scholarly journals CLINICAL-EPIDEMIOLOGICAL CHARACTERIZATION OF GUILLAIN BARRÉ SYNDROME IN A CUBAN CASE SERIE.

2021 ◽  
Vol 2 (2) ◽  
Author(s):  
Zurina Lestayo ◽  
Sistach-Vega Vivian ◽  
Bismary Rodriguez Álvarez ◽  
Adarilis Hoya González
Keyword(s):  
Autoimmune Disease ◽  
Clinical Picture ◽  
Climatic Conditions ◽  
Personal History ◽  
Guillain Barre Syndrome ◽  
Motor Disorder ◽  
Heterogeneous Distribution ◽  
Guillain Barré Syndrome ◽  
History Of ◽  
Guillain Barré

Background: The broad spectrum of Guillain Barré Syndrome (GBS) includes different pathological phenotypes, with a heterogeneous distribution. The reports, by country and region, have shown its great variability and clarified its behavior.Objective: Characterize GBS and define the most frequent phenotypes.Methods: A time series was constructed to analyze the epidemiological behavior of GBS. The demographic, epidemiological, clinical and complementary aspects of 167 patients were retrospectively described. The severity was analyzed and the patients were classified.Results: The mean age was 33 years, 22.8% were children. The incidence decreased with age and a seasonal preference was seen for the month of August, that usually coincides with higher rates of respiratory and digestive infections. Dengue preceded some GBS outbreaks. The Acute Inflammatory Demyelinating Polyradiculopathy (AIDP) variant predominated and was most severe. Regional variants, a recurrent GBS and a family one were detected. Age, personal history of autoimmune disease, preceding infectious phenomenon, latency between the preceding phenomenon and the onset of the clinical picture, the extent of the motor disorder, facial involvement, gait impairment, ventilatory compromise, and degradation of the osteotendinous reflexes, significantly correlated with the severity.Conclusions: The predominance of AIDP coincides with some countries in the area, with varying geographical location and climatic conditions. The incidence decreases with age. The relationship between the severity and the personal history of autoimmune disease, the preceding infectious phenomenon, and the latency between the preceding phenomenon and the onset of the clinical picture, could be reflecting an underlying autoimmune mechanism in each case.

Guillain-Barré syndrome in patients with a recent history of Zika in Cúcuta, Colombia: A descriptive case series of 19 patients from December 2015 to March 2016

2017 ◽  
Vol 37 ◽  
pp. 19-23 ◽  
Author(s):  
Arturo Arias ◽  
Lilian Torres-Tobar ◽  
Gualberto Hernández ◽  
Deyanira Paipilla ◽  
Eduardo Palacios ◽  
...  
Keyword(s):  
Case Series ◽  
Guillain Barre Syndrome ◽  
Recent History ◽  
Guillain Barré Syndrome ◽  
History Of ◽  
Guillain Barré

scholarly journals An Acute, Severe Axonal Sensorimotor Polyneuropathy in the Setting of Nitrous Oxide Abuse

2020 ◽  
Vol 10 (4) ◽  
pp. 293-296
Author(s):  
Jules C. Beal ◽  
Yishan Cheng ◽  
Sabiha Merchant ◽  
Reza Zarnegar
Keyword(s):  
Nitrous Oxide ◽  
Vitamin B12 ◽  
Clinical Picture ◽  
Guillain Barre Syndrome ◽  
Sensory Loss ◽  
Laboratory Evaluation ◽  
Sensorimotor Polyneuropathy ◽  
Guillain Barré Syndrome ◽  
B12 Deficiency ◽  
Guillain Barré

Nitrous oxide, often used as an anesthetic agent, is also increasingly a drug of abuse due to its euphoric and anxiolytic effects. Frequent exposure to nitrous oxide can lead to neurologic complications, including B12 deficiency and resultant subacute myeloneuropathy, as well as direct neurotoxicity. A clinical presentation of acute sensorimotor polyneuropathy mimicking Guillain-Barré syndrome after chronic nitrous oxide abuse has been reported only rarely. Here we present a 17-year-old previously healthy girl presented with 10 days of progressive ascending sensory loss and weakness in the legs. She admitted to heavy nitrous oxide abuse over a period of a year or more. Laboratory evaluation was significant for normal vitamin B12 level with elevated homocysteine. A magnetic resonance imaging (MRI) of her spine showed abnormal signal involving the bilateral dorsal columns. Nerve conduction studies were suggestive of severe axonal sensorimotor polyneuropathy. This patient demonstrates concurrent multifactorial neurologic injury as a result of nitrous oxide abuse. She had a functional vitamin B12 deficiency as indicated by the elevated homocysteine, leading to a subacute combined degeneration that was evident on the MRI. In addition, she had evidence of direct neurotoxicity leading to axonal injury and sensorimotor polyneuropathy reminiscent of Guillain-Barré syndrome. This clinical picture is a serious but seldom reported possible complication if nitrous oxide abuse and should be considered in patients presenting with a clinical picture suspicious for Guillain-Barré syndrome or its variants.

