scholarly journals A Case of Malignant Melanoma of the Uterine Cervix with Disseminated Metastases throughout the Vaginal Wall

2017 ◽  
Vol 2017 ◽  
pp. 1-4 ◽  
Author(s):  
Tomoko Noguchi ◽  
Nami Ota ◽  
Yasushi Mabuchi ◽  
Shigetaka Yagi ◽  
Sawako Minami ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Uterine Cervix ◽  
Pap Smear ◽  
Lung Metastases ◽  
Female Genital Tract ◽  
Figo Stage ◽  
Vaginal Wall ◽  
Pelvic Lymphadenectomy ◽  
Pigmented Lesions ◽  
Node Metastases

Malignant melanoma (MM) in the female genital tract accounts for less than 2% of all melanomas, and the vast majority associated occur in the vulva and vagina. Primary MM of the uterine cervix is extremely rare and its prognosis is very poor. We report a case of primary MM of the cervix with dissemination throughout the vaginal wall. A 66-year-old woman presented with postmenopausal bleeding. Gynecologic examination demonstrated a 2 cm polypoid blackish-pigmented tumor on the cervix with multiple small blackish-pigmented lesions throughout the vaginal wall. Cervical Pap smear cytology showed malignant melanoma. MRI and PET/CT did not detect any distant or lymph node metastases. She underwent radical hysterectomy, pelvic lymphadenectomy, and total vaginectomy. The pathological diagnosis was FIGO stage IIIA primary cervical MM. She received adjuvant chemotherapy with 6 courses of dacarbazine, but 6 months later, multiple lung metastases were detected. Despite 4 courses of anti-PD-1 antibody (nivolumab) treatment, she died of the disease 13 months after surgery.

scholarly journals Primary malignant melanoma of the female genital tract synchronously involving the vulva and uterine cervix

Medicine ◽  
2019 ◽  
Vol 98 (30) ◽  
pp. e16366 ◽  
Author(s):  
Yingxin Pang ◽  
Hang Yuan ◽  
Anji Ren ◽  
Shiqian Zhang ◽  
Peishu Liu
Keyword(s):  
Malignant Melanoma ◽  
Uterine Cervix ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Primary Malignant Melanoma ◽  
Female Genital

scholarly journals Primary malignant melanoma of the uterine cervix treated with radical surgery and adjuvant chemo-radiation using temozolomide and cisplatin: a case report

2019 ◽  
Vol 8 (8) ◽  
pp. 3387
Author(s):  
Goter Doke ◽  
Shyam Tsering ◽  
Hage Nobin ◽  
Dacto Gara
Keyword(s):  
Case Report ◽  
Malignant Melanoma ◽  
Uterine Cervix ◽  
Radical Hysterectomy ◽  
Vaginal Bleeding ◽  
Radical Surgery ◽  
Pelvic Lymphadenectomy ◽  
Primary Malignant Melanoma ◽  
Rare Neoplasm

Primary malignant melanoma of the uterine cervix is a rare neoplasm and the overall prognosis of patients with this disease is very poor. Herein, authors report a case of 45-year-old woman who presented with vaginal bleeding for one months and examination showed an exophytic, 6 cm polypoid blackish-pigmented tumor on the cervix involving vaginal fornix. She underwent abdominal radical hysterectomy with bilateral salpingo-oophorectomy and pelvic lymphadenectomy and further received adjuvant concurrent chemo-radiation with cisplatin (CDDP) and temozolamide but died 7 months after surgery.

scholarly journals Malignant Müllerian Mixed Tumor of the Uterine Cervix with a Small Cell Neuroendocrine Carcinoma Component

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Satoru Munakata ◽  
Emi Iwai ◽  
Tomohito Tanaka ◽  
Michihiko Nakamura ◽  
Takayoshi Kanda
Keyword(s):  
Neuroendocrine Carcinoma ◽  
Uterine Cervix ◽  
Pap Smear ◽  
English Literature ◽  
Pelvic Lymphadenectomy ◽  
Small Cell ◽  
Arterial Infusion ◽  
Small Cell Neuroendocrine Carcinoma ◽  
Cervical Mass ◽  
Mixed Tumors

Malignant Müllerian mixed tumors (MMMTs) of the uterine cervix are extremely rare, accounting for 0.005% of all cervical malignancies. To date, only approximately 50 well-documented cases have been reported. Although several epithelial components have been described in cervical MMMTs, small cell neuroendocrine carcinoma (SCC) has not appeared in the English literature. We present a 43-year-old woman, para 2 gravida 2, who had MMMT with SCC and rhabdomyosarcoma components in the uterine cervix. She was referred to our hospital because of a cervical mass with an abnormal Pap smear result. Cervical biopsy revealed SCC. After neoadjuvant chemotherapy with balloon-occluded arterial infusion, she underwent type II radical hysterectomy with pelvic lymphadenectomy. Histological analysis revealed that the cervical tumor comprised SCC and rhabdomyosarcoma components. Genotype analysis indicated human papillomavirus type 18. She underwent concurrent chemoradiation therapy. The patient had been free of the disease and showed no evidence of recurrence 38 months after operation.

