scholarly journals Risks and benefits of hormone replacement therapy in older men

2004 ◽  
Vol 59 (1) ◽  
pp. 32-38 ◽  
Author(s):  
Fábio Firmbach Pasqualotto ◽  
Antônio Marmo Lucon ◽  
Jorge Hallak ◽  
Eleonora Bedin Pasqualotto ◽  
Sami Arap
Keyword(s):  
Replacement Therapy ◽  
Hormone Replacement ◽  
Older Men ◽  
Controlled Trials ◽  
Clinical Effects ◽  
Androgen Replacement Therapy ◽  
Randomized Controlled ◽  
The Past ◽  
Risks And Benefits ◽  
Potential Benefits

The use of testosterone in older men, known as male hormonal replacement therapy or androgen replacement therapy, has become of increasing interest to both the medical and lay communities over the past decade. Even though the knowledge of the potential benefits and risks of male Androgen Replacement Therapy has increased dramatically, there is still much that needs to be determined. Although there are a number of potential benefits of male Androgen Replacement Therapy and data concerning clinical effects of such replacement have accumulated, as yet there have not been any large multicenter randomized controlled trials of this therapy. It is the purpose of this article to review what is currently known about the possible risks and benefits of male Androgen Replacement Therapy by discussing the clinical trials to date.

scholarly journals Potential Benefits of Berberine in the Management of Perimenopausal Syndrome

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Cristiana Caliceti ◽  
Paola Rizzo ◽  
Arrigo Francesco Giuseppe Cicero
Keyword(s):  
Hormone Replacement Therapy ◽  
Replacement Therapy ◽  
Causes Of Death ◽  
Hormone Replacement ◽  
Life Time ◽  
Isoquinoline Alkaloid ◽  
Clinical Effects ◽  
Potential Benefits ◽  
Perimenopausal Syndrome ◽  
New Strategies

Cardiovascular diseases are one of the leading causes of morbidity and mortality in women after menopause and 56% of all causes of death in Western European countries. Nowadays, with increasing life span, women spend approximately one-third of their life-time in postmenopausal state; therefore, the development of new strategies to improve the prevention and treatment of menopause-associated pathologies is important topic in clinical practice. The studies to assess the safety of hormone replacement therapy in women with estrogen deficiency have not been conclusive due to the relative contraindications; therefore, hormone replacement therapy is prescribed only in selected cases and for a limited time. For this reason, today women are encouraged to use naturally available compounds to prevent or to attenuate menopausal symptoms and correlated pathologies, with fewer side effects. Among these compounds, berberine, an isoquinoline alkaloid derived from plants of the generisBerberis, has been recognized as being capable of decreasing oxidative stress, LDL, triglycerides, and insulin resistance and of improving the mood. This review describes the cellular and clinical effects associated with the use of berberine, which suggest that this molecule could be an effective natural supplement to ensure a smooth peri- and postmenopausal transition.

scholarly journals Treatment Challenges in Severe Eosinophilic Asthma: Differential Response to Anti-IL-5 and Anti-IL-5R Therapy

2021 ◽  
Vol 22 (8) ◽  
pp. 3969
Author(s):  
Agamemnon Bakakos ◽  
Nikoleta Rovina ◽  
Petros Bakakos
Keyword(s):  
Quality Of Life ◽  
Real Life ◽  
Controlled Trials ◽  
Clinical Effects ◽  
Biological Therapies ◽  
Eosinophilic Asthma ◽  
Severe Eosinophilic Asthma ◽  
Randomized Controlled ◽  
The Past

Severe asthma greatly affects patients’ quality of life. Major advances have occurred in the management of severe eosinophilic asthma the past few years due to the new targeted biological therapies. There are three anti-IL-5 mAbs, mepolizumab, reslizumab and benralizumab. Despite the different mechanism of blocking IL-5 the clinical effects are quite similar as randomized controlled trials and real-life studies have shown. Moreover, there are reports of responding to one after failing to respond to another anti-IL-5 therapy. Accordingly, it is challenging to explore the possible differences in the response to anti-IL-5 treatments. This might help us not only understand possible mechanisms that contribute to the resistance to treatment in this particular asthma endotype, but also to phenotype within severe eosinophilic asthma in order to treat our patients more efficiently.

scholarly journals Association between increased serum thyrotropin concentration and the oldest old: what do we know?

2015 ◽  
Vol 13 (1) ◽  
pp. 117-121 ◽  
Author(s):  
Glaucia Cruzes Duarte ◽  
Maysa Seabra Cendoroglo ◽  
Lara Miguel Quirino Araújo ◽  
Clineu de Mello Almada Filho
Keyword(s):  
Cardiovascular Events ◽  
Oldest Old ◽  
Hormone Replacement ◽  
Elevated Serum ◽  
Total Mortality ◽  
Elderly Subjects ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Potential Benefits ◽  
Increase In Risk

To assess studies that evaluate the relation between serum thyrotropin concentration, very old subjects, and their events. We searched the PubMed, SciELO, and LILACS databases for articles published between 2004 and 2012. Our search was restricted to studies involving humans aged 65 years or older, and written in English, Spanish, or Portuguese. Studies that evaluated the association between elevated serum thyrotropin concentration among elderly subjects with subclinical hypothyroidism were chosen since at least in part they included a subpopulation of individuals aged 80 years and above. Thirteen studies were selected. No significant increase in risk of cardiovascular events, coronary heart disease, or total mortality was observed. Elevated thyrotropin concentration was associated with longevity. More randomized controlled trials are required to better define the potential benefits of elevated thyrotropin concentration in this oldest old population, hormone replacement, and longevity.

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