scholarly journals Duration and temporal dispersion measurements in CIDP subjects from the Polyneuropathy And Treatment with Hizentra (PATH) study

2021 ◽  
Vol 2 (3) ◽  
Author(s):  
Deepak Menon ◽  
Joy Vijayan ◽  
John-Philip Lawo ◽  
Orell Mielke ◽  
Mylan Ngo ◽  
...  
Keyword(s):  
Nerve Conduction ◽  
Compound Muscle Action Potential ◽  
Nerve Conduction Studies ◽  
Muscle Action ◽  
Muscle Action Potential ◽  
End Of Treatment ◽  
Immunoglobulin Treatment ◽  
Consistent Method ◽  
The Impact ◽  
Temporal Dispersion

Abstract: Introduction: Distal compound muscle action potential (dCMAP) duration and temporal dispersion (TD) are electrophysiological hallmarks of demyelination and important for the diagnosis of CIDP. While the impact of CIDP treatment on other nerve conduction parameters has been examined, the effects on dCMAP and TD remain unexplored. The aim of the study was to examine the impact of withdrawal of immunoglobulin treatment on dCMAP duration and TD, and also the influence of the measurement technique on dCMAP duration and TD. Methods: Nerve conduction studies were analyzed from the PATH (Polyneuropathy And Treatment with Hizentra) study which randomized patients with CIDP to two doses of IgPro 20 and placebo. Distal CMAP duration and TD were obtained by two methods of measurements (D1 and D2, TD1 and TD2) from the median and peroneal nerves.   Results: The dCMAP and TD were obtained from 389 tracings. While the two methods of measurement showed differences in D1 and D2 with D2 longer than D1 in all the three groups, there was no difference between the TD1 and TD2. There was no difference at baseline in dCMAP duration or TD among the three groups. At the end of treatment, patients in the placebo arm had no worsening of dCMAP and TD compared to baseline or the treated groups. Conclusion: dCMAP duration and TD did not show a difference between treated and placebo groups, and may be less sensitive measures than other nerve conduction parameters when evaluating changes in treatment. The method of dCMAP duration measurement does not affect TD as long as a consistent method is followed.  

Late Responses

2016 ◽  
pp. 312-327
Author(s):  
Ruple S. Laughlin
Keyword(s):  
Nerve Conduction ◽  
Compound Muscle Action Potential ◽  
Motor Nerve ◽  
Clinical Applications ◽  
Nerve Conduction Studies ◽  
Sensory Nerves ◽  
Muscle Action ◽  
Physiological Basis ◽  
Motor Nerve Conduction ◽  
Muscle Action Potential

Late responses are a group of responses occurring after the compound muscle action potential (M-wave) in motor nerve conduction studies and include F-waves, H-reflexes, and axon reflexes. These responses can indirectly measure aspects of proximal conduction that are not obtained with routine motor nerve conduction studies and may be useful in assessing diseases that affect proximal nerves, such as polyradiculopathies. A thorough understanding of the physiological basis, sources of error, and clinical applications and limitations enhances the usefulness of F-waves and H-reflexes as one means to evaluate proximal functioning of the motor and sensory nerves. This chapter will discuss the study methods and applications of F-waves and H-reflexes.

Vincristine Neuropathy in Children: Squatting (Sitting Cross Legged) Predisposes Common Peroneal Nerves to Be More Severely Affected than Tibial Nerves

2019 ◽  
Vol 18 (04) ◽  
pp. 182-184
Author(s):  
Roshan Koul ◽  
Saleem Saleh Naiha Al Harousi ◽  
Sousan AlNabhani ◽  
Amna AlFutaisi
Keyword(s):  
Retrospective Study ◽  
Action Potential ◽  
Nerve Conduction ◽  
Nerve Conduction Velocity ◽  
Compound Muscle Action Potential ◽  
University Hospital ◽  
Muscle Action ◽  
Sultan Qaboos University ◽  
Muscle Action Potential ◽  
Vincristine Neuropathy

Abstract Objective The main objective of this article was to evaluate vincristine neuropathy effect on common peroneal and tibial nerves. Methods A retrospective study was conducted in children with vincristine neuropathy between August 2006 and January 2016 at Sultan Qaboos University Hospital. Results Twenty-eight children (15 females and 13 males) were included in the study. The compound muscle action potential of common peroneal nerves was significantly reduced relative to the tibial nerves (p < 0.05)). There was no difference in latency and nerve conduction velocity between the two nerves. Conclusion Children receiving vincristine demonstrate severe peroneal neuropathy compared with tibial nerves. We conclude that squatting posture effects peroneal nerves and postulate that the peroneal nerves are affected more due to the squatting posture. This squatting posture stretches the nerves that are already affected by the toxic effect of vincristine.

