Prevalence of Respiratory Symptoms, Bronchial Asthma and Obstructive Lung Disease among Tannery Workers

Background/Aims: The widespread use of inhaled corticosteroids (ICS) for the treatment of obstructive lung disease may be associated with both systemic and local side effects. These local side effects; including voice problems, oropharyngeal candidiasis, throat clearing, sense of fullness, pharyngitis, and cough, are generally viewed as minor complications of therapy in what is called steroid inhaler laryngitis (SIL). Few studies have been performed to specifically evaluate local side effects of ICS. However, they can be clinically significant, affect patient's quality of life, hinder compliance with therapy, and mask symptoms of more serious disease. The aim of this study is to examine the effect of ICS on the larynx and subsequent voice changes, and highlighting if these voice problems related to the type of inhaled corticosteroids in order to determine the importance of regular laryngeal examination in those patients. Methods: 40patients with bronchial asthma and 40 patients with COPD admitted to Chest department in Menoufia and Zagazig University Hospitals during the period from March 2017 to March 2019 were included in the study. They were divided according to the type of cortisone used into four groups; group (I): beclomethasone dipropionate (BDP) users, group (II): budesonide (BUD) users, group (III): Ciclesonide users and group (IV): fluticasone propionate (FP) users. They were evaluated as regards videolaryngoscopic examination and acoustic analysis Results: The age of the patients with bronchial asthma ranged from 29 to 42years and the age of the patients with COPD ranged from 31 to 43years. There was a statistically significant difference among the four groups of cortisone inhalation regarding laryngoscopic findings; as presence of congestion (diffuse and local), mucus spills on VF and glottis gap were all higher in frequency among the group of patients used fluticasone FP, while least signs found among ciclesonide users. Also, average pitch, Jitter, H/N ratio and MPT were more worsen in fluticasone group when compared with Ciclesonide group. Conclusion: obstructive lung disease patients may suffer from voice problems related to the type of inhaled corticosteroids that could be fade when therapy is stopped. So, regular laryngeal examination in those patients is important.

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Underdiagnosis of obstructive lung disease: findings from the French CONSTANCES cohort

BMC Pulmonary Medicine ◽

10.1186/s12890-021-01688-z ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Marie-Christine Delmas ◽

Laetitia Bénézet ◽

Céline Ribet ◽

Yuriko Iwatsubo ◽

Marie Zins ◽

...

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Lung Disease ◽

Pulmonary Disease ◽

Obstructive Lung Disease ◽

Respiratory Symptoms ◽

Tobacco Consumption ◽

Population Based ◽

Airflow Limitation ◽

Chronic Obstructive ◽

Obstructive Pulmonary Disease

Abstract Background The burden of undiagnosed obstructive lung disease (OLD) (mainly asthma and chronic obstructive pulmonary disease) is not fully established, and targets for corrective action are yet to be identified. We assessed the underdiagnosis of OLD and its determinants in France. Methods CONSTANCES is a French population-based cohort of adults aged 18–69 years at inception. We analysed data collected at inclusion in 2013–2014. Undiagnosed OLD was defined as spirometry-confirmed airflow limitation (FEV1/FVC < lower limit of normal) without prior diagnosis of asthma, chronic obstructive pulmonary disease, or bronchiectasis. Multivariate analysis was performed with weighted robust Poisson regression models to estimate the adjusted prevalence ratios (aPR) of undiagnosed OLD. Results Spirometry results were available for 19,398 participants. The prevalence of airflow limitation was 4.6%. Overall, 64.4% of adults with airflow limitation did not report a previous diagnosis of OLD. Individuals with high cumulative tobacco consumption (≥ 10 pack-years) (aPR: 1.72 [1.28–2.32]), without respiratory symptoms (aPR: 1.51 [1.28–1.78]), and with preserved lung function (aPR: 1.21 [1.04–1.41] for a 10-point increase in FEV1% predicted) had a higher risk of being undiagnosed. Half of symptomatic individuals with airflow limitation (45% of those with moderate to severe airflow limitation) were undiagnosed with OLD. Conclusion Underdiagnosis of OLD is very common among French adults, even in patients with respiratory symptoms. Efforts should be made in France to raise awareness about OLD in the general population, improve the detection of respiratory symptoms, and increase the use of spirometry among primary care professionals.

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The Relationship between Respiratory Symptoms, Obstructive Lung Disease, and Health Related Quality of Life in the ECRHS.

10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a4070 ◽

2009 ◽

Author(s):

M Voll-Aanerud ◽

TM Eagan ◽

E Plana ◽

ER Omenaas ◽

PS Bakke ◽

...

Keyword(s):

Quality Of Life ◽

Lung Disease ◽

Obstructive Lung Disease ◽

Respiratory Symptoms ◽

Health Related Quality ◽

Related Quality ◽

Health Related ◽

The Relationship

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Physiology and Morphology of Bronchiolitis

PEDIATRICS ◽

10.1542/peds.33.5.792 ◽

1964 ◽

Vol 33 (5) ◽

pp. 792-792

Author(s):

J. J. ROBBINS

Keyword(s):

Lung Disease ◽

Bronchial Asthma ◽

Obstructive Lung Disease ◽

Flow Volume ◽

Outflow Resistance ◽

Pressure Flow ◽

Expiratory Phase ◽

Infancy And Childhood

I was very much interested in Dr. Ingeborg Krieger's excellent study of pressure-flow-volume relationships in acute infantile bronchiolitis, published in Pediatrics, 33:45, 1964. I am wondering if Dr. Krieger is acquainted with the recently published studies by Engel of the anatomy of the bronchiolar tree in infancy and childhood which might well provide an explanation for the seemingly paradoxical lack of rise in outflow resistance and prolongation of expiratory phase as is characteristic of other obstructive lung disease as bronchial asthma.

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