Chronic endogenous depression of youth

2021 ◽  
Vol 121 (5) ◽  
pp. 19
Author(s):  
V.G. Kaleda ◽  
V.V. Migalina
Keyword(s):  
Endogenous Depression

Fenetyline as possible treatment in non-responder depressive patients

1990 ◽  
Vol 5 (1) ◽  
pp. 29-30
Author(s):  
F Lang ◽  
J Pellet ◽  
B Estour
Keyword(s):  
Major Depression ◽  
Sleep Deprivation ◽  
Therapeutic Response ◽  
Manic Episode ◽  
Endogenous Depression ◽  
Recurrent Depression ◽  
Different Types ◽  
Depressive Episodes ◽  
Depressive Patients

SummaryThe authors report the case of a 45-yr-old male who presented from 1979 to 1986 with several severe depressive episodes. The patient fulfilled Feighner criteria for major depression, Newcastle criteria for endogenous depression: the depressive episodes were all classified as severe recurrent depression without melancholia according to DSM III. The patient was resistant to different types of treatment (ECT, tricyclic and MAOI drugs, lithium, sleep deprivation). With a treatment of 10 cg/day of fenetyline, reduced to 5 cg/day after 6 months, (atypical manic episode), the patient improved considerably for 20 rnonths. The therapeutic response decreased after this period but after a month of withdrawal, the patient again responded. The authors cannot explain the duration of this therapeutic response.

Anomaly of histamine methylation in endogenous depression

1982 ◽  
Vol 6 (4-6) ◽  
pp. 483-486 ◽  
Author(s):  
Marie-A. Gagne ◽  
Armin Wollin ◽  
Henri Navert ◽  
Gilbert Pinard
Keyword(s):  
Endogenous Depression ◽  
Histamine Methylation

scholarly journals HLA-DR2 and Sleep Onset REM Periods in Endogenous Depression

1988 ◽  
Vol 152 (2) ◽  
pp. 296-296 ◽  
Author(s):  
Dieter Riemann ◽  
Mathias Berger ◽  
Josef Teuber ◽  
Karl-Henning Usadel
Keyword(s):  
Sleep Onset ◽  
Endogenous Depression

Fluoxetine Efficacy vs Comparative Drugs: An Overview

1988 ◽  
Vol 153 (S3) ◽  
pp. 51-58 ◽  
Author(s):  
Malcolm Lader
Keyword(s):  
Side Effects ◽  
Tricyclic Antidepressants ◽  
Antipsychotic Agents ◽  
Synaptic Cleft ◽  
Endogenous Depression ◽  
Acute Effects ◽  
Anticholinergic Effects ◽  
The Past ◽  
Chronic Effects ◽  
Clinical Action

The tricyclic antidepressants (TCAs) were discovered accidentally by pharmaceutical chemists seeking first, better antihistamines and then antipsychotic agents. Careful clinical assessment revealed the antidepressant properties and suggested that the closer the patient resembled the classical textbook description of ‘endogenous’ depression, the more likely was an adequate clinical response to occur (Kuhn, 1958). However, it was quickly realised that the TCAs possess a plethora of side-effects, particularly sedation and symptoms related to their anticholinergic effects.Despite much research over the past 25 years, it is unclear how TCAs effect clinical improvement. The two main neurotransmitters involved in some way are noradrenaline (Schildkraut, 1965) and 5-hydroxytryptamine (5-HT; serotonin; Van Praag, 1977). It was proposed that TCAs acted by blocking the reuptake of one or other or both of these neurotransmitters, thereby increasing their concentration in the synaptic cleft. However, as well as these acute effects, chronic effects, such as a decrease in the number of central beta-adrenoceptors (‘down-regulation’) occur, and these are probably more relevant to the clinical action.

