scholarly journals Expression of CD44 in previously grafted alveolar bone.

2020 ◽  
Vol 9 (6) ◽  
pp. 449-456
Author(s):  
Ricardo Ernesto Dueñas-Villamil. ◽  
◽  
Leticia Belén Bernard-Gutiérrez ◽  
Diana Susely Hernández-Chavarría ◽  
Mercedes Olaya-Contreras ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Alveolar Bone ◽  
Bone Matrix ◽  
Guided Bone Regeneration ◽  
Tissue Donation ◽  
Institutional Research ◽  
Implant Placement ◽  
Mononuclear Infiltrate ◽  
Hematoxylin Eosin ◽  
Mature Bone

Objetive: To determine the expressions of the bone surface marker CD44 in samples of alveolar bone previously regenerated with allograft, xenograft, and mixed, using the technique of guided bone regeneration. Material and Methods: This exploratory study was approved by the institutional research and ethics committee. By means of intentional sampling and after obtaining informed consent for tissue donation, 20 samples of alveolar bone previously regenerated with guided bone regeneration therapy with particulate bone graft and membrane were taken during implant placement. The samples were stained with hematoxylin-eosin for histological analysis, and by immunohistochemistry for the detection of CD44. Results: Sections with hematoxylin-eosin showed bone tissue with the presence of osteoid matrix and mature bone matrix of usual appearance. Of the CD44+ samples, 80% were allograft and 20% xenograft. The samples with allograft-xenograft were negative. There were no differences in the intensity of CD44 expression between the positive samples. The marker was expressed in osteocytes, stromal cells, mononuclear infiltrate, and some histiocytes. Eighty percent of the CD44+ samples and 100% of the samples in which 60 or more cells were labelled corresponded to allografts (p=0.000). A total of 67% of the samples from the anterior sector, and 40% from the posterior sector were CD44+ (p=0.689). Conclusion: This study shows for the first time that guided bone regeneration using allografts is more efficient for the generation of mature bone determined by the expression of CD44, compared to the use of xenografts and mixed allograft-xenograft, regardless of the regenerated anatomical area.

scholarly journals Hard tissue stability after guided bone regeneration: a comparison between digital titanium mesh and resorbable membrane

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Songhang Li ◽  
Junyi Zhao ◽  
Yu Xie ◽  
Taoran Tian ◽  
Tianxu Zhang ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Bone Regeneration ◽  
Alveolar Bone ◽  
Three Dimensional ◽  
Guided Bone Regeneration ◽  
Titanium Mesh ◽  
Hard Tissue ◽  
Second Stage ◽  
Implant Placement ◽  
Collagen Membranes

AbstractGuided bone regeneration (GBR) uses resorbable and non-resorbable membranes as biological barriers. This study compared the differences in hard tissue stability between GBR using evidence-based digital titanium mesh and resorbable collagen membranes during implant placement. A total of 40 patients (65 implant sites) were enrolled and divided into two groups: resorbable membrane and digital titanium mesh groups. The alveolar bone was analyzed at two- and three-dimensional levels using cone-beam computed tomography and by reconstructing and superimposing the hard tissues at four time points: preoperatively, postoperatively, before second-stage surgery, and 1 year after loading. The use of digital titanium mesh showed less alveolar bone resorption in vertical and horizontal directions two-dimensionally before the second-stage surgery and 1 year after loading. Regarding volumetric stability, the percentage of resorption after 6 months of healing with resorbable membrane coverage reached 37.5%. However, it was only 23.4% with titanium mesh. Although postoperative bone volume was greater at all labial sites with resorbable membrane than with digital titanium mesh, after substantial bone resorption within 1 year of loading, the labial bone thickness at the upper part of implants was thinner with resorbable membrane than with digital titanium mesh. Furthermore, digital titanium meshes made according to ideal bone arch contour reduced soft tissue irritation, and the exposure rate was only 10%. Therefore, although both resorbable membrane and digital titanium mesh in GBR were able to successfully reconstruct the bone defect, digital titanium meshes were better at maintaining the hard tissue volume in the osteogenic space.

scholarly journals Implant placement with guided bone regeneration in esthetic zone- A case report

