Chronic endometritis with normal and thin endometrium during treatment of reproductive-age women: ultrasound and histological correlations

2017 ◽  
Vol 23 (1) ◽  
pp. 29
Author(s):  
I. O. Marinkin ◽  
N. V. Trunchenko ◽  
Yu. V. Seryapina ◽  
Е. V. Nikitenko ◽  
K. Yu. Makarov ◽  
...  
Keyword(s):  
Reproductive Age ◽  
Thin Endometrium ◽  
Chronic Endometritis ◽  
Reproductive Age Women

scholarly journals The role of hysteroresectoscopy in the diagnosis and treatment of reproductive age women with uterine leiomyoma

2021 ◽  
Vol 5 ◽  
pp. 61-64
Author(s):  
M.A. Flaksemberg
Keyword(s):  
Menstrual Cycle ◽  
Histological Examination ◽  
Uterine Leiomyoma ◽  
Endometrial Hyperplasia ◽  
Ultrasound Examination ◽  
Uterine Cavity ◽  
Reproductive Age ◽  
Chronic Endometritis ◽  
Reproductive Age Women ◽  
Ultrasound Findings

The objective: to investigate the features of hysteroscopic picture of the uterine cavity and endometrium condition in women with uterine leiomyoma (UL) and the possibility of using the results to choose a treatment method.Materials and methods. A total amount of reproductive age women with uterine leiomyoma that was examined is 216. Among them 118 women underwent surgical treatment for UL and 98 patients treated with conservative therapy. In addition to general clinical methods, ultrasound examination, hysterorectoscopy, and histological examination of the obtained material was performed, followed by a comparative analysis of the findings.Results. According to hysteroresectoscopy, the uterine cavity in women with UL was more frequently characterized by irregular wall relief (47.7%) and irregular shape (43.1%) due to submucosal (14.4%) and intramural nodes with centripetal growth (30.6% ), which was significantly more frequent compared to ultrasound findings (13.9%, p<0.05). Endometrial polyps predominated among endometrial pathology (55.6%), which was consistent with the histological finding (59.7%) and was twice as frequent as ultrasound findings (23.1%, p<0.05). And endometrial hyperplasia (14.8%), which was consistent with ultrasound findings (18.1%) but was twice as rare compared to histological examination (36.6%, p<0.05). Chronic endometritis was detected at hysteroscopy in less than 1% of subjects, whereas at histological examination, it was 26.4%, p<0.05. Ultrasound examination revealed no endometrial transformation during the cycle in 30.1% of women, which was consistent with a mismatch in endometrial development to the chronological day of the menstrual cycle according to histological examination (23.1%).Conclusion. Hysteroresectoscopy is an important stage in the examination of women with UL, which helps to assess the condition of the uterine cavity, in particular, the degree of deformation of leiomatous nodules, which determines the clinical course of the disease and is a contributing factor to infertility, and affects the choice of treatment tactics in this cohort of patients. Hysteroresectoscopy when combined with ultrasound and histological examination of the endometrium, a more comprehensive characterisation of the endometrial condition (chronic endometritis, mismatch of the day of the menstrual cycle) and the presence of associated pathological processes (polyps and endometrial hyperplasia) that require correction can be obtained.

scholarly journals The problem of "thin" endometrium in reproductive medicine: experience of application of recombinant Interleukin-2 to prepare patients to assisted reproductive technologies programs

2017 ◽  
Vol 66 (4) ◽  
pp. 46-50 ◽  
Author(s):  
Olga V. Lysenko ◽  
Tatyana A. Rozhdzestvenskaya
Keyword(s):  
Assisted Reproductive Technologies ◽  
Interleukin 2 ◽  
Uterine Cavity ◽  
Reproductive Technologies ◽  
Interleukin 10 ◽  
Reproductive Age ◽  
Necrosis Factor Alpha ◽  
Thin Endometrium ◽  
Chronic Endometritis ◽  
Recombinant Interleukin 2

