scholarly journals Association of sleep disorders with heart rate variability in children and adolescents with cystic fibrosis

2022 ◽  
Vol 40 ◽  
Author(s):  
Rodrigo dos Santos Lugao ◽  
Roberta Ribeiro Batista Barbosa ◽  
Pitiguara de Freitas Coelho ◽  
Fernanda Mayrink Gonçalves Liberato ◽  
Pâmela Reis Vidal ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Pulmonary Function ◽  
Children And Adolescents ◽  
Sleep Disorders ◽  
Sleep Apnea Syndrome ◽  
Forced Expiratory Volume ◽  
Cross Sectional ◽  
Obstructive Sleep

ABSTRACT Objective: To assess the association of sleep disorders with the findings of heart rate variability (HRV) in children and adolescents with cystic fibrosis (CF). Methods: Cross-sectional study including children and adolescents aged six to 18 years with a clinical diagnosis of CF. Sociodemographic and clinical data were collected. Sleep disorders were evaluated using baseline nocturnal polysomnography. The autonomic nervous system (ANS) was evaluated through resting HRV. Results: A total of 30 individuals (11.2 years) with a mean forced expiratory volume in the first second (FEV1) of 62.7% were included. The respiratory disturbance index presented a median of 2.6 and obstructive sleep apnea syndrome (OSAS) was identified in 30%. In the HRV analysis, a mean standard deviation of all inter-beat (RR) intervals (SDNN) of 60.8±45.9ms was found. There was a significant correlation between the HRV low-frequency/high-frequency (LF/HF) global modulation index and the minimum SpO2 during sleep in patients with FEV1<60% (r=0.71; p=0.02). The prevalence of sleep disorders and HRV abnormalities was higher in individuals with lesser pulmonary function (FEV1<60%). Conclusions: The results indicate a weak correlation of sleep disorders (minimum SpO2) with HRV parameters (LH/HF) in children and adolescents with CF. When pulmonary function was reduced, a stronger correlation was found, highlighting the influence of disease severity. A high prevalence of ANS disorders, nocturnal hypoxemia, and presence of OSAS was also found.

scholarly journals BODY MASS INDEX AND ALBUMIN LEVELS ARE ASSOCIATED WITH PULMONARY FUNCTION PARAMETERS IN PEDIATRIC SUBJECTS WITH CYSTIC FIBROSIS

2019 ◽  
Vol 37 (4) ◽  
pp. 414-418
Author(s):  
Miriam Isabel Souza dos Santos Simon ◽  
Gabriele Carra Forte ◽  
Paulo José Cauduro Marostica
Keyword(s):  
Body Mass Index ◽  
Cystic Fibrosis ◽  
Pulmonary Function ◽  
Body Mass ◽  
Univariate Analysis ◽  
Cross Sectional Study ◽  
Forced Expiratory Volume ◽  
Tertiary Referral Hospital ◽  
Cross Sectional ◽  
One Year

ABSTRACT Objective: To evaluate the association of body mass index (BMI) and albumin with pulmonary function in cystic fibrosis (CF) pediatric subjects. Methods: This is a cross-sectional study with clinically stable CF’s subjects. Clinical (pulmonary function) and nutritional evaluation (body mass index and albumin) were performed. Univariate analysis was performed using simple linear correlations. Regression analysis was performed using an exit level of p<0.05. Results: Seventy-eight CF’s subjects (mean age 12.8±3.8 years) with mean albumin 4.2±0.4 mg/dL, predicted forced expiratory volume in 1 second (FEV1%) 80.8±22.6 and BMI median percentile 51.2 (1.3-97.7). In the multiple regression models, albumin, age and BMI percentile were associated with pulmonary function. Subjects with lower than 25 BMI percentile had 12.2% lower FEV1%. An albumin increase of 0.1 mg was associated with 2.7% increase in predicted FEV1%, and one year increase in age was associated with reduction in 1.2% of predicted FEV1%. Conclusions: BMI percentile, albumin and age were independently associated with predicted FEV1% in a tertiary referral hospital.

Determinants of heart rate variability in obstructive sleep apnea syndrome during wakefulness and sleep

2005 ◽  
Vol 288 (3) ◽  
pp. H1103-H1112 ◽  
Author(s):  
J. A. Jo ◽  
A. Blasi ◽  
E. Valladares ◽  
R. Juarez ◽  
A. Baydur ◽  
...  
Keyword(s):  
Heart Rate ◽  
Obstructive Sleep Apnea ◽  
Heart Rate Variability ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Normal Subjects ◽  
Sinus Arrhythmia ◽  
Obstructive Sleep ◽  
Apnea Syndrome

