Differential role of entorhinal and hippocampal nerve growth factor in short- and long-term memory modulation

It has been proposed that a single set of operations based on classical interference theory is adequate to describe the phenomena of both short- and long-term memory. An article by Keppel and Underwood (1962) argues that short-term forgetting is due to proactive interference and, by implication, not a result of trace decay. An experiment which varied retention interval and the nature of the interpolated task, gave results which indicate that when the amount forgotten and the nature of errors are considered, a decay model is supported, the proactive interference suggestion being untenable.

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Systematic functional characterization of the intellectual disability-associated SWI/SNF complex reveals distinct roles for the BAP and PBAP complexes in post-mitotic memory forming neurons of the Drosophila mushroom body

10.1101/408500 ◽

2018 ◽

Cited By ~ 1

Author(s):

Melissa C. Chubak ◽

Max H. Stone ◽

Nicholas Raun ◽

Shelby L. Rice ◽

Mohammed Sarikahya ◽

...

Keyword(s):

Intellectual Disability ◽

Mushroom Body ◽

Functional Characterization ◽

Long Term Memory ◽

Term Memory ◽

Functional Understanding ◽

Short And Long Term ◽

Cellular Components

AbstractTechnology has led to rapid progress in the identification of genes involved in neurodevelopmental disorders like intellectual disability (ID), but our functional understanding of the causative genes is lagging. Here, we show that the SWI/SNF chromatin remodeling complex is one of the most overrepresented cellular components disrupted in ID. We systematically investigated the role of individual subunits of this large protein complex in post-mitotic memory forming neurons of the Drosophila mushroom body (MB). Using this approach, we have identified novel differential roles for the two prominent conformations of the Drosophila SWI/SNF complex, known as BAP and PBAP. The PBAP conformation is required post-mitotically for remodeling of the MB γ neurons during morphogenesis and is essential for both short and long-term memory. In contrast, the BAP conformation appears to preferentially effect long-term memory and is associated with γ neuron survival. Our results suggest that different subunits of the SWI/SNF complex may influence learning and memory through diverse and distinct roles in regulating structural plasticity, survival, and functionality of post-mitotic neurons. This study provides novel insight into the neuronal function of individual SWI/SNF subunits and will serve as a basis for understanding SWI/SNF-mediated gene regulatory mechanisms in post-mitotic neurons.

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ROLE OF NEUROTRANSMITTERS AND PROTEIN SYNTHESIS IN SHORT- AND LONG-TERM MEMORY

10.2172/1014070 ◽

1978 ◽

Author(s):

E.L. Bennett ◽

M.R. Rosenzweig ◽

J.F. Flood

Keyword(s):

Protein Synthesis ◽

Long Term Memory ◽

Term Memory ◽

Short And Long Term

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The role of hippocampal nitric oxide (NO) on learning and immediate, short- and long-term memory retrieval in inhibitory avoidance task in male adult rats

Behavioural Brain Research ◽

10.1016/j.bbr.2009.02.011 ◽

2009 ◽

Vol 201 (1) ◽

pp. 166-172 ◽

Cited By ~ 42

Author(s):

Hooman Eshagh Harooni ◽

Nasser Naghdi ◽

Hoori Sepehri ◽

Ali Haeri Rohani

Keyword(s):

Memory Retrieval ◽

Inhibitory Avoidance ◽

Long Term Memory ◽

Avoidance Task ◽

Adult Rats ◽

Male Adult ◽

Term Memory ◽

Short And Long Term

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Neutral ceramidase is a marker for cognitive performance in rats and monkeys

Pharmacological Reports ◽

10.1007/s43440-020-00159-2 ◽

2020 ◽

Author(s):

Liubov S. Kalinichenko ◽

An-Li Wang ◽

Christiane Mühle ◽

Laila Abdel-Hafiz ◽

Erich Gulbins ◽

...

Keyword(s):

Behavioral Plasticity ◽

Memory Performance ◽

Superior Performance ◽

Long Term Memory ◽

Term Memory ◽

Object Memory ◽

Predictive Role ◽

Short And Long Term

Abstract Background Ceramides are lipid molecules determining cell integrity and intercellular signaling, and thus, involved in the pathogenesis of several psychiatric and neurodegenerative disorders. However, little is known about the role of particular enzymes of the ceramide metabolism in the mechanisms of normal behavioral plasticity. Here, we studied the contribution of neutral ceramidase (NC), one of the main enzymes mediating ceramide degradation, in the mechanisms of learning and memory in rats and non-human primates. Methods Naïve Wistar rats and black tufted-ear marmosets (Callithrix penicillata) were tested in several tests for short- and long-term memory and then divided into groups with various memory performance. The activities of NC and acid ceramidase (AC) were measured in these animals. Additionally, anxiety and depression-like behavior and brain levels of monoamines were assessed in the rats. Results We observed a predictive role of NC activity in the blood serum for superior performance of long-term object memory tasks in both species. A brain area analysis suggested that high NC activity in the ventral mesencephalon (VM) predicts better short-term memory performance in rats. High NC activity in the VM was also associated with worse long-term object memory, which might be mediated by an enhanced depression-like state and a monoaminergic imbalance. Conclusions Altogether, these data suggest a role for NC in short- and long-term memory of various mammalian species. Serum activity of NC may possess a predictive role in the assessing the performance of certain types of memory.

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