Primary melanoma of the uterine cervix figo stage III B

The primary malignant melanoma of the uterine cervix is rare, usually diagnosed at an advanced stage and with poor prognosis. The diagnosis is made through histological evaluation and confirmed by special staining procedures. Radical surgery has been used and advocated. However in its advanced stages chemotherapy, immunotherapy or radiotherapy can be employed. A case of a patient with malignant melanoma of the uterine cervix, Stage IIIb, is presented in addition to a clinical and pathological discussion.

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Clinicopathological Aspects of Small Cell Neuroendocrine Carcinoma of the Uterine Cervix: a Multicenter Retrospective Study and Meta-Analysis

Cellular Physiology and Biochemistry ◽

10.1159/000494538 ◽

2018 ◽

Vol 50 (3) ◽

pp. 1113-1122 ◽

Cited By ~ 4

Author(s):

Fan Xu ◽

Jing Ma ◽

Hongyan Yi ◽

Huiquan Hu ◽

Liangsheng Fan ◽

...

Keyword(s):

Lung Cancer ◽

Uterine Cervix ◽

Chemotherapy Regimen ◽

Radical Surgery ◽

Meta Analysis ◽

Figo Stage ◽

Small Cell ◽

Small Cell Lung ◽

Poor Survival ◽

Small Cell Neuroendocrine Carcinoma

Background/Aims: To evaluate the clinicopathologic aspects of small cell neuroendocrine carcinoma of the uterine cervix (SCNEC). Methods: A retrospective review of 40 patients with SCNEC in 3 hospitals from 2009 to 2015 was conducted to assess the survival rates and examine the associations between clinicopathological variables and overall survival (OS). A meta-analysis of 22 studies containing 1901 patients was also conducted to further confirm the results. Results: In the clinical group of 40 patients, the 5-year OS rate was 20%. Advanced International Federation of Gynecology and Obstetrics (FIGO) stage and radiation therapy (RT) were associated with poor survival. However, radical surgery was associated with prolonged survival. In the meta-analysis of 1901 patients, the 2-year disease-free survival (DFS) rate, 5-year DFS rate, 2-year OS rate, 3-year OS rate and 5-year OS rate of SCNEC were 48%, 35%, 62%, 35%, and 35% respectively. Advanced FIGO stage, larger tumor size, lymph node metastasis (LNM) (+), lymphovascular space involvement (LVSI) (+), parametrial involvement (PI) (+), depth of stromal invasion (DSI) > 2/3, and RT were associated with poor survival. However, a chemotherapy regimen similar to that for small cell lung cancer was associated with prolonged survival. Conclusion: Advanced FIGO stage, larger tumor size, LNM (+), LVSI (+), DSI > 2/3, PI (+), and RT were independent predictors of poor prognosis of SCNEC. Radical surgery combined with a chemotherapy regimen similar to that of small cell lung cancer may be a potential therapeutic approach for SCNEC.

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A Case of Malignant Melanoma of the Uterine Cervix with Disseminated Metastases throughout the Vaginal Wall

Case Reports in Obstetrics and Gynecology ◽

10.1155/2017/5656340 ◽

2017 ◽

Vol 2017 ◽

pp. 1-4 ◽

Cited By ~ 2

Author(s):

Tomoko Noguchi ◽

Nami Ota ◽

Yasushi Mabuchi ◽

Shigetaka Yagi ◽

Sawako Minami ◽

...

Keyword(s):

Malignant Melanoma ◽

Uterine Cervix ◽

Pap Smear ◽

Lung Metastases ◽

Female Genital Tract ◽

Figo Stage ◽

Vaginal Wall ◽

Pelvic Lymphadenectomy ◽

Pigmented Lesions ◽

Node Metastases

Malignant melanoma (MM) in the female genital tract accounts for less than 2% of all melanomas, and the vast majority associated occur in the vulva and vagina. Primary MM of the uterine cervix is extremely rare and its prognosis is very poor. We report a case of primary MM of the cervix with dissemination throughout the vaginal wall. A 66-year-old woman presented with postmenopausal bleeding. Gynecologic examination demonstrated a 2 cm polypoid blackish-pigmented tumor on the cervix with multiple small blackish-pigmented lesions throughout the vaginal wall. Cervical Pap smear cytology showed malignant melanoma. MRI and PET/CT did not detect any distant or lymph node metastases. She underwent radical hysterectomy, pelvic lymphadenectomy, and total vaginectomy. The pathological diagnosis was FIGO stage IIIA primary cervical MM. She received adjuvant chemotherapy with 6 courses of dacarbazine, but 6 months later, multiple lung metastases were detected. Despite 4 courses of anti-PD-1 antibody (nivolumab) treatment, she died of the disease 13 months after surgery.

