scholarly journals Treatment of severe chromoblastomycosis with itraconazole and 5-flucytosine association

2010 ◽  
Vol 52 (6) ◽  
pp. 329-331 ◽  
Author(s):  
Vicente Sperb Antonello ◽  
Marcelo Campos Appel da Silva ◽  
Eduardo Cambruzzi ◽  
Dimas Alexandre Kliemann ◽  
Breno Riegel Santos ◽  
...  
Keyword(s):  
Male Patient ◽  
Subcutaneous Tissue ◽  
Subtropical Climate ◽  
Specific Group ◽  
Dematiaceous Fungi ◽  
Disease Treatment ◽  
Clinical Challenge ◽  
Melanized Fungi ◽  
Fungi Infection ◽  
Slow Growing

Chromoblastomycosis is a chronic human melanized fungi infection of the subcutaneous tissue caused by traumatic inoculation of a specific group of dematiaceous fungi through the skin, often found in barefooted agricultural workers, in tropical and subtropical climate countries. We report the case of a male patient presenting a slow-growing pruriginous lesion on the limbs for 20 years, mistreated over that time, which was diagnosed and successfully treated as chromoblastomycosis. Besides the prevalence of this disease, treatment is still a clinical challenge.

scholarly journals CHROMOBLASTOMYCOSIS: A NEGLECTED TROPICAL DISEASE

2015 ◽  
Vol 57 (suppl 19) ◽  
pp. 46-50 ◽  
Author(s):  
Flavio QUEIROZ-TELLES
Keyword(s):  
Subcutaneous Tissue ◽  
Term Therapy ◽  
Neglected Tropical Disease ◽  
Specific Group ◽  
Dematiaceous Fungi ◽  
Physical Methods ◽  
Patient’S Outcome ◽  
Long Term Therapy ◽  
Endemic Mycoses

SUMMARYChromoblastomycosis (CMB) is a chronic fungal infection of the skin and the subcutaneous tissue caused by a transcutaneous traumatic inoculation of a specific group of dematiaceous fungi occurring mainly in tropical and subtropical zones worldwide. If not diagnosed at early stages, patients with CBM require long term therapy with systemic antifungals, sometimes associated with physical methods. Unlike other neglected endemic mycoses, comparative clinical trials have not been performed for this disease. Nowadays, therapy is based on a few open trials and on expert opinion. Itraconazole either as monotherapy or associated with other drugs, or with physical methods, is widely used. Recently, photodynamic therapy has been successfully employed in combination with antifungals in patients presenting with CBM. In the present revision the most used therapeutic options against CBM are reviewed as well as the several factors that may have impact on the patient's outcome.

scholarly journals A Huge Cemento-Ossifying Fibroma of Paranasal Sinus: A Case Report

2012 ◽  
Vol 55 (3) ◽  
pp. 146-149
Author(s):  
Ibrahim Erdim ◽  
Zahide Mine Yazici ◽  
Rasim Yilmazer ◽  
Nurten Sever ◽  
Fatma Tulin Kayhan
Keyword(s):  
Case Report ◽  
Paranasal Sinus ◽  
Male Patient ◽  
Paranasal Sinuses ◽  
Surgical Excision ◽  
Ossifying Fibroma ◽  
Radiological Appearance ◽  
Close Observation ◽  
Slow Growing

Cemento-ossifying fibroma is a well-bordered, slow-growing, benign fibro-osseous disease. Although its localization is generally in the mandible, it can be seen in any area of the craniofacial region. Radiology and histopathology help to diagnose the condition. Treatment is based on close observation and/or surgical excision. In this case, we report the case of a 62-year-old male patient who had a large radiological appearance, cemento-ossifying fibroma in the paranasal sinuses.

scholarly journals Management of pseudo tumour in haemophilia patients

2020 ◽  
Vol 7 (6) ◽  
pp. 2033
Author(s):  
Sherlyn Ambrose ◽  
Giridhar Ashwath ◽  
Sreekar Balasundaram ◽  
Suresh Kumar ◽  
Cecil Ross ◽  
...  
Keyword(s):  
Male Patient ◽  
Soft Tissues ◽  
Hemophilia A ◽  
Rare Complication ◽  
Arterial Embolization ◽  
Surgical Excision ◽  
High Rate ◽  
Treatment Modalities ◽  
Fistula Formation ◽  
Slow Growing

