scholarly journals Pulmonary function in advanced uncomplicated singleton and twin pregnancy

2014 ◽  
Vol 40 (3) ◽  
pp. 244-249 ◽  
Author(s):  
Anwar Hasan Siddiqui ◽  
Nazia Tauheed ◽  
Aquil Ahmad ◽  
Zehra Mohsin
Keyword(s):  
Pulmonary Function ◽  
Pregnant Women ◽  
Respiratory Function ◽  
Twin Pregnancy ◽  
Normal Pregnancy ◽  
Singleton Pregnancy ◽  
Respiratory Parameters ◽  
Test Parameters ◽  
Twin Pregnancies ◽  
Singleton Pregnancies

Objective: Pregnancy brings about significant changes in respiratory function, as evidenced by alterations in lung volumes and capacities, which are attributable to the mechanical impediment caused by the growing foetus. This study was undertaken in order to identify changes in respiratory function during normal pregnancy and to determine whether such changes are more pronounced in twin pregnancy than in singleton pregnancy. Methods: Respiratory function was assessed in 50 women with twin pregnancies and in 50 women with singleton pregnancies (during the third trimester in both groups), as well as in 50 non-pregnant women. We measured the following pulmonary function test parameters: FVC; FEV1; PEF rate; FEV1/FVC ratio; FEF25-75%; and maximal voluntary ventilation. Results: All respiratory parameters except the FEV1/FVC ratio were found to be lower in the pregnant women than in the non-pregnant women. We found no significant differences between women with twin pregnancies and those with singleton pregnancies, in terms of respiratory function. Conclusions: Despite its higher physiological demands, twin pregnancy does not appear to impair respiratory function to any greater degree than does singleton pregnancy.

MATERNAL PROTEINURIA IN TWIN COMPARED WITH SINGLETON PREGNANCIES

2021 ◽  
pp. 18-20
Author(s):  
Arunashis Mallick ◽  
Sagar Shirsath ◽  
Debarshi Jana
Keyword(s):  
Normal Pregnancy ◽  
Urinary Protein Excretion ◽  
Urinary Protein ◽  
Hypertensive Disorder ◽  
Urine Protein ◽  
Singleton Pregnancy ◽  
Protein Excretion ◽  
A Prospective Study ◽  
Twin Pregnancies ◽  
Singleton Pregnancies

INTRODUCTION: The exact amount of albumin ltered each day by kidneys is controversial. Normal rate of albumin excretion is less than 20 mg/day. The upper limit of the urinary protein excretion is 150 mg/d in normal non–pregnant women. Total protein excretion, however, increases to 150-250 mg daily in normal pregnancy due to increase in blood volume and, therefore, the glomerular ltration rate. This study was conducted to compare 24 hour urinary protein excretion in twin and singleton pregnancies, not complicated by hypertension. MATERIALS AND METHODS: This is a prospective study done in the department of Obstetrics and Gynaecology in R.G.Kar Medical College and Hospital, Kolkata from June, 2015 to May, 2016. A total of 86 women (43 twin and 43 singleton pregnancies) participated in this study. Six collections were inadequate based on creatinine excretion and were excluded. So, 80 women (40 twin and 40 singleton pregnancies) comprised the nal cohort. RESULT: In our study four twin pregnancies (ten percent) were found to have proteinuria ≥ 300 mg/day at the time of the specimen collection but no singleton pregnancy had this level of proteinuria. And only one of these twin pregnancies (who had proteinuria ≥ 300 mg/day ) subsequently developed hypertensive disorder in pregnancy. Rest three twin pregnancies were normotensive, yet they showed proteinuria ≥ 300 mg/day. Though statistical analysis of 24 hour urine protein ≥ 300 mg in singleton and twin pregnancies did not show signicans (P0.1238) in our study. CONCLUSION: Twin pregnancy had signicantly more proteinuria as measured by 24 hour urine protein, than singleton pregnancy. And they are more likely to have proteinuria without hypertension and this value can exceed 300 mg/day. So, a reevaluation of the diagnostic criteria for preeclampsia in twin pregnancies is needed.

scholarly journals Comparison of phenylalanine tolerance in singleton and twin pregnancies in patients with phenylketonuria