Introduction. “Thin” endometrium is known affect negatively to reproductive function. Treatment of “thin” endometrium remains a problem and subject of future major studies. Aim. To justify the possibility of applying of recombinant interleikina-2 person late reproductive age patients with “thin” endometrium before using assisted reproductive technologies. Matherials and Methods. We examined a total of 64 late reproductive age women. Three groups of patients were analyzed. The first investigated group included 25 women with histologically proven chronic endometritis; the comparison group included 20 patients with endometrium of the early proliferative phase; the second investigated group included 19 patients with “thin” endometrium, with indications for the conduct of in vitro fertilization. Interleukin 2, interleukin-4, tumor necrosis factor alpha, interleukin-1β, Interleukin-6, interleukin-8, interleukin-10, IFN-γ concentrations were determined by enzyme linked immunosorbent assay in serum and aspirates from the uterine cavity in first investigated group and comparison group. Vaginal ultrasonic examination was made for women of second investigated group in first and second phase of menstrual cycle before and after recombinant human interlejkinom-2 treatment. Statistical data processing was performed using application software package Statistica 6.0 (StatSoft, Ink. 1994–2001), adapted for biomedical research. P < 0.05 was considered significant. Results. Were found that concentrations of interleukin 2, interleukin-10 significantly reduced and concentrations of tumor necrosis factor alpha, interleukin-1β, Interleukin-6 and interleukin-8 significantly increased in aspirates from the uterine cavity in women of late reproductive age with chronic endometritis. All changes occur at the local level in chronic endometritis. Endometrial thickness a statistically significant increase after use of recombinant human interlejkinom-2 in patients with infertility and chronic endometritis. Conclusions. Application of recombinant interleukin-2 in patients with “thin” endometrium can become optimal schema therapy, which requires further study.

scholarly journals The use of real-time PCR for evaluation of endometrial microbiota

2020 ◽  
pp. 14-20
Author(s):  
E.S. Voroshilina ◽  
D.L. Zornikov ◽  
O.V. Koposova ◽  
D.K. Islamidi ◽  
K.Yu. Ignatova ◽  
...  
Keyword(s):  
Real Time ◽  
Real Time Pcr ◽  
Bacterial Load ◽  
Negative Control ◽  
Reproductive Age ◽  
Morphological Pattern ◽  
Chronic Endometritis ◽  
Healthy Women ◽  
Reproductive Age Women ◽  
Lactobacillus Spp

Chronic endometritis (CE) in women of the reproductive age is associated with infertility and recurrent pregnancy loss. The aim of this study was to evaluate the endometrial microbiota by means of real-time PCR in reproductive-age women depending on the morphological pattern of the endometrium. Using the Androflor real-time PCR kit, we analyzed endometrial aspirate collected from 23 patients with chronic endometritis, 30 patients with endometrial hyperplasia, and 19 healthy women. DNA of up to 9 groups of microorganisms was detected in all the analyzed samples in the amounts exceeding negative control. The total bacterial load (TBL) of the detected microorganisms was 10<sup>3</sup>–10<sup>6,4</sup> (median 10<sup>3,8</sup>) GE/ml. Lactobacillus spp. were detected the most often (86.1% of all samples). Opportunistic microorganisms (OM) were identified in 36.1% of all samples, including 22.2% of samples with lactobacilli and 13.9% — without lactobacilli. The variant of microbiota composition with Lactobacillus-dominance (more than 90%. in the TBL) was detected significantly less often in women with chronic endometritis compared to healthy women. Real-time PCR could be used for assessment of endometrial microbiota and allows us to determine its characteristics depending on the morphological pattern.

scholarly journals MORPHOLOGICAL AND MOLECULAR CRITERIA OF THE ENDOMETRIAL RECIPTIVITY VIOLATION IN PATIENTS WITH INFERTILITY ASSOCIATED WITH CHRONIC ENDOMETRITIS

2018 ◽  
Vol 5 (1) ◽  
pp. 19-25
Author(s):  
Tatyana A. Demura ◽  
E. A Kogan ◽  
Yu. M Kossovich ◽  
A. L Unanyan
Keyword(s):  
Menstrual Cycle ◽  
Apical Part ◽  
Endometrial Receptivity ◽  
Reproductive Age ◽  
Control Group ◽  
Chronic Endometritis ◽  
Molecular Features ◽  
Reproductive Age Women ◽  
Morphological Criteria