scholarly journals A horse and a zebra: an atypical clinical picture including Guillain-Barré syndrome, recurrent fever and mesenteric lymphadenopathy caused by two concomitant infections

Infection ◽  
2020 ◽  
Vol 48 (3) ◽  
pp. 471-475
Author(s):  
Felix Amereller ◽  
Christian Lottspeich ◽  
Grete Buchholz ◽  
Karl Dichtl
Keyword(s):  
Clinical Picture ◽  
Yersinia Pseudotuberculosis ◽  
Guillain Barre Syndrome ◽  
Recurrent Fever ◽  
Course Of Disease ◽  
Abdominal Symptoms ◽  
Guillain Barré Syndrome ◽  
Bacterial Gastroenteritis ◽  
Underlying Risk Factor ◽  
Guillain Barré

Abstract Background While Campylobacter jejuni represents the most common cause of bacterial gastroenteritis, Yersinia pseudotuberculosis infections are very rarely diagnosed in adults. Case We report on a previously healthy patient who presented several times at our hospital with fever, Guillain-Barré syndrome, recurrent abdominal symptoms and distinct mesenteric lymphadenopathy, respectively. This complicated and diagnostically challenging course of disease was caused by a C. jejuni and Y. pseudotuberculosis coinfection. Antibiotic treatment with doxycycline was effective. Conclusion Broad serology testing was crucial to discover that two concomitant infections were causing the symptoms. This case demonstrates that when a clinical picture is not fully explained by one known infection, another infection with the same underlying risk factor has to be considered, hence “a horse and a zebra”.

scholarly journals Dysautonomia and hyponatraemia as harbingers of Guillain-Barre syndrome

2019 ◽  
Vol 12 (4) ◽  
pp. e226925 ◽  
Author(s):  
Preet Mukesh Shah ◽  
Vijay Waman Dhakre ◽  
Ramya Veerasuri ◽  
Anand Bhabhor
Keyword(s):  
Blood Pressure ◽  
Secondary Hypertension ◽  
Guillain Barre Syndrome ◽  
Rare Presentation ◽  
Normal Ranges ◽  
Guillain Barré Syndrome ◽  
History Of ◽  
Autonomic Disturbances ◽  
Guillain Barré ◽  
Time Of Presentation

A 56-year-old woman with a medical history of hypertension presented to our hospital with back pain, abdominal pain, vomiting and elevated blood pressure. The laboratory parameters including evaluation for secondary hypertension were within normal ranges at the time of presentation. During her hospitalisation, fluctuations in her blood pressure and pulse were observed which were attributed to autonomic disturbances, the cause of which was unknown. On the seventh day after presentation to the hospital, the patient developed focal seizures and slurred speech which was believed to be secondary to hyponatraemia detected at that time. Hyponatraemia improved with hypertonic saline and she experienced no further seizures. On the eighth day of her admission, she developed acute flaccid paralysis of all her limbs and respiratory distress. We concluded this to be secondary to Guillain-Barre syndrome (GBS). She responded to plasmapheresis.The presence of dysautonomia and hyponatraemia before the onset of paralysis makes this a rare presentation of GBS.

scholarly journals Post-treatment Guillain-Barre Syndrome in a Patient with Brucellosis; A Case Report

2019 ◽  
Vol 4 (2) ◽  
Author(s):  
Navid Manouchheri ◽  
Omid Mirmosayyeb ◽  
Majid Ghasemi ◽  
Shervin Badihian ◽  
Vahid Shaygannejad ◽  
...  
Keyword(s):  
Case Report ◽  
Antimicrobial Treatment ◽  
Lower Limbs ◽  
Guillain Barre Syndrome ◽  
Case Presentation ◽  
Brucella Infection ◽  
Guillain Barré Syndrome ◽  
History Of ◽  
Guillain Barré ◽  
Uncommon Complication

