scholarly journals Provera strazarskih limfnih nodusa kod tiroidnog karcinoma

2003 ◽  
Vol 50 (3) ◽  
pp. 103-106 ◽  
Author(s):  
Radan Dzodic ◽  
Ivan Markovic ◽  
Momcilo Inic ◽  
Neven Jokic ◽  
Milan Zegarac ◽  
...  
Keyword(s):  
Lymph Node ◽  
Thyroid Carcinoma ◽  
Lymph Nodes ◽  
Lymph Node Metastases ◽  
Radical Neck Dissection ◽  
Lymph Node Status ◽  
Blue Dye ◽  
Cervical Lymph Nodes ◽  
Node Metastases ◽  
The Impact

Introduction: Sentinel lymph node (SLN) was defined as the first lymph node that the tumor would drain to, within that tumor?s regional lyphatic basin. In 1998, Kelemen and co-workers have published the first results on SLN lymphonodectomy in thyroid carcinomas. Methodology: Different methods have been used in a goal of lymphatic mapping (application of vital blue dye and/or radio colloid). Results: In a period from 2001 to 2003 we have performed SLN biopsy in 64 patients with thyroid tumors. There were 12 cases of thyroid carcinoma. SLN identification rate was 73,44%. We found no false positive or negative results on definitive histopathology. Discussion: The impact of lymph node metastases in differentiated thyroid carcinoma is still controversial. The management of cervical lymph nodes varies from ?berry peacking? to modified radical neck dissection. There is a significant disproportion in percentage of pre and intraoperatively enlarged lymph nodes (27-45%) and histological confirmed lymph node metastases (80-90%) in papillary thyroid carcinoma. In the current literature the average rate of SLN identification is 91% (66-100%) and when identified, the SLN accurately predicts the disease status of the neck in most patients (80-100%).Conclusion: The SLN biopsy for thyroid carcinoma is good and feasible technique for estimating the cervical lymph node status.

Assessment of cervical lymph node metastases using indirect computed tomography lymphography with iopamidol in a tongue VX2 carcinoma model

2011 ◽  
Vol 125 (8) ◽  
pp. 820-828 ◽  
Author(s):  
Y Shu ◽  
X Xu ◽  
Z Wang ◽  
W Dai ◽  
Y Zhang ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Lymph Node Metastases ◽  
Cervical Lymph Node ◽  
Cervical Lymph Nodes ◽  
Cervical Lymph Node Metastases ◽  
Computed Tomography Images ◽  
Vx2 Carcinoma ◽  
Node Metastases

AbstractObjective:To investigate the performance of indirect computed tomography lymphography with iopamidol for detecting cervical lymph node metastases in a tongue VX2 carcinoma model.Materials and methods:A metastatic cervical lymph node model was created by implanting VX2 carcinoma suspension into the tongue submucosa of 21 rabbits. Computed tomography images were obtained 1, 3, 5, 10, 15 and 20 minutes after iopamidol injection, on days 11, 14, 21 (six rabbits each) and 28 (three rabbits) after carcinoma transplantation. Computed tomography lymphography was performed, and lymph node filling defects and enhancement characteristics evaluated.Results:Indirect computed tomography lymphography revealed bilateral enhancement of cervical lymph nodes in all animals, except for one animal imaged on day 28. There was significantly slower evacuation of contrast in metastatic than non-metastatic nodes. A total of 41 enhanced lymph nodes displayed an oval or round shape, or local filling defects. One lymph node with an oval shape was metastatic (one of 11, 9.1 per cent), while 21 nodes with filling defects were metastatic (21/30, 70 per cent). The sensitivity, specificity, accuracy, and positive and negative predictive values when using a filling defect diameter of 1.5 mm as a diagnostic criterion were 86.4, 78.9, 82.9, 82.6 and 83.3 per cent, respectively.Conclusion:When using indirect computed tomography lymphography to detect metastatic lymph nodes, filling defects and slow evacuation of contrast agent are important diagnostic features.

