scholarly journals Primary lymphoma of the central nervous system: a clinical-pathological and immunohistochemical study of ten autopsy cases

2006 ◽  
Vol 64 (4) ◽  
pp. 976-982 ◽  
Author(s):  
Henrique Costa ◽  
Marcello Franco ◽  
Myriam Dumas Hahn
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
B Cell ◽  
Laboratory Data ◽  
Primary Lymphoma ◽  
System A ◽  
Long Time ◽  
The Central Nervous System ◽  
The Mean ◽  
The Brain

CONTEXT: Primary central nervous system lymphomas (PCNSL) are a rare subgroup of lymphomas generally associated with HIV and EBV. OBJECTIVE: To study ten autopsy cases of PCNSL, to describe the neuropathological findings, to characterize the phenotype of the neoplastic cells, to detect EBV in the lesion and to compare the findings with the clinical and laboratory data of the patients. METHOD: The clinical, histological and immunohistochemical data of ten cases of PCNSL, eight cases from patients with AIDS, identified among 265 autopsies of these patients were analyzed. RESULTS: Seven patients were males and the mean age was 40.9 years. The most frequent symptomatology was focal neurologic deficit (70%). Six patients presented with only one lesion. Histologically, densely cellular and polymorphous neoplasms with angiocentrism were observed, in 90% of cases. An association with other diseases was observed in four cases. Most patients had diffuse large B cell non-Hodgkin’s lymphoma. EBV was detected by immunohistochemistry in only one case. The lack of detection of the virus might have been due to the long time of fixation of the brain which might have inactivate epitopes therefore compromising the testing. CONCLUSION: In the present series, PCNSL presented with focal symptoms, with unifocal or multifocal lesions, with a predominant B-cell CD20 positive phenotype, rarely associated with EBV.

Intravascular large B-cell lymphoma presenting with mass lesions in the central nervous system: A report of five cases

2004 ◽  
Vol 54 (4) ◽  
pp. 231-236 ◽  
Author(s):  
Hiroshi Imai ◽  
Kazuyoshi Kajimoto ◽  
Masashi Taniwaki ◽  
Ikuo Miura ◽  
Yoshihiro Hatta ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
System A ◽  
Large B Cell Lymphoma ◽  
The Central Nervous System ◽  
Mass Lesions ◽  
Large B Cell

Primary lymphoma of the central nervous system: A clinicopathologic analysis of 26 cases

1986 ◽  
Vol 33 (2) ◽  
pp. 95-102 ◽  
Author(s):  
Saeed T. Vakili ◽  
Jans Muller ◽  
Homayoon Shidnia ◽  
Robert L. Campbell
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Primary Lymphoma ◽  
System A ◽  
The Central Nervous System

Primary lymphoma of the central nervous system-a diagnostic challenge

2013 ◽  
Vol 32 (2) ◽  
pp. 57-67 ◽  
Author(s):  
Martina Deckert ◽  
Anna Brunn ◽  
Manuel Montesinos-Rongen ◽  
Maria Rosa Terreni ◽  
Maurilio Ponzoni
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Primary Lymphoma ◽  
Diagnostic Challenge ◽  
System A ◽  
The Central Nervous System

Crosstalk between Gut Microbiota and Central Nervous System: A Focus on Alzheimer's Disease

2018 ◽  
Vol 15 (13) ◽  
pp. 1179-1190 ◽  
Author(s):  
Vilma M. Junges ◽  
Vera E. Closs ◽  
Guilherme M. Nogueira ◽  
Maria G.V. Gottlieb
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Central Nervous System ◽  
Nervous System ◽  
Gut Microbiota ◽  
System A ◽  
Bidirectional Communication ◽  
The Central Nervous System ◽  
The Brain

The role of diet and gut microbiota in the pathophysiology of neurodegenerative diseases, such as Alzheimer's, has recently come under intense investigation. Studies suggest that human gut microbiota may contribute to the modulation of several neurochemical and neurometabolic pathways, through complex systems that interact and interconnect with the central nervous system. The brain and intestine form a bidirectional communication axis, or vice versa, they form an axis through bi-directional communication between endocrine and complex immune systems, involving neurotransmitters and hormones. Above all, studies suggest that dysbiotic and poorly diversified microbiota may interfere with the synthesis and secretion of neurotrophic factors, such as brain-derived neurotrophic factor, gammaaminobutyric acid and N-methyl D-Aspartate receptors, widely associated with cognitive decline and dementia. In this context, the present article provides a review of the literature on the role of the gutbrain axis in Alzheimer's disease.

Rythme nycthéméral de la synthèse protéique ovarienne chez le crustacé oniscoïde Porcellio dilatatus Brandt et rôle du protocérébron

1985 ◽  
Vol 63 (4) ◽  
pp. 799-803 ◽  
Author(s):  
M. Gohar ◽  
C. Souty-Grosset ◽  
P. Juchault
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Protein Synthesis ◽  
Diurnal Rhythm ◽  
Protein Synthesis Rhythm ◽  
The Central Nervous System ◽  
The Mean ◽  
The Brain

In Porcellio dilatatus, ovarian protein synthesis shows a diurnal rhythm with a maximum at the onset of night. Sham-operated females maintain this rhythm, which disappears after the ablation of the central part of the protocerebron. This operation also induces a decrease in the mean level of ovarian protein synthesis. Protocerebron implantation, before the removal of the brain, does not prevent the loss of that rhythm but maintains the same synthesis level as in sham-operated animals. Control of the ovarian protein synthesis rhythm by the central nervous system and the existence of a stimulating neurohormone for that synthesis are discussed.

Glucuronyl 3-sulfate occurs exclusively on distal unmyelinated terminals of selected sensory neurons in the peripheral nervous system

1995 ◽  
Vol 53 ◽  
pp. 958-959
Author(s):  
S.S. Spicer ◽  
B.A. Schulte
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cerebral Cortex ◽  
Peripheral Nervous System ◽  
Sensory Neurons ◽  
Sensory Nerves ◽  
Tissue Antigens ◽  
The Central Nervous System ◽  
The Brain ◽  
Leu 7

Generation of monoclonal antibodies (MAbs) against tissue antigens has yielded several (VC1.1, HNK- 1, L2, 4F4 and anti-leu 7) which recognize the unique sugar epitope, glucuronyl 3-sulfate (Glc A3- SO4). In the central nervous system, these MAbs have demonstrated Glc A3-SO4 at the surface of neurons in the cerebral cortex, the cerebellum, the retina and other widespread regions of the brain.Here we describe the distribution of Glc A3-SO4 in the peripheral nervous system as determined by immunostaining with a MAb (VC 1.1) developed against antigen in the cat visual cortex. Outside the central nervous system, immunoreactivity was observed only in peripheral terminals of selected sensory nerves conducting transduction signals for touch, hearing, balance and taste. On the glassy membrane of the sinus hair in murine nasal skin, just deep to the ringwurt, VC 1.1 delineated an intensely stained, plaque-like area (Fig. 1). This previously unrecognized structure of the nasal vibrissae presumably serves as a tactile end organ and to our knowledge is not demonstrable by means other than its selective immunopositivity with VC1.1 and its appearance as a densely fibrillar area in H&E stained sections.

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