scholarly journals Diagnostic value of procalcitonin and CRP in critically ill patients admitted with suspected sepsis

2015 ◽  
Vol 15 (3) ◽  
pp. 135 ◽  
Author(s):  
Jae-Sik Joen ◽  
Sung-Mi Ji
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Diagnostic Value ◽  
Suspected Sepsis

scholarly journals DIAGNOSTIC UTILITY OF PRESEPSIN AND PROCALCITONIN IN CRITICALLY ILL PATIENTS WITH SUSPECTED SEPSIS: COMPARISON WITH RECENT CLINICAL CRITERIA OF SEPSIS-3

2019 ◽  
Vol 3 (6) ◽  
Author(s):  
Babak Alikiaie ◽  
Sarah Mousavi ◽  
Mohammad Nasri
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Diagnostic Value ◽  
Suspected Sepsis ◽  
Clinical Sepsis ◽  
Clinical Criteria ◽  
Decision Tools ◽  
Sepsis Diagnosis ◽  
Previous Definition ◽  
Definition Of

Background: In this study, we aimed to investigate the diagnostic and prognostic utilities of presepsin and procalcitonin (PCT) in critically ill patients with suspected sepsis, for whom sepsis was diagnosed clinically based on the Survival Sepsis Campaign (SSC) criteria and to compare it with recent criteria of Sepsis-3. Methods: Blood samples for biomarker measurements of presepsin and PCT were drawn on days 1, 3 and 7 of ICU admission in a total of 26 patients. All patients were followed-up until death or discharge. All studied biomarkers were analyzed according to the diagnosis and severity of sepsis and for prognosis (all-cause mortality) at days 1, 3 and 7. Agreement between the diagnosis of clinical sepsis and presepsin or PCT-based sepsis was assessed using Cohen’s kappa Results: Clinical sepsis (based on Sepsis-3) and presepsin or PCT-based sepsis showed poor agreement (Kappa<0.4). Presepsin levels at day1 correlated significantly with mortality (r=0.45, P; 0.02). The diagnostic value of both presepsin and PCT to diagnose sepsis was weak (Area under curve (AUC) <0.75). The overall agreement in sepsis diagnosis was fair to good based on the both clinical criteria (P<0.05, Kappa: 0.5-0.75). More than 80% of patients (N=21) had sepsis based on presepsin upon admission. Both clinical criteria predicated that less than 20% of patients (N=5) had sepsis upon admission. Conclusion: Based on our findings, the overall agreement between the diagnosis of clinical sepsis and presepsin or PCT-based sepsis was poor. Also, our results show that the new Sepsis-3 definitions were accurate and equal to the previous definition of SSC guideline. Although, availability of diagnostic assays is variable in Iran, but, it seems that addition of developing decision tools that utilize biomarkers to help aid the rapid diagnosis of sepsis is necessary and may  improve patient outcomes. Keywords: Presepsin, Pro Calcitonin, Sepsis, Diagnosis

Diagnostic Value of Procalcitonin, Interleukin-6, and Interleukin-8 in Critically Ill Patients Admitted with Suspected Sepsis

2001 ◽  
Vol 164 (3) ◽  
pp. 396-402 ◽  
Author(s):  
STEPHAN HARBARTH ◽  
KATARINA HOLECKOVA ◽  
CÉLINE FROIDEVAUX ◽  
DIDIER PITTET ◽  
BARA RICOU ◽  
...  
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Interleukin 6 ◽  
Diagnostic Value ◽  
Interleukin 8 ◽  
Suspected Sepsis

The Diagnostic Value of Fungal Surveillance Cultures in Critically Ill Patients

2000 ◽  
Vol 1 (4) ◽  
pp. 273-281 ◽  
Author(s):  
Robert K. Pelz ◽  
Pamela A. Lipsett ◽  
Sandra M. Swoboda ◽  
Marie Diener-West ◽  
Janet M. Hammond ◽  
...  
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Diagnostic Value ◽  
Surveillance Cultures

Cytomorphometric Neutrophil and Monocyte Markers May Strengthen the Diagnosis of Sepsis

