Protective Effect of Korean Red Ginseng against 6-Hydroxydopamine-induced Nitrosative Cell Death via Fortifying Cellular Defense System

Yakhak Hoeji ◽  
2016 ◽  
Vol 60 (2) ◽  
pp. 92-99
Author(s):  
Chan Lee ◽  
◽  
Jung-Hee Jang ◽  
Gyu Hwan Park ◽  
◽  
...  
Keyword(s):  
Cell Death ◽  
Protective Effect ◽  
Red Ginseng ◽  
Defense System ◽  
Korean Red Ginseng ◽  
Cellular Defense ◽  
6 Hydroxydopamine

scholarly journals Protective effect of Korean red ginseng on oxaliplatin-mediated splenomegaly in colon cancer

2018 ◽  
Vol 95 (3) ◽  
pp. 161
Author(s):  
Jeonghyun Kang ◽  
Joon Seong Park ◽  
Sung Gwe Ahn ◽  
Jin Hong Lim ◽  
Seung Hyuk Baik ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Protective Effect ◽  
Red Ginseng ◽  
Korean Red Ginseng

scholarly journals Protective effect of Korean Red Ginseng against glucocorticoid-induced osteoporosis in vitro and in vivo

2015 ◽  
Vol 39 (1) ◽  
pp. 46-53 ◽  
Author(s):  
Jinhee Kim ◽  
Hyejin Lee ◽  
Ki Sung Kang ◽  
Kwang-Hoon Chun ◽  
Gwi Seo Hwang
Keyword(s):  
Protective Effect ◽  
Red Ginseng ◽  
Korean Red Ginseng

scholarly journals Protective Effect of Korean Red Ginseng Extract on the Infections by H1N1 and H3N2 Influenza Viruses in Mice

2012 ◽  
Vol 15 (10) ◽  
pp. 855-862 ◽  
Author(s):  
Dae-Goon Yoo ◽  
Min-Chul Kim ◽  
Min-Kyung Park ◽  
Jae-Min Song ◽  
Fu-Shi Quan ◽  
...  
Keyword(s):  
Protective Effect ◽  
Influenza Viruses ◽  
Red Ginseng ◽  
Korean Red Ginseng ◽  
Ginseng Extract ◽  
H3n2 Influenza

scholarly journals Protective effect of Korean Red Ginseng extract against Helicobacter pylori-induced gastric inflammation in Mongolian gerbils

2014 ◽  
Vol 38 (1) ◽  
pp. 8-15 ◽  
Author(s):  
Minkyung Bae ◽  
Sungil Jang ◽  
Joo Weon Lim ◽  
Jieun Kang ◽  
Eun Jung Bak ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Protective Effect ◽  
Mongolian Gerbils ◽  
Red Ginseng ◽  
Korean Red Ginseng ◽  
Ginseng Extract

scholarly journals Induction of Thioredoxin Reductase 1 by Korean Red Ginseng Water Extract Regulates Cytoprotective Effects on Human Endothelial Cells

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Hye Rim Park ◽  
Seung Eun Lee ◽  
Hana Yang ◽  
Gun Woo Son ◽  
Young-Ho Jin ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Cell Death ◽  
Umbilical Vein ◽  
Water Extract ◽  
Thioredoxin Reductase ◽  
Vascular Diseases ◽  
Protective Effects ◽  
Red Ginseng ◽  
Korean Red Ginseng ◽  
Thioredoxin Reductase 1

Korean Red Ginseng is a popular herbal medicine and is widely used in many food products. KRG has biological benefits related to vascular diseases including diabetes, hypertension, atherosclerosis, and other cardiac diseases and KRG has antioxidant and anti-hyperlipidemic actions. KRG decreases the level of oxidative stress and suppresses proinflammatory cytokines and cell adhesion molecules, thus protecting endothelial dysfunction. Mammalian Thioredoxin reductase 1 is an NADPH-dependent selenoprotein, essential for antioxidant defense and DNA synthesis and repair, that regulates the redox system by modulating redox-sensitive transcription factors and thiol-containing proteins. Here, we show that KRG water extract increases the expression of TrxR1 in human umbilical vein endothelial cells via the p38 and PKC-δsignaling pathways. The induction of TrxR1 expression by KRG was confirmed by Western blot analysis and reverse transcription polymerase chain reaction. However, the increase in TrxR1 expression was abolished by specific silencing of the p38 and PKC-δgenes. In addition, we demonstrated that auranofin, a TrxR1 inhibitor, weakens the protective effect of KRG against H2O2-induced cell death as measured by the terminal transferase dUTP nick end labeling assay. These results suggest that KRG may have protective effects in vascular diseases by upregulating TrxR1 in endothelial cells, thereby inhibiting the generation of reactive oxygen species and cell death.

Protective effect of Korean red ginseng extract on cisplatin ototoxicity in HEI-OC1 auditory cells

2009 ◽  
pp. n/a-n/a ◽  
Author(s):  
Gi Jung Im ◽  
Ji Won Chang ◽  
June Choi ◽  
Sung Won Chae ◽  
Eun Ju Ko ◽  
...  
Keyword(s):  
Protective Effect ◽  
Red Ginseng ◽  
Korean Red Ginseng ◽  
Ginseng Extract
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