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A Randomized Trial of Neoadjuvant Chemotherapy Followed by Radical Surgery Versus Radiotherapy Alone in Stage IIIb Carcinoma of the Uterine Cervix

Journal of Gynecologic Surgery ◽

10.1089/gyn.2009.0039 ◽

2010 ◽

Vol 26 (2) ◽

pp. 105-113 ◽

Cited By ~ 3

Author(s):

Noriyuki Yamauchi ◽

Hiroshi Sameshima ◽

Kazuko Fukushima ◽

Kimihiro Nagai ◽

Tsuyomu Ikenoue

Keyword(s):

Neoadjuvant Chemotherapy ◽

Randomized Trial ◽

Uterine Cervix ◽

Radical Surgery ◽

Stage Iiib ◽

Radiotherapy Alone

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Primary malignant melanoma of the uterine cervix treated with radical surgery and adjuvant chemo-radiation using temozolomide and cisplatin: a case report

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20193570 ◽

2019 ◽

Vol 8 (8) ◽

pp. 3387

Author(s):

Goter Doke ◽

Shyam Tsering ◽

Hage Nobin ◽

Dacto Gara

Keyword(s):

Case Report ◽

Malignant Melanoma ◽

Uterine Cervix ◽

Radical Hysterectomy ◽

Vaginal Bleeding ◽

Radical Surgery ◽

Pelvic Lymphadenectomy ◽

Primary Malignant Melanoma ◽

Rare Neoplasm

Primary malignant melanoma of the uterine cervix is a rare neoplasm and the overall prognosis of patients with this disease is very poor. Herein, authors report a case of 45-year-old woman who presented with vaginal bleeding for one months and examination showed an exophytic, 6 cm polypoid blackish-pigmented tumor on the cervix involving vaginal fornix. She underwent abdominal radical hysterectomy with bilateral salpingo-oophorectomy and pelvic lymphadenectomy and further received adjuvant concurrent chemo-radiation with cisplatin (CDDP) and temozolamide but died 7 months after surgery.

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Primary Malignant Melanoma of the Uterine Cervix Treated with Ultraradical Surgery: A Case Report

ISRN Obstetrics and Gynecology ◽

10.5402/2011/683020 ◽

2011 ◽

Vol 2011 ◽

pp. 1-4 ◽

Cited By ~ 4

Author(s):

Luz Calderón-Salazar ◽

David Cantú de Leon ◽

Delia Perez Montiel ◽

Erika Almogabar-Villagrán ◽

Verónica Villavicencio ◽

...

Keyword(s):

Malignant Melanoma ◽

Uterine Cervix ◽

World Literature ◽

Standard Treatment ◽

Pelvic Exenteration ◽

Radical Surgery ◽

Case Reports ◽

Primary Malignant Melanoma ◽

Optimal Management ◽

Distant Disease

Primary melanomas of the uterine cervix are rare tumors with no more than 60 cases reported in the world literature. Poor prognosis is considered for the neoplasia itself as well as for diagnostic tardiness. There is no standard treatment; however, radical surgery is the treatment cornerstone. Our aim was to present the case of a 34-year-old woman with a primary malignant melanoma in the uterine cervix with affectation of the posterior face of the vagina without metastasis. Total infraelevator pelvic exenteration and adjuvant radiotherapy was performed. The patient was under surveillance for 8 years of followup without evidence of local or distant disease. The majority of case reports found suggests radical hysterectomy as the treatment indicated for these patients. Notwithstanding this, survival is very short when patients are treated in this manner. Based on our results and on those reported in the literature, we propose initial treatment with total pelvic exenteration as optimal management for this neoplasia in its initial form.

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Coexisting Malignant Melanoma and Blue Nevus of the Uterine Cervix: An Unusual Combination

Case Reports in Pathology ◽

10.1155/2012/986542 ◽

2012 ◽

Vol 2012 ◽

pp. 1-7

Author(s):

David Parada ◽

Karla B. Peña ◽

Frances Riu

Keyword(s):

Differential Diagnosis ◽

Postmenopausal Woman ◽

Malignant Melanoma ◽

Uterine Cervix ◽

Poor Prognosis ◽

Vaginal Bleeding ◽

Blue Nevus ◽

Unusual Combination ◽

Abnormal Vaginal Bleeding ◽

Immunohistochemical Studies

Malignant melanoma (MM) and blue nevi of the uterine cervix are an extremely rare neoplasm, probably derived from embryologic migration of melanocytes from the neural crest. MM displays aggressive behavior with a poor prognosis. We report the case of a 76-year-old postmenopausal woman abnormal vaginal bleeding. She underwent a hysterectomy and bilateral salpingo-oophorectomy with paraaortic-iliac lymphadenectomy. Histopathological and immunohistochemical studies were consistent with the diagnosis of MM and blue nevi in the uterine cervix. Although it is extremely rare, this case suggests that MM of the uterine cervix should be considered in the differential diagnosis of undifferentiated neoplasm. Early diagnosis is essential in order to warrant a better prognosis, although there are no cases of cure described.