2020 ◽  
Vol 48 (9) ◽  
pp. 030006052093462
Author(s):  
Kamil Konrad Hozyasz ◽  
Joanna Żółkowska ◽  
Katarzyna Chyż
Keyword(s):  
Steady State ◽  
Twin Pregnancy ◽  
Target Range ◽  
Singleton Pregnancy ◽  
Empirical Determination ◽  
Twin Pregnancies ◽  
Frequent Assessment ◽  
Singleton Pregnancies

Objectives Empirical determination of phenylalanine (Phe) tolerance in patients with phenylketonuria (PKU) relies on frequent assessment of blood Phe concentrations in relation to Phe intake from detailed meal records. This study aimed to determine Phe tolerance in twin pregnancies. Methods The reviewed cases included three women with PKU who each had a singleton and twin pregnancy (i.e., they were pregnant twice). All patients were under regular supervision to maintain Phe concentrations in a steady state and determine safe Phe intake. Restriction of Phe in the patient’s diet was determined depending on the amount of Phe intake, which allowed for stable blood Phe concentrations within the target range. Results In all three patients with PKU, the ratio of Phe tolerance during the course of the twin and singleton pregnancies was <1 for most of the pregnancy. The ratio of the increase in Phe tolerance between 29 and 34 weeks of gestation and that between 15 and 28 weeks of gestation was 0.66 and 1.17, 0.51 and 0.14, and 0.76 and 1.42 in the twin and singleton pairs of pregnancies, respectively. Conclusions Our study shows that Phe tolerance in a twin pregnancy is not greater than that in a singleton pregnancy.

The Importance of Plasma Volume Expansion and Nutrition in Twin Pregnancy

1984 ◽  
Vol 33 (1) ◽  
pp. 19-24 ◽  
Author(s):  
D.M. Campbell ◽  
I. MacGillivray
Keyword(s):  
Birth Weight ◽  
Plasma Volume ◽  
Volume Expansion ◽  
Twin Pregnancy ◽  
Nutrient Supply ◽  
Physiological Adaptation ◽  
Singleton Pregnancy ◽  
Plasma Volume Expansion ◽  
Twin Pregnancies ◽  
Singleton Pregnancies

AbstractPhysiological adaptation including expansion in plasma volume is exaggerated in women with twin pregnancies. In singleton pregnancy and multiparous twin pregnancies there is an association between plasma volume expansion and birth weight, but this is not so in primigravid twin pregnancies. Women with twin pregnancies have a similar dietary intake to singleton pregnancies, but it is not known whether there are differences with parity or zygosity. Absorption and utilisation of nutrients may be increased to meet demands for extra fetal growth. Nutrient supply and plasma volume expansion will be further discussed and their association with birth weight presented.

Analysis of Triple Test Results in 27 Cases of Twin Pregnancies

1998 ◽  
Vol 47 (3-4) ◽  
pp. 249-254 ◽  
Author(s):  
M. Perenc ◽  
L. Dudarewicz ◽  
B. Kałużewski
Keyword(s):  
Pregnant Women ◽  
Enzyme Immunoassay ◽  
Trisomy 21 ◽  
Twin Pregnancy ◽  
Clinical Diagnostics ◽  
Control Group ◽  
Singleton Pregnancy ◽  
Microparticle Enzyme Immunoassay ◽  
Β Hcg ◽  
Twin Pregnancies

AbstractThe study comprises 889 pregnant women between 14 and 21 weeks of gestation. The control group consisted of 862 pregant women with unburdened obstetric anamnesis with an uneventful singleton pregnancy. The examined group consisted of 27 pregnant women with uncomplicated twin pregnancy. In the sera of pregant women AFP (Microparticle Enzyme Immunoassay AxSYM Abbott), total (β-hCG (Microparticle Enzyme Immunoassay AxSYM Abbott) and unconjugated estriol (Radioimmunoassay Amerlex-M. 2T Johnson & Johnson Ortho Clinical Diagnostics Ltd.) were determined. The risk of fetal trisomy 21 was calculated with the use of PRISCA 3.0 software, which corrected the MoM values for twin pregnancy. Ulm Index was also calculated. In the majority of twin pregnancies increased concentrations of AFP, total (β-hCG and uE3 in the range over 1,0 MoM was noted. In the group of women below 35 years of age with singleton pregnancies using PRISCA 3.0 software it approximated to 95%. For women older than 35 optimum index for fetal trisomy 21 risk calculation was Ulm Index with the specificity 93,8%. The specificity of AFP determination in the detection of fetal open NTD in singleton pregnancy was 99%. In the group of women with twin pregnancy the obtained specificity of 77,8% for PRISCA 3.0 software is low, a more adavantageous way to calculate the risk of fetal trisomy 21 is Ulm Index with the specificity of 85,2%. The specificity of AFP determination as a screening for fetal open NTD in twin pregnancy was 96,3%.

