Laryngeal adenoid cystic carcinoma: case report

CONTEXT: Adenoid cystic carcinomas are malignant tumors that occur in both the major and the minor salivary glands. A laryngeal location is rare because of the paucity of accessory salivary glands in this area. Adenoid cystic carcinomas account for less than 1% of all malignant tumors in the larynx, and only about 120 cases have been reported in the literature. These tumors have a slight female predisposition, and their peak incidence is in the fifth and sixth decades of life. In this article, we describe a case of laryngeal adenoid cystic carcinoma and discuss its clinical characteristics and treatment. CASE REPORT: We report on a case of laryngeal adenoid cystic carcinoma in a 55 year-old female patient who presented with dyspnea and hoarseness. Features of the diagnostic and therapeutic evaluation are described and the clinical management of such cases is outlined. The clinical course, definitive treatment strategy and surgical procedure, and also adjuvant treatment with irradiation are discussed. Although the tumor is radiosensitive, it is not radiocurable.

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Adenoid Cystic Carcinoma of Lacrimal Gland

JMS SKIMS ◽

10.33883/jms.v15i1.124 ◽

2012 ◽

Vol 15 (1) ◽

pp. 76-77

Author(s):

Mohd Athar ◽

K S Sodhi ◽

S Kala ◽

R K Maurya ◽

S Chauhan ◽

...

Keyword(s):

Local Recurrence ◽

Natural History ◽

Adenoid Cystic Carcinoma ◽

Salivary Glands ◽

Hard Palate ◽

Clinical Course ◽

Fatal Outcome ◽

Minor Salivary Glands ◽

Adenoid Cystic ◽

History Of

Adenoid cystic carcinoma is a relatively uncommon tumour of salivary, glands and is characterised by a prolonged clinical course and a fatal outcome. It was first described as `cylindroma' by Billroth in 1859. Half of these tumors occur in glandular tissues other than the major salivary glands; principally in the hard palate, but they can also arise in the tongue and minor salivary glands. Unusual locations include the external auditory canal, nasopharynx, lacrimal glands, breast, vulva, esophagus, cervix and Cowper glands. The long natural history of this tumor and its tendency for local recurrence are well known. JMS 2012;15(1):76-77.

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ADENOID CYSTIC CARCINOMA OF MINOR SALIVARY GLANDS: CASE REPORT

Oral Surgery Oral Medicine Oral Pathology and Oral Radiology ◽

10.1016/j.oooo.2019.06.333 ◽

2020 ◽

Vol 129 (1) ◽

pp. e82

Author(s):

CAMILA OLIVEIRA SANTOS ◽

ALYNE AMORIM DE ARAÚJO ◽

RODRIGO RESENDE ◽

VANIA DO CARMO ◽

LUISA AGUIRRE BUEXM ◽

...

Keyword(s):

Case Report ◽

Adenoid Cystic Carcinoma ◽

Salivary Glands ◽

Minor Salivary Glands ◽

Adenoid Cystic

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Clinical Utility of MYB Rearrangement Detection and P63/P40 Immunophenotyping in the Diagnosis of Adenoid Cystic Carcinoma of Minor Salivary Glands: A Pilot Study

Oral Surgery Oral Medicine Oral Pathology and Oral Radiology ◽

10.1016/j.oooo.2015.05.057 ◽

2015 ◽

Vol 120 (3) ◽

pp. e154

Author(s):

S. WETZEL ◽

P. ARGYRIS ◽

R. WEHRS ◽

P. GREIPP ◽

D. KNUTSON ◽

...