A hemophilic pseudotumor is one of the rare complications of hemophilia that results from repetitive bleeding, forming an expanding destructive encapsulated hematoma and necrosed tissue. It has a considerable amount of morbidity. These have become rare over the years with better treatment modalities like factor replacement. Presently, excision is the preferred treatment by many authors. There are instances where surgical excision is not feasible. In such situations, radiotherapy and arterial embolization should be considered either alone or as an adjunct to surgery. A 32 years old male patient, with severe hemophilia A diagnosed with an abdominal tumour 7 years ago during routine screening, that progressively grew to encompass the lower abdominal area. A 44 years old male patient with hemophilia A presented with slow growing swelling over the left gluteal region since, 10 years associated with ulceration and bleeding since, 3 days. The management of a patient with a haemophilic pseudo tumour is complex, with a high rate of potential complications. Surgical excision is the treatment of choice but can only be carried out by a multidisciplinary surgical team. The main postoperative complications are rebleed, infection, fistula and pathological fractures. Pelvic pseudo tumours can even become complicated by fistula formation to the large bowel and by obstruction of the ureters. Untreated pseudo tumours will ultimately destroy soft tissues, erode bone, and may produce neurovascular complications. The hemophilic pseudo tumour is a rare entity which is slow growing painless tumour, with few reports worldwide in the management of this rare complication.

scholarly journals Schwannoma of the External Auditory Canal: A Rare Location

2015 ◽  
Vol 7 (3) ◽  
pp. 147-148 ◽  
Author(s):  
Harendra Kumar ◽  
Samvartika Somavanshi ◽  
Arti Agrawal ◽  
Dharmendra Kumar ◽  
Hari Singh
Keyword(s):  
Head And Neck ◽  
Schwann Cells ◽  
Male Patient ◽  
External Auditory Canal ◽  
Nervous Systems ◽  
Autonomic Nervous ◽  
Rare Location ◽  
Slow Growing

ABSTRACT Schwannomas are benign slow-growing encapsulated tumors arising from the Schwann cells that ensheath the axons of the peripheral, cranial, and autonomic nervous systems. About 25 to 45% of all Schwannomas are seen in the head and neck but Schwannoma of the external auditory canal is rare. We report a case of Schwannoma of the external auditory canal in a 18-year-old male patient. How to cite this article Kumar D, Somavanshi S, Kumar H, Agrawal A, Singh H. Schwannoma of the External Auditory Canal: A Rare Location. Int J Otorhinolaryngol Clin 2015;7(3):147-148.

Scalp pilar tumor with intranuclear fibrils

1984 ◽  
Vol 42 ◽  
pp. 44-45
Author(s):  
B. S. Lim
Keyword(s):  
Microscopic Examination ◽  
Subcutaneous Tissue ◽  
Squamous Carcinoma ◽  
Electron Microscopic Examination ◽  
Mental Patient ◽  
Low Grade ◽  
Electron Microscopic ◽  
Morphological Finding ◽  
Slow Growing ◽  
Cut Surface

Pilar tumor is considered by some to be a low grade squamous carcinoma. Although there are instances of metastasis to regional nodes, the tumor is extremely slow growing and recurrence are rare. Electron microscopic examination of this tumor revealed new morphological finding of intranuclear fibrils.Description of the tumor: A large, nodular, fungating and focally ulcerated tumor was noted in the center of the scalp of a mental patient. This mass measured 8.0x4.0x3.0 cm. On cut surface the tumor was well circumscribed and appeared to extend deep into the subcutaneous tissue. On inspection this lesion was gray-white and granular and in some areas there were foci of calcification, hemorrhage and necrosis.

“COPPER PENNY” OF PATHOLOGY- CHROMOBLASTOMYCOSIS- A CASE REPORT AND BRIEF REVIEW OF LITERATURE.

2021 ◽  
pp. 42-44
Author(s):  
Shreekant Bharti ◽  
Avinash Singh ◽  
Sanjay Pandey ◽  
Prannoy Das
Keyword(s):  
Differential Diagnosis ◽  
Histopathological Examination ◽  
Subcutaneous Tissue ◽  
Skin Lesions ◽  
Review Of Literature ◽  
Fonsecaea Pedrosoi ◽  
Healing Ulcer ◽  
Dematiaceous Fungi ◽  
Chronic Skin ◽  
Prevalent Species

Chromoblastomycosis (CBM) is a chronic, granulomatous, mycosis of the skin and subcutaneous tissue produced by the traumatic implantation of various dematiaceous fungi. The most prevalent species (90%) is Fonsecaea pedrosoi. We report a case of a 29 year male presented with complaints of non- healing ulcer since 6-7 months and underwent exploration and curettage. It was diagnosed as chromoblastomycosis in histopathological examination on identication of characteristic copper pennies/sclerotic bodies. Later on patient responded well to oral antifungal and antibiotic therapy. To conclude, CBM although infrequent, must be considered in the differential diagnosis of chronic skin lesions.

scholarly journals Melanized Fungi in Human Disease

2010 ◽  
Vol 23 (4) ◽  
pp. 884-928 ◽  
Author(s):  
Sanjay G. Revankar ◽  
Deanna A. Sutton
Keyword(s):  
Brain Abscess ◽  
Systemic Disease ◽  
Clinical Syndrome ◽  
Pathological Examination ◽  
Fungal Sinusitis ◽  
Dematiaceous Fungi ◽  
Allergic Fungal Sinusitis ◽  
Geographic Ranges ◽  
Melanized Fungi