scholarly journals Comparative assessment of fetomaternal outcome in twin pregnancy with singleton pregnancy at tertiary care centre

2017 ◽  
Vol 6 (6) ◽  
pp. 2395
Author(s):  
Divya Gupta ◽  
Premlata Mital ◽  
Bhanwar Singh Meena ◽  
Devendra Benwal ◽  
. Saumya ◽  
...  
Keyword(s):  
Twin Pregnancy ◽  
Tertiary Care ◽  
Comparative Assessment ◽  
P Value ◽  
Care Centre ◽  
Tertiary Care Centre ◽  
Singleton Pregnancy ◽  
Medical College ◽  
Obstetrics And Gynaecology ◽  
Twin Pregnancies

Background: Multiple pregnancy remains one of the highest risk situations for the mother, foetus and neonate despite recent advances in obstetrics, perinatal and neonatal care. Twin pregnancies have increased rates of obstetric and perinatal complications compared to singletons Objective of present study was comparative assessment of fetomaternal outcome in twin pregnancy with singleton pregnancy in Obstetrics and Gynaecology Department of S.M.S. Medical College, Jaipur.Methods: This was a hospital based, prospective observational study done in the Department of Obstetrics and Gynaecology. S.M.S. Medical College, Jaipur from April 2015 to March 2016. 150 women with twin pregnancy and 150 women with singleton pregnancies at gestation age of 28 weeks and above coming for delivery and consented for the study were included in the study. Women with chronic medical disorder or chronic hypertension were excluded from the study. Maternal and neonatal outcome recorded and analysed.Results: Occurrence of twin in our study was 2.82%. Risk of preterm labour was about nine times higher in twin pregnancies than the singleton (OR: 2.74, 95% CI; 1.4494-5.1884, P value 0.001). The risk of premature rupture of membrane was increased by 2.74 times in twin pregnancies (OR:2.74; 95% CI: 1.4494-5.1884, p value .001). There was 3-time increased risk of malpresentation (OR 3.14; CI:1.7184-5.7480, p value .00002) and 2.28 times increase in hypertensive disorder (OR 2.28; 95% CI: 1.0727-4.8823, p value .03) in twin pregnancies. The risk of asphyxia and septicaemia was 2.5 times more in twins.Conclusions: Twin pregnancy is a high-risk pregnancy with more complications in mother and foetus and is a great challenge for obstetrician. So, it should be managed carefully at tertiary care centre to reduce the maternal and perinatal mortality and morbidity.

Maternal Nutrition in Twin Pregnancy

1982 ◽  
Vol 31 (3-4) ◽  
pp. 221-227 ◽  
Author(s):  
Doris M. Campbell ◽  
Ian MacGillivray ◽  
Sheena Tuttle
Keyword(s):  
Protein Intake ◽  
Twin Pregnancy ◽  
Maternal Nutrition ◽  
Dietary Zinc ◽  
Nitrogen Intake ◽  
The Relationship ◽  
Twin Pregnancies ◽  
Urinary Nitrogen ◽  
Singleton Pregnancies

Energy and protein intake as measured by 24-hour urinary nitrogen values are similar in twin and singleton pregnancies. The relationship between urinary nitrogen and nitrogen intake is equally significant in twin and singleton pregnancies. Dietary zinc, copper, and iron are not different in women with twins, nor are the levels of these elements in plasma. These observations are surprising in view of the extra fetal demands on the mother and the different adaptation of twin pregnancies.

