scholarly journals Frequency of alleles associated with celiac disease in patients with autoimmune thyroid disease

2021 ◽  
Vol 34 ◽  
Author(s):  
Clédia Silveira Flores da SILVA ◽  
Natalia Rodrigues CARDOZO ◽  
Raíssa ZANATTA ◽  
Augusto SCHNEIDER ◽  
Carlos Castilho de BARROS ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Gastrointestinal Symptoms ◽  
Human Leukocyte ◽  
Thyroid Diseases ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid ◽  
Leukocyte Antigen ◽  
Polymerase Chain ◽  
Genetic Profiles

ABSTRACT Objective To determine the frequency of Human leukocyte antigen alleles and to verify the association of the presence of these alleles with symptoms and other diseases related to celiac disease in patients with autoimmune thyroid diseases. Methods A questionnaire on the symptoms and diseases associated with celiac disease was applied. Genomic deoxyribonucleic acid was extracted by collecting cells from the oral mucosa. The alleles (DQA1*0501; DQB1*0201; DRB1*04) were identified by means of the polymerase chain reaction. Results A total of 110 patients with autoimmune thyroid diseases participated in this study. It was observed that 66.4% of the individuals carried at least one of the alleles assessed and that 58.2% of the individuals were positive for at least one of the DQ2 alleles (DQA1*0501; DQB1*0201) and out of these 18.2% were positive for both DQ2 alleles (DQA1*0501; DQB1*0201). With regard to DQ8 (DRB1*04), 21.8% of the studied population was positive for this allele and 3.6% was positive for both DQ2 (DQA1*0501; DQB1*0201) and DQ8 (DRB1*04). A significant association was found between the presence of the DRB1*04 allele and gastrointestinal symptoms (p=0.02). A significant association of the DRB1*04 allele with type 1 diabetes mellitus (p=0.02) was observed. Conclusion The genetic profiles most commonly associated with celiac disease, such as DQ2 (DQA1*0501; DQB1*0201) and DQ8 (DRB1*04) were around 20.0% prevalent in the studied population. These are risk haplotypes for celiac disease especially when symptoms and diseases related to celiac disease are present. Therefore, it is important to screen patients to investigate a potential diagnosis for celiac disease.

scholarly journals Human Leukocyte Antigen HLA in Korean patients with Autoimmune Thyroid Diseases

1986 ◽  
Vol 1 (2) ◽  
pp. 243-249 ◽  
Author(s):  
Kap Bum Huh ◽  
Hyun Chul Lee ◽  
Hyeon Man Kim ◽  
Hye Ree Lee ◽  
Chein Soo Hong ◽  
...  
Keyword(s):  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Thyroid Diseases ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid ◽  
Leukocyte Antigen ◽  
Korean Patients

Analysis of diabetes-associated autoantibodies in children and adolescents with autoimmune thyroid diseases

2019 ◽  
Vol 32 (4) ◽  
pp. 355-361 ◽  
Author(s):  
Marta Rydzewska ◽  
Justyna Michalak ◽  
Anna Bossowska ◽  
Shu Chen ◽  
Sarah Black ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Study Groups ◽  
Thyroid Diseases ◽  
Control Group ◽  
Acid Decarboxylase ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid ◽  
Glutamic Acid Decarboxylase Autoantibodies ◽  
Group 2

Abstract Background Zinc transporter 8 autoantibodies (ZnT8Abs) together with glutamic acid decarboxylase autoantibodies (GADAbs), insulinoma antigen 2 autoantibodies (IA-2Abs) and insulin autoantibodies (IAbs) are markers of type 1 diabetes mellitus (T1DM). We studied the prevalence of ZnT8Ab in children with autoimmune thyroid diseases (AITDs) to assess the association of AITDs and T1DM at the serological level. Methods The study groups consisted of 44 children with Graves’ disease (GD), 65 children with Hashimoto’s thyroiditis (HT), 199 children with T1DM with or without AITDs and 58 control children. ZnT8Ab, GADAb, IA-2Ab, IAb, 21-hydroxylase autoantibodies (21-OHAbs) and acetylcholine receptor autoantibodies (AChRAbs) were measured. Results ZnT8Abs were found in 4/44 (9.1%) patients with GD, and 4/44 (9.1%) patients with GD were positive for GADAb. Of the 65 HT patients, six (9.2%) were positive for ZnT8Ab, while four (6.2%) were positive for GADAb. In the T1DM group, 128/199 (64%) of the patients were positive for ZnT8Ab, 133/199 (67%) for GADAb and 109/199 (55%) for IA-2Ab. One GD patient and one HT patient were positive for all the four diabetes-associated autoantibodies. Two HT patients were positive for three diabetes autoantibodies. Two GD (4.5%) and five HT (7.7%) patients were positive for 21-OHAb only. None of the patients had AChRAb. In the control group, 2/58 (3.4%) were positive for GADAb and 2/58 (3.4%) were positive for ZnT8Ab. Conclusions Diabetes-associated autoantibodies including ZnT8Ab were found in children and adolescents with GD and HT.

