scholarly journals Antipyretic efficacy and tolerability of oral ibuprofen, oral dipyrone and intramuscular dipyrone in children: a randomized controlled trial

2006 ◽  
Vol 124 (3) ◽  
pp. 135-140 ◽  
Author(s):  
Judith Prado ◽  
Raúl Daza ◽  
Oscar Chumbes ◽  
Iván Loayza ◽  
Luis Huicho
Keyword(s):  
Single Dose ◽  
Primary Outcome ◽  
Controlled Trial ◽  
Emergency Ward ◽  
Over The Counter ◽  
Randomized Controlled ◽  
Associated Symptoms ◽  
Oral Ibuprofen ◽  
To Receive ◽  
Single Blind

CONTEXT AND OBJECTIVE: Dipyrone is a widely used over-the-counter antipyretic in Latin America, and elsewhere among Latin immigrants. Despite limited evidence, physicians often prescribe oral ibuprofen or intramuscular dipyrone as the most effective antipyretics. Our aim was to compare the antipyretic efficacy and tolerability of a single dose of oral ibuprofen, oral dipyrone or intramuscular dipyrone in febrile children. DESIGN AND SETTING: Randomized, single-blind clinical trial, at San Bartolomé Mother-Child National Teaching Hospital, Lima, Peru. METHODS: Children from six months to six years old with fever (rectal temperature: 38.3 to 39.8° C) in the emergency ward between February and June 2003 were eligible. Seventy-five children were randomly assigned to receive a single dose of oral ibuprofen (10 mg/kg), oral dipyrone (15 mg/kg) or intramuscular dipyrone (15 mg/kg). The primary outcome was mean temperature reduction after 30, 45, 60, 90 and 120 minutes. Secondary outcomes were fever-associated symptoms and clinical adverse events. RESULTS: Fever decreased by about 0.5° C after 45 minutes and by about 1.0° C after 120 minutes in all three groups. Mean temperatures were similar for the three groups at all times. There was a significant decrease in fever-associated symptoms for all groups. Six patients (four receiving oral dipyrone and two receiving ibuprofen) were withdrawn because of vomiting within 20 minutes after first dose of study medication. One patient assigned to oral ibuprofen presented transient urticaria. CONCLUSIONS: Antipyretic efficacy and tolerability were similar for oral ibuprofen, oral dipyrone and intramuscular dipyrone. Oral antipyretics seem more appropriate for feverish children.

scholarly journals Cervical Pessary versus Expectant Management for the Prevention of Delivery Prior to 36 Weeks in Women with Placenta Previa: A Randomized Controlled Trial

2019 ◽  
Vol 09 (02) ◽  
pp. e160-e166
Author(s):  
Irene Stafford ◽  
Thomas Garite ◽  
Kimberly Maurel ◽  
C. Combs ◽  
Kent Heyborne ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Primary Outcome ◽  
Placenta Previa ◽  
Controlled Trial ◽  
Expectant Management ◽  
Randomized Controlled ◽  
Cervical Pessary ◽  
Multicenter Randomized Controlled Trial ◽  
To Receive ◽  
Type Of Delivery

Objective This multicenter randomized controlled trial compared cervical pessary (CP) versus expectant management (EM) in women with placenta previa between 22.0 and 32.0 in prolonging gestation until ≥ 36.0 weeks' gestation. Study Design This study took place from November 2016 to June 2018. Women were randomized to receive either the Bioteque CP or EM. The pessary was removed at ≥ 36.0 weeks unless indicated. The primary outcome was gestational age (GA) at delivery, with secondary outcomes including need for transfusion, number and duration of antepartum admissions, type of delivery, and neonatal outcomes. A total of 140 patients were needed to show a 3-week prolongation of pregnancy in the pessary group; however, the trial was stopped early due to budgetary issues. Results Of the 33 eligible women, 17 were enrolled. Although not statistically significant, the mean GA at delivery in the CP group was greater than women in the EM group (36.5 ± 1.23 vs. 36.0 ± 2.0; p = 0.1673). The number and duration of antepartum admissions was greater in the EM group (2.7 ± 0.58 vs. 16.0 ± 22.76 days; p = 0.1264) as well. Conclusion Although the study was underpowered to determine the primary outcome, safety and feasibility of CP in pregnancies complicated with previa were demonstrated.

