scholarly journals MRI Detection of Nonproliferative Tumor Cells in Lymph Node Metastases Using Iron Oxide Particles in a Mouse Model of Breast Cancer

2013 ◽  
Vol 6 (3) ◽  
pp. 347-354 ◽  
Author(s):  
Vasiliki Economopoulos ◽  
Yuhua Chen ◽  
Catherine McFadden ◽  
Paula J Foster
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Iron Oxide ◽  
Mouse Model ◽  
Tumor Cells ◽  
Lymph Node Metastases ◽  
Iron Oxide Particles ◽  
Node Metastases ◽  
Oxide Particles

Mr Lymphography Using Iron Oxide Particles

1993 ◽  
Vol 34 (1) ◽  
pp. 10-15 ◽  
Author(s):  
M. Taupitz ◽  
S. Wagner ◽  
B. Hamm ◽  
D. Dienemann ◽  
R. Lawaczeck ◽  
...  
Keyword(s):  
Lymph Node ◽  
Iron Oxide ◽  
Lymph Nodes ◽  
Lymph Node Metastases ◽  
Pulse Sequences ◽  
Signal Loss ◽  
Iron Oxide Particles ◽  
Imaging Results ◽  
Node Metastases ◽  
Oxide Particles

MR images of the iliac lymph nodes of 25 VX2 carcinoma-bearing rabbits and of 5 tumor-free rabbits were obtained at 1.5 T before and after endolymphatic administration of superparamagnetic iron oxide particles (SPIO) at a dose of 1 μmol Fe per extremity. Imaging results were correlated with histology. In unenhanced images intranodal metastases were not detectable with any of the pulse sequences used and the signal intensities of tumor-free and metastatic lymph nodes did not differ significantly. After administration of the contrast medium, a significant signal loss (p≤0.05) occurred in the healthy lymph node tissue, whereas the signal intensity of lymph node metastases remained unchanged. In SPIO enhanced images, the threshold size for detection of lymph node metastases was 2 mm. Metastatic involvement was detected in 28 of the 30 tumorous lymph nodes with the SE 2 000/15 sequence but in a smaller number of lymph nodes with the sequences SE 500/22 (n = 27) and 2 000/65 (n = 21).

scholarly journals Breast Cancer Prognosis and Occult Lymph Node Metastases, Isolated Tumor Cells, and Micrometastases

2010 ◽  
Vol 102 (6) ◽  
pp. 410-425 ◽  
Author(s):  
M. de Boer ◽  
J. A. A. M. van Dijck ◽  
P. Bult ◽  
G. F. Borm ◽  
V. C. G. Tjan-Heijnen
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Tumor Cells ◽  
Lymph Node Metastases ◽  
Breast Cancer Prognosis ◽  
Cancer Prognosis ◽  
Isolated Tumor Cells ◽  
Node Metastases
Sign in / Sign up

Export Citation Format

Share Document