scholarly journals Phytochemical screening and anti-virulence properties of Ceiba pentandra and Ceiba aesculifolia (Malvaceae) bark extracts and fractions

2018 ◽  
Vol 96 (3) ◽  
pp. 415
Author(s):  
Naybi Muñoz-Cazares ◽  
Silvia Aguilar-Rodríguez ◽  
Rodolfo García-Contreras ◽  
Marcos Soto-Hernández ◽  
Mariano Martínez-Vázquez ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Inhibitory Activity ◽  
Bacterial Infections ◽  
Anatomical Study ◽  
Ceiba Pentandra ◽  
Sensing Systems ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum ◽  
Novel Strategy ◽  
Ceiba Aesculifolia

<p><strong>Background</strong>: Inhibition of quorum sensing systems (QSS-I) is a novel strategy in the treatment of bacterial infections. To date, plants are the major source of metabolites with this inhibitory activity. Thus, species of Mexican flora can be important resources for obtaining metabolites with QSS-I activity.</p><p><strong>Hypothesis</strong>: We hypothesized that extracts from species of the genus <em>Ceiba</em> have metabolites with inhibitory activity against bacterial quorum sensing systems.</p><p><strong>Species studied</strong>: <em>Ceiba pentandra </em>(L.) Gaertn.<em> </em>and <em>Ceiba aesculifolia (</em>Kunth) Britten &amp; Baker f. (Malvaceae).</p><p><strong>Study site and years of study</strong><strong>: We collected <em>Ceiba </em>bark in the municipalities of </strong>Tierra Blanca, Veracruz, and Acatlan, Oaxaca, in August 2013.</p><p><strong>Methods</strong>: We determined the effect of extracts from <em>C. aesculifolia</em> and <em>C. pentandra</em> against QSS-regulated phenotypes of <em>Chromobacterium violaceum</em> and <em>Pseudomonas aeruginosa</em>. Extracts were fractionated and the main metabolites were identified. As support in the identification of the species, we carried out an anatomical study of the bark.</p><p><strong>Results</strong>: Hexane and dichloromethane extracts of both species of <em>Ceiba</em> exhibited QSS-I activity. We identified four fractions rich in terpene and sterol compounds with the ability to attenuate virulence factors in <em>P. aerugiosa</em>. The histological analysis appears to support the presence of some differences in the barks that can facilitate identification of the two species.</p><p><strong>Conclusions</strong>: The extracts and fractions of the two species of <em>Ceiba </em>are sources of phytochemicals with the ability to regulate bacterial quorum sensing systems positively or negatively.</p>

scholarly journals Specificity and complexity in bacterial quorum-sensing systems

2016 ◽  
Vol 40 (5) ◽  
pp. 738-752 ◽  
Author(s):  
Lisa A. Hawver ◽  
Sarah A. Jung ◽  
Wai-Leung Ng
Keyword(s):  
Quorum Sensing ◽  
Sensing Systems ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum

Bacterial Quorum Sensing During Infection

2020 ◽  
Vol 74 (1) ◽  
pp. 201-219 ◽  
Author(s):  
Sheyda Azimi ◽  
Alexander D. Klementiev ◽  
Marvin Whiteley ◽  
Stephen P. Diggle
Keyword(s):  
Quorum Sensing ◽  
Bacterial Infections ◽  
Pathogenic Bacteria ◽  
Human Infection ◽  
Future Research ◽  
Virulence Determinants ◽  
Plant Laboratory ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum

Bacteria are highly interactive and possess an extraordinary repertoire of intercellular communication and social behaviors, including quorum sensing (QS). QS has been studied in detail at the molecular level, so mechanistic details are well understood in many species and are often involved in virulence. The use of different animal host models has demonstrated QS-dependent control of virulence determinants and virulence in several human pathogenic bacteria. QS also controls virulence in several plant pathogenic species. Despite the role QS plays in virulence during animal and plant laboratory-engineered infections, QS mutants are frequently isolated from natural infections, demonstrating that the function of QS during infection and its role in pathogenesis remain poorly understood and are fruitful areas for future research. We discuss the role of QS during infection in various organisms and highlight approaches to better understand QS during human infection. This is an important consideration in an era of growing antimicrobial resistance, when we are looking for new ways to target bacterial infections.