Motor Nerve Conduction Studies

2016 ◽  
pp. 257-291
Author(s):  
Lyell K. Jones ◽  
James C. Watson
Keyword(s):  
Action Potential ◽  
Nerve Conduction ◽  
Compound Muscle Action Potential ◽  
Motor Nerve ◽  
Conduction Block ◽  
Neuromuscular Diseases ◽  
Muscle Action ◽  
Motor Nerve Conduction ◽  
Muscle Action Potential ◽  
Nerve Disease

A compound muscle action potential (CMAP) is the summated action potential recorded from muscle during a motor nerve conduction study (NCS). Motor NCSs with recording of CMAPs may be used for several purposes in assessing neuromuscular diseases, including providing objective measurements of the extent and localization of the cause of weakness; determining the underlying pathological abnormality, such as conduction block or slowing of conduction at a localized area of neurapractic injury; identifying the changes associated with Wallerian degeneration and regeneration in the motor nerve; and assisting (along with needle EMG) in distinguishing peripheral nerve disease from lower motor neuron disease, neuromuscular junction disease, and myopathies. This chapter will review the concepts and techniques of motor NCS and CMAP recording, will describe the technique and measurements, and will discuss the findings in various neuromuscular diseases.

scholarly journals Nerve Conduction Study in Healthy Individuals: a Gender Based Study

1970 ◽  
Vol 8 (3) ◽  
pp. 169-175 ◽  
Author(s):  
Dilip Thakur ◽  
BH Paudel ◽  
BK Bajaj ◽  
CB Jha
Keyword(s):  
Action Potential ◽  
Nerve Conduction Study ◽  
Nerve Conduction ◽  
Compound Muscle Action Potential ◽  
Sensory Nerve ◽  
Sensory Nerve Action Potential ◽  
Muscle Action ◽  
Muscle Action Potential ◽  
Sensory Nerve Action ◽  
Motor Nerves

Background: Nerve conduction study (NCS) assesses peripheral nerve functions and has clinical implication. Objective: To study effect of gender on NCS variables in healthy adults. Settings and Design: Department of Physiology, B.P. Koirala Institute of Health Sciences, Dharan, Nepal. Material and Method: The study was done in 34 (m=19, 32±11 years; f=15, 32±12 years) consenting healthy adults. The compound muscle action potential (CMAP) and sensory nerve action potential (SNAP) were recorded. Statistical analysis: The effect of gender on NCS variables was analyzed using Mann Whitney U test. Results: Male vs. female: males had increased CMAP and F-wave latencies (ms) in all tested motor nerves. CMAP duration (ms) was longer in males (p<0.05) in all tested motor nerves: right median (5.9±1.3 vs. 4.92±0.65), left median (5.54±0.91 vs. 4.72±0.57), right ulnar (5.55±1.01 vs. 4.56±0.59), left ulnar (5.71±0.97 vs. 4.64±0.51), right tibial (6.58±0.95 vs. 5.95±0.71), and left tibial (6.98±1.31 vs. 6.21±0.78). Females showed higher sural SNAP amplitude (µV) (23.26±9.23 vs. 15.94±8.42). SNAP duration (ms) was longer in males: right ulnar (1.16±0.19 vs. 1.03±0.06). SNAP latencies (ms) were also longer in males: right sural (2.61±0.44 vs. 2.21±0.36). Males had greater height (165.9±4.74 vs. 149.3±7.24) and weight (60.4±7.2 vs. 53±7.2).Conclusion: Gender has definite effects on NCS variables. Males had higher CMAP amplitude, longer latencies and duration. SNAP latencies and duration were longer in males whereas amplitude was higher in females. Without adjustment for these factors, the sensitivity and specificity of NCS will decrease when using the same reference data in patients with different gender. Keywords: compound muscle action potential; gender; nerve conduction study; sensory nerve action potential DOI: 10.3126/hren.v8i3.4210Health Renaissance, September-December 2010; Vol 8 (No.3);169-175