Keyword(s):

Pilot Study ◽

Adenoid Cystic Carcinoma ◽

Salivary Glands ◽

Clinical Utility ◽

Minor Salivary Glands ◽

Adenoid Cystic

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Epidemiologic Characteristics of Salivary Gland Tumors in an Iranian Population

Shiraz E-Medical Journal ◽

10.5812/semj.107675 ◽

2021 ◽

Vol In Press (In Press) ◽

Author(s):

Nafise Shamloo ◽

Alireza Ghanadan ◽

Fahimeh Sadat Hashemian ◽

Maedeh Ghorbanpour

Keyword(s):

Salivary Gland ◽

Adenoid Cystic Carcinoma ◽

Salivary Glands ◽

Pleomorphic Adenoma ◽

Malignant Tumors ◽

The Body ◽

Salivary Gland Tumors ◽

Benign Tumors ◽

Cross Sectional ◽

Adenoid Cystic

Background: Salivary gland tumors include a wide variety of benign and malignant tumors in the oral and maxillofacial region. Although these tumors are not common, they are not rare. The prevalence of these tumors varies with regard to age, gender, and their location in the body. Objectives: This study aimed to evaluate the frequency of benign and malignant salivary gland tumors in patients referred to three referral hospitals in Tehran, Iran. Methods: This retrospective cross-sectional study examined the demographic and pathologic records of the patients with salivary gland tumors submitted to the Department of Pathology of Amir Alam, Loghman Hakim, and Shohada Hospitals from 2005 to 2016. In this study, the histological variants of salivary gland tumors and clinical parameters such as age, gender, and the location of the tumor were examined. The clinical data were analyzed using SPSS software version 21. Results: Of 137632 patient records, 1180 cases were salivary gland tumors. Pleomorphic adenoma in 794 cases (67.3%) and adenoid cystic carcinoma in 109 cases (9.2%) were the most common tumors, respectively. Salivary gland tumors were more common in males, and the participants’ mean age was 42.86 ± 16.5 years. The most common site was parotid and minor salivary glands, with 937 (79.4%) and 137 (12%) cases, respectively. Conclusions: In this study, the most common benign tumor was pleomorphic adenoma in the parotid gland, and the most common malignant tumor was adenoid cystic carcinoma in the major salivary glands. Furthermore, benign tumors were more frequent than malignant tumors.

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Nasopharyngeal Hyalinizing Clear Cell Carcinoma: A Case Report and Review of the Literature

Allergy & Rhinology ◽

10.1177/2152656719889030 ◽

2019 ◽

Vol 10 ◽

pp. 215265671988903 ◽

Cited By ~ 1

Author(s):

Madison J. Malfitano ◽

Meghan N. Norris ◽

Wesley H. Stepp ◽

Griffin D. Santarelli ◽

T. Danielle Samulski ◽

...

Keyword(s):

Case Report ◽

Salivary Glands ◽

Clear Cell ◽

Malignant Tumors ◽

Treatment Strategies ◽

Low Grade ◽

Minor Salivary Glands ◽

Presenting Symptoms ◽

Nasopharyngeal Mass ◽

The Right

Background Hyalinizing clear cell carcinomas (HCCCs) are rare, low-grade, malignant tumors which most often arise from the minor salivary glands primarily in palate and tongue but can arise in any location with minor salivary glands including the nasopharynx. Methods A case report of primary nasopharyngeal HCCC is presented. Because of the rarity of this tumor and location, a literature search was conducted to determine the most common presenting symptoms, treatment strategies, and outcomes. Results A 48-year-old man underwent biopsy of a 4.5 cm mass of the right nasopharynx with pathology suggesting an intermediate grade mucoepidermoid carcinoma. After discussing management with the patient, an endoscopic resection was performed. Final pathology revealed an HCCC which was confirmed after negative Mastermind-like 2 (MAML2) and positive Ewing sarcoma breakpoint region 1 (ESWR1) gene rearrangements on fluorescence in situ hybridization (FISH) studies. Literature review of other nasopharyngeal HCCC cases shows diverse presentation and overall excellent prognosis through surgical and radiation therapy. Conclusion HCCCs are rare, low-grade malignant tumors of the minor salivary glands and can present as a nasopharyngeal mass. Presenting symptoms are diverse but frequently involve otologic and sinonasal disturbances. HCCC is an indolent tumor with an excellent prognostic outcome when treated appropriately with surgical resection and adjuvant radiotherapy.