scholarly journals MALIGNANT MELANOMA OF UTERINE CERVIX IN A YOUNG FEMALE

2019 ◽  
pp. 1-2
Author(s):  
Purvi Rathod
Keyword(s):  
Malignant Melanoma ◽  
Uterine Cervix ◽  
Genital Tract ◽  
External Beam Radiotherapy ◽  
Female Genital Tract ◽  
Young Female ◽  
Rare Cancer ◽  
Female Genital

Malignant melanoma is a rare cancer, its incidence being 1% of all cancers. Malignant melanoma of the female genital tract is even rarer with incidence of 3% to 7% of all malignant melanomas. It usually occurs in postmenopausal women. We present a case of malignant melanoma of the uterine cervix in a multiparous premenopausal 29 year old female. She underwent a modified radical hysterectomy. She was stage III and was treated with external beam radiotherapy to the pelvis followed by brachytherapy. Since then the patient was on regular follow up until she developed lung metastasis. Malignant melanoma of the cervix has very less data in literature. Through this case report we will emphasize on the role of radiotherapy in malignant melanoma of uterine cervix

scholarly journals PRIMARY MALIGNANT MELANOMA UTERINE CERVIX

2016 ◽  
Vol 2 (1) ◽  
Author(s):  
Asghar H Asghar ◽  
Sadia Rizvi ◽  
Akhtar Ahmed ◽  
Ahmed N Abbasi ◽  
Abid Jamal ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Uterine Cervix ◽  
Locally Advanced ◽  
Female Genital Tract ◽  
Pelvic Surgery ◽  
Primary Malignant Melanoma ◽  
Common Site ◽  
Rare Tumour ◽  
Premenopausal Female ◽  
Diagnostic Work

A 40-year-old premenopausal female presented with foul-smelling per vaginal discharge for 3 months. Diagnostic work revealed a locally advanced primary malignant melanoma of uterine cervix. The patient declined pelvic surgery and was treated with Dacarbazine. Malignant melanoma is a rare tumour of skin and has been ranked in the top ve cancers of Australia and Sweden. It is a tumour of melanocytes which forms melanin pigment in the skin. In men, the most common site is trunk while in females common site is limbs. However, melanoma can arise from mucosal surfaces where the melanocytes are present. Most common mucosal sites are head and neck followed by female genital tract. Key words: Cervix, dacarbazine, malignant melanoma 

scholarly journals Primary malignant melanoma of the female urethra − a case report

2018 ◽  
Vol 71 (5-6) ◽  
pp. 191-194
Author(s):  
Jovan Hadzi-Djokic ◽  
Vladimir Vasic ◽  
Dragoslav Basic ◽  
Silvana Lukic ◽  
Milomir Tufegdzic ◽  
...  
Keyword(s):  
Case Report ◽  
Malignant Melanoma ◽  
Vaginal Wall ◽  
Anterior Vaginal Wall ◽  
Pelvic Lymphadenectomy ◽  
Primary Malignant Melanoma ◽  
High Recurrence Rate ◽  
High Concentration ◽  
Large Tumor ◽  
Vaginal Introitus

Introduction. Malignant melanoma accounts for 3% of all cancers in Europe. Malignant melanoma of the genitourinary tract is very rare, accounting for 1% of all cases. In addition, primary malignant melanoma of the urethra accounts for 0.2% of all melanomas and 4% of all urethral cancers. The abnormal migration of melanocytes during the embryonic development may explain their occurrence in the urethra. Also, vulva contains a relatively high concentration of melanocytes, so it may be the reason for higher incidence of malignant melanomas in females than in males, especially located at the meatus or in the distal urethra. Case Report. A 60-year-old woman presented with a solid tumor protruding through the vaginal introitus. Computerized tomography revealed a 5 cm large tumor of the urethra, infiltrating the bladder neck and the anterior vaginal wall. In addition, a bilateral pelvic lymphadenopathy was observed. The patient underwent anterior pelvic exenteration with urethrectomy, bilateral pelvic lymphadenectomy and bilateral ureterocutaneostomy, followed by immunochemotherapy. Nonetheless, the patient died 10 months after the surgery. Conclusion. Urethral melanoma is a tumor with a very poor prognosis and high recurrence rate (71%), even after wide surgical resection, adjuvant radiotherapy, chemo and immunotherapy.

scholarly journals Primary non-Hodgkin's lymphoma of the uterine cervix: A case report