2021 ◽  
Vol 4 (1) ◽  
pp. 61-66
Author(s):  
A Maharjan ◽  
S Joshi ◽  
A Verma ◽  
RS Gorkhali
Keyword(s):  
Case Report ◽  
Bone Regeneration ◽  
Soft Tissues ◽  
Alveolar Bone ◽  
Guided Bone Regeneration ◽  
Surgical Approaches ◽  
Implant Placement ◽  
Narrow Ridge ◽  
Common Technique

Alveolar ridge deficiency is considered a major limitation for successful implant placement, as well as for the long-term success rate, especially in the anterior maxillary region. Implants placed without regard for prosthetic position often results in dental restorations that are functionally and esthetically compromised. Adequate peri-implant bone support is essential for immediate and long-term implant stability, as well as for future esthetic outcome. To achieve this goal, augmentation of lost bone is often necessary. A variety of surgical approaches have been proposed to enhance the alveolar bone volume. Guided bone regeneration (GBR) is the most common technique for localized bone augmentation. GBR, by application of cell occlusive membranes that mechanically exclude non-osteogenic cell populations from the surrounding soft tissues, has become a well-documented and highly successful procedure for localized augmentation of the atrophic jaw before or simultaneously with implant placement. This case report presents simultaneous approach of guided bone regeneration and implant placement in the maxillary anterior region with narrow ridge defect.

Guided bone regeneration for immediate non-submerged implant placement using bioabsorbable materials in Beagle dogs

1998 ◽  
Vol 9 (5) ◽  
pp. 303-312 ◽  
Author(s):  
Gérard Brunel ◽  
Edmond Benqué ◽  
Frédéric Elharar ◽  
Catherine Sansac ◽  
Jean François Duffort ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Guided Bone Regeneration ◽  
Beagle Dogs ◽  
Implant Placement

scholarly journals Management of Retrograde Peri-Implantitis Using an Air-Abrasive Device, Er,Cr:YSGG Laser, and Guided Bone Regeneration

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Nikolaos Soldatos ◽  
Georgios E. Romanos ◽  
Michelle Michaiel ◽  
Ali Sajadi ◽  
Nikola Angelov ◽  
...  
Keyword(s):  
Case Report ◽  
Bone Density ◽  
Bone Regeneration ◽  
Guided Bone Regeneration ◽  
Etiologic Factor ◽  
Ridge Preservation ◽  
X Rays ◽  
Case Description ◽  
Implant Placement ◽  
Maxillary Molar

Background. The placement of an implant in a previously infected site is an important etiologic factor contributing to implant failure. The aim of this case report is to present the management of retrograde peri-implantitis (RPI) in a first maxillary molar site, 2 years after the implant placement. The RPI was treated using an air-abrasive device, Er,Cr:YSGG laser, and guided bone regeneration (GBR). Case Description. A 65-year-old Caucasian male presented with a draining fistula associated with an implant at tooth #3. Tooth #3 revealed periapical radiolucency two years before the implant placement. Tooth #3 was extracted, and a ridge preservation procedure was performed followed by implant rehabilitation. A periapical radiograph (PA) showed lack of bone density around the implant apex. The site was decontaminated with an air-abrasive device and Er,Cr:YSGG laser, and GBR was performed. The patient was seen every two weeks until suture removal, followed by monthly visits for 12 months. The periapical X-rays, from 6 to 13 months postoperatively, showed increased bone density around the implant apex, with no signs of residual clinical or radiographic pathology and probing depths ≤4 mm. Conclusions. The etiology of RPI in this case was the placement of an implant in a previously infected site. The use of an air-abrasive device, Er,Cr:YSGG, and GBR was utilized to treat this case of RPI. The site was monitored for 13 months, and increased radiographic bone density was noted.

scholarly journals Collagen vs expanded polytetrafluorethylene membranes during guided-bone regeneration simultaneous with implant placement – a systematic review

2019 ◽  
Vol 8 (2) ◽  
pp. 59
Author(s):  
Sales Antônio Barbosa Junior ◽  
Angélica Maroli ◽  
Gabriel Kalil Rocha Pereira ◽  
Atais Bacchi
Keyword(s):  
Systematic Review ◽  
Bone Regeneration ◽  
Guided Bone Regeneration ◽  
Implant Placement