The goal is to study the morphological and molecular features of endometrial receptivity in reproductive-age women with chronic endometritis and infertility and unsuccessful attempts in vitro fertilization (IVF) in anamnesis. Material and methods. The study included 120 reproductive-age women with morphologically verified chronic endometritis: the first group included 64 patients with infertility and unsuccessful IVF attempts in history; in the 2nd group there were 56 women without violation of the fertility; the control group consisted of 30 healthy reproductive-age women, in whom samples of the endometrium were taken in the II phase of the menstrual cycle. A comparative analysis of the morphological and molecular criteria of endometrial receptivity in all study groups was carried out. Results. In patients of the 1st group there was a significant twofold prevalence rate of the average duration of chronic endometritis since the moment of its morphological verification, which led to a critical decrease in the receptivity of the endometrium and the development of infertility has been established in 5.50 ± 0.06 years (p < 0.001). In the first group of patients following morphological features of chronic endometritis were established: the presence of classical signs of inflammation in the mucous membrane of the uterus with an autoimmune component revealed in 90.6% of observations: high expression of CD16, CD20, CD56 and low HLA-DRII (p < 0.001). Morphological criteria of endometrial receptivity disorders in patients with infertility on the background of chronic endometritis were such as the delay in the maturation of the endometrium from the day of the menstrual cycle and a decrease in the number of mature pinopodia in the apical part of the superficial epitheliocytes. Molecular criteria of the infertility in the endometrial receptivity violation include the significant decrease in the expression of steroid ER and PR receptors in glands and stroma, LIF in glands and in the surface of the pinopodia, CLDN4 - in the apical part of the superficial epithelial cells and in the base of the pinopodia (p < 0.001). Conclusion. Chronic endometritis, associated with the infertility, in 90.6% of cases has an autoimmune genesis and is characterized by a long (more than 5 years) course with the development of morphological and molecular criteria of endometrial receptivity disorders.

Etiological structure and diagnosis of abnormal uterine bleeding

GYNECOLOGY ◽  
2018 ◽  
Vol 20 (2) ◽  
pp. 14-17
Author(s):  
G E Chernukha ◽  
I A Ivanov ◽  
Z N Efendieva ◽  
M R Dumanovskaya ◽  
A V Asaturova
Keyword(s):  
Diagnostic Accuracy ◽  
Endometrial Hyperplasia ◽  
Ultrasound Examination ◽  
Abnormal Uterine Bleeding ◽  
Uterine Bleeding ◽  
Histological Diagnosis ◽  
Reproductive Age ◽  
Endometrial Polyps ◽  
Chronic Endometritis ◽  
Endometrial Pathology

Abnormal uterine bleeding (AUB) is one of the most common indications for hysteroscopy. Most of the AUB cases occur due to endometrial or myometrium pathology. Among it, endometrial polyps (EP) and chronic endometritis (CE) prevalent in reproductive age, while endometrial hyperplasia (EH) and EP dominate in perimenopause. It was determined that EP and CE are characterized with menorrhagia and metrorrhagia approximately equally, whereas EH reveals AUB with oligomenorrhoea. Verification of exact endometrial pathology by ultrasound examination is hindered, that results in deviations of ultrasound and histological diagnosis. The usage of ultrasound data and AUB’s characteristics may improve the diagnostic accuracy on preadmission period.

Folate Status and Depressive Symptoms in Reproductive-Age Women

2011 ◽  
Vol 7 (2) ◽  
pp. 96-102 ◽  
Author(s):  
Hiroko Watanabe ◽  
Takashi Sugiyama ◽  
Hiromitsu Chihara ◽  
Hideoki Fukuoka
Keyword(s):  
Depressive Symptoms ◽  
Reproductive Age ◽  
Folate Status ◽  
Reproductive Age Women

scholarly journals Prevalence of Underweight, Overweight, and Obesity Among Reproductive-Age Women and Adolescent Girls in Rural China

2016 ◽  
Vol 106 (12) ◽  
pp. 2103-2110 ◽  
Author(s):  
Yuan He ◽  
An Pan ◽  
Ying Yang ◽  
Yuanyuan Wang ◽  
Jihong Xu ◽  
...  
Keyword(s):  
Adolescent Girls ◽  
Rural China ◽  
Overweight And Obesity ◽  
Reproductive Age ◽  
Reproductive Age Women
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