽  
Author(s):  
Selman Kesici ◽  
Murat Tanyıldız ◽  
Filiz Yetimakman ◽  
Benan Bayrakci
Keyword(s):  
Mechanical Ventilation ◽  
Hospital Stay ◽  
Plasma Exchange ◽  
Intravenous Immunoglobulin ◽  
Treatment Strategy ◽  
Guillain Barre Syndrome ◽  
Novel Treatment ◽  
Guillain Barré Syndrome ◽  
The Mean ◽  
Guillain Barré

Objective: Intravenous immunoglobulin and plasma exchange are proven treatments for Guillain-Barré syndrome. Despite these treatments, the prognosis for severe Guillain-Barré syndrome is still not satisfactory. This article seeks for a logical timing for plasma exchange–intravenous immunoglobulin synergy, which may improve outcome in severe Guillain-Barré syndrome requiring mechanical ventilation. Study Design: This study is an open-label study. Nine pediatric severe Guillain-Barré syndrome patients requiring mechanical ventilation were treated with novel treatment strategy named as “zipper method.” In this method, following diagnosis of Guillain-Barré syndrome, plasma exchange was started immediately. In the first session of plasma exchange, one and a half volume of patients’ plasma was removed by using 5% albumin as replacement solution. At the end of the plasma exchange session, 0.4 g/kg intravenous immunoglobulin infusion was started immediately. Second plasma exchange session was applied with one volume change after 24 hours from the end of the intravenous immunoglobulin infusion. Each plasma exchange session was followed by intravenous immunoglobulin infusions. This plasma exchange–intravenous immunoglobulin cycle was repeated for 5 times. Results: Among the 9 patients, the mean mechanical ventilation duration was 7 (5-14) days and the mean hospital stay was 18 (10-30) days. Medical Research Council sum score was increased in all patients, especially after the third session. All patients survived and all patients were able to walk unaided on the 28th day of admission. Conclusion: The zipper method as a novel treatment modality seems to reduce mortality, speed up weaning from mechanical ventilation, and shorten hospital stay, with excellent outcome in severe Guillain-Barré syndrome patients, who require intensive care. This technique stands as a promising immunomodulation strategy for various scenarios.

scholarly journals Are Repeated Cycles of Intravenous Immunoglobulin Justified in Patients With Poorly Responsive Guillain-Barré Syndrome?

2019 ◽  
Vol 10 (3) ◽  
pp. 224-228
Author(s):  
Hussein Algahtani ◽  
Bader Shirah ◽  
Khalid Alrefaei ◽  
Mohammed Albassam ◽  
Nawal Abdelghaffar
Keyword(s):  
Case Report ◽  
Intravenous Immunoglobulin ◽  
Guillain Barre Syndrome ◽  
Gadolinium Enhancement ◽  
Multicenter Trials ◽  
Guillain Barré Syndrome ◽  
Reasonable Approach ◽  
Life Threatening ◽  
Guillain Barré ◽  
The Cost

Guillain-Barré syndrome (GBS) is a life-threatening form of inflammatory polyneuropathy. Immunotherapy with intravenous immunoglobulin (IVIG) has been used successfully in the treatment of GBS. In this case report, we present a severe axonal form of GBS that showed improvement after 3 cycles of IVIG. Repeated cycles of IVIG may be an option for treating severe forms of GBS not responding to the first course of such treatment. The recent work suggests that patients who are severely affected and have severe gadolinium enhancement on the magnetic resonance imaging of the spine should be considered for retreatment with IVIG. Although the cost of management was high, the outcome was excellent, which is definitely considered a reasonable approach. This case report is an urgent call for performing large multicenter trials on the use of repeated cycles of IVIG in the management of severe cases of GBS.

scholarly journals A case report of Guillain Barré syndrome revealing underlying infective endocarditis due to Cardiobacterium hominis

Medicine ◽  
2019 ◽  
Vol 98 (15) ◽  
pp. e15014
Author(s):  
Kévin Diallo ◽  
Caroline Jacquet ◽  
Corentine Alauzet ◽  
Isabelle Beguinot ◽  
Thierry May ◽  
...  
Keyword(s):  
Case Report ◽  
Infective Endocarditis ◽  
Guillain Barre Syndrome ◽  
Guillain Barré Syndrome ◽  
Guillain Barré
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