scholarly journals A One-Tube Polymerase Chain Reaction Protocol Demonstrates CC Chemokine Overexpression in Graves’ Disease Glands

1999 ◽  
Vol 84 (8) ◽  
pp. 2873-2882
Author(s):  
Yaqoub Ashhab ◽  
Orlando Dominguez ◽  
Mireia Sospedra ◽  
Carme Roura-Mir ◽  
Anna Lucas-Martín ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Needle Aspiration ◽  
Graves Disease ◽  
Tissue Samples ◽  
Autoimmune Thyroid ◽  
Leukocyte Antigen ◽  
Cc Chemokine ◽  
Inflammatory Protein ◽  
Cc Chemokines ◽  
Polymerase Chain

An adaptation of mixed oligonucleotide primed amplification of complementary DNA to detect the profile of CC chemokines in biological samples is presented. By introducing normalization, two correction coefficients, performing a single amplification reaction, and five parallel hybridizations, intrasample and intersample comparisons can be reliably made. This protocol of single tube PCR CC chemokine profiling was applied to tissue samples from an autoimmune thyroid condition, Graves’ disease, and from a nonautoimmune condition, multinodular goiter. Results demonstrate overexpression of CC chemokines in Graves’ disease, statistically significant for macrophage inflammatory protein-1α and -1β, which correlated with the aberrant human leukocyte antigen class II expression by thyrocytes, as assessed by flow cytometry. Overexpression of CC chemokines probably plays a major role in determining the characteristics of the lymphocytes migrating to the thyroid gland and influences the course of the disease. The study of chemokine profile should be more informative than the study of isolated chemokines and cytokines, and as it can be applied to fine needle aspiration biopsies, it may be useful to clinical research.

scholarly journals Fetal cell microchimerism: a protective role in autoimmune thyroid diseases

2015 ◽  
Vol 173 (1) ◽  
pp. 111-118 ◽  
Author(s):  
Valentina Cirello ◽  
Roberta Rizzo ◽  
Milena Crippa ◽  
Irene Campi ◽  
Daria Bortolotti ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Protective Role ◽  
Systemic Autoimmune Disease ◽  
Fetal Cell ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid ◽  
Leukocyte Antigen ◽  
Fetal Cells ◽  
Maternal Immune System ◽  
Polymorphic Pattern

ObjectiveThe physiological persistence of fetal cells in the circulation and tissue of a previously pregnant woman is called fetal cell microchimerism (FCM). It has been hypothesized to play a role in systemic autoimmune disease; however, only limited data are available regarding its role in autoimmune thyroid disease (AITD).DesignCirculating FCM was analyzed in a large series of previously pregnant women with Graves' disease (GD), Hashimoto's thyroiditis (HT), or no disease (healthy controls (HCs)). To exclude the possible bias related to placental factors, the polymorphic pattern of human leukocyte antigen-G (HLA-G) gene, which is known to be involved in the tolerance of fetal cells by the maternal immune system, was investigated.MethodsFCM was evaluated by PCR in the peripheral blood, and the Y chromosome was identified by fluorescencein situhybridization in some GD tissues.HLA-Gpolymorphism typing was assessed by real-time PCR.ResultsFCM was significantly more frequent in HC (63.6%) than in GD (33.3%) or HT (27.8%) women (P=0.0004 andP=0.001 respectively). A quantitative analysis confirmed that circulating male DNA was more abundant in HC than it was in GD or HT. Microchimeric cells were documented in vessels and in thyroid follicles. In neither GD/HT patients nor HC women was theHLA-Gtyping different between FCM-positive and FCM-negative cases.ConclusionThe higher prevalence of FCM in HC as compared to GD and HT patients suggests that it plays a possible protective role in autoimmune thyroid disorders. Placental factors have been excluded as determinants of the differences found. The vascular and tissue localization of microchimeric cells further highlights the ability of those cells to migrate to damaged tissues.