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Carcinosarcoma del cuello uterino: reporte de un caso y revisión de la literatura

Revista de Obstetricia y Ginecología de Venezuela ◽

10.51288/00810314 ◽

2021 ◽

Vol 81 (03) ◽

pp. 297-302

Author(s):

Fátima Palomo Rodríguez ◽

Marta Romero Matas ◽

Álvaro Gutiérrez Domingo ◽

Manuel Pantoja Garrido

Keyword(s):

Side Effects ◽

Uterine Cervix ◽

Poor Prognosis ◽

Advanced Stage ◽

Cervical Mass ◽

Published Evidence ◽

Specific Protocol ◽

Low Incidence ◽

Cervical Tumors ◽

Radio Chemotherapy

Cervical carcinosarcomas are extremely rare, accounting for less than 0.5% of cervical tumors. Due to its low incidence there is no specific protocol of action, which is associated with a poor prognosis. It is frequently diagnosed in postmenopausal women and in advanced stage, with large tumors with vaginal and parametrial metastases. Surgery is considered the treatment of choice, requiring in some cases adjuvant radio-chemotherapy. The prognosis will depend fundamentally on the stage at the time of diagnosis. Since there is little published evidence on this type of tumors we see the need for the publication of cases and reviews of the literature in this regard, to develop unified protocols for the management of this rare pathology. We present the case of a 51-yearold woman who consulted for postmenopausal metrorrhagia, observing a cervical mass with vaginal involvement, corresponding to a carcinosarcoma of the cervix; receiving treatment with radio-chemotherapy, with few side effects and good response. Keywords: Carcinosarcoma, uterine cervix, chemotherapy, radiotherapy, surgery.

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Primary anorectal malignant melanomas: retrospective analysis of 11 cases in a single center

Turkish Journal of Surgery ◽

10.47717/turkjsurg.2021.4810 ◽

2021 ◽

Vol 37 (1) ◽

pp. 63-67

Author(s):

Erol Pişkin ◽

Osman Aydın ◽

Abdullah Şenlikçi ◽

Mehmet Yiğit Özgün ◽

Volkan Öter ◽

...

Keyword(s):

Malignant Melanoma ◽

Poor Prognosis ◽

Surgical Results ◽

Rare Tumor ◽

Tumor Depth ◽

Single Center ◽

Anorectal Malignant Melanoma ◽

Advanced Stages ◽

Training And Research ◽

Anorectal Region

Objective: Anorectal malignant melanoma is a rare tumor with poor prognosis. In this study, it was aimed to present our surgical results by reviewing the literature retrospectively in 11 patients who underwent surgery for ARMM in our clinic. Material and Methods: The patients who underwent surgery for anorectal malignant melanoma in Yuksek İhtisas Training and Research Hospital between 2007-2018 were included in the study. Results: Four patients were males and seven were females. Mean age was 54.18. The tumor was in the rectum in 4 cases, in the anorectal region in 3 cases and in the anal canal in 4 cases. Wide local excision was performed in 3 cases and APR was performed in 8 cases. Four of the cases were stage I, 6 were stage II and 1 was stage III. Mean tumor size was 4.73 cm, and mean tumor depth was 13.6 mm. Mean number of metastatic lymph nodes was 10.37. Median survival was 12 months. Conclusion: Anorectal malignant melanoma is a type of tumor diagnosed in late and advanced stages due to lack of specific findings. Although ARMM is rare, when rectal bleeding, pain, hemorrhoids and changes in bowel habits are observed, ARMM should be kept in mind.

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Adenoid cystic carcinoma of the uterine cervix

Orvosi Hetilap ◽

10.1556/oh.2012.29149 ◽

2012 ◽

Vol 153 (11) ◽

pp. 435-437

Author(s):

Péter Sámuel Nagy ◽

Zoltán Tóth ◽

Péter Gőcze ◽

László Ádám

Keyword(s):

Cervical Cancer ◽

Adenoid Cystic Carcinoma ◽

Rare Disease ◽

Uterine Cervix ◽

Poor Prognosis ◽

Stage Iiib ◽

Cancer Stage ◽

Adenoid Cystic ◽

Irradiation Therapy ◽

History Of

This report presents the history of a 35-year-old patient with adenoid cystic cervical cancer stage IIIB. Adenoid cystic carcinoma of the uterine cervix is a rare disease with poor prognosis. Following irradiation therapy, the patient was declared tumor free, and 20 years after diagnosis and treatment, she has no pathological signs or symptoms. Orv. Hetil., 2012, 153, 435–437.

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