pH-sensitive polyvinylpyrrolidone-acrylic acid hydrogels: Impact of material parameters on swelling and drug release

In this study, we fabricated pH-sensitive polyvinylpyrrolidone/acrylic acid (PVP/AA) hydrogels by a free-radical polymerisation method with variation in the content of monomer, polymer and cross-linking agent. Swelling was performed in USP phosphate buffer solutions of pH 1.2, 5.5, 6.5 and 7.5 with constant ionic strength. Network structure was evaluated by different parameters and FTIR confirmed the formation of cross-linked hydrogels. X-ray crystallography showed molecular dispersion of tramadol HCl. A drug release study was carried out in phosphate buffer solutions of pH 1.2, 5.5 and 7.5 for selected samples. It was observed that swelling and drug release from hydrogels can be modified by changing composition and degree of cross-linking of the hydrogels under investigation. Swelling coefficient was high at higher pH values except for the one containing high PVP content. Drug release increased by increasing the pH of the medium and AA contents in hydrogels while increasing the concentration of cross-linking agent had the opposite effect. Analysis of the drug release mechanism revealed non-Fickian transport of tramadol from the hydrogels.

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Synthesis and Characterization of Chemically Cross-Linked Acrylic Acid/Gelatin Hydrogels: Effect of pH and Composition on Swelling and Drug Release

International Journal of Polymer Science ◽

10.1155/2015/187961 ◽

2015 ◽

Vol 2015 ◽

pp. 1-15 ◽

Cited By ~ 52

Author(s):

Syed Majid Hanif Bukhari ◽

Samiullah Khan ◽

Muhammad Rehanullah ◽

Nazar Mohammad Ranjha

Keyword(s):

Acrylic Acid ◽

Phosphate Buffer ◽

Sol Gel ◽

Ammonium Persulfate ◽

Cross Linking ◽

Release Mechanism ◽

Ph Values ◽

Allergy Treatment ◽

Model Drug ◽

Release Data

This present work was aimed at synthesizing pH-sensitive cross-linked AA/Gelatin hydrogels by free radical polymerization. Ammonium persulfate and ethylene glycol dimethacrylate (EGDMA) were used as initiator and as cross-linking agent, respectively. Different feed ratios of acrylic acid, gelatin, and EGDMA were used to investigate the effect of monomer, polymer, and degree of cross-linking on swelling and release pattern of the model drug. The swelling behavior of the hydrogel samples was studied in 0.05 M USP phosphate buffer solutions of various pH values pH 1.2, pH 5.5, pH 6.5, and pH 7.5. The prepared samples were evaluated for porosity and sol-gel fraction analysis. Pheniramine maleate used for allergy treatment was loaded as model drug in selected samples. The release study of the drug was investigated in 0.05 M USP phosphate buffer of varying pH values (1.2, 5.5, and 7.5) for 12 hrs. The release data was fitted to various kinetic models to study the release mechanism. Hydrogels were characterized by Fourier transformed infrared (FTIR) spectroscopy which confirmed formation of structure. Surface morphology of unloaded and loaded samples was studied by surface electron microscopy (SEM), which confirmed the distribution of model drug in the gel network.

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Drug release from pH-sensitive interpenetrating polymer networks hydrogel based on poly (ethylene glycol) macromer and poly (acrylic acid) prepared by UV cured method

Archives of Pharmacal Research ◽

10.1007/bf02976814 ◽

1996 ◽

Vol 19 (1) ◽

pp. 18-22 ◽

Cited By ~ 12

Author(s):

In-Sook Kim ◽

Sung-Ho Kim ◽

Chong-Su Cho

Keyword(s):

Drug Release ◽

Acrylic Acid ◽

Ethylene Glycol ◽

Polymer Networks ◽

Ph Sensitive ◽

Interpenetrating Polymer Networks ◽

Poly Ethylene Glycol ◽

Poly Ethylene ◽

Poly Acrylic Acid

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Fabrication of novel dual thermo- and pH-sensitive poly (N-isopropylacrylamide-N-methylolacrylamide-acrylic acid) electrospun ultrafine fibres for controlled drug release

Materials Science and Engineering C ◽

10.1016/j.msec.2020.111050 ◽

2020 ◽

Vol 115 ◽

pp. 111050 ◽

Cited By ~ 1

Author(s):

Zhimei Wei ◽

Qingyu Lin ◽

Jie Yang ◽

Shengru Long ◽

Gang Zhang ◽

...