2016 ◽  
Vol 33 (12) ◽  
pp. 656-662
Author(s):  
Joy Mammen ◽  
Jui Choudhuri ◽  
Joshua Paul ◽  
Thomas Isaiah Sudarsan ◽  
T. Josephine ◽  
...  
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Blood Donors ◽  
Area Under The Curve ◽  
Standard Test ◽  
Suspected Sepsis ◽  
Predictive Values ◽  
Reactive Protein ◽  
Sensitivity Specificity

Background: The diagnosis of sepsis is challenging in the absence of a gold standard test. Recent studies have explored the role of neutrophil and monocyte volume, conductivity, and scatter (VCS), derived from automated hematology analyzers, in diagnosing sepsis. We assessed the diagnostic accuracy of VCS parameters in critically ill patients with sepsis. Methodology: In this prospective study, VCS parameters, procalcitonin, and C-reactive protein (CRP) were assessed in patients with proven sepsis (cases) and 2 control groups (intensive care unit [ICU] patients without sepsis and healthy blood donors). The diagnostic property of each test was explored by calculating sensitivity, specificity, negative and positive predictive values, and area under the curve (AUC). Results: The study included 65 patients with sepsis, 58 nonseptic ICU controls, and 98 blood donors. Procalcitonin and CRP were not significantly different ( P > .06) between patients with sepsis and nonseptic patients. Mean (95% confidence interval [CI]) neutrophil volume (MNV) was significantly higher ( P < .001) in patients with sepsis (165.5; 95%CI 161.6-169.4) than in nonseptic (157.3; 95%CI 154.6-160.1) patients and donors (148.9; 95%CI 147.9-150). A similar pattern was seen with mean monocyte volume (MMoV). Neutrophil and monocyte conductivity and scatter parameters were variably associated. The AUC was highest for MMoV (0.74) and lowest for CRP (0.62). Among all parameters, MNV and MMoV had the highest specificity of 85% and 80%, respectively. Conclusion: In critically ill patients with suspected sepsis, VCS parameters may help strengthen the diagnostic probability of sepsis. Future studies may explore the role of serial monitoring of VCS to track response to antimicrobial therapy.

scholarly journals Prognostic and diagnostic value of eosinopenia, C-reactive protein, procalcitonin, and circulating cell-free DNA in critically ill patients admitted with suspicion of sepsis

Critical Care ◽  
2014 ◽  
Vol 18 (3) ◽  
pp. R116 ◽  
Author(s):  
Jose Garnacho-Montero ◽  
María J Huici-Moreno ◽  
Antonio Gutiérrez-Pizarraya ◽  
Isabel López ◽  
Juan Márquez-Vácaro ◽  
...  
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Diagnostic Value ◽  
C Reactive Protein ◽  
Cell Free Dna ◽  
Reactive Protein ◽  
Free Dna ◽  
Circulating Cell Free Dna

scholarly journals PROCALCITONIN FOR IMPROVED ASSESSMENT AND AN ANSWER TO SEPSIS DILEMMA IN CRITICALLY ILL - A MYTH, A HYPE, OR A REALITY ?

2014 ◽  
Vol 04 (01) ◽  
pp. 057-065
Author(s):  
Raghava Sharma ◽  
Maniyar Vijayakumar
Keyword(s):  
Septic Shock ◽  
Clinical Practice ◽  
Material Culture ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Tertiary Care ◽  
Specific Marker ◽  
Suspected Sepsis ◽  
Number Of Patients