ELECTROLYTES IN URINE IN ENDOGENOUS DEPRESSION

1972 ◽  
Vol 48 (4) ◽  
pp. 337-349 ◽  
Author(s):  
N. Bjørum ◽  
E. T. Mellerup ◽  
O. J. Rafaelsen
Keyword(s):  
Endogenous Depression

ERYTHROCYTE CATION TRANSPORT DISTURBANCES IN PATIENTS WITH ENDOGENOUS DEPRESSION

1984 ◽  
Vol 11 (3) ◽  
pp. 319-326 ◽  
Author(s):  
Janusz Rybakowski ◽  
Elżzbieta Potok ◽  
Włlodzimierz Strzyżewski ◽  
Cecylia Nowakowska
Keyword(s):  
Cation Transport ◽  
Endogenous Depression

Hormone responses to fenfluramine and placebo challenge in endogenous depression

1992 ◽  
Vol 43 (2) ◽  
pp. 137-146 ◽  
Author(s):  
Pesach Lichtenberg ◽  
Baruch Shapira ◽  
Dan Gillon ◽  
Seth Kindler ◽  
Thomas B. Cooper ◽  
...  
Keyword(s):  
Endogenous Depression ◽  
Hormone Responses

CS05-01 - Interpersonal therapy

2011 ◽  
Vol 26 (S2) ◽  
pp. 1782-1782
Author(s):  
J. Aldenhoff
Keyword(s):  
T Lymphocytes ◽  
Psychiatric Disorders ◽  
Strong Evidence ◽  
Unipolar Depression ◽  
Endogenous Depression ◽  
Interpersonal Therapy ◽  
Treatment Conditions ◽  
American Psychiatry ◽  
Biological Studies ◽  
Biological State

Interpersonal therapy of depression was created and established in American psychiatry in the 80ties. At that time european and especially german psychiatry was still dominated by the concept of endogenous depression, which suggested a somehow biologically determined aetiology which was not very likely to be influenced by psychotherapeutic access.However, the empiric approach to evaluate therapy regardless of aetiology, which is very typical for IPT, produced strong evidence for the effectiveness of IPT in unipolar depression and many other psychiatric disorders.On this basis, a diversity of biological studies became possible which aimed to the elucidation of neurobiological mechanisms of psychotherapy.The first data indicate that biological state markers change when the patient responds, regardless if he received Psycho- or pharmacotherapy. However, no empirical findings suggested, how IPT might be linked to neurobiological phenomena.We followed the suggestion by E. Kandel, that the phosphorylation of cAMP-responsive-binding-protein (pCREB) could be a crucial factor in the process of psychic improvement. Therefore we studied pCREB in human T-lymphocytes under different treatment conditions in unipolar depression. The results will be presented.

The Efficacy and Tolerability of Combined Antidepressant Treatment in Different Depressive Subgroups

1993 ◽  
Vol 162 (3) ◽  
pp. 363-368 ◽  
Author(s):  
Sinead O'brien ◽  
Patrick McKeon ◽  
Myra O'regan
Keyword(s):  
Treatment Group ◽  
Side Effects ◽  
Major Depression ◽  
Orthostatic Hypotension ◽  
Antidepressant Treatment ◽  
Combined Treatment ◽  
Endogenous Depression ◽  
Double Blind Study ◽  
Double Blind ◽  
Global Improvement

Eighty patients admitted to hospital with major depression were randomly allocated to six weeks of treatment with tranylcypromine, amitriptyline, or tranylcypromine and amitriptyline in combination, in a double-blind study. Scores on the HRSD improved significantly in all three groups, but there were no differences between the three groups. Patients on tranylcypromine and amitriptyline combined improved more according to their self-ratings after six weeks, and response was earlier as measured by a clinical global improvement scale. Those with endogenous depression improved more than those with neurotic depression, irrespective of treatment group. Combined treatment was less well tolerated than single treatments and gave rise to more side-effects, although there was no serious toxicity. Orthostatic hypotension was observed more frequently in patients on combined treatment. This group also experienced a significant increase in weight and prolongation of the P-R interval on ECG.

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