Enlarged waist combined with elevated triglycerides (hypertriglyceridemic waist phenotype) and HDL-cholesterol in patients with heart failure

ABSTRACT CONTEXT AND OBJECTIVE: The association of serum triglycerides plus waist circumference seems to be a good marker of cardiovascular risk and has been named the “hypertriglyceridemic waist” phenotype. The aim of our study was to investigate the association between the hypertriglyceridemic waist phenotype and HDL-cholesterol among patients with heart failure. DESIGN AND SETTING: Cross-sectional study in a tertiary-level hospital in southern Brazil. METHODS: We included patients with heart failure aged > 40 years. Anthropometric assessment (weight, height, waist and hip circumferences) was performed; body mass index (BMI) and waist-hip ratio were calculated and lipid measurements (serum total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides) were collected. In men and women, respectively, waist circumference ≥ 94 cm and ≥ 80 cm, and triglycerides ≥ 150 mg/dl were considered abnormal and were used to identify the hypertriglyceridemic waist phenotype. Analyses of covariance were used to evaluate possible associations between levels of HDL-cholesterol and the hypertriglyceridemic waist phenotype, according to sex. RESULTS: 112 participants were included, of whom 62.5% were men. The mean age was 61.8 ± 12.3 years and the mean ejection fraction was 40.1 ± 14.7%. Men and woman presented mean HDL-cholesterol of 40.5 ± 14.6 and 40.9 ± 12.7 mg/dl, respectively. The prevalence of the hypertriglyceridemic waist phenotype was 25%. There was a significant difference in mean HDL-cholesterol between men with and without the hypertriglyceridemic waist phenotype (32.8 ± 14.2 versus 42.1 ± 13.7 mg/dl respectively; P = 0.04), even after adjustment for age, body mass index, type 2 diabetes mellitus, use of statins and heart failure etiology. CONCLUSIONS: The hypertriglyceridemic waist phenotype is significantly associated with lower HDL-cholesterol levels in men with heart failure.

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The Metabolic Syndrome among Postmenopausal Women in Gorgan

International Journal of Endocrinology ◽

10.1155/2012/953627 ◽

2012 ◽

Vol 2012 ◽

pp. 1-6 ◽

Cited By ~ 14

Author(s):

Abdoljalal Marjani ◽

Sedigheh Moghasemi

Keyword(s):

Metabolic Syndrome ◽

Body Mass Index ◽

Waist Circumference ◽

Postmenopausal Women ◽

Body Mass ◽

Hdl Cholesterol ◽

Waist To Hip Ratio ◽

Positive Correlation ◽

The Metabolic Syndrome ◽

The Mean

Introduction. The present study aimed to assess the metabolic syndrome among postmenopausal women in Gorgan, Iran.Materials and Methods. The study was conducted on hundred postmenopausal women who were referred to the health centers in Gorgan. Metabolic syndrome was diagnosed using Adult Treatment Panel III (ATP III) guidelines.Results. The mean body mass index, waist circumference, hip, circumference waist-to-hip ratio, diastolic blood pressure, and triglyceride and fasting blood glucose levels were significantly high among postmenopausal women with metabolic syndrome, but the mean HDL-cholesterol was significantly low (P<0.05). Overall prevalence of metabolic syndrome was 31%. Body mass index and waist circumference had a positive correlation with a number of metabolic syndrome factors (P<0.001). Body mass index, waist circumference, and waist-to-hip ratio had a positive correlation with each other (P<0.001). BMI had relatively high correlation with WC (P<0.001).Conclusions. Our results show that postmenopausal status might be a predictor of metabolic syndrome. Low HDL-cholesterol level and high abdominal obesity are the most frequent characteristics in comparison to other metabolic components. Our study also showed some related factors of metabolic syndrome among postmenopausal women. These factors may increase cardiovascular risk among postmenopausal women with metabolic syndrome.

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Diet variety mediates the effect of appetite on dietary nutritional insufficiency in patients with heart failure

European Journal of Cardiovascular Nursing ◽

10.1093/eurjcn/zvab060.057 ◽

2021 ◽

Vol 20 (Supplement_1) ◽

Author(s):

C Andreae ◽

TA Lennie ◽

ML Chung

Keyword(s):