Phenotypic Heterogeneity in Bacterial Quorum Sensing Systems

2019 ◽  
Vol 431 (23) ◽  
pp. 4530-4546 ◽  
Author(s):  
Vera Bettenworth ◽  
Benedikt Steinfeld ◽  
Hilke Duin ◽  
Katrin Petersen ◽  
Wolfgang R. Streit ◽  
...  
Keyword(s):  
Quorum Sensing ◽  
Phenotypic Heterogeneity ◽  
Sensing Systems ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum

scholarly journals When being alone is enough: noncanonical functions of canonical bacterial quorum-sensing systems

2016 ◽  
Vol 11 (11) ◽  
pp. 1447-1459 ◽  
Author(s):  
Bobbi Xayarath ◽  
Nancy E Freitag
Keyword(s):  
Quorum Sensing ◽  
Sensing Systems ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum

scholarly journals Bacterial Quorum Sensing and Microbial Community Interactions

mBio ◽  
2018 ◽  
Vol 9 (3) ◽  
Author(s):  
Rhea G. Abisado ◽  
Saida Benomar ◽  
Jennifer R. Klaus ◽  
Ajai A. Dandekar ◽  
Josephine R. Chandler
Keyword(s):  
Quorum Sensing ◽  
Bacterial Infections ◽  
Molecular Mechanisms ◽  
Cell Communication ◽  
Microbial Interactions ◽  
Community Interactions ◽  
Bacterial Populations ◽  
Bacterial Quorum Sensing ◽  
A Cell ◽  
Bacterial Quorum

ABSTRACTMany bacteria use a cell-cell communication system called quorum sensing to coordinate population density-dependent changes in behavior. Quorum sensing involves production of and response to diffusible or secreted signals, which can vary substantially across different types of bacteria. In many species, quorum sensing modulates virulence functions and is important for pathogenesis. Over the past half-century, there has been a significant accumulation of knowledge of the molecular mechanisms, signal structures, gene regulons, and behavioral responses associated with quorum-sensing systems in diverse bacteria. More recent studies have focused on understanding quorum sensing in the context of bacterial sociality. Studies of the role of quorum sensing in cooperative and competitive microbial interactions have revealed how quorum sensing coordinates interactions both within a species and between species. Such studies of quorum sensing as a social behavior have relied on the development of “synthetic ecological” models that use nonclonal bacterial populations. In this review, we discuss some of these models and recent advances in understanding how microbes might interact with one another using quorum sensing. The knowledge gained from these lines of investigation has the potential to guide studies of microbial sociality in natural settings and the design of new medicines and therapies to treat bacterial infections.

The ability of natural ketones to interact with bacterial quorum sensing systems

2014 ◽  
Vol 29 (4) ◽  
pp. 167-171 ◽  
Author(s):  
V. A. Plyuta ◽  
A. A. Popova ◽  
O. A. Koksharova ◽  
A. E. Kuznetsov ◽  
I. A. Khmel
Keyword(s):  
Quorum Sensing ◽  
Sensing Systems ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum

A Boolean network model of bacterial quorum-sensing systems

2018 ◽  
Vol 21 (2) ◽  
pp. 123
Author(s):  
Gonzalo A. Ruz ◽  
Ana Zúñiga ◽  
Eric Goles
Keyword(s):  
Quorum Sensing ◽  
Network Model ◽  
Boolean Network ◽  
Sensing Systems ◽  
Boolean Network Model ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum

A Boolean network model of bacterial quorum-sensing systems

2018 ◽  
Vol 21 (2) ◽  
pp. 123
Author(s):  
Gonzalo A. Ruz ◽  
Ana Zúñiga ◽  
Eric Goles
Keyword(s):  
Quorum Sensing ◽  
Network Model ◽  
Boolean Network ◽  
Sensing Systems ◽  
Boolean Network Model ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum

scholarly journals A Modular View of the Diversity of Cell-Density-Encoding Schemes in Bacterial Quorum-Sensing Systems

2014 ◽  
Vol 107 (1) ◽  
pp. 266-277 ◽  
Author(s):  
Bastian Drees ◽  
Matthias Reiger ◽  
Kirsten Jung ◽  
Ilka B. Bischofs
Keyword(s):  
Quorum Sensing ◽  
Cell Density ◽  
Sensing Systems ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum

Inhibition of Bacterial Quorum Sensing Systems by Metal Nanoparticles

2017 ◽  
pp. 123-138
Author(s):  
Krystyna I. Wolska ◽  
Anna M. Grudniak ◽  
Katarzyna Markowska
Keyword(s):  
Quorum Sensing ◽  
Metal Nanoparticles ◽  
Sensing Systems ◽  
Bacterial Quorum Sensing ◽  
Bacterial Quorum
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