Functional Polymorphisms of the Type 1 and Type 2 Iodothyronine Deiodinase Genes in Autoimmune Thyroid Diseases

2018 ◽  
Vol 47 (5) ◽  
pp. 534-542 ◽  
Author(s):  
Naoya Inoue ◽  
Mikio Watanabe ◽  
Yuka Katsumata ◽  
Naoko Ishido ◽  
Yoh Hidaka ◽  
...  
Keyword(s):  
Thyroid Diseases ◽  
Autoimmune Thyroid Diseases ◽  
Iodothyronine Deiodinase ◽  
Autoimmune Thyroid ◽  
Functional Polymorphisms

scholarly journals The role of common genetic markers in susceptibility to type 1 diabetes and autoimmune thyroid diseases

2011 ◽  
Vol 14 (2) ◽  
pp. 23-31 ◽  
Author(s):  
Ekaterina Alexandrovna Repina
Keyword(s):  
Type 1 Diabetes ◽  
Genetic Markers ◽  
Current Data ◽  
Thyroid Diseases ◽  
Single Patient ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid

This review generalizes current data on the genes responsible for combined susceptibility to type 1 diabetes and autoimmune thyroid diseases. Analysisof the role of common genetic markers facilitates understanding their contribution to the development of each of the two or several concomitantautoimmune diseases affecting a single patient

scholarly journals Genetic Association Study of IL2RA, IFIH1, and CTLA-4 Polymorphisms With Autoimmune Thyroid Diseases and Type 1 Diabetes

2020 ◽  
Vol 8 ◽  
Author(s):  
Hanna Borysewicz-Sańczyk ◽  
Beata Sawicka ◽  
Natalia Wawrusiewicz-Kurylonek ◽  
Barbara Głowińska-Olszewska ◽  
Anna Kadłubiska ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Association Study ◽  
Genetic Association ◽  
Genetic Association Study ◽  
Thyroid Diseases ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid

Autoimmune polyglandular syndromes in the adults: the genetic and immunological diagnostic criteria

2014 ◽  
Vol 60 (3) ◽  
pp. 43-52 ◽  
Author(s):  
A A Larina ◽  
E A Troshina ◽  
O N Ivanova
Keyword(s):  
Adrenal Insufficiency ◽  
Thyroid Diseases ◽  
Primary Adrenal Insufficiency ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid ◽  
Aire Gene ◽  
Patients At Risk ◽  
Type 3 ◽  
Cortical Dysfunction

At present, four main types of autoimmune polyglandular syndromes (APS) are distinguished. Type 1 APS is associated with candidiasis, primary hypoparathyroidism, and primary adrenal insufficiency developing in the childhood as a result of mutations in the AIRE gene. Type 2 APS involves primary adrenal insufficiency in combination with autoimmune thyroid diseases and/or type 1 diabetes mellitus. Type 3 APS is characterized by the combination of autoimmune thyroid diseases with other endocrine and non-endocrine autoimmune pathologies in the absence of adrenal cortical dysfunction and hypoparathyriodism. Type 4 APS is presented by the combinations of autoimmune diseases other than the aforementioned ones. The above syndromes usually manifest themselves at the age between 20 and 60 years; they are of the polygenic type and associated with the genetic markers, such as HLAII-complex haplotypes, CTLA-4, PTPN22, FOXP3 genes, etc. In addition, the latent forms of APS have been described that occur in the populations much more frequently than the manifest disorders. These latent diseases can exert strong influence on the compensation and risk of complications of the underlying pathology. Of great importance in this context is the timely identification of the groups of patients at risk of developing clinical forms of APS among the subjects presenting with a single endocrine pathology.

Sign in / Sign up

Export Citation Format

Share Document