Effect of rhubarb (Rheum emodi) in primary dysmenorrhoea: a single-blind randomized controlled trial

2015 ◽  
Vol 12 (1) ◽  
Author(s):  
Hina Rehman ◽  
Wajeeha Begum ◽  
Farzana Anjum ◽  
Humyra Tabasum ◽  
Shabnam Zahid
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Menstrual Pain ◽  
Randomized Controlled ◽  
Primary Dysmenorrhoea ◽  
Associated Symptoms ◽  
Experimental Group ◽  
Single Blind

Abstract: The aim of this study was to investigate and evaluate the efficacy of: A randomized, single-blind, standard controlled trial compared efficacy of: The menstrual pain was significantly decreased in both groups after three-cycle intervention. Significant changes were observed in VAS (p<0.001) and VMSS (p<0.001) in the experimental group. There is a significant (p<0.001) reduction in duration of pain in both the groups. Associated symptoms and QOL were markedly improved after treatment (p<0.001).: It has been clear from the above result that

A Brief Intervention of Physical Activity Education and Counseling in Community Rehabilitation: A Feasibility Randomized Controlled Trial

2021 ◽  
pp. 1-8
Author(s):  
Emily T. Green ◽  
Narelle S. Cox ◽  
Anne E. Holland
Keyword(s):  
Physical Activity ◽  
Primary Outcome ◽  
Controlled Trial ◽  
Stage Of Change ◽  
Or Education ◽  
Randomized Controlled ◽  
Education Material ◽  
Community Rehabilitation ◽  
To Receive

This study aimed to assess the feasibility of delivering a brief physical activity (PA) intervention to community rehabilitation clients. Participants were randomized to receive one session of stage-of-change-based PA education and counseling in addition to written educational material, or education material alone. Outcomes were measured at baseline and 3 months; the primary outcome was feasibility, measured by the percentage of those who were eligible, consented, randomized, and followed-up. A total of 123 individuals were both eligible and interested in participating, 32% of those screened on admission to the program. Forty participants consented, and 35 were randomized, with mean age 72 years (SD = 12.2). At baseline, 66% had recently commenced or intended to begin regular PA in the next 6 months. A total of 30 participants were followed-up. It is feasible to deliver education and counseling designed to support the long-term adoption of regular PA to community rehabilitation clients. Further refinement of the protocol is warranted (ACTRN12617000519358).

A single dose of erythropoietin reduces perioperative transfusions in cardiac surgery: results of a prospective single-blind randomized controlled trial

Transfusion ◽  
2015 ◽  
Vol 55 (7) ◽  
pp. 1644-1654 ◽  
Author(s):  
Luca Weltert ◽  
Beatrice Rondinelli ◽  
Ricardo Bello ◽  
Mauro Falco ◽  
Alessandro Bellisario ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Cardiac Surgery ◽  
Single Dose ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Single Blind

scholarly journals Supervised Exercises Compared With Radial Extracorporeal Shock-Wave Therapy for Subacromial Shoulder Pain: 1-Year Results of a Single-Blind Randomized Controlled Trial

2011 ◽  
Vol 91 (1) ◽  
pp. 37-47 ◽  
Author(s):  
Kaia Engebretsen ◽  
Margreth Grotle ◽  
Erik Bautz-Holter ◽  
Ole Marius Ekeberg ◽  
Niels Gunnar Juel ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Shoulder Pain ◽  
Primary Outcome ◽  
Controlled Trial ◽  
Extracorporeal Shock Wave Therapy ◽  
Primary Outcome Measure ◽  
Shock Wave Therapy ◽  
Randomized Controlled ◽  
Extracorporeal Shock Wave ◽  
Single Blind

