Tumor Necrosis Factor Promotes Human T-Cell Development in Nonobese Diabetic/Severe Combined Immunodeficient Mice

The human OX-40 cell surface antigen is a CD4+ T cell activation marker that acts as a costimulatory receptor and is a member of the nerve growth factor receptor/tumor necrosis factor (TNF) receptor family. Using a soluble form of the receptor, the extracellular region fused with human immunoglobulin Fc, we expression cloned the human OX-40 ligand cDNA from a library derived from an activated B lymphoblastoid cell line MSAB. The encoded protein is identified as gp34, a type II transmembrane antigen previously known to be expressed only by human T cell lymphotropic virus 1-infected cells. We describe gp34 as a new member of the TNF family, and find that the recombinant ligand expressed in COS cells costimulates phorbol myristate acetate, phytohemagglutinin, and anti-CD3-induced CD4+ T cell proliferation.

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Review for "Tumor necrosis factor receptor family co‐stimulation increases regulatory T cell activation and function via NF‐κB"

10.1002/eji.201948393/v1/review1 ◽

2019 ◽

Keyword(s):

T Cell ◽

Tumor Necrosis Factor ◽

T Cell Activation ◽

Regulatory T Cell ◽

Tumor Necrosis ◽

Cell Activation ◽

Tumor Necrosis Factor Receptor ◽

And Function ◽

Necrosis Factor ◽

Receptor Family

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Murine tumorlytic factor, immunologically distinct from tumor necrosis factor-α and -β, induced in the serum of mice treated with a T-cell mitogen of Corynebacterium kutscheri

Immunology Letters ◽

10.1016/0165-2478(95)00029-5 ◽

1995 ◽

Vol 46 (1-2) ◽

pp. 101-106 ◽

Cited By ~ 4

Author(s):

Eiji Kita ◽

Norio Matsui ◽

Masayoshi Sawaki ◽

Keiichi Mikasa ◽

Noriaki Katsui

Keyword(s):

T Cell ◽

Tumor Necrosis Factor ◽

Tumor Necrosis ◽

Tumor Necrosis Factor Α ◽

Cell Mitogen ◽

Factor Α ◽

Necrosis Factor

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T cell receptor-dependent cell death of T cell hybridomas mediated by the CD30 cytoplasmic domain in association with tumor necrosis factor receptor-associated factors.

Journal of Experimental Medicine ◽

10.1084/jem.183.2.669 ◽

1996 ◽

Vol 183 (2) ◽

pp. 669-674 ◽

Cited By ~ 115

Author(s):

S Y Lee ◽

C G Park ◽

Y Choi

Keyword(s):

Cell Death ◽

T Cell ◽

Tumor Necrosis Factor ◽

T Cell Receptor ◽

Tumor Necrosis ◽

Tumor Necrosis Factor Receptor ◽

Cell Receptor ◽

Cytoplasmic Domain ◽

Activated T Cells ◽

Necrosis Factor

CD30 is a member of the tumor necrosis factor superfamily and a surface marker for Hodgkin's disease. Normal activated T cells and several virally transformed T or B cell lines also show CD30 expression. The interaction of CD30 with its ligand induces cell death or proliferation, depending on the cell type. In this report we characterize the signals mediated by the intracellular domain of CD30 and show that, in combination with signal(s) transduced by the T cell receptor, the multimerization of CD30 cytoplasmic domain induces Fas(CD95)-independent cell death in T cell hybridomas. Deletion analysis shows that the COOH-terminal 66 amino acids of CD30 are required to induce cell death. Using the yeast two-hybrid system, we have identified that the same region of CD30 interacts with tumor necrosis factor receptor-associated factor (TRAF)1 and TRAF2. These results indicate that TRAF1 and/or TRAF2 play an important role in cell death in addition to their previously identified roles in cell proliferation.

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