Effects of Dietary Supplementation with Allium hookeri Root on the Antioxidant Enzyme Activities in Streptozotocin-Induced Diabetic Rats

2018 ◽  
Vol 28 (3) ◽  
pp. 179-187
Author(s):  
Myung-Wha Kim ◽  
Hye Kyoung Han
Keyword(s):  
Antioxidant Enzyme ◽  
Enzyme Activities ◽  
Dietary Supplementation ◽  
Diabetic Rats ◽  
Antioxidant Enzyme Activities ◽  
Allium Hookeri

Effect of Carnosine on Renal Function, Oxidation and Glycation Products in the Kidneys of High-Fat Diet/Streptozotocin-Induced Diabetic Rats

2017 ◽  
Vol 125 (05) ◽  
pp. 282-289 ◽  
Author(s):  
Abdurrahman Fatih Aydın ◽  
Canan Küçükgergin ◽  
İlknur Bingül ◽  
Işın Doğan-Ekici ◽  
Semra Doğru-Abbasoğlu ◽  
...  
Keyword(s):  
Renal Function ◽  
Antioxidant Enzyme ◽  
Enzyme Activities ◽  
High Fat Diet ◽  
Protein Carbonyl ◽  
Diabetic Rats ◽  
Oxidation Products ◽  
Antioxidant Enzyme Activities ◽  
High Fat ◽  
Antioxidant Power

Abstract High fat diet (HFD) and low dose of streptozotocin (STZ)-treated rats provide an animal model for type 2 Diabetes Mellitus (T2DM). Oxidative stress plays a role in the development of diabetic complications. Carnosine (CAR) has antioxidant and antiglycating properties. We investigated effects of CAR on renal function, oxidation and glycation products in HFD+STZ-rats. Rats were fed with HFD (60% of total calories from fat) for 4 weeks and then a single dose STZ (40 mg/kg; i.p.) was applied. Rats with blood glucose levels above 200 mg/dL were fed with HFD until the end of the 12th week. CAR (250 mg/kg body weight; i.p.; 5 times a week) was administered to rats for the last 4 weeks. Glycated hemoglobin (HbA1c), glucose, lipids, and andrenal function tests in serum as well as reactive oxygen species, malondialdehyde, protein carbonyl, advanced oxidation protein products, advanced glycation end products (AGEs), antioxidant power, and antioxidant enzyme activities and their mRNA expressions in kidneys were determined. CAR treatment did not alter glucose and HbA1c, but it decreased serum lipids, creatinine, and urea levels in HFD+STZ rats. Oxidation products of lipids and proteins and AGEs levels decreased, but antioxidant enzyme activities and their mRNA expressions remained unchanged due to CAR treatment. Our results indicate that CAR treatment alleviated renal function and decreased accumulation of oxidation and glycation products in kidneys in HFD+STZ-rats.

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