Abstract: Background and objectives: “Sepsis is a major cause for mortality in critically ill patients all over the world. The number of patients presenting with sepsis, septic shock is gradually increasing in daily clinical practice. Mortality in sepsis is mainly due to a delay in diagnosis and initiation of specific therapy(antibiotics).This is in turn mainly attributed to the difficulty in differentiating infectious trigger(sepsis) from non infectious triggers as both present with similar clinical features. Lack of specific marker adds to this dilemma of differentiating infectious and non infectious factors in critically ill patients.Recently there are some reports from European countries on role of Procalcitonin (PCT) in critically ill patients. Draw backs of these studies are galore mainly due to the difficulties in interpretation of results, as varying definitions for sepsis are used. But also there is paucity of data on Procalcitonin from Indian sub continent. Hence in the present single centre prospective observational study conducted at tertiary care medical college hospital , A total of 50 adult patients with sepsis fulfilling ACCP/SCCM guidelines were included, out of which 23 were in SIRS/Sepsis, 14 in severe sepsis and 13 in septic shock. Procalcitonin was evaluated in the first 24 hours after admission and before initiation of any antibiotic therapy. The role of procalcitonin was analyzed in relation to confirming sepsis, assessing the severity of sepsis and assessing the prognosis(possible out come) of sepsis. Combined role of procalcitonin with other indicators especially ESR, SOFA Score, Blood/relevant material culture was explored. Results: Our study confirmed the importance of procalcitonin in critically ill patients particularly in improving the predictive power while solving the sepsis dilemma. Conclusions: From our study, we conclude that Procalcitonin is not a myth nor a hype but it is a hard reality and is an answer to sepsis dilemma. It is therefore preferable to add Procalcitonin into the standard workup of critically ill patients with suspected sepsis in every day clinical practice.

Predictive value of procalcitonin and interleukin 6 in critically ill patients with suspected sepsis

2002 ◽  
Vol 28 (9) ◽  
pp. 1220-1225 ◽  
Author(s):  
Ville Pettilä ◽  
Marja Hynninen ◽  
Olli Takkunen ◽  
Pentti Kuusela ◽  
Matti Valtonen
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Interleukin 6 ◽  
Predictive Value ◽  
Suspected Sepsis

scholarly journals Diagnostic Value of Monocyte Chemoattractant Protein-1, Soluble Mannose Receptor, Presepsin, and Procalcitonin in Critically Ill Children Admitted with Suspected Sepsis

2021 ◽  
Author(s):  
Noha Hassuna ◽  
Ebtesam Elgezawy ◽  
Suzan Mousa ◽  
Reem AbdelAziz ◽  
Reham Ibrahem ◽  
...  
Keyword(s):  
Critically Ill ◽  
Ventilatory Support ◽  
Mannose Receptor ◽  
Diagnostic Value ◽  
Critically Ill Children ◽  
Suspected Sepsis ◽  
Discriminative Performance ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein

Background: The differentiation between systemic inflammatory response syndrome (SIRS) and sepsis, which is sometimes difficult, is very important as it determines essential treatment decisions, such as selection, initiation, and duration of antibiotic therapy. Thus we aimed to investigate the diagnostic value of procalcitonin (PCT), monocyte chemoattractant protein-1 (MCP-1), soluble mannose receptor (sMR), presepsin as early biomarkers of pediatric sepsis in comparison to SIRS in a group of severely ill children. Methods: The study included 58 and 24 children diagnosed as having sepsis and SIRS without infection respectively. All the plasma levels of the studied sepsis biomarkers were measured and ROC curves were created for all the tested parameters to discriminate between sepsis and SIRS. Results: The best discriminative performance was for MCP-1 with AUC of 0.996 (0.986-1.005) with sensitivity 98.3% and specificity 100%. The sMR had the highest sensitivity (100%), with AUC equals 0.952(.0.887-1.017) and specificity of 91.8%. The cut-off values for PCT, presepsin, sMR, and MCP-1 and were: 2.1 ng/ml, 256 pg/ml, 24 ng/ml and 105 pg/ml, respectively. In septic cases, both soluble Mannose Receptor and Procalcitonin have positive correlations with the severity of sepsis (PRISM III), low GCS, ventilatory support, use of inotropic drugs, and mortality rate (r= 0.950, 0.812, 0.795, 0.732 and 0.861respectively) for soluble Mannose Receptor and (0.536, 0.473, 0.422, 0.305 and 0.474 respectively) for Procalcitonin. By the logistic regression analysis, the sMR was the only significant predictor of sepsis. Conclusion: The present study has found that sMR, presepsin, and MCP-1 are new biomarkers that can be used to differentiate between sepsis and SIRS in critically-ill children. These findings may direct clinicians in their practical decision-making and complex management of severely-ill children who need much interference in short time.

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