2004 ◽  
Vol 12 (2) ◽  
pp. 119-120
Author(s):  
Milica Zivaljevic ◽  
Tamara Vujkov ◽  
Darjana Jovanovic ◽  
Aljosa Mandic ◽  
Olgica Mihajlovic ◽  
...  
Keyword(s):  
Uterine Cervix ◽  
Multidisciplinary Approach ◽  
Pap Smear ◽  
Abdominal Hysterectomy ◽  
Disease Recurrence ◽  
Pelvic Lymphadenectomy ◽  
Node Metastasis ◽  
Cervical Biopsy ◽  
Limited Experience ◽  
Hodgkin's Lymphomas

Primary uterine cervical non-Hodgkin's lymphomas (NHL) are rare. Limited experience dictates careful pretherapy evaluation and multidisciplinary approach in treatment planning. A 53-year-old woman presented with postmenopausal bleeding and PAP smear IIIb. Cervical biopsy and endocervical curettage biopsy revealed NHL of the uterine cervix. Abdominal hysterectomy with bilateral adnexectomy was followed by pelvic lymphadenectomy due to lymph node metastasis, 21 months after the primary operation. Subsequently, the patient received postoperative chemotherapy. Seven years after the onset of NHL she is alive with no evidence of disease recurrence.

scholarly journals Primary Malignant Melanoma of the Cervix: A Case Report and a Review of the Literature

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Michail Diakosavvas ◽  
Zacharias N. Fasoulakis ◽  
Maria Kouroupi ◽  
Marianna Theodora ◽  
Lola Inagamova ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Radical Hysterectomy ◽  
Treatment Guidelines ◽  
Treatment Options ◽  
Staging System ◽  
Surgical Excision ◽  
Figo Stage ◽  
Pelvic Lymphadenectomy ◽  
Primary Malignant Melanoma ◽  
Treatment Modalities

Background. Gynecologic melanomas are extremely rare malignancies, and primary malignant melanoma of the cervix (PMMC) is the rarest among them all, with less than 100 cases reported so far. Although some conditions have been correlated with the pathogenesis of this entity, no specific risk factor has been yet identified, with vaginal bleeding being the most common symptoms. The diagnosis is based on physical examination with speculum assessment and cytologic and histopathologic findings accompanied with immunohistochemical staining of lesion’s biopsies. Case Presentation. We report a case of PMMC in a 34-year-old para-2 patient, among the youngest cases of PMMC reported, that presented to our clinic for routine examination. Gynecologic examination demonstrated a dark, heavily fully pigmented cervical growth completely covering the entire external cervical os. Biopsy obtained and showed malignant melanoma. She underwent radical hysterectomy with bilateral salpingo-oophorectomy and pelvic lymphadenectomy. The pathological diagnosis was FIGO stage IB1 PMMC. Despite 2 courses of anti-PD-1 antibody (Nivolumab) treatment, the patient passed away 13 months after diagnosis (12 months after surgery). Conclusions. Early diagnosis and subsequently early treatment are of high importance regarding patients’ prognosis and survival. No standardized protocols or treatment guidelines specific for this rare cancer have been issued; thus, clinicians are called to assess each case individually. Current treatment options are based on surgical excision mostly with radical hysterectomy, but in advanced or recurrent state of the disease, other treatment modalities, such as chemotherapy, radiotherapy, and immunotherapy, can be employed. Prognosis for these patients is very poor, and survival rate remains extremely low, with the median OS reported being less than 2 years. Reporting and publishing of such cases are both of paramount importance for the better understanding of this uncommon cervical malignancy, and further biological and clinical investigations are required for more suitable and effective therapies to be determined. A new staging system, specific to PMMC, could be of great use for the better correlation of the disease’s stage and prognosis of these patients.

scholarly journals Primary melanoma of the uterine cervix figo stage III B

1998 ◽  
Vol 116 (4) ◽  
pp. 1778-1780 ◽  
Author(s):  
Júlio César Teixeira ◽  
José Roberto Salina ◽  
Luiz Carlos Teixeira ◽  
Liliana Aparecida Lucci De Angelo Andrade
Keyword(s):  
Malignant Melanoma ◽  
Uterine Cervix ◽  
Poor Prognosis ◽  
Radical Surgery ◽  
Primary Melanoma ◽  
Figo Stage ◽  
Stage Iiib ◽  
Histological Evaluation ◽  
Advanced Stage ◽  
Advanced Stages

The primary malignant melanoma of the uterine cervix is rare, usually diagnosed at an advanced stage and with poor prognosis. The diagnosis is made through histological evaluation and confirmed by special staining procedures. Radical surgery has been used and advocated. However in its advanced stages chemotherapy, immunotherapy or radiotherapy can be employed. A case of a patient with malignant melanoma of the uterine cervix, Stage IIIb, is presented in addition to a clinical and pathological discussion.

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