Heart Failure ◽

Body Mass Index ◽

Body Mass ◽

Food Diary ◽

Diet Variety ◽

Patients With Heart Failure ◽

Limited Food ◽

Food Variety ◽

The Mean ◽

Nutritional Insufficiency

Abstract Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): National Institutes of Health R01 NR 009280 & P20 NR 010679 Background Poor appetite is commonly reported in patients with heart failure, which may lead to a diet with limited food variety. Limited food variety, in turn, can result in dietary nutritional insufficiencies. Purpose The purpose of the study was to determine whether the relationship between appetite and dietary nutritional insufficiencies was mediated through diet variety. Methods In this secondary analysis, patients with heart failure rated appetite on a 10-point visual analog scale from 1 to 10. Nutritional insufficiency and diet variety were assessed by a four-day food diary analyzed by Nutrition Data Systems. Nutrition insufficiency was defined as the total number of 18 minerals and vitamins that were insufficient in the diet. Diet variety was calculated as the number of 23 food types consumed over the 4 days. A mediation analysis was conducted controlling for age, gender, New York Heart Association (NYHA), and body mass index using the PROCESS v3.5 macro program with 5,000 bootstrap samples in SPSS. Results A total of 238 patients (mean age 61, SD = 12; male n = 164, 69%; NYHA III/IV, n = 107, 45%) were included. The mean body mass index was 30 kg/m2 (SD = 7). The mean appetite score was 7.5 (SD = 2.3). The mean number of micronutrient insufficiencies was 4.7 (SD = 3.5), and the mean diet variety score was 12.4 (SD = 2.6). Appetite was not directly associated with nutrition insufficiency (effect = -.1802; 95% CI = -.3715, .0111) controlling co-variates. However, there was a significant indirect effect of appetite on nutrition insufficiency through diet variety controlling for covariates (effect = -.0828: 95% CI = -.1585, -.0150). Conclusions Diet variety mediated the association between appetite and dietary micronutrient insufficiency in patients with heart failure. The findings suggest that dietary intervention aimed at increasing patients’ appetite may increase diet variety and enhance the nutritional quality of diets of patients with heart failure.

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Association of Body Mass Index With Clinical Outcomes in Patients With Heart Failure With Reduced Ejection Fraction Treated With Sacubitril/Valsartan

Journal of Cardiovascular Pharmacology and Therapeutics ◽

10.1177/10742484211024441 ◽

2021 ◽

pp. 107424842110244

Author(s):

Kazuhiko Kido ◽

Christopher Bianco ◽

Marco Caccamo ◽

Wei Fang ◽

George Sokos

Keyword(s):

Heart Failure ◽

Body Mass Index ◽

Propensity Score ◽

Ejection Fraction ◽

Clinical Outcomes ◽

Body Mass ◽

Normal Weight ◽

Reduced Ejection Fraction ◽

Propensity Score Weighting ◽

Patients With Heart Failure

Background: Only limited data are available that address the association between body mass index (BMI) and clinical outcomes in patients with heart failure with reduced ejection fraction who are receiving sacubitril/valsartan. Methods: We performed a retrospective multi-center cohort study in which we compared 3 body mass index groups (normal, overweight and obese groups) in patients with heart failure with reduced ejection fraction receiving sacubitril/valsartan. The follow-up period was at least 1 year. Propensity score weighting was performed. The primary outcomes were hospitalization for heart failure and all-cause mortality. Results: Of the 721 patients in the original cohort, propensity score weighting generated a cohort of 540 patients in 3 groups: normal weight (n = 78), overweight (n = 181), and obese (n = 281). All baseline characteristics were well-balanced between 3 groups after propensity score weighting. Among our results, we found no significant differences in hospitalization for heart failure (normal weight versus overweight: average hazard ratio [AHR] 1.29, 95% confidence interval [CI] = 0.76-2.20, P = 0.35; normal weight versus obese: AHR 1.04, 95% CI = 0.63-1.70, P = 0.88; overweight versus obese groups: AHR 0.81, 95% CI = 0.54-1.20, P = 0.29) or all-cause mortality (normal weight versus overweight: AHR 0.99, 95% CI = 0.59-1.67, P = 0.97; normal weight versus obese: AHR 0.87, 95% CI = 0.53-1.42, P = 0.57; overweight versus obese: AHR 0.87, 95% CI = 0.58-1.32, P = 0.52). Conclusion: We identified no significant associations between BMI and clinical outcomes in patients diagnosed with heart failure with a reduced ejection fraction who were treated with sacubitril/valsartan. A large-scale study should be performed to verify these results.

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Body Habitus and Prognosis in Patients With Heart Failure After Acute Decompensation. A Comparison of Survival According to Body-Mass Index

Journal of Cardiac Failure ◽

10.1016/j.cardfail.2010.07.218 ◽

2010 ◽

Vol 16 (9) ◽

pp. S172

Author(s):

Aya Banno ◽

Shun Kohsaka ◽

Kazuki Ohshima ◽

Yutaka Endo ◽

Masashi Takahashi ◽

...