Age-Related Change in Peripheral Nerve Conduction: Compound Muscle Action Potential Duration and Dispersion

Gerontology ◽  
1999 ◽  
Vol 45 (3) ◽  
pp. 168-173 ◽  
Author(s):  
Katsumi Kurokawa ◽  
Yasuyo Mimori ◽  
Eiji Tanaka ◽  
Tatsuo Kohriyama ◽  
Shigenobu Nakamura
Keyword(s):  
Action Potential ◽  
Peripheral Nerve ◽  
Nerve Conduction ◽  
Action Potential Duration ◽  
Compound Muscle Action Potential ◽  
Muscle Action ◽  
Age Related ◽  
Muscle Action Potential

scholarly journals The Promising Application of a New Ulnar Nerve Compound Muscle Action Potential Measurement Montage in Amyotrophic Lateral Sclerosis

2022 ◽  
Author(s):  
Yixuan Zhang ◽  
Jingyue Ma ◽  
Shuo Zhang ◽  
Zhou Yu ◽  
Dongsheng Fan
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Action Potential ◽  
Ulnar Nerve ◽  
Nerve Conduction ◽  
Compound Muscle Action Potential ◽  
Muscle Action ◽  
Potential Measurement ◽  
Muscle Action Potential ◽  
Als Patients ◽  
Lateral Sclerosis

Abstract Objective Detecting peripheral nerve damage by electrophysiology examination accurately and sensitively is important for the follow-up evaluation of amyotrophic lateral sclerosis(ALS). In this study, we applied a new proximal E2 electrode in the ulnar motor nerve conduction study with E1 on abductor digiti minimi(ADM), and investigated its effect on the compound muscle action potential(CMAP) of the ulnar nerve. Methods We included 64 ALS patients and 64 age- and sex- matched controls. Patients characteristics were collected for phenotype, symptom duration and site of onset. The revised ALS Functional Rating Scale(ALSFRS-R) was evaluated at the time of administration to assess the severity of ALS. The ulnar nerve CMAP was recorded using an E1 electrode on the muscle belly and an E2 electrode on distal tendon(traditional montage, CMAP-dE2) and proximal tendon(new montage, CMAP-pE2) respectively. Results The waveform of CMAP-pE2 was steadier presenting a uniform unilobed pattern. In the controls, there were no significant differences between the amplitudes of CMAP-dE2 and CMAP-pE2(p=0.96). In ALS patients, the amplitude of CMAP-pE2 was significantly lower than that of CMAP-dE2(p<0.01), especially for patients with ADM spontaneous activity and muscular atrophy. Using the new method, the damaged axons were more likely to be stratified into more severe decreased levels. Furthermore, the decline of CMAP-pE2 was significantly correlated with ALSFRS-R(p<0.01). Conclusions The new electrode configuration in the ulnar nerve conduction test could reflect the degree of axonal injury much more sensitively after the presence of ulnar nerve degeneration and was more suitable for the evaluation of disease progression.

scholarly journals A novel mutation of the COLQ gene causes congenital myasthenic syndromes: A case report

2021 ◽  
Vol 26 (4) ◽  
pp. 845-847
Author(s):  
Shiyi Yang ◽  
Jing Luo ◽  
Fei Xiao
Keyword(s):  
Case Report ◽  
Neuromuscular Junctions ◽  
Clinical Symptoms ◽  
Novel Mutation ◽  
Compound Muscle Action Potential ◽  
Nerve Conduction Studies ◽  
Muscle Action ◽  
Congenital Myasthenic Syndromes ◽  
Muscle Action Potential ◽  
Myasthenic Syndromes

Congenital myasthenic syndromes (CMS) are a group of heterogeneous disorders of the neuromuscular junctions, characterised by fluctuating and fatigable weakness with an early onset. Endplate acetylcholinesterase deficiency (EAD) due to mutations in COLQ is a subtype of CMS whose key clue for diagnosis is repetitive compound muscle action potential (R-CMAP) under nerve conduction studies. In light of the significant overlap of clinical symptoms, misdiagnosis is common for CMS, causing delayed or incorrect treatments. Here, we report a case of CMS due to a novel mutation in COLQ with a typical R-CMAP and discuss the significance of R-CMAP for diagnosis.

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