SUMMARY Melanized or dematiaceous fungi are associated with a wide variety of infectious syndromes. Many are soil organisms and are generally distributed worldwide, though certain species appear to have restricted geographic ranges. Though they are uncommon causes of disease, melanized fungi have been increasingly recognized as important pathogens, with most reports occurring in the past 20 years. The spectrum of diseases with which they are associated has also broadened and includes allergic disease, superficial and deep local infections, pneumonia, brain abscess, and disseminated infection. For some infections in immunocompetent individuals, such as allergic fungal sinusitis and brain abscess, they are among the most common etiologic fungi. Melanin is a likely virulence factor for these fungi. Diagnosis relies on careful microscopic and pathological examination, as well as clinical assessment of the patient, as these fungi are often considered contaminants. Therapy varies depending upon the clinical syndrome. Local infection may be cured with excision alone, while systemic disease is often refractory to therapy. Triazoles such as voriconazole, posaconazole, and itraconazole have the most consistent in vitro activity. Further studies are needed to better understand the pathogenesis and optimal treatment of these uncommon infections.

scholarly journals A Subdermal Osteochondroma in a Young Girl

2017 ◽  
Vol 2017 ◽  
pp. 1-4 ◽  
Author(s):  
Heather A. Cole ◽  
Hernan Correa ◽  
Jonathan G. Schoenecker
Keyword(s):  
Growth Plate ◽  
Subcutaneous Tissue ◽  
Excisional Biopsy ◽  
Benign Tumors ◽  
Deep Fascia ◽  
Long Bones ◽  
Imaging Studies ◽  
Dermal Layer ◽  
Slow Growing ◽  
Growing Mass

Osteochondromas are common benign tumors of cartilage and bone. They are usually found as contiguous bone with a cartilage cap at the end of the growth plate of long bones. Similar to structure are extraskeletal osteochondromas. However, unlike typical osteochondromas, extraskeletal osteochondromas are noncontinuous with bone. To our knowledge, all reported extraskeletal osteochondromas have been contained within fascial compartments. Here we present the case of a 5-year-old female who had a slow growing mass of the anterior distal right thigh. Imaging studies revealed an ossified mass extending from dermal layer of the subcutaneous tissue with no connection to the underlying deep fascia. An excisional biopsy was performed and proved to be a subdermal extraskeletal osteochondroma.

scholarly journals Buschke -Loewenstein tumor: identification of HPV type 6 and 11

2012 ◽  
Vol 87 (1) ◽  
pp. 131-134 ◽  
Author(s):  
Juliana Casagrande Tavoloni Braga ◽  
Sidney Roberto Nadal ◽  
Monica Stiepcich ◽  
Valéria Maria de Souza Framil ◽  
Helena Muller
Keyword(s):  
In Situ Hybridization ◽  
Male Patient ◽  
Destructive Behavior ◽  
Giant Condyloma ◽  
Giant Condyloma Acuminatum ◽  
Tumor Identification ◽  
Hpv Types ◽  
Slow Growing

The authors report a case of exuberant giant condyloma acuminatum of Buschke-Loewenstein in a male patient, slow-growing, progressive and with locally destructive behavior in the inguinal, body of the penis, scrotum, perineal and perianal regions. After surgery he showed no signs of recurrence in 20 months of follow-up. The identification of HPV types 6 and 11 was performed using in situ hybridization.

scholarly journals New Insights in the Management of Antipsychotics in the Treatment of Schizophrenia in a Patient with Prolactinoma: A Case Report and Review of the Literature

2010 ◽  
Vol 2010 ◽  
pp. 1-3 ◽  
Author(s):  
Elvis Henrique Santos Andrade ◽  
Pedro Mario Pan ◽  
Paula F. Ramalho da Silva ◽  
Ary Gadelha
Keyword(s):  
Case Report ◽  
Male Patient ◽  
Pituitary Adenomas ◽  
Dopamine Agonists ◽  
The Other ◽  
Psychotic Episode ◽  
Review Of The Literature ◽  
First Psychotic Episode ◽  
Clinical Challenge ◽  
Dopaminergic Systems

Prolactinomas are the commonest pituitary adenomas and the major pathological cause of hyperprolactinaemia. Symptomatic prolactinomas are treated mainly by dopamine agonists; surgery and radiotherapy are options for nonresponders. Schizophrenia treatment is based on antipsychotics, which acts mainly at serotonergic and dopaminergic systems. We report a case of a 39-year-old schizophrenic male patient that was diagnosed with a macroprolactinoma 8 years after his first psychotic episode. The association of Schizophrenia and prolactinoma represents a clinical challenge once the treatment of one disease can exacerbate the symptoms of the other.

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