Chronic HCV infection: An internist’s opinion (Part 2)

2016 ◽  
Vol 88 (11) ◽  
pp. 138-148
Author(s):  
M L Zubkin ◽  
V I Chervinko ◽  
Yu V Ovchinnikov ◽  
E V Kryukov ◽  
O N Kotenko
Keyword(s):  
Diabetes Mellitus ◽  
Antiviral Agents ◽  
Hcv Infection ◽  
Cardiovascular Disorders ◽  
Extrahepatic Manifestations ◽  
Endocrine Diseases ◽  
Chronic Hcv Infection ◽  
Chronic Hcv ◽  
Relationship Of ◽  
The Relationship

Hepatitis C virus (HCV) infection results in not only chronic hepatitis and subsequent complications as liver cirrhosis and hepatocellular carcinoma, but also in a significant number of other diseases, the so-called extrahepatic manifestations of chronic HCV infection. In addition to lymphoproliferative and autoimmune disorders discussed in Part 1 of this review, many other diseases turned to be associated with chronic HCV infection. Part 2 of this review is dedicated to the analysis of the relationship of chronic HCV-infection to the development of some endocrine diseases, such as thyroiditis and diabetes mellitus, and cardiovascular disorders. It also provides the characteristics of the currently available antiviral agents and considers whether they may be used in patents with extrahepatic manifestations of chronic HCV infection.

scholarly journals Extrahepatic Manifestations and Autoantibodies in Patients with Hepatitis C Virus Infection

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Takashi Himoto ◽  
Tsutomu Masaki
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hcv Infection ◽  
Hepatitis C Virus Infection ◽  
Extrahepatic Manifestations ◽  
Autoimmune Thyroid ◽  
Organ Specific ◽  
Chronic Hcv Infection ◽  
Chronic Hcv ◽  
The Relationship

Patients with chronic hepatitis C virus (HCV) infection frequently have many extrahepatic manifestations, as persistent HCV infection often triggers lymphoproliferative disorders and metabolic abnormalities. These manifestations primarily include autoimmune disorders such as cryoglobulinemia, Sjögren’s syndrome, and autoimmune thyroid disorders. It has been well established that chronic HCV infection plays important roles in the production of non-organ-specific autoantibodies, including antinuclear antibodies and smooth muscle antibodies, and organ-specific autoantibodies such as thyroid autoantibodies. However, the clinical significance of autoantibodies associated with the extrahepatic manifestations caused by HCV infection has not been fully recognized. In this paper, we mainly focus on the relationship between extrahepatic manifestations and the emergence of autoantibodies in patients with HCV infection and discuss the clinical relevance of the autoantibodies in the extrahepatic disorders.

The relationship of histology to genotype in chronic HCV infection

2008 ◽  
Vol 17 (3) ◽  
pp. 144-151 ◽  
Author(s):  
Jonathan C. L. Booth ◽  
Graham R. Foster ◽  
Tanya Levine ◽  
Howard C. Thomas ◽  
Robert D. Goldin
Keyword(s):  
Hcv Infection ◽  
Chronic Hcv Infection ◽  
Chronic Hcv ◽  
Relationship Of ◽  
The Relationship

scholarly journals Association of C-type lectin 18 levels with extrahepatic manifestations in chronic HCV infection

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Tsai-Ling Liao ◽  
Ya-Lang Huang ◽  
Yi-Ming Chen ◽  
Hsiu-Chin Lee ◽  
Der-Yuan Chen ◽  
...  
Keyword(s):  
Hcv Infection ◽  
Extrahepatic Manifestations ◽  
Chronic Hcv Infection ◽  
Chronic Hcv

scholarly journals Virus Elimination by Direct-Acting Antiviral Agents Impacts Glucose Homeostasis in Chronic Hepatitis C Patients

2022 ◽  
Vol 12 ◽  
Author(s):  
Chun-Han Cheng ◽  
Chia-Ying Chu ◽  
Huan-Lin Chen ◽  
I-Tsung Lin ◽  
Chia-Hsien Wu ◽  
...  
Keyword(s):  
Glucose Homeostasis ◽  
Antiviral Agents ◽  
Hcv Infection ◽  
Treatment Experience ◽  
Factors Associated ◽  
Direct Acting Antiviral ◽  
Chronic Hcv Infection ◽  
Hcv Genotype 1 ◽  
Chronic Hcv ◽  
Direct Acting

Background and AimsChronic hepatitis C virus (HCV) infection is associated with dysregulation of glucose homeostasis, including insulin resistance (IR) and type 2 diabetes. However, independent risk factors associated with IR in chronic HCV-infected patients have not been detailly elucidated. Previous data regarding the impact of HCV elimination by direct-acting antiviral agents (DAAs) on glucose homeostasis is insufficient and controversial. This study aimed to analyze the independent factors associated with IR and to evaluate the changes in glucose homeostasis in chronic HCV-infected patients treated with DAAs therapies.MethodsWe screened 704 patients with chronic HCV infection who underwent treatment with interferon-free DAAs. Patients’ baseline characteristics, biochemical and virological data were collected. The outcome measurements were their IR and β-cell function assessed by the homeostasis model assessment (HOMA) method at baseline and 12-weeks post-treatment.ResultsHigh IR (HOMA-IR ≥ 2.5) was observed in 35.1% of the patients. Multivariable logistic regression analysis revealed that body mass index (BMI) >25 kg/m2, treatment experience, elevated baseline levels of alanine aminotransferase (ALT) and triglyceride, as well as Fibrosis-4 score >3.25 were independently associated with high IR. In patients who achieved sustained virological response (SVR), no significant change in mean HOMA-IR was observed from baseline to 12-weeks post-treatment (2.74 ± 2.78 to 2.54 ± 2.20, p = 0.128). We observed a significant improvement in β-cell secretion stress from 121.0 ± 110.1 to 107.6 ± 93.0 (p = 0.015). Subgroup analysis revealed that SVR was associated with a significant reduction in mean HOMA-IR in patients with baseline HOMA-IR ≥ 2.5 (5.31 ± 3.39 to 3.68 ± 2.57, p < 0.001), HCV genotype 1 (3.05 ± 3.11 to 2.62 ± 2.05, p = 0.027), and treatment experience (4.00 ± 3.37 to 3.01 ± 2.49, p = 0.039).ConclusionsThere were several independent factors associated with IR in patients with chronic HCV infection, including obesity, treatment experience, high serum ALT and triglyceride levels, as well as advanced hepatic fibrosis. After viral elimination by DAAs, we observed a significant reduction in mean HOMA-IR in patients with baseline high IR, HCV genotype 1, and treatment experience.