scholarly journals Study of maternal and fetal outcome in twin pregnancy

2017 ◽  
Vol 6 (6) ◽  
pp. 2272 ◽  
Author(s):  
Lata Singh ◽  
Kiran Trivedi
Keyword(s):  
Mortality Rate ◽  
Perinatal Mortality ◽  
Twin Pregnancy ◽  
Fetal Outcome ◽  
Medical Sciences ◽  
Maternal Complications ◽  
Perinatal Mortality Rate ◽  
Increased Risk ◽  
Twin Pregnancies ◽  
Singleton Pregnancies

Background: Multiple pregnancies are associated with an increased risk of obstetric complications as well as perinatal morbidity and mortality especially in developing countries. The present study aims to understand the maternal and perinatal outcomes of multiple and singleton pregnancies delivering at Rajendra Institute of Medical Sciences, Ranchi, India. Aim of study was to investigate the maternal and fetal outcome in twin pregnancies in Rajendra Institute of Medical Sciences (RIMS), RanchiMethods: This comparative prospective study was conducted in the department of obstetrics and gynecology, Rajendra Institute of Medical Sciences, Ranchi from the period of 1st April 2015 to 30th September 2016. Consecutive sampling was done till the sample size of 75 was reached for both twin and singleton pregnancies. It included all women admitted in antenatal ward and labor room with clinical or ultrasound diagnosis of twin pregnancy after 28 weeks of gestation.Results: The incidence of twins in this study was 1.85%. Mean maternal age was 25.25±4.5 years for twin pregnancies and 23.53 ± 3.3 for singleton pregnancies. Twins were seen more in multigravida (70.7%) as compared to primigravida (29.3%). Preterm labor (74.7%), anemia (44%) and hypertensive disorders (32%) and PPH (13.33%) were the most common complication in twin pregnancies. Significantly higher rate of LSCS were seen in twin pregnancies (32.67%) as compared to singletons 18.67%. Mean weight of first twin was 2.03±0.52kg and for second twin it was 1.98±0.51kg. There was higher incidence of moderate to severe asphyxia, IUGR and higher rate of NICU admissions in twins as compared to singletons. Perinatal mortality rate of monchrionic pregnancy was 30% and it was 10.2% for dichorionic pregnancy which shows a significant association of perinatal mortality rate and chorionicity.Conclusions: Good antenatal care, with increased rest and nutritional supplementation, early detection of fetal and maternal complications together with thorough intranatal and postnatal vigilance, can lower both maternal and fetal dangers.

scholarly journals NEC in Twin Pregnancies: Incidence and Outcomes

2014 ◽  
Vol 3 (4) ◽  
Author(s):  
Sathyaprasad C Burjonrappa ◽  
Brian Shea ◽  
Diya Goorah
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Medical Records ◽  
Lead Time ◽  
Twin Pregnancy ◽  
Antenatal Screening ◽  
Singleton Pregnancy ◽  
Average Lead ◽  
Gastrointestinal Emergency ◽  
Twin Pregnancies

Background: Necrotizing Enterocolitis (NEC) is the most common gastrointestinal emergency in neonates. Previously established risk factors for the development of NEC include prematurity and low birth weight. However, it is not clear to date as to whether the etiology of NEC is due to host, environmental, or yet other unknown factors. We analyzed the differences in incidence of NEC in twin pregnancies to further clarify its etio-pathogenesis.Methods: After IRB approval, a retrospective search of the medical records of the Department of Pediatric Surgery was done to identify all the neonates treated for surgical NEC from 2006-2013. Patients that had been treated for NEC elsewhere and subsequently transferred in to our facility were excluded. The medical records of the resulting 45 patients were then analyzed for demographics, antenatal screening, risk factors, treatment (medical and surgical), and outcomes. The resulting data was then analyzed using relative risk calculations and standard statistical tests.Results: Of the 45 patients who developed surgical NEC, 9 neonates (20%) were born of a twin pregnancy. There were no cases in which both twin A and twin B developed NEC. NEC in twin pregnancy neonates showed a female preponderance (p<0.0001) and developed universally in the first born of the twins. Birth weight, time of onset of NEC, hospital stay and mortality were similar between twin and non-twin NEC. There was an average lead-time of three weeks to development of NEC in both singletons and twin pregnancies.Conclusion: There is a remarkable higher incidence of NEC amongst twins. Abnormal colonization of the gastrointestinal tract appears to be an immediate postpartum event. NEC in twin pregnancy does not appear to have a deleterious outcome compared to NEC in singleton pregnancy.

scholarly journals Twin pregnancy, the study of maternal and perinatal outcome: what being a twin is like?