R421 – Ubc9: A Novel Marker of Lymph Nodes Metastases in SCCHN

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P184-P184
Author(s):  
Ohad Ronen ◽  
James P Malone ◽  
Sophia Ran
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Head And Neck ◽  
Lymph Node Metastases ◽  
Squamous Cell Cancer ◽  
Cell Cancer ◽  
Cervical Lymph Nodes ◽  
Adjacent Mucosa ◽  
Node Metastases ◽  
Tissue Specimens

Problem Lymph node metastases (LNM) are the single most significant prognostic factor in squamous cell cancer of the head and neck (SCCHN). Therapy often relies on the ability to detect disease in cervical lymph nodes. We previously demonstrated that Ubiquitin-conjugating enzyme (Ubc9), an enzyme involved in post-translational modification, is over-expressed in SCCHN compared to peritumoral adjacent mucosa. Furthermore, Ubc9 is not expressed in normal mucosa. The present study was designed to examine the expression of Ubc9 in SCCHN LNM and to determine whether Ubc9 may serve as a marker. Methods A portion of primary tumor, normal adjacent mucosa, when available, and metastatic lymph nodes were harvested from patients with a histologic diagnosis of SCCHN. Tissue specimens were immediately snap-frozen in liquid nitrogen. The frozen tissue specimens were stained with antibodies to Ubc9 using standard Immunohistochemical techniques. Results Twelve patients with SCCHN LNM were available for staining. Sites of primary tumor specimens included larynx (n=7) and oropharynx (n=3). All of the lymph nodes had strong expression of Ubc9 in the metastatic deposits of SCCHN but not in the surrounding lymph node tissue. Conclusion Detection of Ubc9 expression in cervical lymph nodes from patients with SCCHN may serve as a distinct molecular marker for the presence of lymph node metastases. The findings also suggest that Ubc9 plays an important role in tumorigenesis and possibly tumor progression of head and neck squamous cell cancer. Further exploration of Ubc9 in head and neck cancer is warranted. Significance Ubc9 expression in SCCHN LNM can increase the sensitivity of diagnosis in the primary site as well as in suspected lymph node metastases. Early and accurate diagnosis of LNM can potentially improve regional control of the disease. Support Part of the study was supported by a grant from SIU School of Medicine.

scholarly journals Expression and function of the chemokine receptor CCR7 in thyroid carcinomas

2006 ◽  
Vol 191 (1) ◽  
pp. 229-238 ◽  
Author(s):  
Margarida Sancho ◽  
Joaquim Miguel Vieira ◽  
Cristina Casalou ◽  
Marta Mesquita ◽  
Teresa Pereira ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Lymph Node ◽  
Thyroid Carcinoma ◽  
Lymph Nodes ◽  
Chemokine Receptor ◽  
Lymph Node Metastases ◽  
Thyroid Cells ◽  
Thyroid Carcinomas ◽  
Ccr7 Expression ◽  
Node Metastases

The chemokine receptor CCR7 plays a critical role in lymphocyte and dendritic cell trafficking into and within lymph nodes, the preferential metastatic site for papillary (PTC) and medullary (MTC) thyroid carcinomas. In order to determine a possible role for CCR7 in mediating the metastatic behaviour of thyroid carcinomas, we analysed its expression in normal and tumoral thyroid tissues of different histotypes and studied the in vitro effects of its activation by the CCR7 ligand, CCL21. Using real-time quantitative-PCR, we observed that CCR7 expression was higher in PTCs and MTCs than in follicular and poorly differentiated thyroid carcinomas. CCR7 expression was ninefold higher in classic compared with follicular variants of PTCs, and its expression in MTCs was significantly correlated with lymph node metastases. Immunohistochemical staining for CCR7 showed protein expression in neoplastic thyroid cells, with higher intensity in PTCs, MTCs and their lymph node metastases (LNMs). We further showed that CCL21 stimulation of a CCR7-expressing thyroid tumour cell line (TPC-1) promotes cell proliferation and migration, and the chemotactic effect of CCL21 in these cells involves actin polymerization, increased β1-integrin expression and increased matrix metalloproteinase secretion. Taken together, our results demonstrate that CCR7 activation on thyroid carcinoma cells by CCL21 – a chemokine abundantly expressed in lymph nodes – favours tissue invasion and cell proliferation, and therefore may promote thyroid carcinoma growth and LNM.