Keyword(s):

Drug Release ◽

Acrylic Acid ◽

Controlled Drug Release ◽

Ph Sensitive

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Preparation of a novel pH-sensitive hydrogel based on acrylic acid and polyhedral oligomeric silsesquioxane for controlled drug release of theophylline

Polymer Bulletin ◽

10.1007/s00289-014-1161-y ◽

2014 ◽

Vol 71 (8) ◽

pp. 1877-1889 ◽

Cited By ~ 6

Author(s):

Deyong Huang ◽

Chunling Zhang ◽

Kaifeng Yu ◽

Tingting Wang ◽

Jianxin Mu

Keyword(s):

Drug Release ◽

Acrylic Acid ◽

Polyhedral Oligomeric Silsesquioxane ◽

Controlled Drug Release ◽

Ph Sensitive ◽

Oligomeric Silsesquioxane ◽

Ph Sensitive Hydrogel

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Synthesis and Properties of Thermo- and pH-Sensitive Poly[(Sodium Humate)-(N-Isopropylacrylamide)-(Acrylic Acid)] Intelligent Hydrogel

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.781-784.536 ◽

2013 ◽

Vol 781-784 ◽

pp. 536-541

Author(s):

Xiao Mi Zhou ◽

Xiao Ran Sun ◽

Guang Yue Li

Keyword(s):

Acrylic Acid ◽

Suspension Polymerization ◽

Ammonium Persulfate ◽

Continuous Phase ◽

Ph Sensitive ◽

Cross Linking ◽

Swelling Ratio ◽

Inverse Suspension Polymerization ◽

Sensitive Characteristics ◽

Intelligent Hydrogel

A novel intelligent hydrogel of poly(Humic acid - Nisopropylacrylamide - Acrylic acid) (P(NIPAAm-HA-AA)) was prepared at 70°C by inverse suspension polymerization. The reactions include uses N,N-methylene-bis-acrylamide (MBA) as a cross-linking agent, ammonium persulfate (KPS) as an initiator, cyclohexane as a continuous phase and span-65 as dispersant. The influence such as concentration of monomers and cross-linking agent, mole fraction of span-65 in mixed monomers, and temperature of polymerization on the property of resulting P(NIPAAm-HA-AA) hydrogels was investigated in detail. Fourier transform infrared (FTIR) demonstrated that NIPAAm, HA and AA was synthetized successfully. The results showed that the swelling ratio (SR) of modified hydrogel was improved significantly with the dosage of NIPAAm. It was also observed that the thermosensitive and pH sensitive characteristics was strongly affected by concentrations of NIPAAm. At last, we choose NIPAAm: HA=0.3.

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Synthesis and characterization of oral drug delivery, a pH – sensitive silver nanocomposite based on sodium alginate extracted from Sargassum asperifolium collected from Jazan coasts, KSA

10.1101/557231 ◽

2019 ◽

Author(s):

Fatimah. A. Agili ◽

Sahera. F. Mohamed

Keyword(s):

Electron Microscope ◽

Drug Release ◽

Sodium Alginate ◽

Oral Drug Delivery ◽

Drug Carrier ◽

Gastric Fluid ◽

Ph Sensitive ◽

Oral Drug ◽

Release Mechanism ◽

X Ray

AbstractThe pH-sensitive nanocomposite composed of sodium alginate/ Pectin/ Tannic acid – silver SA/Pec/TA-Ag was prepared using microwave irradiation and employed as a carrier for Propranolol drug. Physico-chemical characteristics of the prepared systems using Fourier Transform Infrared Spectroscopy (FTIR), X-ray Diffraction (XRD), Field Emission Scanning Electron Microscope (FESEM), High-Resolution Transmission Electron Microscope (HRTEM), Dynamic light Scattering instrument (DLS), and Energy Dispersive X-Ray Analysis (EDX). The percentage drug release was 96% at pH 7.4 within 420 min. The drug release data was fitted into different kinetic models included zero order, First order, Higuchi and Ritger-Peppas model. The release mechanism is non-Fickian character where it controlled by diffusion and relaxation of polymer chains. It can be concluded that SA/Pec/TA-Ag nanocomposite is candidate for the oral drug carrier specific for intestinal system and has stability against gastric fluid.

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Physicochemical characterization and release properties of oral drug delivery: A pH-sensitive nanocomposite based on sodium alginate–pectin–tannic acid–silver

Polymers and Polymer Composites ◽

10.1177/0967391119895073 ◽

2019 ◽

Vol 28 (8-9) ◽

pp. 598-608

Author(s):

Fatimah A Agili ◽

Sahera FM Aly

Keyword(s):

Electron Microscope ◽

Drug Release ◽

Sodium Alginate ◽

Tannic Acid ◽

Drug Carrier ◽

Ph Sensitive ◽

Diffraction Field ◽

Oral Drug ◽

Release Mechanism ◽

X Ray

A pH-sensitive nanocomposite formed from sodium alginate (SA)/pectin (Pec)/tannic acid (TA)–silver (Ag) was developed using microwave irradiation and it was applied as a carrier for propranolol drug. TA acts as a cross-linker and a reducing agent for Ag ions. Physicochemical characteristics of the fabricated system using Fourier transform infrared spectroscopy, X-ray diffraction, field-emission scanning electron microscope, high-resolution transmission electron microscope, dynamic light scattering instrument, and energy dispersive X-ray analysis. The swelling percent and the drug release were observed to be pH-sensitive. The occurrence of Ag nanoparticles in the network enhances the drug release that is 96% at pH 7.4 within 420 min. The drug release data were adjusted into different kinetic models involved zero order, first order, Higuchi, and Ritger–Peppas models. The release mechanism is a non-Fickian character where it controls by diffusion and relaxation of polymer chains. It can be concluded that SA/Pec/TA-Ag nanocomposite is a candidate for the oral drug carrier specific for the intestinal system and has ability against the gastric fluid.

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