Keyword(s):

Heart Failure ◽

Body Mass Index ◽

Body Mass ◽

Body Habitus ◽

Patients With Heart Failure ◽

Acute Decompensation

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Insulin resistance in relation to clinical, endocrine and metabolic profile of infertile women with polycystic ovary syndrome

Bangabandhu Sheikh Mujib Medical University Journal ◽

10.3329/bsmmuj.v14i1.50989 ◽

2021 ◽

Vol 14 (1) ◽

pp. 1-6

Author(s):

Shakeela Ishrat ◽

Marufa Hossain ◽

Subrata Kumar Biswas

Keyword(s):

Insulin Resistance ◽

Metabolic Syndrome ◽

Body Mass Index ◽

Waist Circumference ◽

Polycystic Ovary Syndrome ◽

Body Mass ◽

Polycystic Ovary ◽

Ovary Syndrome ◽

Infertile Women ◽

Significant Difference

The objective of this study is to explore how hyperinsulinemia and insulin resistance relate to the clinical, endocrine and metabolic factors in the infertile women with polycystic ovary syndrome. This study was conducted on 121 consecutive infertile women with polycystic ovary syndrome attending the Infertility unit from January 2017 to December 2017. They were divided into two groups: insulin resistant and insulin sensitive. There was significant difference in body mass index and waist circumference between the two groups. Serum lipids were not associated with insulin resistance. Hyperinsulinemia was significantly associated with metabolic syndrome. Reducing body mass index and waist circumference may improve insulin resistance in infertile women with polycystic ovary syndrome. Screening the infertile women with polycystic ovary syndrome for hyperinsulinemia and insulin resistance and subsequent counseling is recommended to address the long-term risks of metabolic syndrome.

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Comparação entre a evolução de pré-escolares com fibrose cística identificados por triagem neonatal ou por sintomatologia clínica

Scientia Medica ◽

10.15448/1980-6108.2018.2.29566 ◽

2018 ◽

Vol 28 (2) ◽

pp. 29566

Author(s):

Magali Santos Lumertz ◽

Ângela De Moura ◽

Leonardo Araújo Pinto ◽

Paulo Augusto Moreira Camargos ◽

Paulo José Cauduro Marostica

Keyword(s):

Body Mass Index ◽

Cystic Fibrosis ◽

Pulmonary Function ◽

Body Mass ◽

Screening Test ◽

Preschool Age ◽

Index Number ◽

Significant Difference ◽

The Mean

AIMS: To compare clinical, laboratory and spirometric parameters of preschoolers (ages from three to six years old) with cystic fibrosis identified by abnormal newborn screening test (NS group), with data of patients whose diagnostic suspicion arose from characteristic clinical signs and symptoms (CS group).METHODS: Retrospective cohort study, with a sample obtained from the medical charts of patients who received specialized and multidisciplinary outpatient follow-up. All the included children had a confirmed diagnosis of cystic fibrosis by sweat electrolyte testing and/or genetic sequencing. Variables included sex, weight, height, body mass index, number of hospitalizations per year, Pseudomonas aeruginosa colonization, presence of pancreatic insufficiency and Shwachman score, which covers four domains: general activity, nutrition, radiological examination and physical evaluation, each one scored between 5 and 25 points. A total score ≤40 points indicates severe state, and ≥86 points indicates excellent state. For comparison of pulmonary function, data from the last spirometry performed before the age of six years were used. Outcomes were compared by chi-square or Student's t test, with a significance limit of 0.05.RESULTS: Twenty-four patients were included in the study, seven children in the NS group and 17 children in the CS group. The children of the NS group started follow-up with a mean age of 1.51±2.04 months, and those of the CS group started with 3.77±1.80 months (p=0.014). The mean Shwachman score was 94.40±2.19 in the NS vs. 87.67±8.00 in the CS group (p=0.018). The mean Z score for body mass index was 0.95±1.02 in the NS group vs. 0.51±1.05 in the CS group (p=0.051). Spirometric variables had slightly higher values in the NS group, with no statistically significant difference between groups.CONCLUSIONS: The results suggest that those patients diagnosed with cystic fibrosis from the neonatal screening test suspicion benefited from an early intervention, being able to initiate pulmonary function tests and receive treatment and counseling earlier. Evaluation of clinical parameters with the Shwachman score showed that benefits could be already observed at the preschool age.

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