scholarly journals LEVELS I–VII FOLLOWING THYROIDECTOMY FOR PAPILLARY THYROID CANCER

2020 ◽  
Vol 19 (5) ◽  
pp. 76-81
Author(s):  
V. S. Parshin ◽  
A. A. Veselova ◽  
V. S. Medvedev ◽  
S. A. Ivanov ◽  
A. D. Kaprin
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Papillary Thyroid Cancer ◽  
Lymph Node Metastases ◽  
Cervical Lymph Node ◽  
Papillary Thyroid ◽  
Cervical Lymph Nodes ◽  
Cervical Lymph Node Metastases ◽  
Node Metastases

Introduction. Cervical lymph node metastases can occur not only in patients when they are first diagnosed with papillary thyroid cancer but also in patients who have undergone thyroidectomy. Objective. The aim of this study was to assess the potential utility of neck ultrasound in diagnosing cervical lymph node metastases (levels I–VII) in patients who underwent surgical treatment for papillary thyroid cancer.Material and Methods. B-mode sonography of all nodal levels in the neck was performed using a linear array transducer in the frequency range of 7.5–13 MHz, power mapping and panoramic scan to locate regional lymph node metastases. All lymph nodes removed during reoperations were submitted for histological evaluation. Sonographic examinations of cervical lymph nodes of the levels I–VII were performed in 2875 patients who had undergone thyroidectomy in different regions of the Russian Federation. The patients were admitted to our clinic to receive radioactive iodine therapy. All neck levels were assessed by ultrasound.Results. Sonography revealed cervical lymph node metastases in 267 (9.2 %) of 2875 patients with papillary thyroid cancer who had undergone thyroidectomy. Nodal metastasis in level VI only occurred in 70 (2.4 %) patients, in levels II–III–IV only in 150 (5.21 %), in level VB only in 32 (1.11 %), and at the same time in level VI and in levels II–III–IV in 15 (0.52 %) patients. There were no metastases in levels I, VA, VII of the neck. Solitary metastases to all levels were found in 7.5 %, multiple metastases in 1.2 %, and conglomerates in 0.6 % of cases. Solitary metastases in level VI were noted in 56 (1.9 %), in levels II–III–IV in 125 (4.3 %), and in level VB in 29 (1.0 %) patients. Multiple metastases in level VI were detected in 11 (0.38 %), in levels II–III–IV in 21 (0.73 %), and in level VB in 3 (0.1 %) patients. Median metastasis size was 2.1 ± 1.6 cm.Conclusion. Post-thyroidectomy patients were found to have cervical lymph node metastases. Ultrasound scanning of the neck should be considered a key examination if there are cicatricial changes as it enables to identify metastasis and to determine its location. The maximal number of metastases was noted in levels II–III–IV. Cervical lymph node metastases occurred less frequently in the central level and level VB. The predominant metastatic pattern was solitary. There was an essential difference in metastatic spread to cervical lymph nodes between postthyroidectomy patients and patients who were first diagnosed with papillary thyroid cancer. 

scholarly journals Mixed Medullary – Papillary Thyroid Carcinoma with mixed lymph node metastases: a case report

2020 ◽  
Author(s):  
Vanessa Guerreiro ◽  
Cláudia Costa ◽  
Joana Oliveira ◽  
Ana Paula Santos ◽  
Mónica Farinha ◽  
...  
Keyword(s):  
Case Report ◽  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Lymph Nodes ◽  
Papillary Carcinoma ◽  
Lymph Node Metastases ◽  
Papillary Thyroid ◽  
Node Metastases

Medullary and papillary thyroid carcinoma are two distinct neoplasms. Its simultaneous is uncommon and its occurrence as a mixed follicular medullary carcinomas is extremely rare. We present a 60-year-old man with the mixed medullary-papillary carcinoma of the thyroid and papillary and medullary component metastases on lymph nodes.

