Health effects of low-dose ionising radiation: recent advances and their implications.

2010 ◽  
Vol 140 (2) ◽  
pp. 103-136 ◽  
Author(s):  
L. T. Dauer ◽  
A. L. Brooks ◽  
D. G. Hoel ◽  
W. F. Morgan ◽  
D. Stram ◽  
...  

2019 ◽  
Vol 70 (2) ◽  
pp. 104-108
Author(s):  
Dauren Botbayev ◽  
Gloria Ravegnini ◽  
Giulia Sammarini ◽  
Polat Kazymbet ◽  
Elisabetta Cilli ◽  
...  

AbstractIndividuals chronically exposed to low-level ionising radiation (IR) run the risk of harmful and long-term adverse health effects, including gene mutations and cancer development. The search for reliable biomarkers of IR exposure in human population is still of great interest, as they may have a great implementation potential for the surveillance of occupationally exposed individuals. In this context, and considering previous literature, this study aimed to identify mutations in the human interferon alpha-2b (hIFNα-2b) as a potential biomarker of occupational chronic low-dose IR exposure linking low-IR exposure to the effects on haematopoiesis and reduced immunity. The analysis was performed in the genomic DNA of 51 uranium miners and 38 controls from Kazakhstan, and in 21 medical radiology workers and 21 controls from Italy. hIFNα-2b gene mutations were analysed with the real-time polymerase chain reaction (PCR) or Sanger sequencing. However, none of the investigated workers had the hIFNα-2b mutation. This finding highlights the need for further research to identify biomarkers for early detection of health effects associated with chronic low-dose IR exposure.


2015 ◽  
Vol 764 ◽  
pp. 90-100 ◽  
Author(s):  
Michaela Kreuzer ◽  
Anssi Auvinen ◽  
Elisabeth Cardis ◽  
Janet Hall ◽  
Jean-Rene Jourdain ◽  
...  

2020 ◽  
Author(s):  
María Teresa García-Valverde ◽  
Verónica Sánchez de Medina ◽  
Verónica Codesido ◽  
Jesús Hidalgo-García ◽  
Carlos Ferreiro-Vera

In the last decades, cannabinoids, the active constituents of Cannabis sativa L., have been attracting a strong interest, regarding the health effects associated with the use of Cannabis and Cannabis-derived products. The progressive legalization of this species in several countries has prompted an increasing concern about the characterization and quantification of cannabinoids in diverse chemotypes of the plant, as well as the obtained final products. Therewith, Process and Product Quality Assurance (PPQA) becomes a mandatory practise to verify the Good Manufacturing Practices (GMP). Gas chromatography is one of the most used techniques in this sense due to its high attainable resolution. However, sample complexity and the thermal lability of cannabinoids hinder the analysis. In this chapter, a fully description of the recent advances in the Cannabis sativa L. analysis by gas chromatography will be presented, including different approaches that have come up to solve the obstacles encountered.


PLoS ONE ◽  
2016 ◽  
Vol 11 (9) ◽  
pp. e0162027 ◽  
Author(s):  
Niels Hadrup ◽  
Terje Svingen ◽  
Karen Mandrup ◽  
Kasper Skov ◽  
Mikael Pedersen ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document