THE DIURNAL PATTERN OF PLASMA GROWTH HORMONE CONCENTRATION IN CHILDREN AND ADOLESCENTS

1966 ◽  
Vol 34 (2) ◽  
pp. 147-153 ◽  
Author(s):  
W. M. HUNTER ◽  
W. M. RIGAL

SUMMARY The diurnal pattern of plasma growth hormone levels has been investigated in nine children, without endocrinopathy, aged 8–15 yr., from whom blood samples were taken hourly during the day and 2-hourly at night. Growth hormone was undetectable (< 1 μmg./ml.) during the first 2 hr. after meals but the levels rose thereafter to values many times higher than those found in adults. High values were consistently encountered during the night.

1966 ◽  
Vol 34 (2) ◽  
pp. 139-146 ◽  
Author(s):  
W. M. HUNTER ◽  
J. A. R. FRIEND ◽  
J. A. STRONG

SUMMARY Plasma growth hormone (GH) levels were measured at intervals throughout the day in various subjects. Several healthy men showed increased levels 3–4 hr. after a meal. Plasma GH was generally low in obese subjects with or without diabetes. Four acromegalic patients had consistently and markedly raised levels which were unaffected by food. In two thyrotoxic patients GH values were not different from normal.


1988 ◽  
Vol 66 (4) ◽  
pp. 853-855 ◽  
Author(s):  
Bruce A. Barrett ◽  
Brian A. McKeown

During the increased locomotor activity of migration many salmonids do not actively feed and it is likely that metabolic alterations occur to facilitate the mobilization of stored reserves. The present laboratory study was designed to simulate the occurrence of exercise and starvation as natural parameters of migration and to assess the effects of such parameters on levels of plasma growth hormone, which might indicate alterations in metabolism during migration. Juvenile steelhead trout, Salmo gairdneri, were starved for a 30-day period. Starved individuals exhibited a marked increase in plasma growth hormone concentration (38.6 ± 6.7 ng/mL) compared with control individuals held on a normal feeding regime (6.4 ± 1.84 ng/mL). A subgroup of fish from the starved group were exercised by being forced to swim at 1.5 body lengths/s for a 24-h period. Exercised individuals exhibited plasma growth hormone levels in excess of 140 ng/mL. There was no significant difference between the plasma growth hormone levels of unexercised starved fish and exercised fed fish.


1968 ◽  
Vol 47 (3) ◽  
pp. 427-435 ◽  
Author(s):  
Helen G. Morris ◽  
Jacqueline R. Jorgensen ◽  
Shirley A. Jenkins

1989 ◽  
Vol 113 (2) ◽  
pp. 173-182 ◽  
Author(s):  
J. M. Bassett

SUMMARYTo investigate whether late pregnancy results in increased resistance to insulin action in ewes, a group of 18 crossbred ewes (six with twin foetuses) were given intravenous injections of glucose (0·25 g/kg) and insulin (0·25 U/kg) about 18days before full term and again during lactation, about 36 days after delivery. Before the injections, basal plasma concentrations of glucose, free fatty acids and growth hormone were lower during pregnancy than during lactation, but insulin concentrations were similar on the two occasions and cortisol concentrations were higher during pregnancy.Rates of glucose removal and insulin secretory responses to the glucose injection were similar on the two occasions, both in ewes with single lambs and in those with twins. Insulin injection also resulted in similar decreases in glucose concentration on the two occasions in all ewes. Recovery from hypoglycaemia was somewhat delayed during pregnancy whencompared with lactation, but less so than in wether sheep given a similar injection of insulin. The plasma free fatty acid concentration decreased more slowly after glucose injection during pregnancy than in lactation. Responses of plasma cortisol concentration toinsulin-induced hypoglycaemia were similar on the 2 days, but plasma growth hormone concentration increased far more in lactating ewes after both injections.The results did not indicate increased antagonism to insulin action in ewes during late pregnancy, but did show that changes in the counter-regulatory hormones after the disturbances to glucose homeostasis may differ markedly in the two situations and suggest that hyper-responsiveness of the system regulating growth hormone secretion contributes to the increased plasma growth hormone concentration observed in lactating animals.


1997 ◽  
Vol 7 (1) ◽  
pp. 48-60 ◽  
Author(s):  
Richard R. Suminski ◽  
Robert J. Robertson ◽  
Fredric L. Goss ◽  
Silva Arslanian ◽  
Jie Kang ◽  
...  

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