scholarly journals Nodal Positive Breast Cancer and Its Regional Lymph Node Involvement

2021 ◽  
Author(s):  
Heidrun Maennle ◽  
Matthias Frank ◽  
Felix Momm ◽  
Jan Willem Siebers
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Lymph Node Metastases ◽  
Regional Lymph Node ◽  
Lymph Node Status ◽  
Nodal Stage ◽  
Node Metastases ◽  
Level I ◽  
Positive Breast Cancer

Abstract Purpose: In breast cancer, the lymph node status is of prognostic importance and a decisive factor in therapy planning. This study shows the distribution of lymph nodes metastases of node-positive breast cancer patients. Risk factors for lymph node metastases are described.Methods: 2095 patients with primary breast cancer were analyzed. Analysis included descriptive analysis (median, standard deviation, ranges) and statistical analysis (Chi², discriminant analysis).Results: The nodal stage was positive in 39.4% of all patients and negative in 60.6%. If the nodal stage was positive, only 1 lymph node was involved in 36% of the patients; more than 1 lymph node was involved in 64% of the patients. With an increasing number of lymph node metastases in level I, the probability of an involvement in level III also increases (F 437.845, p = .000). Other indicators are evidence of hemangiosis (F 247.728, p = .000) or lymphangiosis (F 167.368, P = .000). Despite <10 affected lymph nodes, 3.4% of the patients had nodal stage N3 due to level III involvement.Conclusion: Even with only a small number of lymph node metastases in level I higher lymphatic stations are often affected. The data cannot lead to a decision regarding an operation or radiation indication, but they can better substantiate the risk for certain therapy decisions.

scholarly journals Report on Unusual Sites of Lymph Node Metastases in Nasopharyngeal Carcinoma

2021 ◽  
pp. 1821-1826
Author(s):  
Dang Nguyen Van ◽  
Thao Bich Nguyen ◽  
Nhung Thu Nguyen Thi ◽  
Quang Le Van
Keyword(s):  
Lymph Node ◽  
Nasopharyngeal Carcinoma ◽  
Lymph Node Metastasis ◽  
Lymph Nodes ◽  
Lymph Node Metastases ◽  
Treatment Plan ◽  
Cervical Lymph Nodes ◽  
Node Metastasis ◽  
Appropriate Treatment ◽  
Node Metastases

Nasopharyngeal carcinoma (NPC) is amongst the most common malignancies of head and neck cancers. Most patients are admitted to the hospital with advanced disease. NPC has a tendency toward early metastatic spread to cervical lymph nodes, and levels II and III are most commonly involved. A few reports have indicated specific metastatic sites of nasopharyngeal cancer, including lymph node metastasis and distant metastasis. Evidence of histopathology and immunohistochemistry is required to prove NPC origin. In many cases, surgery can be performed to obtain accurate evidence of the pathology. However, surgery can also affect the overall treatment plan and strategy for NPC and should be considered in the specific circumstances of the disease. Multidisciplinary consultation is required for these uncommonly specific metastases. Paying attention to the specific lymph node metastasis sites of NPC plays an important role in accurately diagnosing the stage, thereby giving an appropriate treatment strategy. It is also important in determining radiotherapy volumes because radiotherapy is the standard therapy for this disease. Herein, we are reporting 2 cases of NPC with clinical metastasis to unusual lymph node sites such as the parotid salivary gland and the cheek. Histological analyses from the resected specimens confirmed its nasopharyngeal origin. Lymph node metastases in the parotid gland and the cheek are unusual. In diagnosis and follow-up, it is necessary to evaluate carefully to make an accurate diagnosis and appropriate treatment plans for patients as well as early detect recurrent metastases at uncommon sites of lymph nodes.

Mixed medullary-papillary thyroid carcinoma with mixed lymph node metastases

2020 ◽  
Author(s):  
Vanessa Guerreiro ◽  
Cláudia Costa ◽  
Joana Oliveira ◽  
Ana Paula Santos ◽  
Mónica Farinha ◽  
...  
Keyword(s):  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Lymph Node Metastases ◽  
Papillary Thyroid ◽  
Node Metastases
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