scholarly journals Expression and function of the chemokine receptor CCR7 in thyroid carcinomas

2006 ◽  
Vol 191 (1) ◽  
pp. 229-238 ◽  
Author(s):  
Margarida Sancho ◽  
Joaquim Miguel Vieira ◽  
Cristina Casalou ◽  
Marta Mesquita ◽  
Teresa Pereira ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Lymph Node ◽  
Thyroid Carcinoma ◽  
Lymph Nodes ◽  
Chemokine Receptor ◽  
Lymph Node Metastases ◽  
Thyroid Cells ◽  
Thyroid Carcinomas ◽  
Ccr7 Expression ◽  
Node Metastases

The chemokine receptor CCR7 plays a critical role in lymphocyte and dendritic cell trafficking into and within lymph nodes, the preferential metastatic site for papillary (PTC) and medullary (MTC) thyroid carcinomas. In order to determine a possible role for CCR7 in mediating the metastatic behaviour of thyroid carcinomas, we analysed its expression in normal and tumoral thyroid tissues of different histotypes and studied the in vitro effects of its activation by the CCR7 ligand, CCL21. Using real-time quantitative-PCR, we observed that CCR7 expression was higher in PTCs and MTCs than in follicular and poorly differentiated thyroid carcinomas. CCR7 expression was ninefold higher in classic compared with follicular variants of PTCs, and its expression in MTCs was significantly correlated with lymph node metastases. Immunohistochemical staining for CCR7 showed protein expression in neoplastic thyroid cells, with higher intensity in PTCs, MTCs and their lymph node metastases (LNMs). We further showed that CCL21 stimulation of a CCR7-expressing thyroid tumour cell line (TPC-1) promotes cell proliferation and migration, and the chemotactic effect of CCL21 in these cells involves actin polymerization, increased β1-integrin expression and increased matrix metalloproteinase secretion. Taken together, our results demonstrate that CCR7 activation on thyroid carcinoma cells by CCL21 – a chemokine abundantly expressed in lymph nodes – favours tissue invasion and cell proliferation, and therefore may promote thyroid carcinoma growth and LNM.

scholarly journals Mixed Medullary – Papillary Thyroid Carcinoma with mixed lymph node metastases: a case report

2020 ◽  
Author(s):  
Vanessa Guerreiro ◽  
Cláudia Costa ◽  
Joana Oliveira ◽  
Ana Paula Santos ◽  
Mónica Farinha ◽  
...  
Keyword(s):  
Case Report ◽  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Lymph Nodes ◽  
Papillary Carcinoma ◽  
Lymph Node Metastases ◽  
Papillary Thyroid ◽  
Node Metastases

Medullary and papillary thyroid carcinoma are two distinct neoplasms. Its simultaneous is uncommon and its occurrence as a mixed follicular medullary carcinomas is extremely rare. We present a 60-year-old man with the mixed medullary-papillary carcinoma of the thyroid and papillary and medullary component metastases on lymph nodes.

scholarly journals Provera strazarskih limfnih nodusa kod tiroidnog karcinoma

2003 ◽  
Vol 50 (3) ◽  
pp. 103-106 ◽  
Author(s):  
Radan Dzodic ◽  
Ivan Markovic ◽  
Momcilo Inic ◽  
Neven Jokic ◽  
Milan Zegarac ◽  
...  
Keyword(s):  
Lymph Node ◽  
Thyroid Carcinoma ◽  
Lymph Nodes ◽  
Lymph Node Metastases ◽  
Radical Neck Dissection ◽  
Lymph Node Status ◽  
Blue Dye ◽  
Cervical Lymph Nodes ◽  
Node Metastases ◽  
The Impact