Objetivo: Esta revisão sistemática avaliou a influência do tipo de membrana (colágeno reabsorvível ou politetrafluoretileno expandido não reabsorvível; e-PTFE) na regeneração óssea guia associada à colocação do implante. Métodos: Qualquer tipo de estudo clínico ou revisão de literatura foi pesquisada nas bases de dados MEDLINE / PubMed e Cochrane. Dois revisores independentes examinaram títulos / resumos de artigos e o texto completo de estudos potencialmente elegíveis. Quando os dados estavam disponíveis, a meta-análise pareada foi realizada usando modelo estatístico aleatório. Resultados: Nove estudos preencheram os critérios de inclusão, considerando 685 implantes em 360 pacientes. A regeneração óssea vertical não diferiu com o uso das duas membranas em 8 dos 9 estudos incluídos. Meta-análise não mostrou maior ganho ósseo vertical ou perda óssea vertical após a regeneração com qualquer uma das membranas. Os resultados mostraram uma tendência de maior ganho ósseo na regeneração óssea guiada horizontal com membranas de e-PTFE não reabsorvíveis (relatadas por 2 de 3 estudos). Todos os estudos mostraram claramente que ambas as membranas foram eficazes no aumento do volume ósseo. Não houve uma tendência clara de qualquer uma das duas membranas em causar mais complicações. Conclusão: o colágeno reabsorvível e as membranas não-reabsorvíveis de PTFE-e são igualmente eficazes na regeneração óssea guiada vertical; no entanto, a regeneração óssea guiada horizontal parece se beneficiar com o uso das membranas não reabsorvíveis. Ambas as membranas mostraram-se eficazes na regeneração óssea guiada e similares em relação às complicações.

scholarly journals Bone Regeneration Using a Three-Dimensional Hexahedron Channeled BCP Block Combined with Bone Morphogenic Protein-2 in Rat Calvarial Defects

Materials ◽  
2019 ◽  
Vol 12 (15) ◽  
pp. 2435 ◽  
Author(s):  
So-Yeun Kim ◽  
Eun-Bin Bae ◽  
Jae-Woong Huh ◽  
Jong-Ju Ahn ◽  
Hyun-Young Bae ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Alveolar Bone ◽  
Three Dimensional ◽  
Bone Morphogenetic Protein 2 ◽  
Graft Material ◽  
Implant Placement ◽  
Morphogenetic Protein ◽  
Human Bone Morphogenetic Protein ◽  
Calvarial Defects ◽  
Rat Calvarial Defect

It is important to obtain sufficient bone mass before implant placement on alveolar bone, and synthetic bone such as biphasic calcium phosphate (BCP) has been studied to secure this. This study used a BCP block bone with a specific structure of the three-dimensional (3D) hexahedron channel and coating with recombinant human bone morphogenetic protein-2 (rhBMP-2) impregnated carboxymethyl cellulose (CMC) was used to examine the enhancement of bone regeneration of this biomaterial in rat calvarial defect. After the preparation of critical-size calvarial defects in fifteen rats, defects were divided into three groups and were implanted with the assigned specimen (n = 5): Boneplant (untreated 3D hexahedron channeled BCP block), Boneplant/CMC (3D hexahedron channeled BCP block coated with CMC), and Boneplant/CMC/BMP (3D hexahedron channeled BCP block coated with CMC containing rhBMP-2). After 4 weeks, the volumetric, histologic, and histometric analyses were conducted to measure the newly formed bone. Histologically, defects in the Boneplant/CMC/BMP group were almost completely filled with new bone compared to the Boneplant and Boneplant/CMC groups. The new bone volume (P < 0.05) and area (P < 0.001) in the Boneplant/CMC/BMP group (20.12% ± 2.17, 33.79% ± 3.66) were much greater than those in the Boneplant (10.77% ± 4.8, 16.48% ± 9.11) and Boneplant/CMC (10.72% ± 3.29, 16.57% ± 8.94) groups, respectively. In conclusion, the 3D hexahedron channeled BCP block adapted rhBMP-2 with carrier CMC showed high possibility as an effective bone graft material.

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