2019 ◽  
Vol 8 (11) ◽  
pp. 4457
Author(s):  
Smitha K. ◽  
Jasiya Afreen M. H.
Keyword(s):  
Perinatal Outcome ◽  
Twin Pregnancy ◽  
Mode Of Delivery ◽  
Neonatal Morbidity ◽  
Hyaline Membrane Disease ◽  
Perinatal Complications ◽  
Maternal Complications ◽  
Singleton Pregnancy ◽  
Risk Pregnancy ◽  
Twin Pregnancies

Background: Twin pregnancy is considered as a high-risk pregnancy due to associated high maternal and perinatal morbidity mortality in comparison with singleton pregnancy. The objectives of this study were to study the maternal and perinatal complications in twin pregnancies. To find out various factors that contribute to adverse perinatal outcome.Methods: This retrospective study was conducted at Kempegowda Institute of Medical Sciences Hospital, Bengaluru. 92 women with twin pregnancies admitted in KIMS Hospital from September 2014 to September 2018, both booked and referred patients were studied. Individual patient parameters like age, parity, gestational age, mode of delivery, maternal complications were tabulated. Neonatal morbidity and mortality were noted, data thus obtained was analysed and results studied.Results: In the study the incidence of twin pregnancies was more in second gravida (53%). 72% of the patients were admitted between 28-36 weeks of gestation with preterm labour (23%) as the main cause for admission. Anaemia (8.69%), hypertensive disorders of pregnancies (17.39%), PPROM (21%), single foetal demise (5%) and IUGR (5.4%) were the antenatal complications observed. Out of the 92 patients, 29 (35.4%) patients delivered by vaginal route whereas 53 (64.6%) had to undergo C-section. DCDA twin constituted 66% of twins in the study and mal presentation was the commonest indication for caesarean section (50%). Among the 164 babies out of 92 twin pregnancies 8 babies were still born and 12 babies died by the end of one week due to complications related to prematurity like hyaline membrane disease, IVH.Conclusions: Early detection of twin pregnancies and proper antenatal care reduces both maternal and perinatal complication thereby improving maternal and perinatal outcome.

scholarly journals Causes of patients’ obstetric complications after ART

2017 ◽  
Vol 66 (3) ◽  
pp. 25-33 ◽  
Author(s):  
Olga N. Arzhanova ◽  
Yulia M. Paikacheva ◽  
Anna V. Ruleva ◽  
Roman V. Kapustin ◽  
Natalya G. Nichiporuk
Keyword(s):  
Pregnant Women ◽  
Older Women ◽  
Main Group ◽  
High Risk Group ◽  
Placental Insufficiency ◽  
Physical Disorder ◽  
Singleton Pregnancy ◽  
Art Programs ◽  
Group I ◽  
Singleton Pregnancies

Chronic placental insufficiency remains a major cause of perinatal morbidity and mortality. In this regard, prediction of this pregnancy complications becomes particularly relevant. Currently, the frequency of pregnancy as result of assisted reproductive technology (ART) increases among the population. Pregnancies after ART administration compare to naturally occurred are accompanied by a higher risk of miscarriage as well as the formation of placental insufficiency. Older women with endocrine and physical disorder participate in the ART programs most frequently. The aim of our study was to investigate the course of pregnancy, after ART administration, selection groups threatened by the development of placental insufficiency. 261 medical records of women with singleton pregnancies after ART have been studied. It was the main group. 167 women had a chronic placental insufficiency. There were allocated two groups of pregnant women: group I – 86 patients with placental insufficiency and preeclampsia, group II – 81 women with placental insufficiency indeed. The comparison group consisted of 30 women without infertility with a normal singleton pregnancy. The development of placental insufficiency in the main group (after ART) depends on a large causes of somatic pathology due to age of pregnant women as well. Therefore, patients after ART have to allocate in the high risk group of developing preeclampsia and placental insufficiency.

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