Cytokine receptor signalling through two novel families of transducer molecules: Janus kinases, and signal transducers and activators of transcription

1995 ◽  
Vol 147 (1) ◽  
pp. 11-23 ◽  
Author(s):  
J Finidori ◽  
P A Kelly
Keyword(s):  
Cytokine Receptor ◽  
Janus Kinases ◽  
Signal Transducers ◽  
Receptor Signalling ◽  
Signal Transducers And Activators

Expression of the janus kinases – signal transducers and activators of transcription pathway in Hassall's corpuscles of the human thymus

2000 ◽  
Vol 113 (6) ◽  
pp. 427-431 ◽  
Author(s):  
Hajime Nishio ◽  
Kiyoshi Matsui ◽  
Hiroko Tsuji ◽  
Akiyoshi Tamura ◽  
Koichi Suzuki
Keyword(s):  
Janus Kinases ◽  
Signal Transducers ◽  
Human Thymus ◽  
Signal Transducers And Activators

Janus kinases in cytokine signalling

1996 ◽  
Vol 351 (1336) ◽  
pp. 159-166 ◽  
Keyword(s):  
Tyrosine Phosphorylation ◽  
Tyrosine Kinases ◽  
Janus Kinase ◽  
Cytokine Receptor ◽  
Protein Tyrosine Kinases ◽  
Signalling Pathways ◽  
Functional Responses ◽  
Janus Kinases ◽  
Signal Transducers ◽  
Catalytic Domains

Hematopoiesis is largely regulated by the binding of cytokines to receptors of the cytokine receptor superfamily. Although lacking catalytic domains, members of the cytokine receptor superfamily mediate ligand dependent activation of tyrosine phosphorylation which is critical for all receptor functions. Recent studies have demonstrated that this is mediated through the association and activation of members of the Janus kinase (Jak) family of protein tyrosine kinases. The activated Jaks phosphorylate the receptors, creating docking sites for SH2 containing signalling proteins which are tyrosine phosphorylated following their association with the receptor complex. Among the substrates of tyrosine phosphorylation are members of the signal transducers and activators of transcription family of proteins (Stats). Various cytokines induce the tyrosine phosphorylation and activation of one or more of the six family members. The pattern of Stat activation provides a level of cytokine individuality that is not observed in the activation of other signalling pathways. Although not required for mitogenic responses, it is speculated that the Stats may mediate many of the cytokine specific functional responses of hematopoietic cells.

Peripheral but not central axotomy induces changes in Janus kinases (JAK) and signal transducers and activators of transcription (STAT)

2000 ◽  
Vol 12 (4) ◽  
pp. 1165-1176 ◽  
Author(s):  
Franz-Werner Schwaiger ◽  
Gerhard Hager andreas B. Schmitt ◽  
Andrea Horvat ◽  
Gundel Hager ◽  
Robert Streif ◽  
...  
Keyword(s):  
Janus Kinases ◽  
Signal Transducers ◽  
Signal Transducers And Activators

scholarly journals Immunolocalisation of the janus kinases (JAK)-signal transducers and activators of transcription (STAT) pathway in human epidermis

2001 ◽  
Vol 198 (5) ◽  
pp. 581-589 ◽  
Author(s):  
HAJIME NISHIO ◽  
KIYOSHI MATSUI ◽  
HIROKO TSUJI ◽  
AKIYOSHI TAMURA ◽  
KOICHI SUZUKI
Keyword(s):  
Human Epidermis ◽  
Janus Kinases ◽  
Signal Transducers ◽  
Stat Pathway ◽  
Signal Transducers And Activators

A novel type-1 cytokine receptor from fish involved in the Janus kinase/Signal transducers and activators of transcription (Jak/STAT) signal pathway

2007 ◽  
Vol 44 (13) ◽  
pp. 3355-3363 ◽  
Author(s):  
Mudjekeewis D. Santos ◽  
Motoshige Yasuike ◽  
Hidehiro Kondo ◽  
Ikuo Hirono ◽  
Takashi Aoki
Keyword(s):  
Signal Pathway ◽  
Janus Kinase ◽  
Cytokine Receptor ◽  
Signal Transducers ◽  
Type 1 Cytokine ◽  
Signal Transducers And Activators
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