Vortioxetine suppresses epileptiform activity and cognition deficits in a chronic PTZ-induced kindling rat model

2021 ◽  
Vol 23 (6) ◽  
pp. 893-900
Author(s):  
Mehmet Taskiran ◽  
Gokhan Unal
Keyword(s):  
Rat Model ◽  
Epileptiform Activity

Effects of antiepileptic drugs on induced epileptiform activity in a rat model of dysplasia

2002 ◽  
Vol 50 (3) ◽  
pp. 251-264 ◽  
Author(s):  
Matthew D Smyth ◽  
Nicholas M Barbaro ◽  
Scott C Baraban
Keyword(s):  
Antiepileptic Drugs ◽  
Rat Model ◽  
Epileptiform Activity

scholarly journals Spontaneous epileptiform activity in a rat model of bilateral subcortical band heterotopia

Epilepsia ◽  
2018 ◽  
Vol 60 (2) ◽  
pp. 337-348 ◽  
Author(s):  
Surajit Sahu ◽  
Emmanuelle Buhler ◽  
Jean‐Christophe Vermoyal ◽  
Françoise Watrin ◽  
Alfonso Represa ◽  
...  
Keyword(s):  
Rat Model ◽  
Epileptiform Activity ◽  
Subcortical Band Heterotopia ◽  
Band Heterotopia

Epileptiform activity and changes in field potential responses induced by low [Mg2+]0 in a genetic rat model of absence epilepsy

1998 ◽  
Vol 803 (1-2) ◽  
pp. 19-26 ◽  
Author(s):  
V. Armand ◽  
S. Gabriel ◽  
P. Hoffmann ◽  
U. Heinemann ◽  
M. Vergnes
Keyword(s):  
Rat Model ◽  
Epileptiform Activity ◽  
Field Potential ◽  
Absence Epilepsy

Epileptiform activity extinguished by amygdala infusion of the neurotoxin ibotenate in a rat model of temporal lobe epilepsy

2002 ◽  
Vol 97 (2) ◽  
pp. 450-454 ◽  
Author(s):  
John R. Pace ◽  
Russell R. Lonser ◽  
R. Duncan Kirkby ◽  
Neal Jeffries ◽  
Michael A. Rogawski ◽  
...  
Keyword(s):  
Amino Acid ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Rat Model ◽  
Seizure Activity ◽  
Excitatory Amino Acid ◽  
Epileptiform Activity ◽  
Recurrent Seizure ◽  
Content Type ◽  
Fine Print

Object. The long-term antiseizure effects of local convection-enhanced infusion of the excitotoxin ibotenate were examined in a rat model of temporal lobe epilepsy. Methods. A single injection of kainate, an epileptogenic excitatory amino acid, into the left amygdala elicited chronic spontaneous recurrent seizure activity for at least 36 days after the injection. Two weeks after the injection, infusion of ibotenate, a nonepileptogenic excitatory amino acid that is an axon-sparing neuronal cell toxin, into the left amygdala and piriform lobe induced immediate and permanent extinction of electrical and behavioral seizure activity. Conclusions. Lesioning of an epileptic focus by convective distribution of ibotenate can produce an enduring suppression of seizure activity, indicating a chemical neurosurgical approach for epilepsy therapy.

Focal Epileptogenesis in a Rat Model of Polymicrogyria

1999 ◽  
Vol 81 (1) ◽  
pp. 159-173 ◽  
Author(s):  
Kimberle M. Jacobs ◽  
Bryan J. Hwang ◽  
David A. Prince
Keyword(s):  
Rat Model ◽  
Epileptiform Activity ◽  
Field Potential ◽  
Excitatory Input ◽  
Synaptic Connectivity ◽  
Epileptogenic Zone ◽  
Cortical Malformation ◽  
Rat Cortex ◽  
Aspartate Receptor ◽  
Focal Zone

Jacobs, Kimberle M., Bryan J. Hwang, and David A. Prince. Focal epileptogenesis in a rat model of polymicrogyria. J. Neurophysiol. 81: 159–173, 1999. Polymicrogyria, a developmental cortical malformation associated with epilepsy, can be modeled in rats with a transcortical freeze lesion on the day of birth (P0) or P1. We have used field potential recordings to characterize the incidence, propagation patterns, and distribution of epileptiform activity in slices from rats with experimental microgyri. Interictal-like epileptiform activity was evoked in slices from 85% of freeze-lesioned rats aged P12–P118. These data show age-specific properties of epileptogenesis, including: a delay in onset, a decrease in the incidence of epileptiform activity in rats >P40 that was specific to those lesioned on P0 as opposed to P1, and a shift in the likely site of initiation to areas further from the microgyrus in mature animals. Several observations suggest that the area adjacent to the microgyrus, which appears histologically normal in Nissl stains, contains the necessary epileptogenic neuronal circuits: 1) in 78% of slices, epileptiform activity could be evoked only from a focal zone adjacent to the microgyrus (paramicrogyral zone) and not within the microgyrus proper; 2) epileptiform activity consistently originated from a particular site within this paramicrogyral zone, independent of the location of the stimulating electrode, suggesting that the generator is outside of the microgyrus; 3) evoked epileptiform activities in the paramicrogyral cortex were unaltered after separation of this zone from the microgyrus with a transcortical cut; and 4) the short-latency graded field potential evoked in the paramicrogyral zone contained an additional negativity not seen in control slices. The epileptiform activity was blocked reversibly by N-methyl-d-aspartate receptor antagonists in slices from mature as well as immature freeze-lesioned rats. These results suggest that aberrant synaptic connectivity develops in rat cortex surrounding the microgyrus and produces a focal epileptogenic zone whose capacity to generate epileptiform activities does not depend on connections with the malformation itself. We hypothesize that afferents, originating from cortical and extracortical sites, lose their targets in the region of the malformation and make appropriate laminar contacts in the cortex adjacent to the malformation, creating an overabundance of excitatory input to this cortical zone. Increased excitatory feedback onto specific cortical elements may be one factor involved in epileptogenesis in this model of a cortical malformation.

scholarly journals Initiation of epileptiform activity in a rat model of periventricular nodular heterotopia

Epilepsia ◽  
2011 ◽  
Vol 52 (12) ◽  
pp. 2304-2314 ◽  
Author(s):  
Naranzogt Tschuluun ◽  
H. Jürgen Wenzel ◽  
Emily T. Doisy ◽  
Philip A. Schwartzkroin
Keyword(s):  
Rat Model ◽  
Epileptiform Activity ◽  
Periventricular Nodular Heterotopia ◽  
Nodular Heterotopia

scholarly journals Frequency-dependent characterisation of impedance changes during epileptiform activity in a rat model of epilepsy

2018 ◽  
Vol 39 (8) ◽  
pp. 085003 ◽  
Author(s):  
Sana Hannan ◽  
Mayo Faulkner ◽  
Kirill Aristovich ◽  
James Avery ◽  
David Holder
Keyword(s):  
Rat Model ◽  
Epileptiform Activity ◽  
Frequency Dependent

scholarly journals Increased pCREB expression and the spontaneous epileptiform activity in a BCNU-treated rat model of cortical dysplasia

Epilepsia ◽  
2015 ◽  
Vol 56 (9) ◽  
pp. 1343-1354 ◽  
Author(s):  
Paolo Pennacchio ◽  
Francesco Noé ◽  
Vadym Gnatkovsky ◽  
Ramona Frida Moroni ◽  
Ileana Zucca ◽  
...  
Keyword(s):  
Rat Model ◽  
Epileptiform Activity ◽  
Cortical Dysplasia
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