Background Evidence from a recent randomized controlled trial indicated that supervised exercises (SE) were more effective than radial extracorporeal shock-wave therapy (rESWT) for the treatment of subacromial shoulder pain in the short to medium term. Little knowledge exists about the long-term results of rESWT for subacromial pain. Objective The aim of this study was to evaluate the results of rESWT and SE provided to patients with subacromial shoulder pain after 1 year. Design This was a single-blind randomized controlled trial. Setting The study was conducted in the outpatient clinic of the Physical Medicine and Rehabilitation Department at Oslo University Hospital, Ullevaal, Norway. Patients One hundred four patients with subacromial shoulder pain lasting at least 3 months participated. Patients were randomly assigned to either an rESWT group (n=52) or an SE group (n=52). Intervention The rESWT intervention consisted of one session weekly for 4 to 6 weeks. The SE intervention consisted of two 45-minute sessions per week for up to 12 weeks. Measurements The primary outcome measure was the Shoulder Pain and Disability Index. Secondary outcome measures were questions regarding pain and function and work status. Results After 1 year, an intention-to-treat analysis showed no significant differences between the 2 groups for the primary outcome measure (−7.6 points, 95% confidence interval=−16.6 to 0.5) and pain, function, and medication use. Twenty-nine participants (60%) in the SE group versus 24 participants (52%) in the rESWT group were categorized as clinically improved. Thirty-eight participants in the SE group were at work compared with 30 participants in the rESWT group (odds ratio=1.1, 95% confidence interval=1.0 to 1.2). Fewer patients in the SE group had received additional treatments between 18 weeks and 1 year. Limitations The lack of a placebo control group, the lack of a cost-benefit analysis, and the small sample size were limitations of the study. Conclusion No significant difference was found between the SE and rESWT groups at the 1-year follow-up. More participants in the SE group had returned to work.

scholarly journals Effect of Sulodexide on Urinary Biomarkers of Kidney Injury in Normoalbuminuric Type 2 Diabetes: A Randomized Controlled Trial

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Bancha Satirapoj ◽  
Wisit Kaewput ◽  
Ouppatham Supasyndh ◽  
Prajej Ruangkanchanasetr
Keyword(s):  
Type 2 Diabetes ◽  
Placebo Group ◽  
Primary Outcome ◽  
Early Stage ◽  
Controlled Trial ◽  
Kidney Injury ◽  
Randomized Controlled ◽  
The Mean ◽  
To Receive

Glycosaminoglycans or sulodexide has shown benefits in early experimental diabetic nephropathy (DN) models, but its efficacy in patients with early stage of DN is unknown.Methods. Twenty patients were randomly assigned to the placebo group and another 20 patients were randomly assigned to receive sulodexide 100 mg/day for 14 weeks. Primary outcome was a change of urinary TGF-beta1, albuminuria, and glomerular filtration rate (GFR). All patients had stable metabolic profiles for at least 90 days before randomization.Results. Urinary TGF-beta1 increased significantly in the placebo group but did not change significantly in the sulodexide group. Additionally, the mean change of urine TGF-beta1 in the placebo group was significantly higher than that in the sulodexide group (8.44±9.21versus2.17±6.96 pg/mg Cr,P=0.02). Mean changes of urinary albumin were15.05±30.09 μg/mg Cr (P=0.038) in the placebo group and13.89±32.25 μg/mg Cr (P=0.069) in the sulodexide group. No consistent patterns of side effects were observed.Conclusion. In this 14-week trial, benefits of sulodexide in preventing the increase of urinary TGF-beta1 were observed in patients with normoalbuminuric type 2 diabetes. The study suggests that sulodexide treatment may provide additional renoprotection in early stage DN. This trial is registered withTCTR20140806001.

