Association of Polymorphisms of the ACE, СMА1 and BDKRB2 Genes with the State of Oxygen Transport System in Young Men with Different Levels of Motor Activity

2019 ◽  
Vol 7 (3) ◽  
pp. 251-260 ◽  
Author(s):  
Al’bina Z. Dautova ◽  
◽  
Valentina G. Shamratova ◽  
Elena V Vorob’eva ◽  
◽  
...  
2015 ◽  
Vol 4 (2) ◽  
pp. 74-77
Author(s):  
Albina Zufarovna Dautova ◽  
Valentina Gusmanovna Shamratova

In the study, we investigated the association of polymorphic locus CMA 1/B (G1903A) with indicators of oxygen transport system of the body. To determine the nucleotide substitutions in the gene CMA1/B, we used RFLP- analysis, PCR products were digested with the restriction enzyme BstXI. Analysis of the distribution of frequencies of alleles and genotypes CMA1/B showed statistically significant differences in the frequency of polymorphic variants of genotypes between athletes and controls. Athletes have predominant genotype A/A (0,52), and G/G (0,4), whereas in the control group, the most common genotype A/G (0,58). Using factor analysis, we revealed differences in the structure of the association between indicators of oxygen transport system depending on the genotype of the gene CMA. It was revealed the association of polymorphic gene variants with red blood parameters, hemodynamic and respiratory systems, as well as with physical endurance and tolerance to the muscular load. The closest connection between the studied traits detected at polymorphic variants CMA A/A. At this genotype physical endurance largely depends on the state of the circulatory system and the respiratory system functional reserves. It was also shown the correlation between adaptive capabilities of cardiovascular system and efficiency of the heart functioning with the level of motor activity. The interaction complex of the features that characterize the activities of the cardiorespiratory system, system, causes the formation of the final phenotype, which obviously explains the detected frequency distribution of different genotypes in athletes.


Author(s):  
V. Yakhnenko ◽  
◽  
I. Klimenkov ◽  
N. Sudakov ◽  
S. Kirilchik ◽  
...  

1977 ◽  
Vol 69 (1) ◽  
pp. 247-260 ◽  
Author(s):  
JOE W. KICENIUK ◽  
DAVID R. JONES

1. The capabilities of the oxygen transport system of rainbow trout in supplying the increased oxygen demands in exercise, in a water tunnel at 9–10.5 °C, have been investigated by increasing the velocity of water flow, with a 1 h period between increments, up to the maximum swimming speed (critical velocity, Ucrit). 2. At Ucrit, NO2 was elevated above the resting level by 7.5 times. The logarithm of NOO2 was linearly related to the swimming speed expressed as a proportion of Ucrit. Vg increased in almost direct proportion to the increase in NOO2. 3. Heart rate rose slightly at half Ucrit and reached a maximum, 1.6 times the resting rate, as Ucrit was approached. Ventral and dorsal aortic mean blood pressures rose by 60% and 20% respectively at Ucrit while their pulse pressures doubled. Central venous pressure was virtually unchanged. 4. P a, Oa, O2 fell slightly during exercise but Ca, Oa, O2 was unaffected. On the other hand Pv, Ov, O2 halved and Cv, Ov, O2 fell from 3.17 (S.E. = 0.3) to 0.6(S.E. = 0.7) mmol/1. Cardiac output increased by about 3 times resting values. 5. The results are discussed and an attempt is made to estimate the maximum capabilities of the components of the oxygen transport system in sustained exercise.


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