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Adenoid cystic carcinoma of major and minor salivary glands

The American Journal of Surgery ◽

10.1016/0002-9610(71)90440-5 ◽

1971 ◽

Vol 122 (6) ◽

pp. 756-762 ◽

Cited By ~ 64

Author(s):

Stuart W. Leafstedt ◽

John F. Gaeta ◽

Kumao Sako ◽

Frank C. Marchetta ◽

Donald P. Shedd

Keyword(s):

Adenoid Cystic Carcinoma ◽

Salivary Glands ◽

Minor Salivary Glands ◽

Adenoid Cystic

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Epidemiology and treatment of adenoid cystic carcinoma of the minor salivary glands: A meta-analytic study

Medicina Oral Patología Oral y Cirugia Bucal ◽

10.4317/medoral.17200 ◽

2011 ◽

pp. e884-e889 ◽

Cited By ~ 15

Author(s):

N. Martinez-Rodriguez ◽

I. Leco-Berrocal ◽

L. Rubio-Alonso ◽

O. Arias-Irimia ◽

JM. Martinez-Gonzalez

Keyword(s):

Adenoid Cystic Carcinoma ◽

Salivary Glands ◽

Analytic Study ◽

Minor Salivary Glands ◽

Adenoid Cystic

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Adenoid cystic carcinoma of intraoral minor salivary glands

Oral Oncology ◽

10.1016/j.oraloncology.2008.01.005 ◽

2008 ◽

Vol 44 (11) ◽

pp. 1026-1031 ◽

Cited By ~ 37

Author(s):

B. Bianchi ◽

C. Copelli ◽

R. Cocchi ◽

S. Ferrari ◽

N. Pederneschi ◽

...

Keyword(s):

Adenoid Cystic Carcinoma ◽

Salivary Glands ◽

Minor Salivary Glands ◽

Adenoid Cystic

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Clinicopathological profile of adenoid cystic carcinoma of minor salivary gland tumour: our experience at a tertiary care centre

International Journal of Otorhinolaryngology and Head and Neck Surgery ◽

10.18203/issn.2454-5929.ijohns20203195 ◽

2020 ◽

Vol 6 (8) ◽

pp. 1460

Author(s):

Prakash Mylanahalli Doddrangaiah ◽

Bharath Kanna Karunakaran ◽

Roopa S. Mallali ◽

Afshan Fathima

Keyword(s):

Salivary Gland ◽

Adenoid Cystic Carcinoma ◽

Salivary Glands ◽

Hard Palate ◽

Minor Salivary Gland ◽

Salivary Gland Tumour ◽

Minor Salivary Glands ◽

Adenoid Cystic ◽

Minor Salivary Gland Tumour ◽

Gland Tumour

Background: Adenoid cystic carcinoma (ACC) is a rare malignant tumour originating from minor salivary glands. It is known for perineural spread, local recurrences and distant metastasis. The minor salivary gland tumour represents 3% of all head and neck neoplasms, whereas ACC constitutes about 0.5% of all malignant salivary gland neoplasms. This study was done to evaluate the clinical presentation and histopathological findings of minor salivary gland tumour.Methods: This study was done in the department of ENT, Bangalore Medical College and Research Institute from May 2017 to July 2019. Of the 25 patients with minor salivary gland tumour, 10 patients with ACC were considered for the present study. A detailed clinical and histopathological evaluation was done. Results were documented and tabulated in excel sheet. Results: We analysed data of 25 (16 female, 9 male) patients in the age group of 30-60 years, of which 10 patients had adenoid cystic carcinoma of minor salivary gland tumour. The most frequent site of tumour occurrence was noted in the hard palate (6 patients), followed by retromolar trigone (2 patients), floor of mouth (1 patient) and tongue (1 patient). The histopathological pattern noted most commonly in our study: cribriform pattern (6 cases), tubular (1 case) and solid (3 cases).Conclusions: ACC of minor salivary glands is rare. The otorhinolaryngologist should bear this clinical entity in mind when encountered with a painless swelling over the hard palate. This would lead to an early diagnosis and prompt management in such patients.

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