Introduction: Sentinel lymph node (SLN) was defined as the first lymph node that the tumor would drain to, within that tumor?s regional lyphatic basin. In 1998, Kelemen and co-workers have published the first results on SLN lymphonodectomy in thyroid carcinomas. Methodology: Different methods have been used in a goal of lymphatic mapping (application of vital blue dye and/or radio colloid). Results: In a period from 2001 to 2003 we have performed SLN biopsy in 64 patients with thyroid tumors. There were 12 cases of thyroid carcinoma. SLN identification rate was 73,44%. We found no false positive or negative results on definitive histopathology. Discussion: The impact of lymph node metastases in differentiated thyroid carcinoma is still controversial. The management of cervical lymph nodes varies from ?berry peacking? to modified radical neck dissection. There is a significant disproportion in percentage of pre and intraoperatively enlarged lymph nodes (27-45%) and histological confirmed lymph node metastases (80-90%) in papillary thyroid carcinoma. In the current literature the average rate of SLN identification is 91% (66-100%) and when identified, the SLN accurately predicts the disease status of the neck in most patients (80-100%).Conclusion: The SLN biopsy for thyroid carcinoma is good and feasible technique for estimating the cervical lymph node status.

Lymph Node Metastases in Thyroid Carcinomas: CT Diagnosis

2001 ◽  
Vol 45 (6) ◽  
pp. 581
Author(s):  
Ji Seon Joo ◽  
Hyung Jin Kim ◽  
Kyung Jin Kang ◽  
Young Kuk Cho ◽  
Myung Kwan Lim ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastases ◽  
Ct Diagnosis ◽  
Thyroid Carcinomas ◽  
Node Metastases

Mixed medullary-papillary thyroid carcinoma with mixed lymph node metastases

2020 ◽  
Author(s):  
Vanessa Guerreiro ◽  
Cláudia Costa ◽  
Joana Oliveira ◽  
Ana Paula Santos ◽  
Mónica Farinha ◽  
...  
Keyword(s):  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Lymph Node Metastases ◽  
Papillary Thyroid ◽  
Node Metastases

Assessment of cervical lymph node metastases using indirect computed tomography lymphography with iopamidol in a tongue VX2 carcinoma model

2011 ◽  
Vol 125 (8) ◽  
pp. 820-828 ◽  
Author(s):  
Y Shu ◽  
X Xu ◽  
Z Wang ◽  
W Dai ◽  
Y Zhang ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Lymph Node Metastases ◽  
Cervical Lymph Node ◽  
Cervical Lymph Nodes ◽  
Cervical Lymph Node Metastases ◽  
Computed Tomography Images ◽  
Vx2 Carcinoma ◽  
Node Metastases

AbstractObjective:To investigate the performance of indirect computed tomography lymphography with iopamidol for detecting cervical lymph node metastases in a tongue VX2 carcinoma model.Materials and methods:A metastatic cervical lymph node model was created by implanting VX2 carcinoma suspension into the tongue submucosa of 21 rabbits. Computed tomography images were obtained 1, 3, 5, 10, 15 and 20 minutes after iopamidol injection, on days 11, 14, 21 (six rabbits each) and 28 (three rabbits) after carcinoma transplantation. Computed tomography lymphography was performed, and lymph node filling defects and enhancement characteristics evaluated.Results:Indirect computed tomography lymphography revealed bilateral enhancement of cervical lymph nodes in all animals, except for one animal imaged on day 28. There was significantly slower evacuation of contrast in metastatic than non-metastatic nodes. A total of 41 enhanced lymph nodes displayed an oval or round shape, or local filling defects. One lymph node with an oval shape was metastatic (one of 11, 9.1 per cent), while 21 nodes with filling defects were metastatic (21/30, 70 per cent). The sensitivity, specificity, accuracy, and positive and negative predictive values when using a filling defect diameter of 1.5 mm as a diagnostic criterion were 86.4, 78.9, 82.9, 82.6 and 83.3 per cent, respectively.Conclusion:When using indirect computed tomography lymphography to detect metastatic lymph nodes, filling defects and slow evacuation of contrast agent are important diagnostic features.

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