scholarly journals Intensified Oral Hygiene Care in Stroke-Associated Pneumonia: A Pilot Single-Blind Randomized Controlled Trial

2020 ◽  
Vol 57 ◽  
pp. 004695802096877
Author(s):  
Dong Yuan ◽  
Jing Zhang ◽  
Xiaoxue Wang ◽  
Su Chen ◽  
Yue Wang
Keyword(s):  
Randomized Controlled Trial ◽  
Oral Hygiene ◽  
Controlled Trial ◽  
Control Group ◽  
Randomized Controlled ◽  
Vulnerable Patient ◽  
Patient Groups ◽  
To Receive ◽  
Single Blind

In this pilot, single-blind, randomized controlled trial, we investigated the effects of intensified oral hygiene care (IOHC) on reducing stroke-associated pneumonia (SAP) incidence. Patients admitted within 24 hours of stroke onset were recruited and randomized to receive IOHC or routine oral hygiene care. The occurrence of SAP was checked and oral swabs were obtained during the 7-day follow-up. The SAP incidence was lower, though not significantly, in the IOHC group than in the control group. IOHC successfully decreased SAP incidence among patients who were male, had higher National Institutes of Health Stroke Scale and Debris Index scores, and lower Glasgow Coma Scale and Gugging Swallowing Screen scores. Furthermore, IOHC significantly decreased the prevalence of oral suspected SAP pathogens. These results suggest that IOHC can decrease the incidence of SAP in the most vulnerable patient groups and lower the prevalence of suspected oral SAP pathogens.

scholarly journals A Randomized Controlled Trial of Ceftriaxone and Doxycycline, With or Without Metronidazole, for the Treatment of Acute Pelvic Inflammatory Disease

2020 ◽  
Author(s):  
Harold C Wiesenfeld ◽  
Leslie A Meyn ◽  
Toni Darville ◽  
Ingrid S Macio ◽  
Sharon L Hillier
Keyword(s):  
Single Dose ◽  
Pelvic Inflammatory Disease ◽  
Clinical Improvement ◽  
Inflammatory Disease ◽  
Primary Outcome ◽  
Controlled Trial ◽  
Mycoplasma Genitalium ◽  
Double Blind ◽  
Randomized Controlled ◽  
Acute Pelvic Inflammatory Disease

Abstract Background Anaerobic organisms are important pathogens in acute pelvic inflammatory disease (PID). The currently recommended PID regimen of a single dose of ceftriaxone and doxycycline for 14 days has limited anaerobic activity. The need for broader anaerobic coverage is unknown and concerns have been raised about metronidazole tolerability. Methods We conducted a randomized, double-blind, placebo-controlled trial comparing ceftriaxone 250 mg intramuscular single dose and doxycycline for 14 days, with or without 14 days of metronidazole in women with acute PID. The primary outcome was clinical improvement at 3 days following enrollment. Additional outcomes at 30 days following treatment were the presence of anaerobic organisms in the endometrium, clinical cure (absence of fever and reduction in tenderness), adherence, and tolerability. Results We enrolled 233 women (116 to metronidazole and 117 to placebo). Clinical improvement at 3 days was similar between the 2 groups. At 30 days following treatment, anaerobic organisms were less frequently recovered from the endometrium in women treated with metronidazole than placebo (8% vs 21%, P &lt; .05) and cervical Mycoplasma genitalium was reduced (4% vs 14%, P &lt; .05). Pelvic tenderness was also less common among women receiving metronidazole (9% vs 20%, P &lt; .05). Adverse events and adherence were similar in each treatment group. Conclusions In women treated for acute PID, the addition of metronidazole to ceftriaxone and doxycycline was well tolerated and resulted in reduced endometrial anaerobes, decreased M. genitalium, and reduced pelvic tenderness compared to ceftriaxone and doxycycline. Metronidazole should be routinely added to ceftriaxone and doxycycline for the treatment of women with acute PID. Clinical Trials Registration NCT01160640.

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