Extrahepatic Manifestations of Chronic HCV Infection

2021 ◽  
Vol 384 (11) ◽  
pp. 1038-1052
Author(s):  
Patrice Cacoub ◽  
David Saadoun
Keyword(s):  
Hcv Infection ◽  
Extrahepatic Manifestations ◽  
Chronic Hcv Infection ◽  
Chronic Hcv

scholarly journals Hepatic resection for two giant hepatocellular carcinoma after oral direct-acting antiviral therapy: Is there a relationship?

2018 ◽  
Vol 8 (2) ◽  
pp. 32 ◽  
Author(s):  
Mohamed Abdel Wahab ◽  
Ahmed Shehta ◽  
Mahmoud Ali
Keyword(s):  
Hepatocellular Carcinoma ◽  
Antiviral Drugs ◽  
Hcv Infection ◽  
Dramatic Improvement ◽  
Direct Acting Antiviral ◽  
Increased Risk ◽  
Chronic Hcv Infection ◽  
Chronic Hcv ◽  
Direct Acting ◽  
The Relationship

Introduction: Direct-acting antiviral drugs have been recently introduced for management of chronic hepatitis C virus (HCV) patients. Those medications have achieved a dramatic improvement of sustained virologic response (SVR) reaching almost 90%. However, reports regarding the increased risk of occurrence or recurrence of hepatocellular carcinoma (HCC) in chronic HCV patients who achieved SVR after direct-acting antiviral drugs are controversial.Methods: We report two cases of giant HCCs complicating chronic HCV infection after direct-acting antiviral drugs-based therapies and were managed by major hepatic resection.Results: Two male patients with chronic HCV infection received several regimens oral direct acting antiviral drugs with a SVR for 3 and 6 months, respectively. They complained of progressive right hypochondrial pain and abdominal enlargement. Two large HCCs were diagnosed (16.2 cm * 17.6 cm * 16.9 cm, and 18 cm * 13 cm * 16.5 cm in dimensions) with markedly elevated serum alpha feto-protein (36,000 and 7,000 ng/ml, respectively). Due to the presence of adequate residual liver volume, the decision was to proceed for surgical resection. Central hepatectomy and extended right hemi-hepatectomy were performed, respectively. Patients had smooth postoperative course and were discharged after 10 and 9 days, respectively.Conclusion: The relationship between direct-acting antiviral drugs and HCC is controversial. Those cases add support to the accumulating literature suggesting the relationship of HCC development in chronic HCV patients receiving direct-acting antiviral drugs. Further prospective studies with adequate long term follow up are needed to prove or disprove this relationship.

scholarly journals CHRONIC HEPATITIS C VIRUS INFECTION

2010 ◽  
Vol 17 (04) ◽  
pp. 557-562
Author(s):  
DILSHAD MUHAMMAD ◽  
KHALID AMIN ◽  
AMIN ANJUM ◽  
Masood Javed
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Socioeconomic Status ◽  
Type 2 Diabetes Mellitus ◽  
Liver Disease ◽  
Odds Ratio ◽  
Hcv Infection ◽  
Chronic Hcv Infection ◽  
Chronic Hcv

Objectives: (1) To seek the association between chronic HCV infection and type 2 diabetes, mellitus. (2) To verify the effect of age, sex, socioeconomic status, obesity and presence of cirrhosis on the association of chronic HCV infection. Design. Case control study. Setting: DHQ Hospital, Faisalabad. Subjects: The subjects were divided into two groups. One was with positive anti-HCV antibody on ELISA method and other was without liver disease and negative for anti-HCV. Both the groups contained 500 subjects each and were selected according to the inclusion and exclusion criteria. Intervention: After a brief interview regarding age, residence, family history of diabetes, socioeconomic status, both the groups underwent weight and height measurements. The body mass was calculated according to the formulae. Ultrasonography of abdomen was done of all the patients of study groups to assess the liver status. Main outcome measures: Chi – squaretest was applied to see the association and then odds ratio was calculated to check the strength of association. Results: Diabetes mellitus was detected in 174 patients (34.8%) out of 500 patients in the group A as compared to 30 patients (6%) out of 500 patients in the group B. having chisquare value of 127.69 and significance of 0.000 with HCV +/ HCV- Odds ratio 0.120 and 95% CI0.079-0.181. Conclusions: There is strongassociation between HCV infection and type 2 diabetes mellitus. Severity of Liver Disease was strong associated factor.

Sign in / Sign up

Export Citation Format

Share Document