Heart rate variability (HRV) is mediated by at least three primary mechanisms: 1) vagal feedback from pulmonary stretch receptors (PSR), 2) central medullary coupling between respiratory and cardiovagal neurons (RCC), and 3) arterial baroreflex (ABR)-induced fluctuations. We employed a noninvasive experimental protocol in conjunction with a minimal model to determine how these sources of HRV are altered in obstructive sleep apnea syndrome (OSAS). Respiration, heart rate, and blood pressure were monitored in eight normal subjects and nine untreated OSAS patients in relaxed wakefulness and stage 2 and rapid eye movement sleep. A computer-controlled ventilator delivered inspiratory pressures that varied randomly from breath to breath. Application of the model to the corresponding subject responses allowed the delineation of the three components of HRV. In all states, RCC gain was lower in OSAS patients than in normal subjects ( P < 0.04). ABR gain was also reduced in OSAS patients ( P < 0.03). RCC and ABR gains increased from wakefulness to sleep ( P < 0.04). However, there was no difference in PSR gain between subject groups or across states. The findings of this study suggest that the adverse autonomic effects of OSAS include impairment of baroreflex gain and central respiratory-cardiovascular coupling, but the component of respiratory sinus arrhythmia that is mediated by lung vagal feedback remains intact.

scholarly journals FACTORS ASSOCIATED TO QUALITY OF LIFE IN CHILDREN AND ADOLESCENTS WITH CYSTIC FIBROSIS

2020 ◽  
Vol 38 ◽  
Author(s):  
Nelbe Nesi Santana ◽  
Célia Regina Moutinho de Miranda Chaves ◽  
Christine Pereira Gonçalves ◽  
Saint Clair dos Santos Gomes Junior
Keyword(s):  
Quality Of Life ◽  
Cystic Fibrosis ◽  
Nutritional Status ◽  
Children And Adolescents ◽  
Functional Capacity ◽  
Clinical Status ◽  
Forced Expiratory Volume ◽  
Cross Sectional ◽  
Function Test

ABSTRACT Objective: To verify the association between quality of life, functional capacity and clinical and nutritional status in children and adolescents with cystic fibrosis (CF). Methods: Cross-sectional study, including patients from eight to 18 years old with CF. Quality of life, functional capacity, nutritional status and clinical status were evaluated with the Cystic Fibrosis Questionnaire; the 6-minute walk test (6MWT) and manual gripping force (MGF); the height percentiles for age and body mass index for age and respiratory function test, respectively. Pearson and Spearman correlation tests and logistic regression were used to analyze the data. Results: A total of 45 patients, 13.4±0.5 years old, 60% female, 60% colonized by Pseudomonas aeruginosa and 57.8% with at least one F508del mutation participated in the study. When assessing the perception of quality of life, the weight domain reached the lowest values, and the digestive domain, the highest. In the pulmonary function test, the forced expiratory volume of the first second was 77.3±3.3% and the 6MWT and MGF presented values within the normal range. There was an association between quality of life and functional capacity, nutritional status and clinical status of CF patients. Conclusions: The study participants had good clinical conditions and satisfactory values of functional capacity and quality of life. The findings reinforce that the assessment of quality of life may be important for clinical practice in the management of treatment.

scholarly journals Is FEV1 associated with quality of life in children with cystic fibrosis? An original article

2019 ◽  
Vol 6 (1) ◽  
pp. e06-e06
Author(s):  
Rohola Shirzadi ◽  
Safoura Navaei ◽  
Mohammadreza Modaresi ◽  
Farzad Masiha
Keyword(s):  
Quality Of Life ◽  
Cystic Fibrosis ◽  
Pulmonary Function ◽  
Medical Center ◽  
Cross Sectional Study ◽  
Forced Expiratory Volume ◽  
Psychological Status ◽  
Cross Sectional ◽  
The Mean

Introduction: Cystic fibrosis (CF) is a serious genetic life-shortening disease. Quality of life (QoL) measurement related to CF children is a relatively new field of research, which includes the patient’s perspective in research and clinical practice. Objectives: This study aimed to evaluate the QoL in children with CF and its association with FEV1 (forced expiratory volume in 1 second). Patients and Methods: This cross-sectional study was carried out on 7-14 years old children with CF attending children’s medical center from March 2017 to March 2018. Throat swab cultures and spirometry evaluation was performed for all patients. FEV1 was determined and the 6-min walk test (6MWT) was conducted. The patient’s psychological status was assessed using the Persian version of pediatric QoL inventory. ANOVA, t test, and chisquare tests were used for data analysis. Results: Seventy-six subjects with the mean age of 10.49±3.18 years were studied since 59% of them (n=44) were boys. The mean total QoL was 65.34±17.73. Patients with lower pulmonary function had a lower QoL. There was a significant association between FEV1 and school and emotional functioning (P=0.005 and P=0.002, respectively). A significant association was found between SPO2 (peripheral capillary oxygen saturation) reduction after 6MWT and FEV1 decline (P=0.001). Additionally, a significant association was detected between FEV1 and the distance walked during 6MWT (P=0.030). Conclusion: Regarding the association between pulmonary function and QoL in CF patients and lower QoL score in our study, the importance of assessing pulmonary function in these patients should not be neglected.

Evaluation of the upper airway in children and adolescents with cystic fibrosis and obstructive sleep apnea syndrome

2009 ◽  
Vol 73 (12) ◽  
pp. 1780-1785 ◽  
Author(s):  
Regina Terse Trindade Ramos ◽  
Cristina Salles ◽  
Paloma Baiardi Gregório ◽  
Alessandro Tunes Barros ◽  
Angélica Santana ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Children And Adolescents ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Upper Airway ◽  
Obstructive Sleep ◽  
Apnea Syndrome
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