Introduction: Guillain-Barre Syndrome is an uncommon complication during acute brucellosis. Case presentation: In this study, we present a case of Guillain-Barre Syndrome in a 22-year old male patient with complaints of weakness in his lower limbs. He had a history of acute Brucella infection for four months and received antimicrobial medication. Conclusion: the patients can be affected by GBS after antimicrobial treatment.

scholarly journals Guillain Barre Syndrome pada Kehamilan

2020 ◽  
Vol 9 (2) ◽  
pp. 256
Author(s):  
Hermin Sabaruddin ◽  
Pribakti Budinurdjaja ◽  
Fakhrurrazy Fakhrurrazy
Keyword(s):  
Physical Examination ◽  
First Trimester ◽  
Clinical Syndrome ◽  
Guillain Barre Syndrome ◽  
High Morbidity ◽  
Autoimmune Reaction ◽  
Guillain Barré Syndrome ◽  
History Of ◽  
Guillain Barré ◽  
In Pregnancy

Guillain-Barre Syndrome (GBS) is a clinical syndrome characterized by the presence of the complete flaksid that occurs in acute. GBS associated with autoimmune reaction that affect peripheral nerve, radix, and cranial nerve. The incidence of GBS is 1 – 2 per 100,000 people/year. The incident was followed by increased age and the increasing population of obstetrics. GBS in pregnancy ranged from 13% in the first trimester, 47% in the second trimester, and 40% in the third trimester. In this case report reported Mrs. M 27 years old with a diagnosis of G2P1A0 h. 39-40 weeks + insimanation + living single fetal Presentation Head + Inpartu kala II + GBS + Failed + Vacuum Severily Underweight (BMI = 17) + TBJ 3000 Gr. Diagnosis of GBS are enforced based on anamnesis, physical examination and complementary examinations. From a previous illness history found anamnesis the weakness of limbs beginning in 2016. A history of the use of breathing apparatus and admitted tot the ICU in the first pregnancy. Mrs. M had a history of infections before being diagnosed with GBS. On this second pregnancy patients cannot move lower extremity but upper extermity is still functioning. Physical examination result of mothers and babies in the normal range even though found in conditions of severily BMI underweight. The patient finally decided to SC (section caesaria) and applied the IUD intracaesarean GBS in pregnancy is a coincidental. GBS is rarely aggravate pregnancy, but if not quickly identified and handled can enhance the high morbidity in both mother and fetus. In acute attacks (AIDP) in pregnant women with GBS increase stress on the mother or the fetus. The stress that occurs can also stimulate the immune system to produce prostaglandins, resulting in premature birth. Patients can give birth when the gestational age is still 7 months. It was different in the second pregnancy in this case where the patient was diagnosed with chronic inflammatory demyelinating polyradiculopathy (CIDP) so that GBS did not affect the mother and the fetus.

scholarly journals A case of a recurrent GBS

2017 ◽  
Vol 5 (2) ◽  
pp. 135-138
Author(s):  
Md Mahabub Morshed ◽  
AKM Ferdous Rahman ◽  
Syed Tariq Reza ◽  
Muhammad Asaduzzaman ◽  
Mohammad Selim ◽  
...  
Keyword(s):  
Mechanical Ventilation ◽  
Past History ◽  
Complete Recovery ◽  
Guillain Barre Syndrome ◽  
Respiratory Compromise ◽  
Cerebrospinal Fluid Analysis ◽  
Fluid Analysis ◽  
Guillain Barré Syndrome ◽  
History Of ◽  
Guillain Barré

Background: Guillain-Barré syndrome is an acquired polyradiculo-neuropathy, often preceded by an antecedent event. It is a monophasic disease but a recurrence rate of 1–6 % is documented in a subset group of patients.Case presentation: Thirty-five-years-old female with past history of near complete recovery following Guillain-Barré syndrome 17 years back presented with acute, ascending symmetrical flaccid quadriparasis extending to bulbar muscles and respiratory compromise needing mechanical ventilation. Nerve conduction study revealed AMAN variant of Guillain-Barré syndrome. Cerebrospinal fluid analysis done after 1 weeks during recurrent episode revealed albuminocytologic dissociation. She was treated with intravenous immunoglobulin resulting in a remarkable recovery.Conclusion: Recurrence of Guillain-Barré syndrome can occur in a subset of patients with Guillain-Barré syndrome even after many years of asymptomatic period. Most patients with recurrent GBS respond favourably to treatment with plasmapheresis or IVIG.Bangladesh Crit Care J September 2017; 5(2): 135-138

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